Abstract: This invention relates to a composition comprising a substantially pure enzyme capable of degrading arabinoxylan and having a molecular weight of about 45,000. More preferably this invention relates to such an enzyme which has a pH optimum between about 6.5 to about 7.0. The enzyme is derived from bacteria capable of hydroloyzing plant cell wall material, preferably from Bacillus most preferably from Bacillus subtilis. This invention further relates to such a composition which is further capable of selectively dissociating feraxan from a maize cell wall preparation. Additionally, compositions of this invention are unable to degrade Rhodymenia (1.fwdarw.3),(1.fwdarw.4)-.beta.-D-xylan and larch arabino-(1.fwdarw.4)-.beta.-D-xylan.
Type:
Grant
Filed:
July 22, 1988
Date of Patent:
September 4, 1990
Assignee:
The Regents of the University of California
Abstract: A preparation for activating hemocytes of bivalves for pearl production containing a mitogen as an effective component, and a method for producing pearl through nucleus insertion operation of a bivalve for pearl production which comprises treating a section of the mantle part of a donor to be inserted with a mitogen.By the treatment with the present preparation, hemocytes of the wound site due to the nucleus insertion operation are activated, tissue growth of the section of the mantle part of the donor is accelerated and a good pearl sac is formed around the nucleus. As a result, the number ejected nuclei is decreased and the pearl quality and production amount are enhanced.These effects are further enhanced by using a mitogen treated with an aluminum adjuvant or the like.
Type:
Grant
Filed:
August 2, 1988
Date of Patent:
September 4, 1990
Assignee:
Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
Abstract: An ointment base for external use is provided which contains a water-soluble protein and monohydric alcohol or/and oleginous substance and additionally contains a wetting agent. The present ointment base offers a markedly improved percutaneous absorption of drugs, as compared with the conventional ointment bases.
Abstract: The invention relates to new peptide derivatives of the general Formula I ##STR1## wherein R is a group derived from any oligopeptide by removing a terminal amino group, or--if the oligopeptide comprises a diamino carboxylic acid--the amino group in the .omega.-position, or the terminal and .omega.-amino groups; andstands for the integral number 1 or 2and acid addition slats thereof and a process for the preparation thereof.The new compounds of the general Formula I exhibit antitumor activity.
Type:
Grant
Filed:
April 19, 1985
Date of Patent:
August 21, 1990
Assignee:
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.
Abstract: A process and nourishing agent for treating and nourishing the scalp and hair to promote conditions for the natural growth of hair on a human head for the reversal of male pattern baldness in individual cases. The process includes the steps of cleansing the scalp and hair, opening the pores and follicles in the scalp and softening and removing clogging deposits from the pores and hair follicles, and then applying to the scalp a nourishing agent comprising a mixture of chalaza extracted from chicken eggs, unflavored powdered gelatin, and aqueous saline solution. In the preferred form of the invention, the pores of the scalp and hair follicles are opened and sanitized by repeated applications of a benzoic acid mixture and heat, and the clogging deposits and foreign matter are softened and separated by the application of a carbamide peroxide solution and heat.
Abstract: New strains of Lactobacillus acidophilus capable of adhering to the tissue cells of various species of animals are described. At least one new strain exhibits calcium-independent attachment which is enhanced by the presence of calcium. The strains may be used in a suitable carrier as a dietary supplement for providing a source of the strain of bacteria in an animal.
Abstract: Dietary compositions, especially cow's milk-based infant formulas, are fortified with bile salt-activated lipase. Methods are provided for feeding newborn and premature infants which include administration of bile salt-activated lipase to increase fat digestion and therefore growth rate. Similarly, a method is provided to treat subjects for inadequate pancreatic enzyme production by administration of bile salt-activated lipase in conjunction with ingestion of fats.
Abstract: A mixture of a substance having thrombolytic activity and of an antithrombotic substance which is suitable for controlling vascular disorders caused by thrombosis is described.
Type:
Grant
Filed:
February 13, 1989
Date of Patent:
July 31, 1990
Assignee:
BASF Aktiengesellschaft
Inventors:
Volker Eschenfelder, Bernhard Schmied, Klaus Ruebsamen
Abstract: A composition comprising LYCD together with known topically active useful medicinal agents such as antiwrinkling, antibiotic, anticancer, antifungal, antiinflammatory, antiviral, steroid, and wound healing agents. The LYCD works together with the other active ingredients to achieve a synergistic result more effective than can be obtained from the topical agents individually, and more effective than could be predicted from the mere addition of the known efficacies of the individual ingredients.
Abstract: The invention relates to a process for the fermentation of carbohydrates by bacteria of the genus Xanthomonas for the production of a polysaccharide of the xanthane type, in which the source of nitrogen consists of a gelatin with a molecular weight of less than 5000.Application: preparation of xanthane.
Abstract: The administration of Somatostatin and growth hormone releasing factor at useful dosage levels alleviates the symptoms of various neuropsychiatric disorders.Growth hormone and neuropsychiatric responses to the administration of growth hormone releasing factor to mammals indicate its usefulness as an antemortem marker for senile dementia of the Alzheimer's type.
Abstract: The method comprises forming a sporocide having a defined period of sporocidal activity comprising three components including a peroxide or peroxide generating material, a peroxidase and a salt of iodide which serves as a donor molecule; storing the three components in a nonreacting state to maintain the sporocide in an inactive state and admixing the three components in a aqueous based carrier to cause a catalyzed reaction by said peroxidase for generating free radicals and/or byproducts from the iodide salt (donor molecule) and contacting the surface or object to be sterilized with the activated mixture. The concentration level of the three components can be selected such that an active sporocidal state is maintained for any desired period of time.
Abstract: Disclosed herein are improved processes for preparing variant human t-PA proteins exhibiting improved pharmacokinetic properties relative to natural t-PA. One such illustrated variant, devoid of amino acids corresponding to amino acids 1 through 44 of natural t-PA, is shown to exhibit a plasma half-life of greater than about 15 times the plasma half-file of natural t-PA, as well as a clearance rate of less than about 1/10 the clearance rate of natural t-PA. Also disclosed are improved processes for treating vascular disease employing pharmaceutical compositions which incorporate therapeutically effective amounts of such t-PA variants with pharmaceutically acceptable diluents or excipients.
Type:
Grant
Filed:
April 29, 1988
Date of Patent:
June 19, 1990
Assignee:
Genentech, Inc.
Inventors:
Deborah L. Higgins, William E. Holmes, Adair J. Hotchkiss
Abstract: Normal human colon fibroblast tissue plasminogen activator is separated by lysine-Sepharose affinity chromatography into Types I and II glycoforms and characterized with respect to the relative incidence of each type of oligosaccharide comprising the respective Types I and II glycoforms.
Type:
Grant
Filed:
March 11, 1988
Date of Patent:
May 22, 1990
Assignee:
Monsanto Company
Inventors:
Joseph Feder, Susan C. Howard, Arthur J. Wittwer, Thomas W. Rademacher, Raj B. Parekh, Raymond A. Dwek
Abstract: A method is provided for individuals under treatment for or at risk of atherosclerotic, vascular, cardiovascular, and/or thrombotic disease by administering a composition which comprises a protein source; a carbohydrate source; and at least one lipid selected from the group consisting of: gamma-linolenic acid; eicosapentaenoic acid; docosahexaenoic acid; sterodonic acid; and linolenic acid. Both an enteral and parenteral composition are provided.
Type:
Grant
Filed:
August 28, 1989
Date of Patent:
April 24, 1990
Assignee:
Baxter International Inc.
Inventors:
Richard Cotter, Robert C. Johnson, Michael Ward, David C. Madsen, Anthony J. Valicenti, Michael P. Menard, Hugh N. Tucker
Abstract: A talc-base body powder composition having an unique composition of desirable characteristics including moisture absorbency, anti-ammonia, anti-bacterial and anti-fungal effects making it specially useful for infant skin care purposes consisting essentially of talc, cornstarch, calcium undeclyenate and citric or ascorbic acid in critical proportions.