Patents Examined by Ja-Na Hines
  • Patent number: 6290959
    Abstract: Uroplakins Ia and Ib are the major urothelial receptors of type 1 fimbriated microorganisms. These uroplakins are used to screen compounds for treating urinary tract infections by testing if the compounds inhibit bacterial adhesion to the uroplakins. Additionally, compounds which inhibit adhesion of microorganisms expressing type 1 fimbriae, such as Tamm-Horsfall protein, are used to treat or inhibit infection by these microorganisms.
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: September 18, 2001
    Assignee: New York University
    Inventors: Xue-Ru Wu, Tung-Tien Sun
  • Patent number: 6274327
    Abstract: This invention relates to new polypeptides which exhibit kinase activity or, more specifically, which show phosphoinositide (PI) 3-kinase activity. Such polypeptides are involved in pathways responsible for cellular growth and differentiation. An isolated polypeptide which possesses PI3-kinase activity when produced by recombinant production in insect cells is disclosed.
    Type: Grant
    Filed: May 27, 1998
    Date of Patent: August 14, 2001
    Assignee: Ludwig Institute for Cancer Research
    Inventors: Ian D. Hiles, Michael J. Fry, Ritu Dhand, Michael D. Waterfield, Peter J. Parker, Masayuki Otsu, George Panayoutou, Stefano Volinia, Ivan Gout
  • Patent number: 6248325
    Abstract: The present invention provides a human glutathione s-transferase (HGST) and polynucleotides which identify and encode HGST. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HGST and a method for producing HGST. The invention also provides for agonists, antibodies, or antagonists specifically binding HGST, and their use, in the prevention and treatment of cancer and other diseases associated with the expression of HGST. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HGST for the treatment of cancer and other diseases associated with the expression of HGST. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HGST.
    Type: Grant
    Filed: May 11, 1999
    Date of Patent: June 19, 2001
    Assignee: Incyte Genomics
    Inventors: Surya K. Goli, Jennifer L. Hillman
  • Patent number: 6242268
    Abstract: Homogeneous assays for determining quantitatively the extent of a specific binding reaction can be carried out effectively on very dilute solutions using measurements of fluorescence if a fluorescence measurement scheme that is capable of rejecting short-lived background fluorescence is employed and if the fluorescent group being measured has the following properties: a. the group being measured must be a rare earth metal chelate complex combination; b. the chelate must be water-soluble; c. the complex combination must also be stable in extremely dilute aqueous solutions, that is, the measured chelate must have at least one ligand having a metal-to-ligand binding constant of at least about 1013M−1 or greater and it must have a fluorescent emission that is long-lived compared to the longest decay lifetime of ambient substances and have a half life of from 0.01 to 50 msec.
    Type: Grant
    Filed: November 2, 1998
    Date of Patent: June 5, 2001
    Assignee: EG&G Wallac
    Inventors: Irwin Wieder, Ron L. Hale
  • Patent number: 6232080
    Abstract: The present invention concerns a method of treating LBP-mediated LPS-induced myeloid cell activation comprising administering a therapeutically effective amount of an anti-LBP monoclonal antibody molecule. A therapeutic composition comprising anti-LBP antibody molecules in a pharmaceutically acceptable excipient is also contemplated.
    Type: Grant
    Filed: May 19, 1998
    Date of Patent: May 15, 2001
    Assignee: The Scripps Research Institute
    Inventors: Theo Kirkland, Peter Tobias, Richard Ulevitch, Ann Moriarty, Didier Leturcq
  • Patent number: 6207157
    Abstract: A conjugate vaccine for Nontypeable Haemophilus influenzae comprising lipooligosaccharide from which esterified fatty acids have been removed conjugated to an immunogenic carrier. The vaccine is useful for prevention of otitis media and respiratory infections in mammals.
    Type: Grant
    Filed: April 23, 1997
    Date of Patent: March 27, 2001
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Xin-Xing Gu, Chao-Ming Tsai, David J. Lim, John B. Robbins
  • Patent number: 6197599
    Abstract: A device comprises a solid support and multiple immobilized agents for protein detection is described. The immobilized agents are mainly proteins, such as antibodies and recombinant proteins. The immobilized agents can be synthesized peptides or other small chemicals. Agents are individually deposited in a predetermined order, so that each of the agents can be identified by the specific position it occupies on the support. The immobilized agents on the solid support retain their protein binding capability and specificity. Methods employing the device are extremely powerful in screening protein expression patterns, protein posttranslational modifications and protein—protein interactions.
    Type: Grant
    Filed: July 30, 1998
    Date of Patent: March 6, 2001
    Inventors: Guorong Chin, Yingyi Wang
  • Patent number: 6183986
    Abstract: Disclosed and claimed is an isolated DNA molecule having a nucleotide sequence encoding substantially pure OspA, as well as vectors containing such DNA, uses of such DNA, and compositions containing such vectors.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 6, 2001
    Assignee: Symbicom Aktiebolag
    Inventors: Sven Bergstrom, Alan G. Barbour, Louis A. Magnarelli
  • Patent number: 6162435
    Abstract: A Mycoplasma hyopneumoniae protein prepared by recombinant DNA or synthetic means, DNA sequences coding for the protein, an expression vector and transformed host containing the DNA sequences, a vaccine based on the protein, a vaccine based on the DNA sequences, methods of treating swine to prevent enzootic pneumonia using the vaccines, and diagnostic tests based on the protein or antibodies raised against it for detecting the presence of Mhyo infection in swine herds.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: December 19, 2000
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: F. Chris Minion, Tsungda Hsu
  • Patent number: 6159469
    Abstract: The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.
    Type: Grant
    Filed: October 30, 1997
    Date of Patent: December 12, 2000
    Assignee: Human Genome Sciences, Inc.
    Inventors: Gil H. Choi, Charles A. Kunsch, Steven C. Barash, Patrick J. Dillon, Brian Dougherty, Michael R. Fannon, Craig A. Rosen
  • Patent number: 6143505
    Abstract: The instant invention provides for the identification, diagnosis, monitoring, and treatment of invasive cells using the laminin 5 gamma-2 chain protein or nucleic acid sequence, or antibodies thereto.
    Type: Grant
    Filed: February 18, 1997
    Date of Patent: November 7, 2000
    Inventors: Karl Tryggvason, Pekka Kallunki, Charles Pyke
  • Patent number: 6143537
    Abstract: A method for stabilizing analyses with antibodies and antibody fragments comprises dissolving the analyte in a liquid to form a solution, adding analyte-specific antibodies, fragments of such antibodies, or both to the solution, heating the solution, and then cooling and filtering the solution. The filtered solution may be diluted in a suitable matrix.
    Type: Grant
    Filed: January 5, 1999
    Date of Patent: November 7, 2000
    Assignee: Medical Analysis Systems, Inc.
    Inventors: Shing F. Kwan, Ivan E. Modrovich, Rebecca J. Hunt
  • Patent number: 6139831
    Abstract: Apparatus and method for immobilizing molecules, particularly biomolecules such as DNA, RNA, proteins, lipids, carbohydrates, or hormones onto a substrate such as glass or silica; patterns of immobilization can be made resulting in addressable, discrete arrays of molecules on a substrate, having applications in bioelectronics, DNA hybridization assays, drug assays, etc.
    Type: Grant
    Filed: May 28, 1998
    Date of Patent: October 31, 2000
    Assignee: The Rockfeller University
    Inventors: Ganaganor Visweswara Shivashankar, Albert J. Libchaber
  • Patent number: 6140044
    Abstract: A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.
    Type: Grant
    Filed: September 14, 1995
    Date of Patent: October 31, 2000
    Assignee: Affymetrix, Inc.
    Inventors: Donald M. Besemer, Virginia W. Goss, James L. Winkler
  • Patent number: 6132977
    Abstract: SNAP-25 (synaptosomal associated protein) is purified from cerebrospinal or amniotic fluid for immunoassay and quantitation. Quantitation of these proteins is useful in the diagnosis and monitoring of brain disorders and diseases such as schizophrenia and Alzheimer's.
    Type: Grant
    Filed: March 13, 1998
    Date of Patent: October 17, 2000
    Assignee: University of New Mexico
    Inventors: Peter M. Thompson, Nora Perrone-Bizzozero
  • Patent number: 6117641
    Abstract: The present invention relates to rapid, reliable and effective assays for screening and identifying pharmaceutically effective compounds that specifically inhibit the biological activity of fungal GTPase proteins, particularly GTPases involved in cell wall integrity, hyphael formation, and/or other cellular functions critical to pathogenesis.
    Type: Grant
    Filed: April 11, 1996
    Date of Patent: September 12, 2000
    Assignees: Mitotix, Inc., The John Hopkins University
    Inventors: Vivian Berlin, David E. Levin, Yoshikazu Ohya
  • Patent number: 6117421
    Abstract: A process for the detection of cpn10 in serum or other biological fluids including the steps of (i) raising antibody to cpn10; (ii) reacting said antibody with a sample of biological fluid suspected of containing cpn10; and (iii) detecting the presence of cpn10 in said sample by a signal amplification resulting from production of a cpn10-antibody complex. There is also provided a process for promotion of cell growth or immunosuppression including the step of administration of cpn10 to a mammalian subject. There is also provided recombinant cpn10.
    Type: Grant
    Filed: May 29, 1996
    Date of Patent: September 12, 2000
    Assignee: The University of Queensland
    Inventors: Halle Morton, Alice Christina Cavanagh
  • Patent number: 6111080
    Abstract: A monoclonal antibody which specifically reconizes a receptor that binds to proteins that contain the amino acid sequence Arg-Gly-Asp which on binding said proteins causes the cells to become substantially more phagocytic.
    Type: Grant
    Filed: June 8, 1993
    Date of Patent: August 29, 2000
    Assignee: Washington University
    Inventor: Eric J. Brown
  • Patent number: 6106836
    Abstract: The present invention relates to a vaccine container that contains one or more freeze-dried vaccine components. The vaccine component or components are present in two or more freeze-dried bodies, at least one of which is a lyosphere.Furthermore, the invention relates to methods for the preparation of such a vaccine container.Also, the invention relates to a vaccine pack, comprising the vaccine container.
    Type: Grant
    Filed: February 17, 1999
    Date of Patent: August 22, 2000
    Assignee: Akzo Nobel N.V.
    Inventors: Antonius Theodorus Maria Wilderbeek, Hans Almer Middelbeek
  • Patent number: 6040194
    Abstract: An in vivo method and apparatus for detecting an analyte in an individual. A sensor that includes a fluorescence reagent is placed in communication with the body fluids of the individual suspected of containing the analyte in such a way that once in place said sensor does not exit the skin of the individual. The sensor is configured to retain the fluorescence reagent while allowing analyte to diffuse into and out of said sensor. The sensor is illuminated transdermally, and the fluorescence from the fluorescence reagent associated with the presence of the analyte is measured.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 21, 2000
    Assignee: Sensor Technologies, Inc.
    Inventors: William L. Chick, David E. Wolf, Richard A. Cardullo