Patents Examined by James O. Thomas
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Patent number: 4149011Abstract: Intermediate compound useful in the preparation of Benzimidazol-5-yl alanine derivatives useful as antihypertensive agents.Type: GrantFiled: August 8, 1977Date of Patent: April 10, 1979Assignee: Merck & Co., Inc.Inventors: Chandravadan N. Talaty, Jeremy Wright, Nicolas Zenker
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Patent number: 4115652Abstract: A process for the preparation of an amino-nitro-phenol by partial reduction of a polynitrophenol by contacting the polynitrophenol with an aqueous ammonia solution and a sulfide ion, the ammonia being present in an amount of 1 to 8 mols ammonia per mol of polynitrophenol and the sulfide being present in an amount of 2.5 to 6 mols sulfide ion per mol polynitrophenol, the process being conducted at a temperature of from room temperature to 100.degree. C.Type: GrantFiled: March 30, 1977Date of Patent: September 19, 1978Assignee: Bayer AktiengesellschaftInventors: Karl Linhart, Adolf Friedrich
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Patent number: 4062973Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or halogen,R.sub.2 is hydroxyl, alkoxy of 1 to 6 carbon atoms, aralkoxy of 7 to 10 carbon atoms, amino, (alkyl of 1 to 3 carbon atoms)-amino, piperidino or morpholino, andn is 0, 1 or 2,Diastereoisomers thereof and, when R.sub.2 is hydroxyl, non-toxic, pharmacologically acceptable salts thereof formed with an inorganic or organic base; the compounds, their diastereoisomers and the salts are useful as antithrombotics, anti-hypercholesteremics and anti-hyperglyceridemics.Type: GrantFiled: October 6, 1976Date of Patent: December 13, 1977Assignee: Boehringer Ingelheim GmbHInventors: Josef Nickl, Berthold Narr, Erich Muller, Josef Roch, Walter Haarmann
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Patent number: 4046804Abstract: .alpha.,.alpha.-Dimethyl-4-(.alpha.,.alpha.,.beta.,.beta.-tetrafluorophenet hyl)benzylamine isethionate monohydrate and processes for its preparation are disclosed.Type: GrantFiled: October 1, 1976Date of Patent: September 6, 1977Assignee: Merck & Co., Inc.Inventors: Edward M. Cohen, Earl R. Oberholtzer
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Patent number: 4021492Abstract: The .alpha.,.alpha.-dibromo-substituted or unsubstituted-4-pivaloyl toluenes, e.g., .alpha.,.alpha.-dibromo-4-pivaloyl toluene, are prepared by bromination of a corresponding p-pivaloyl toluene with liquid bromine at a temperature of at least 125.degree. C.Type: GrantFiled: November 12, 1975Date of Patent: May 3, 1977Assignee: Sandoz, Inc.Inventors: Jerome Linder, William J. Houlihan
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Patent number: 4001285Abstract: The invention provides novel compounds of formula ##STR1## in which R signifies a hydrocarbon radical of 5 to 22 carbon atoms, which may be substituted,R.sub.1 and R.sub.2, which may be the same or different, each signifies a hydrogen atom or a lower alkyl radical which may be substituted, provided that at least one of R.sub.2 and R.sub.1 or the R.sub.1 's signifies hydroxyalkyl or carboxyalkyl, in which the alkyl radical contains 1 to 4 carbon atoms, or a radical of formula --CH.sub.2 SO.sub.3.sup.- M.sup.+, --CH.sub.2 --CH.sub.2 --O).sub.p H, --CH.sub.2 --CH(CH.sub.3)O).sub.p H, --CH.sub.2 --CH.sub.2 --CN or --CH.sub.2 --CH.sub.2 CONH.sub.2,p signifies 1 to 10,X signifies --CONH--, ##STR2## --O-- or --S--, m signifies 0 to 6,n or the n's, which may be the same or different when m is greater than 1, each signifies from 1 to 8,a signifies 0 or 1 andM.sup.+ signifies hydrogen, an ammonium cation or an equivalent of a metal cation, and quaternary ammonium derivatives thereof, useful as textile finishing agents.Type: GrantFiled: February 3, 1975Date of Patent: January 4, 1977Assignee: Sandoz Ltd.Inventor: Richard Hochreuter
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Patent number: 3991189Abstract: 1,2,4-TRIAZINE-1,4-DI-N-oxides (1,4) useful as microbicides having the formula (I): ##SPC1##whereinX.sup.1 and X.sup.2 which may be the same or different are hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, halogen alkyl or halogen; andA is selected from the group ofI. R which is unsubstituted or substituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted aralkyl;Ii. --COR.sup.1 in which R.sup.1 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl;Iii. --COCH.sub.2 COCH.sub.3 ; andIv. --CONHR.sup.2 where R.sup.2 is substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl or substituted unsubstituted aryl.Processes for making formula (I) compounds are also disclosed.Type: GrantFiled: July 28, 1975Date of Patent: November 9, 1976Assignee: Bayer AktiengesellschaftInventors: Florin Seng, Kurt Ley, Brigitte Hamburger, Franz Bechlars
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Patent number: 3968246Abstract: A method of disinfecting hard surfaces by applying thereto N-trimethylbenzyl ethylenediamine, and the use of said compound in admixture with anionic, cationic or non-ionic surfactants to provide a disinfectant and cleansing composition.Type: GrantFiled: July 10, 1975Date of Patent: July 6, 1976Assignee: Millmaster Onyx CorporationInventors: John J. Merianos, Phillip Adams
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Patent number: 3959376Abstract: The quaternary ammonium or phosphonium salts of halogenated lower alkene compounds such as 4-chloro-2-alkenyl trimethyl ammonium chloride are prepared by reacting a tri-lower alkyl amine or tri-lower alkyl phosphine with 3,4-dihaloalkene-1.Type: GrantFiled: January 28, 1974Date of Patent: May 25, 1976Assignee: Celanese CorporationInventor: Louis E. Trapasso
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Patent number: 3959383Abstract: A two-stage conversion of methanol to formaldehyde characterized in that silver crystals having a size range of 8 to 40 screen mesh are employed as a catalyst in the second stage converter and space velocity in said converter is maintained within a range of from 250,000 to 600,000 reciprocal hours. The process yields a high strength formaldehyde product containing small amounts of methanol.Type: GrantFiled: March 7, 1974Date of Patent: May 25, 1976Assignee: E. I. Du Pont de Nemours and CompanyInventor: Evan S. Northeimer, deceased