Patents Examined by James Martinelli
  • High-molecular weight DNA sample tracking tags for next generation sequencing
    Patent number: 11001834
    Abstract: The present invention provides synthetic nucleic acid molecule tags that can be added into samples for identification and tracking. Among other things, the present invention provides synthetic, high-molecular weight concatemers, which can be combined with samples to yield hundreds of millions of unique identifiers. Examples applications for which the synthetic nucleic acid molecule tags can be used, include industrial, research and clinical applications.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: May 11, 2021
    Assignee: KAPA BIOSYSTEMS, INC.
    Inventors: Paul McEwan, Martin Ranik, Eric van der Walt
  • Biomarkers for prenatal diagnosis of congenital cytomegalovirus
    Patent number: 9261505
    Abstract: The invention provides compositions and methods useful for early detection of congenital CMV infection, predicting the likelihood and severity of congenital CMV disease, and monitoring the efficacy of therapeutic approaches. Compositions of the present invention include biomarkers that are differentially expressed in CMV-infected mothers and fetuses compared to uninfected individuals.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: February 16, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Lenore Pereira, Ekaterina Maidji, Takako Tabata, Susan Jane McDonagh
  • Imaging and selective retention of phospholipid ether analogs
    Patent number: 7632644
    Abstract: The present invention generally relates to imaging and selective retention of phospholipid ether analogs in various neoplastic tissues. Specifically, the present invention relates to imaging and methods for selective retention of analogs, for example, NM404, in cancers such as Colorectal Cancer.
    Type: Grant
    Filed: May 10, 2006
    Date of Patent: December 15, 2009
    Assignee: Cellectar, Inc.
    Inventors: Jamey P. Weichert, Marc Longino, Sharon Weber, Joseph O. Nwankwo
  • Nucleic acid mutation detection in histologic tissue
    Patent number: 6025127
    Abstract: Methods are provided for detection of target neoplastic nucleic acids in a tissue specimen, including a tumor margin or lymph node, and reagents therefor, wherein the nucleic acids are preferably mutant tumor suppressor genes or proto oncogenes. Methods for treatment of cell proliferative diseases utilizing ribozymes or antisense oligonucleotides specific for the target mutant nucleic acids and/or replacement wild type genes are also disclosed.
    Type: Grant
    Filed: January 14, 1994
    Date of Patent: February 15, 2000
    Assignee: The Johns Hopkins University School of Medicine
    Inventor: David Sidransky
  • Non-sucrose fermenting Pedioccus pentosaceus
    Patent number: 4508738
    Abstract: Non-sucrose fermenting strains of Pediococcus pentosaceus are described. The non-sucrose fermenting Pediococcus pentosaceus strains have been cured to remove a single, natural plasmid which has been found to control the fermentation of sucrose to produce lactic acid. The natural plasmid removed is between about 30 to 35 megadaltons in molecular weight. Compositions including the non-sucrose fermenting strains of Pediococcus pentosaceus are useful for food fermentations, particularly meat fermentations.
    Type: Grant
    Filed: March 17, 1982
    Date of Patent: April 2, 1985
    Assignee: Microlife Technics, Inc.
    Inventor: Carlos F. Gonzalez