Abstract: The present invention pertains to a medical treatment device (10) for stimulating neurons of a patient to suppress a pathologically synchronous activity of the neurons. The device (10) comprises a non-invasive stimulation unit (12) configured for simultaneously administering at least one acoustic stimulus and at least one non-acoustic stimulus to a patient's body, each of which is configured to suppress the pathologically synchronous activity when being administered to the patient's body.

Abstract: The present disclosure provides systems and methods for performing a clinical assessment of a neurological disease, disorder, or condition. In an aspect, a system may comprise sensors, which sensors are configured to acquire sensor data of the subject over a period of time; and which mobile electronic device, comprises: an electronic display; a wireless transceiver; and one or more computer processors configured to (i) receive the sensor data from the sensors, (ii) process the sensor data or features extracted therefrom using a trained algorithm to generate an output indicative of a state of a neurological disease, disorder, or condition of the subject, and (iii) based at least in part on the generated output, perform a clinical assessment on the subject.

Abstract: The present disclosure discloses a multi-electrode miniature electrical stimulation system, including a BOOST circuit and a voltage doubling circuit; the core of the BOOST circuit is a switching power chip; a stimulation waveform control circuit includes several half-bridge drive circuits; each half-bridge drive circuit is correspondingly connected with one electrode, and any half-bridge drive circuit can output a bidirectional stimulation current; a voltage-controlled constant current source circuit includes an operational amplifier, a multi-channel analog switch and several diffusing power tubes; the operational amplifier works in a negative feedback working state.

Abstract: A balance prosthesis device for an individual including a sensor module configured to obtain a sensor signal indicative of a balance or equilibrium state of the individual, a processing module configured to determine at least one neurostimulation signal based at least in part on the obtained sensor signal, and a transmitter module configured to transmit the determined neurostimulation signal to a neurostimulation device of the individual. The neurostimulation signal is configured to elicit an artificial sensation in a specific sensory cortex area of the individual via directly stimulating afferent sensory axons of the central or peripheral nervous system of the individual targeting sensory neurons of the sensory cortex area not directly associated with vestibulocortical pathways of the individual. The elicited artificial sensation provides a balance indication to the individual in order to support, mimic, substitute or enhance the natural sense of balance of the individual.

Abstract: Methods, systems, and devices for controlling external devices are described. A method may include receiving physiological data associated with a user from a wearable device, and identifying one or more physiological states, physical activities, or both, associated with the user based on the physiological data. Physiological states may include physiological states associated with waking up, falling asleep, anxiety, relaxation, and the like. The method may further include transmitting an instruction to one or more external devices based on the one or more physiological states, physical activities, or both, where the instruction is configured to selectively modify one or more operational parameters associated with the one or more external devices.

Abstract: A phototherapeutic system in accordance with an embodiment of the present technology includes a housing at least partially defining an irradiation zone configured to accommodate at least a portion of a human subject. The system further comprises an ultraviolet (UV) radiation source configured to direct UV radiation along a radiation path extending from the radiation source to the irradiation zone. The radiation source includes a concentrated source at which UV radiation is generated, and a collimating reflector (or lens) configured to reflect (or refract) the UV radiation and thereby increase collimation of the UV radiation. The system still further comprises a filter, a spreader, and a collimator disposed successively farther downstream from the radiation source along the radiation path. The spreader and the collimator respectively decrease and increase collimation of the UV radiation before the UV radiation reaches the subject.

Abstract: A medical device is configured to sense at least one cardiac electrical signal and generate pacing pulses according to a first pacing therapy by generating pacing pulses for delivery to a first combination of ventricular pacing sites including at least one ventricular conduction system pacing site. The medical device may be configured to determine a ventricular conduction condition based on a QRS signal feature of the sensed cardiac signal during the first pacing therapy. The medical device may change to a second pacing therapy different than the first pacing therapy based on the determined ventricular conduction condition.

Abstract: Described herein is a liquid embolic delivery device designed to minimize excess embolic solvent buildup therein. The liquid embolic delivery device generally comprises an outer catheter, an inner catheter that is longitudinally moveable within the outer catheter. The inner catheter is used for an initial embolic solvent flush and to deliver liquid embolic, while the outer catheter is used to remove excess solvent.

Abstract: A neuromodulator may include a neuromodulation generator and a plurality of electrodes. A programming system may be configured to wirelessly communicate with the neuromodulator. The programming system may be configured to receive user input for use in creating at least two block sequence descriptions for at least two neuromodulation sites, respectively. Each of the at least two block sequence descriptions may define both a sequence of blocks for each of the at least two neuromodulation sites and timing relationships between the blocks in the sequences. Each of the blocks may correspond to a neuromodulation field generated using a corresponding neuromodulation parameter set. The programming system may be configured to translate the block sequence descriptions into neuromodulator instructions and wireless communicate the neuromodulator instructions to the neuromodulator for use by the neuromodulator to deliver the neuromodulation to each of the at least two neuromodulation sites.

Abstract: A glaucoma treatment apparatus including an imaging device capable of imaging the anterior segment of the eye, a treatment laser, an algorithm programmed to determine a location and a cross sectional area of a treatment based on a customized anatomy of the anterior segment of the eye including the trabecular meshwork (TM), the Schlemm's Canal (SC) and collector channels (CCS), obtained from pre-operative images of the anterior segment of the eye, a pre-operative intraocular pressure (IOP) level and a target IOP reduction as an inputs, and a processor configured to actuate the apparatus to create an outflow channel with a cross-sectional area and location or multiple outflow channels with multiple cross-sectional areas and locations from the anterior chamber (AC) to the SC across the TM, as determined by the algorithm to achieve the target intraocular pressure (IOP) reduction. Also disclosed is a method of reducing intraocular pressure in an eye.

Abstract: Described herein are systems, methods, and apparatuses for identifying LQTS in a subject. A system may include an electrocardiogram (ECG) sensor configured to detect an ECG datum. A system may include a computing device configured to receive an electrocardiogram (ECG) datum; train an LQTS determination machine learning model on a training dataset including a plurality of example ECG data as inputs correlated to a plurality of example LQTS data as outputs; and generate an LQTS determination datum as a function of the ECG datum using the trained LQTS determination machine learning model. A system may include a display configured to display an LQTS determination datum.

Abstract: An optical sensor can be multiplexed for different clients/features including estimating information or characteristics of a user's physiological signals. Additionally, the clients/features can include estimating information or characteristics independent from a user's physiological signals. As the number of clients increase and/or as the requirements for the clients increase, flexibility can be provided to accommodate the various clients. Parallelization of the optical sensor can be used to improve performance as the number of clients increase. For example, the hardware and software architecture can assemble patterns of time slots that measure all desired light paths for the multiple clients and distribute the corresponding measurements to each client according to the client requests. In some examples, the scanning sequence can be represented by frames including slots associated with multiple clients to compress the representation for larger or more complex scan sequences.

Abstract: A system and method for selecting a preferred intraocular lens, for implantation into an eye, includes a controller having a processor and a tangible, non-transitory memory on which instructions are recorded. The controller is in communication with a diagnostic module adapted to store pre-operative anatomic data of the eye as an eye model. The controller is configured to determine respective imputed post-operative variables for each of a plurality of intraocular lenses, via a projection module. A respective pseudophakic eye model is generated for each of the plurality of intraocular lenses by incorporating the respective imputed post-operative variables into the eye model. A ray tracing module is executed in the respective pseudophakic eye model to determine at least one respective metric for the plurality of intraocular lenses. The preferred intraocular lens is selected based on a comparison of the respective metric.

Abstract: A controller system for a robotic surgical system can include a first instrument controller comprising a first plurality of motors configured to steer a first attachable robotically controlled medical device, a second instrument controller comprising a second plurality of motors configured to steer a second attachable robotically controlled medical device, and a camera controller comprising a plurality of motors and configured to steer an attachable robotically controlled endoscopic camera.

Abstract: The present disclosure describes devices and methods for detecting motoneuron excitability in a subject in need. The method includes stimulating a cutaneous distribution of a patient's vagus nerve within a patient's ear with a nerve stimulating signal; detecting F-wave occurrence with an evoked electromyography paradigm; and adjusting one or more parameters of the nerve stimulating signal to change the F-wave occurrence.

Abstract: A medical device is configured to deliver anti-tachycardia pacing (ATP) in the presence of T-wave alternans. The device is configured to detect a ventricular tachyarrhythmia from a cardiac electrical signal received by the medical device. In response to the detected ventricular tachyarrhythmia, the device delivers a plurality of ATP pulses at alternating time intervals. The alternating time intervals comprise at least a first ATP time interval separating a first pair of the ATP pulses and a second ATP time interval different than the first ATP time interval. The second ATP time interval consecutively follows the first ATP time interval and separates a second pair of the ATP pulses.

Abstract: The patent application describes an adaptable neuromodulation device for transcranial electrical brain stimulation. The system can generate complex poly-modulated waveforms by combining multiple pulse parameters in a randomized manner across dimensions like amplitude, frequency, phase, timing, and polarity. It leverages both digital and analog modulation techniques for waveform versatility. The device features pathway optimization algorithms that tune stimulation using neural feedback data to target specific brain region shapes with greater precision. It also enables closed-loop operation for responsiveness to physiological changes. The application details the mathematical and computational foundations, spanning graph theory to generate digital twins. It highlights applications from cognitive enhancement to seizure control. Overall, the innovation promises versatility and precision in non-invasive neuromodulation through adaptable, optimized waveforms grounded in sophisticated modeling.

Abstract: An infant monitoring device is disclosed having a band or sock configured to wrap around the foot or other portion of an infant. The sock houses a removable sensing module configured to couple to the sock and measure health parameters of the infant. The sensing module is removably couplable with a base station that charges the sensing module. The sensing module transmits and receives information from the base station. Both the base station and the sensing module can transmit and receive information from a remote location.

Abstract: A stimulation device includes a body containing at least one stimulation means adapted to be transcutaneously attached to the neck of a subject. The stimulation means is adapted to generate a stimulating signal during a stimulating state. The stimulation means is positioned to be in stimulating contact with the sternocleidomastoid muscle and the trunks of the lesser occipital nerve, greater auricular nerve, transverse cervical nerve or supraclavicular nerve with their autonomic fibers synchronously. The stimulation can be provided in the form an electrical, optical, vibrational, thermal, mechanical and/or magnetic stimulation. The stimulation device can be used bilaterally on the right and left sides of the subject's neck, working as a system in a synchronous or alternating manner.

Abstract: Devices and methods of use for introduction and implantation of an electrode as part of a minimally invasive technique. An implantable baroreflex activation system includes a control system having an implantable housing, an electrical lead, attachable to the control system, and an electrode structure. The electrode structure is near one end of the electrical lead, and includes a monopolar electrode, a backing material having an effective surface area larger than the electrode, and a releasable pivotable interface to mate with an implant tool. The electrode is configured for implantation on an outer surface of a blood vessel and the control system is programmed to deliver a baroreflex therapy via the monopolar electrode to a baroreceptor within a wall of the blood vessel.