Patents Examined by Ja-Na A. Hines
  • Molecular biology tools for algal engineering
    Patent number: 9018013
    Abstract: The present invention provides compositions and methods for the genetic manipulation of Algal cells. The compositions and methods allow enhanced transfer of genetic material into Algal cells and the cloning and selection of genetically modified cells. Expression of proteins encoded by the genetic material will be enhanced by the methods and compositions of the invention.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: April 28, 2015
    Assignee: Life Technologies Corporation
    Inventors: Farzad Haerizadeh, Todd Peterson, Wen Chen, Ewa Lis
  • Cell wall components of enterococci and uses thereof
    Patent number: 9005622
    Abstract: The present invention relates to enterococcal cell wall components and their uses in the prevention and therapy of bacterial infection.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: April 14, 2015
    Assignees: Forschungszentrum Borstel, Universitätsklinikum Freiburg
    Inventors: Johannes Hübner, Christian Theilacker, Otto Holst, Zbigniew Kaczynski
  • Method for purification of colistin and purified colistin components
    Patent number: 9005990
    Abstract: The present invention concerns a method of purifying colistin using reverse phase chromatography, wherein loading a column with colistin base in acetic acid and high ethanol concentration and eluting with low ethanol concentration is performed.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: April 14, 2015
    Assignee: Xellia Pharmaceuticals APS
    Inventors: Torben Koch, Carsten Overblle Petersen
  • Polypeptides having cellobiohydrolase I activity and polynucleotides encoding same
    Patent number: 8993299
    Abstract: The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: March 31, 2015
    Assignee: Novozymes A/S
    Inventors: Lene Lange, Wenping Wu, Dominique Aubert, Sara Landvik, Kirk Matthew Schnorr, Ib Groth Clausen
  • Combinations of gene deletions for live attenuated vaccine strains
    Patent number: 8986708
    Abstract: Shigella vaccine strains whose primary attenuating feature is deletion of the virG(icsA) gene and additional two or more deletions in setAB(shET1), senA(shET2), senB(shET2-2), stxAB, and msbB2 genes. Thus, the vaccine strain will have three or more deletions in the identified genes, will be safer, and will reduce or eliminate symptoms of fever and diarrhea in humans. The following specific vaccine strains have been constructed: WRSS3 (?senA, ?senB, ?virG, ?msbB2), WRSf2G15 (?virG, ?setAB, ?senA, ?senB, ?msbB2), and WRSd5 (?virG, ?stxAB, ?senA, ?senB, ?msbB2).
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: March 24, 2015
    Assignee: The United States of America as represented by the Secretary of the Army, on behalf of the Walter Reed Army Institute of Research
    Inventors: Malabi M. Venkatesan, Ryan T. Ranallo, Shoshana Barnoy
  • Polypeptides having cellobiohydrolase I activity and polynucleotides encoding same
    Patent number: 8986969
    Abstract: The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: March 24, 2015
    Assignee: Novozymes A/S
    Inventors: Lene Lange, Wenping Wu, Dominique Aubert, Sara Landvik, Kirk Matthew Schnorr, Ib Groth Clausen
  • Peptide sequences and compositions
    Patent number: 8986703
    Abstract: Provided is a polypeptide composition comprising one or more polypeptides, which polypeptides are immunogenic in a vertebrate such that they cause the vertebrate to produce immune system cells capable of recognizing at least one epitope from an arthropod saliva protein fraction, wherein the arthropod saliva protein fraction has a mass of 40 kDA or less, and wherein the polypeptides are selected independently from: the polypeptide sequences of SEQ ID 1-44 or sub-sequences from these sequences, the sub-sequences having 7 amino acids or more; or from polypeptide sequences having 85% homology or more with one or more of the above sequences and contained in one or more of the following databases: GenBank, Protein Data Bank (PDB), SwissProt, Protein Information Resource (PIR), Protein Research Foundation (PRF), or CDS translations of these.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: March 24, 2015
    Assignee: PepTcell, Ltd.
    Inventors: Gregory Alan Stoloff, Wilson Romero Caparros-Wanderley
  • Device and method for isolating cells, bioparticles and/or molecules from liquids
    Patent number: 8969073
    Abstract: The invention describes an appliance and a method, with the help of which specific bio-particles, but also dissolved bio-molecules can be recognized in and separated from fluids making use of suitable carriers and known immobilization methods. The appliance can be used both discontinuously and also for direct and continuous treatment of fluids. Fields of application of the invention are animals, bio-technology (including biological research) and medicinal diagnostics. Areas of application of the invention comprise, among others, therapy of humans, in particular direct treatment of blood.
    Type: Grant
    Filed: January 30, 2007
    Date of Patent: March 3, 2015
    Assignee: pluriSelect GmbH
    Inventor: Hans Werner Heinrich
  • Non-heating detection method for dermatophyte
    Patent number: 8962264
    Abstract: The present invention provides a method of detecting dermatophyte, which does not require a complicated operation such as an enzyme treatment and a heat treatment. The present invention provides a method of detecting dermatophyte, including a step of extracting a dermatophyte component from a sample with a treatment liquid containing a non-ionic surfactant or a zwitterionic surfactant, and a kit for diagnosing dermatophyte infection, containing a treatment liquid comprising the above surfactant, and an antibody specifically recognizing a dermatophyte component, which are housed in separate containers.
    Type: Grant
    Filed: March 19, 2007
    Date of Patent: February 24, 2015
    Assignees: National University Corporation University of Fukui, JNC Corporation
    Inventor: Sakon Noriki
  • A25 bacteriophage lysin
    Patent number: 8951532
    Abstract: The invention relates to the identification, sequencing, and isolation of an A25 bacteriophage lysin gene that expresses a protein involved in the lysis of bacterial cells during the phage life cycle. The invention further relates to methods for lysing certain bacteria using lysin, which are useful for example in a diagnostic procedure designed to detect these bacteria.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: February 10, 2015
    Assignee: Alere Scarborough, Inc.
    Inventors: Brion Mermer, William J. Palin, Nancy Turcotte
  • Modified pneumonia pneumolysin (PLY) polypeptides
    Patent number: 8951531
    Abstract: This disclosure relates to modified Streptococcus pneumonia pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against invasive pneumococcol diseases caused by S. pneumonia The modified pneumolysm proteins comprise amino acid substitutions at threonine 65, glycine 293 and cysteine 428 Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: February 10, 2015
    Assignee: The Kingdom of the Netherlands, Represented by the Minister of Health, Welfare and Sport, on Behalf of the Minister, The National Institute of Public Health and the Environment
    Inventors: Eliud Oloo, Raymond Oomen, Martina Ochs-Onolemhemhen, Jeremy Yethon
  • Synthetic lipid biology for combinatorial engineering of endotoxin
    Patent number: 8945587
    Abstract: The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure relates to genetic engineering of Gram-negative bacteria expressing different species of lipid A on their surface. In one embodiment, the present disclosure provides for an engineered strain of E. coli according to Table 1. In another embodiment, the present disclosure provides for a lipopolysaccharide purified from an engineered strain of E. coli according to Table 1.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: February 3, 2015
    Assignee: The Board of Regents of The University of Texas System
    Inventors: M. Stephen Trent, Brittany Needham, David Giles, Marvin Whiteley
  • Methods for purification of bacterial cells and cell components
    Patent number: 8932580
    Abstract: The present invention relates to a method for the selective purification of bacterial cells and/or cell components, whereby the purification is performed by means of a solid support.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: January 13, 2015
    Assignees: Hyglos Invest GmbH, Biomerieux S.A.
    Inventors: Michael Schutz, Renate Grassl, Roman Meyer, Sibylle Frick, Ingrid Robl, Thomas Zander, Stefan Miller
  • Chimera comprising bacterial cytotoxin and methods of using the same
    Patent number: 8920809
    Abstract: This invention provides, a recombinant polypeptide encoding a chimera. The chimera includes a DNase I fragment or a homologue thereof and a Cdt fragment or a homologue thereof. Further, the invention provides methods, utilizing the recombinant polypeptide encoding the chimera, such as a method for inhibiting the proliferation of a neoplastic cell, a method for treating a neoplastic disease in a human subject, a method for inhibiting or suppressing a neoplastic disease in a human subject, and a method for reducing the symptoms associated with a neoplastic disease in a human subject.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: December 30, 2014
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Joseph M. Dirienzo
  • Health-beneficial preparation and production method
    Patent number: 8921060
    Abstract: The invention relates to the area of health-beneficial preparations and production methods thereof, in particular to the use of thermally pre-treated Lactobacillus preparations having specific bonding capacity for Streptococcus mutans for caries prophylaxis. The invention further relates to the Lactobacillus preparations and thermal pasteurization.
    Type: Grant
    Filed: October 11, 2010
    Date of Patent: December 30, 2014
    Assignee: BASF SE
    Inventor: Bryan Cooper
  • Botulinum neurotoxin antigenic compositions and methods
    Patent number: 8916162
    Abstract: Methods and compositions pertaining to botulinum neurotoxin (BoNT) light chain epitopes are provided. In particular, the methods and compositions relate to the use of real and mimetic BoNT light chain epitopes for generating an immune response in a subject, and for immunization against BoNT toxicity. Methods and compositions for detecting, isolating, and purifying BoNT epitopes and anti-BoNT antibodies are also provided.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: December 23, 2014
    Inventor: Alexey Gennadievich Zdanovsky
  • Method for constructing novel bacterium belonging to the genus
    Patent number: 8889120
    Abstract: A method for producing bacteria belonging to the genus Bifidobacterium having excellent viability even under various conditions with different environmental factors, novel bacteria belonging to the genus Bifidobacterium obtained by the method, and a method for detecting the bacteria are provided. By subculturing and storing bacteria belonging to the genus Bifidobacterium alternately in systems under conditions with different environmental factors, the bacteria belonging to the genus Bifidobacterium exhibiting excellent viability under all the conditions used for the alternate subculturing and storing can be produced.
    Type: Grant
    Filed: February 21, 2011
    Date of Patent: November 18, 2014
    Assignee: Kabushiki Kaisha Yakult Honsha
    Inventors: Tomoyuki Sako, Mika Miura, Yasuhisa Shimakawa, Koji Miyazaki, Junji Fujimoto, Koichi Watanabe
  • Bacterium comprising a regulated nucleic acid
    Patent number: 8889121
    Abstract: The present invention encompasses a recombinant bacterium comprising a regulated rfaH nucleic acid, as well as a vaccine comprising said recombinant bacterium. Other embodiments of the present invention encompass a recombinant bacterium comprising a regulated rfaH nucleic acid and a regulated rfc nucleic acid, while additional embodiments encompass a recombinant bacterium comprising a regulated rfaH nucleic acid and at least one nucleic acid encoding at least one exogenous antigen.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: November 18, 2014
    Assignee: The Arizona Board of Regents for an on Behalf of Arizona State University
    Inventors: Roy Curtiss, III, Qingke Kong
  • antigens for vaccine and diagnostic use
    Patent number: 8889142
    Abstract: The present invention is related to antigen from Chlamydia trachomatis which are recognized by specific antibodies from individuals infected with Chlamydia or which can induce T cells from the same individuals to secrete gamma-interferon. The T cell reactive antigens are present in a whole-cell lysate and have apparent molecular weights of 5-12, 16-20, 25-35 and 58-74 kDa as determined by SDS-PAGE. The antigens of the invention are believed to be useful in vaccines but also as diagnostic compositions.
    Type: Grant
    Filed: October 11, 2005
    Date of Patent: November 18, 2014
    Assignee: Statens Serum Institut
    Inventors: Michael Theisen, Anja Olsen, Robert Leah, Frank Follmann, Klaus Jensen, Peter Andersen
  • Active antiangiogenic therapy
    Patent number: 8883724
    Abstract: Application of oligonucleotide and polypeptide sequences of molecules of the family of the vascular permeability factor (VPF), their receptors, and co-receptors, as well as their modifications, in the active immunotherapy of pathologic entities in which course is associated to the increase of angiogenesis. These procedures can be employed in the single or combined therapy for the treatment of cancer and its metastasis, acute and chronic inflammatory processes, infectious diseases, autoimmune diseases, diabetic and newborn retinopathies, organ transplant rejection, macular degeneration, neovascular glaucoma, hemangioma, and angiofibroma, among others.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: November 11, 2014
    Assignee: Centro de Ingenieria Genética y Biotecnologia
    Inventors: Mónica Bequet Romero, Boris Ernesto Acevedo Castro, Jorge Victor Gavilondo Cowley, Luis Enrique Fernández Molina, Omar Lopez Ocejo, Ricardo de la Caridad Silva Rodriguez, Alexis Musachio Lasa, Ernesto Galban Rodriguez, Dania Marcia Vásquez Blomquist