Patents Examined by Jacob Cheu
  • Compositions and methods for characterizing a myopathy
    Patent number: 8778618
    Abstract: The invention provides compositions, methods, and kits diagnosing, monitoring, and otherwise characterizing a myopathy and for detecting the presence of autoantibodies in a biological sample.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: July 15, 2014
    Assignee: The Johns Hopkins University
    Inventors: Livia Angela Casciola-Rosen, Lisa Christopher-Stine, Andrew Mammen, Antony Rosen
  • Assays for detecting modified compounds
    Patent number: 8778614
    Abstract: Provided are methods and compositions which are useful for separating, isolating, detecting, and quantifying compounds of interest which have been modified chemically, enzymatically or catalytically from other compounds which have not been so modified. The modifications may take the form of functional groups which are gained, lost or retained by the compounds of interest.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: July 15, 2014
    Assignee: Enzo Life Sciences, Inc.
    Inventors: Elazar Rabbani, Joshua Rabbani, Praveen Pande, Jannis G. Stavrianopoulos
  • Health test for a broad spectrum of health problems
    Patent number: 8771962
    Abstract: Provided herein are methods and devices for the detection of conditions or disorders by detecting altered levels of stress response pathway biomarkers. Also provided are methods and reagents for identifying panels of biomarkers associated with a condition or disorder.
    Type: Grant
    Filed: October 2, 2009
    Date of Patent: July 8, 2014
    Inventor: Sarka O. Southern
  • Immuno-PET imaging of antibodies and immunoconjugates and uses therefor
    Patent number: 8771966
    Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: July 8, 2014
    Assignee: Genentech, Inc.
    Inventors: Mark Dennis, Jan Marik, Paul Polakis, Bonnee Rubinfeld, Simon Williams
  • Method of diagnosing Sjogren's disease
    Patent number: 8765387
    Abstract: Provided are methods and compositions for determining whether an individual has Sjögren's disease (SD). The method entails determining in a biological sample from the individual the presence of antibodies directed to salivary gland protein 1 (SP-I), parotid secretory protein (PSP), carbonic anhydrase 6 (C A6), or determining a combination of the antibodies. Determining that the individual has SD is based on the presence of the antibodies. The method provides for detection of early SD. Kits for antibody detection containing the antigens to which the antibodies of SD patients are directed are also provided.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: July 1, 2014
    Assignee: The Research Foundation of State University of New York
    Inventors: Julian L. Ambrus, Long Shen
  • Dual-target biosensor cell assays
    Patent number: 8759013
    Abstract: A method and apparatus, as defined herein, for use in compound screening, compound profiling, or both assays, for example, against two different cellular targets in, for example, a single cell-type.
    Type: Grant
    Filed: October 10, 2012
    Date of Patent: June 24, 2014
    Assignee: Corning Incorporated
    Inventors: Ye Fang, Anthony Glenn Frutos, David Harry Randle, Elizabeth Tran
  • Assay system for determining binding of hydrophobic drugs
    Patent number: 8759011
    Abstract: The invention comprises a method for the determination of the binding coefficient of a hydrophobic chemical compound comprising: g. Providing an assay plate with a plurality of rows and columns of test vessels; h. Providing the majority of the test vessels in said assay plate with a polymer, wherein in each row the amount of polymer coating per test vessel is increased; i. Filling each test vessel with a solution of binding partner to which the binding coefficient should be assayed, wherein in each column the amount of binding partner is increased; j. Adding the hydrophobic compound and incubate the plate; k. Determining the concentration of said compound in said polymer or in the solution; l. Calculating the protein binding coefficient of the compound.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: June 24, 2014
    Assignee: Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO
    Inventor: Wouter Henricus Johannes Vaes
  • Serial multiple antigen colocalization in paraffin-embedded tissue
    Patent number: 8753824
    Abstract: The present invention provides a novel method called Sequential IMmunoPeroxidase Labeling and Erasing (SIMPLE) that enables the simultaneous visualization of at least five markers within a single tissue section. Utilizing the alcohol-soluble peroxidase substrate 3-amino-9-ethylcarbazole (AEC), combined with a rapid non-destructive method for antibody-antigen dissociation, the present application discloses the ability to erase the results of a single immunohistochemical stain while preserving tissue antigenicity for repeated rounds of labeling. The present invention also provides methods for visualizing multiple antigens simultaneously.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: June 17, 2014
    Assignee: University of Virginia Patent Foundation
    Inventors: Jason A. Papin, James W. Mandell, George F. Glass
  • Methods and kits for detecting ITA in a biological sample
    Patent number: 8753825
    Abstract: Methods for detecting invasive trophoblast antigen (ITA) in biological samples comprise screening the samples for ITA using antibodies that bind to the ITA. The methods are useful to detect pregnancy, trophoblastic diseases, and Down's syndrome in fetuses of pregnant women. Some methods include screening the samples with a plurality of capture antibodies that specifically bind ITA. Chemiluminescent immunoassays are disclosed. The methods may be practiced with the diagnostic kits of the invention.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: June 17, 2014
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Murugan R. Pandian, Julie Y. Yu
  • Method for the detection of organ or tissue injury
    Patent number: 8748109
    Abstract: This invention relates to methodology for detecting, assessing and/or diagnosing the presence of organ or tissue injury. More specifically, the present invention relates to methodology for detecting particular serum biomarkers that can be used in the detection, assessment and/or diagnosis of organ (e.g. liver) or tissue (e.g. skin) injury.
    Type: Grant
    Filed: July 5, 2010
    Date of Patent: June 10, 2014
    Assignee: The University of Liverpool
    Inventors: Daniel Antoine, Dominic Williams, Kevin Park
  • Follistatin-like protein-1 as a biomarker for inflammatory disorders
    Patent number: 8741584
    Abstract: The present invention relates to methods and compositions for diagnosis of inflammatory disorders, and in non-limiting embodiments, of inflammatory disorders associated with elevated interleukin-1? (“IL-1?”), based on increased levels of follistatin-like protein 1 (“FSTL-1”). In particular non-limiting embodiments, the invention further provides for methods of identifying subjects with systemic onset juvenile idiopathic arthritis (“SOJIA”) who are at increased risk for developing macrophage activation syndrome (“MAS”) comprising detecting, in said subjects, hyper-increased levels of FSTL-1. In additional non-limiting embodiments, the invention provides for methods of identifying subjects with Kawasaki disease who are at increased risk of developing aortic aneurysms comprising detecting, in said subjects, hyper-increased levels of FSTL-1.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: June 3, 2014
    Assignee: University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: Raphael Hirsch, David C. Wilson
  • Method of identifying compounds that inhibit fertilization
    Patent number: 8741583
    Abstract: A method of identifying compounds that inhibit fertilization is provided. The method can include selecting compounds that bind to equatorin protein. Two types of equatorin protein, a long form and a short form, can be present in the testis. The amino acid sequence of mouse equatorin from positions 101 to 146 including the 138th O-glycosylated threonine residue contains an epitope recognized by anti-equatorin antibody MN9 that has an effect of inhibiting fertilization. In addition, the MN9 antibody also binds to human sperm. Compounds that bind to the epitope can inhibit fertilization. Both forms of mouse equatorin can be used as well as human equatorin to identify compounds that inhibit fertilization.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: June 3, 2014
    Assignee: National University Corporation Chiba University
    Inventors: Kiyotaka Toshimori, Chizuru Ito, Kenji Yamatoya, Keiichi Yoshida
  • Cellular assay employing detectable protein
    Patent number: 8741559
    Abstract: Provided herein are assays useful, for example, for determining the activity of a protein involved in a cellular process. In some embodiments, the activity of the protein is assessed using a nucleic acid tag, and in particular, by detecting the presence of a nucleic acid tag. Such assays can be used, for example, to study the effects of test compounds as modulators, e.g., inhibitors, agonists and antagonists, of protein activity.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: June 3, 2014
    Assignee: DiscoveRx Corporation
    Inventors: Daniel Kelly Treiber, Warren G. Lewis, Lisa M. Wodicka
  • Methods and devices for detecting obstructive uropathy and associated disorders
    Patent number: 8735080
    Abstract: Methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: May 27, 2014
    Assignee: Rules-Based Medicine, Inc.
    Inventors: Samuel T. Labrie, James P. Mapes, Ralph L. McDade, Dominic Eisinger, Karri L. Ballard, Michael D. Spain
  • Method for risk stratification in stable coronary artery disease
    Patent number: 8735079
    Abstract: An in vitro method for the risk stratification of patients with stable arteriosclerosis, especially stable coronary artery disease, is disclosed wherein the concentration of procalcitonin is determined in the circulation of such patients using a highly sensitive PCT assay, and wherein within the range of PCT concentrations in the typical normal range of healthy individuals cutoff values are defined which distinguish groups of individual patients with stable arteriosclerosis in accordance with personal cardiac risk, and patients are allotted to one of said risk groups on the basis of their individual PCT concentrations.
    Type: Grant
    Filed: August 1, 2008
    Date of Patent: May 27, 2014
    Assignee: B.R.A.H.M.S GmbH
    Inventors: Andreas Bergmann, Joachim Struck, Nils G. Morgenthaler, Jana Papassotiriou, Stefan Blankenberg, Karl Lackner, Hans Rupprecht, Christoph Bickel
  • Assay method
    Patent number: 8728800
    Abstract: The invention provides a cassette-based automated assay for homocysteine.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: May 20, 2014
    Assignee: Axis Shield ASA
    Inventors: Frank Frantzen, Arne Ludvig Faaren, Arne Kristian Nordhei
  • Methods for measuring protein content
    Patent number: 8722345
    Abstract: A process for measuring the amount of an antigen in a sample comprising the steps of binding the antigen to a solid phase, forming an antigen-antibody immunocomplex on the solid phase by applying a detection antibody that is specific for the antigen, liberating the detection antibody from the immunocomplex by applying a competing molecule that disrupts the immunocomplex by competing against the antigen for binding to the detection antibody, collecting the liberated detection antibody; and quantifying the liberated detection antibody to measure the amount of the antigen in the sample.
    Type: Grant
    Filed: January 1, 2013
    Date of Patent: May 13, 2014
    Inventor: Jiandi Zhang
  • Risk markers for cardiovascular disease
    Patent number: 8722344
    Abstract: Provided herein methods for determining whether a subject, particularly a human subject, is at risk of developing, having, or experiencing a complication of cardiovascular disease, and methods of treating subjects who are identified by the current methods of being at risk for cardiovascular disease. In one embodiment, the method comprises determining levels of one or more oxidized apolipoprotien A-I related biomolecules in a bodily sample from the subject. Also, provided are kits and reagents for use in the present methods. Also provided are methods for monitoring the status of cardiovascular disease in a subject or the effects of therapeutic agents on subjects with cardiovascular disease. Such method comprising determining levels of one or more oxidized apolipoprotein A-I related molecules in bodily samples taken from the subject over time or before and after therapy.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: May 13, 2014
    Assignee: The Cleveland Clinic Foundation
    Inventors: Stanley L. Hazen, Michael Kinter, Marc S. Penn, Jonathan Smith, Lemin Zheng
  • Methods and devices for rapid and specific detection of multiple proteins
    Patent number: 8709789
    Abstract: A method is provided for detecting multiple analytes via their interactions with reagents. The analytes are immobilized on an analyte support and are divided into subdivisions by a blotting apparatus. Reagents are applied, each to a specific subdivision of the analyte support and binds to the analytes there.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: April 29, 2014
    Assignee: Hypromatrix, Inc.
    Inventor: Yingjian Wang
  • Method for measuring human megalin
    Patent number: 8703430
    Abstract: This invention provides a method for measuring human megalin that can be performed in a simpler manner within a shorter period of time than is possible with conventional techniques, and that can also quantify human megalin. This invention also provides a method that enables diagnosis of functional diseases, which are specific to cells, tissues, or organs, in a site-directed manner at an early stage. Measurement of human megalin enables detection of a disease in an organ in which megalin expression is observed.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: April 22, 2014
    Assignees: Niigata University, Denka Seiken Co., Ltd.
    Inventors: Shinya Ogasawara, Shuhei Miura, Akihiko Saito, Tetsuro Takeda