Abstract: A method of making antibodies to hirudin by immunizing with an immunogenic composition containing polymerized hirudin monomers in the absence of carrier protein is taught.
Type:
Grant
Filed:
February 20, 1996
Date of Patent:
April 13, 2004
Assignee:
Farmitalia Carlo Erba S.r.l.
Inventors:
Antonio Molinari, Marco Gerna, Carla Giorgetti, Jacqueline Lansen, Romeo Roncucci
Abstract: A polypeptide analog capable of immunologically mimicking a linear hGPIIb antigenic determinant expressed when platelet-associated GPIIb-IIIa binds fibrinogen is disclosed. An antibody that immunoreacts with the polypeptide and hGPIIb when hGPIIb is present as a platelet-associated GPIIb-IIIa/fibrinogen complex is also disclosed. Further disclosed are diagnostic systems and methods for assaying fibrinogen-bound platelets in a vascular fluid sample using the polypeptides and/or antibodies of the invention.
Type:
Grant
Filed:
May 15, 1992
Date of Patent:
March 12, 1996
Assignee:
The Scripps Research Institute
Inventors:
Edward F. Flow, Mark H. Ginsberg, Joseph C. Loftus
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