Abstract: A method and composition for the topical application of a yohimbine or derivative or stereoisomer thereof, or effective .alpha..sub.2 -antagonists, skin for inhibiting melanogenesis in the skin leading to skin lightening. The yohimbine may be provided as a natural extract, for example, as an extract of Johimbe bark.

Abstract: Nanoparticulate crystalline therapeutic substances formulated with stabilizers and pharmaceutically acceptable clays to enhance contact between the crystalline therapeutic substances and the gastrointestinal tract and to provide extended therapeutic effect.

Abstract: Phosphate-binding polymers are provided for removing phosphate from the gastrointestinal tract. The polymers are orally administered, and are useful for the treatment of hyperphosphatemia.

Abstract: Directly compressible, wax-containing granules having improved flow properties are obtained when waxes are admixed in the melt with certain flow improving additives, followed by cooling and granulation of the admixture. In certain embodiments of the invention, only the wax itself melts in the melt combination of the wax(es) and additives(s), and in other cases both the wax(es) and the additives(s) will both melt. In either case, the melt combination of the wax(es) with the additive(s) yields, upon cooling and granulation, a wax-containing particulate drug diluent having improved and unexpected flow properties.

Abstract: A method for increasing fertility in males with impairment of testosterone synthesis, comprising the step of injecting slow-release microcapsules or microspheres containing testosterone directly into the testes. The testosterone-laden microcapsules or microspheres act as temporary Leydig cells and release testosterone directly into the testicular parenchyma and maintain high intratesticular concentrations of testosterone needed for spermatogenesis.