Patents Examined by James Rogers
  • Patent number: 9708365
    Abstract: The present invention provides an improved method for the purification of monoclonal antibody from cell culture. Process of purification of the desired monoclonal antibody comprises affinity, hydrophobic interaction and optionally ion exchange column chromatography. It provides more than 99% purity of the desired monoclonal antibody.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: July 18, 2017
    Assignee: Cadila Healthcare Limited
    Inventors: Sanjeev Kumar Mendiratta, Sanjay Bandyopadhyay, Avanish Kumar Singh
  • Patent number: 9701694
    Abstract: The present invention relates to compounds that are useful as metal ligands and which either contain a molecular recognition moiety or can be bound to a molecular recognition moiety and methods of making these compounds. Once the compounds that contain a molecular recognition moiety are coordinated with a suitable metallic radionuclide, the coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging. The invention therefore also relates to methods of diagnosis and therapy utilising the radiolabelled compounds of the invention.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: July 11, 2017
    Inventors: Paul Stephen Donnelly, Michelle Therese Ma, Denis Bernard Scanlon
  • Patent number: 9694080
    Abstract: A pharmaceutical composition for controlled release of an active substance, the composition being a matrix composition of: (a) a substantially water soluble or crystalline polymer, (b) an active substance, and optionally, (c) one or more pharmaceutically acceptable excipients having a water solubility of at least 1 mg/ml at ambient temperature. The matrix composition does not contain a water dispersible or water soluble surface active agent that has at least one domain, which is compatible with the polymer in the matrix composition, and which substantially eliminates water diffusion between the interface between the polymer crystals.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: July 4, 2017
    Assignee: EGALET LTD.
    Inventors: Gina Fischer, Daniel Bar-Shalom, Lillian Slot, Anne-Marie Lademann, Christine Andersen
  • Patent number: 9687546
    Abstract: Polyphosphazene polymers having immunomodulating activity, and the biomedical use of such polyphosphazene polymers, in conjunction with an antigen or an immunogen are disclosed.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: June 27, 2017
    Assignee: Innovo Biopolymers, LLC
    Inventors: Alexander Andrianov, Alexander Marin
  • Patent number: 9683012
    Abstract: The present invention relates to a method for preparing a population of antibodies to have high purity and high quality by removing antibody isoforms and impurities through the use of a cation exchange column, a hydrophobic interaction column, and an anion exchange column successively, without using a protein A column; and to a population of antibodies prepared by the above method.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: June 20, 2017
    Inventors: Ji Yong Yoon, Dong Eun Lee, Won Kyum Kim, Jeong Won Youn, Jung Eun Baek
  • Patent number: 9683013
    Abstract: The present invention relates to a method of separating one or more immunoglobulin containing proteins from a liquid. The method includes first contacting the liquid with a separation matrix comprising ligands immobilized to a support; allowing the immunoglobulin containing proteins to adsorb to the matrix by interaction with the ligands; followed by an optional step of washing the matrix containing the immunoglobulin containing proteins adsorbed thereon; and recovering said immunoglobulin containing proteins by contacting the matrix with an eluent which releases the proteins. The method improves upon previous separation methods in that each of the ligands comprises one or more of a protein A domain (E, D, A, B, C), or protein Z, or a functional variant thereof, with at least one of the monomers having a substitution of the Asparagine at the position corresponding to N28 of B domain of Protein A or Protein Z, and wherein the ligand provides an increase in elution pH compared to non-substituted ligand.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: June 20, 2017
    Inventors: Tomas Bjorkman, Elin Monie, Gustav Rodrigo
  • Patent number: 9675696
    Abstract: A method and kits thereof for increasing the efficiency of anti-adhesive compositions by parenterally administering a composition comprising an effective amount of at least one pharmaceutically-acceptable anti-adhesive non-ionic polymer to a site of injury, controlling inflammation at the site of injury, and reducing pain.
    Type: Grant
    Filed: November 14, 2006
    Date of Patent: June 13, 2017
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: Kathy L. Chamness
  • Patent number: 9676842
    Abstract: A method of inhibiting alternative complement pathway activation in a mammal includes administering an amount of an antibody and/or fragment thereof that specifically binds to an epitope of the N terminus end of properdin effective to the inhibit alternative complement pathway in the subject.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: June 13, 2017
    Inventor: Rekha Bansal
  • Patent number: 9668955
    Abstract: Disclosed are petrolatum-like compositions that include metathesized unsaturated polyol esters. Also disclosed are emulsions that include metathesized unsaturated polyol esters. The petrolatum-like compositions may be used as substitutes for petroleum-based petrolatum. The emulsions may be water-in-oil or oil-in-water emulsions and may be suitable for a variety of end uses.
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: June 6, 2017
    Assignee: Elevance Renewable Sciences, Inc.
    Inventors: Diza Pearl Braksmayer, Timothy A. Murphy, Stephen E. Russell, Michael John Tupy, Scott A. Walters
  • Patent number: 9663552
    Abstract: The invention provides a washing method for affinity chromatography in which a wash solution comprising arginine, or an arginine derivative, at pH greater than 8.0, is effective in removing impurities without the presence of a nonbuffering salt, while simultaneously increasing product concentration in the eluate and maintaining a high percent yield of recovered product.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: May 30, 2017
    Assignee: Novartis AG
    Inventor: Achim Frauenschuh
  • Patent number: 9655981
    Abstract: This disclosure is directed to mixed micelle compositions for administration of e.g., therapeutic agents or imaging agents to a subject.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: May 23, 2017
    Assignees: Omeros Corporation, University of Washington through it's center For Commercialization
    Inventors: Wayne R. Gombotz, Suzie Pun, Christopher Mount, Tae Hee Kim, Benjamin W. Dulken
  • Patent number: 9657054
    Abstract: For the removal of high molecular weight compounds from recombinantly produced polypeptides generally chromatographic methods are employed. It has been found that underivatized controlled pore glass (uCPG) selectively binds high molecular weight compounds present in a solution. The purified polypeptide can be recovered e.g. from the flow through of a chromatography column containing uCPG as chromatography material. It has been found that this effect is pronounced at a pH value of about 4 to 6 in buffered solutions. With approximately 100 m2 to 150 m2 uCPG surface per g of polypeptide almost 80% to 95% of the high molecular weight compounds are removed with a yield of 80% to 90% of polypeptide.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: May 23, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Stefan Hepbildikler, Wolfgang Kuhne, Eva Rosenberg, Gerhard Winter
  • Patent number: 9657055
    Abstract: The invention discloses a polypeptide capable of binding immunoglobulins or immunoglobulin-containing proteins, which polypeptide comprises six or more domains of protein Z or the C domain of protein A or a functional variant thereof. It also discloses separation matrices comprising the polypeptide and methods of using the separation matrices for separation of immunoglobulins or immunoglobulin-containing proteins.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: May 23, 2017
    Assignee: GE Healthcare BioProcess R&D AB
    Inventors: Hans J. Johansson, Ronnie Palmgren
  • Patent number: 9650411
    Abstract: The present invention relates to a method for purifying a protein by separating the protein from impurities in a non-adsorption mode using an activated carbon. In particular, the present invention relates to a method for purifying an antibody using the activated carbon instead of protein A affinity chromatography.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 16, 2017
    Inventor: Takashi Ishihara
  • Patent number: 9649332
    Abstract: The present invention provides a composition comprising a polymer of a ?-hydroxy short-medium chain fatty acid, which is used for delivering the ?-hydroxy short-medium chain fatty acid or an oligomer thereof to the large intestine. In case the composition is administrated orally, the composition will be delivered to the large intestine, without being degraded in the stomach or short intestine, and degraded by the large intestinal bacterial flora and release the short-medium chain fatty acid or an oligomer thereof. The released short-medium chain fatty acid or an oligomer thereof has useful physiological activities and is effective for treating or preventing inflammatory diseases or cancer in the large intestine.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: May 16, 2017
    Assignee: EARTHUS, INC.
    Inventors: Kazunari Ushida, Masaki Kuriyama
  • Patent number: 9636426
    Abstract: The present invention provides a fluorescent molecular probe for efficient fluorescent detection (visualization) of tumors or for implementing fluorescent detection and photodynamic treatment, more specifically, the present invention provides a macromolecular fluorescent molecular probe for fluorescent detection of tumor, comprising a complex comprising a fluorescent molecule and a biocompatibie macromolecule.
    Type: Grant
    Filed: September 5, 2012
    Date of Patent: May 2, 2017
    Inventors: Hiroshi Maeda, Makoto Hashizume, Jun Fang, Hideaki Nakamura, Haibo Qin, Steffen Hackbarth, Masaharu Murata
  • Patent number: 9631050
    Abstract: Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.
    Type: Grant
    Filed: May 14, 2016
    Date of Patent: April 25, 2017
    Assignees: International Business Machines Corporation, Agency For Science, Technology And Research
    Inventors: Daniel J. Coady, Richard A. Dipietro, Amanda C. Engler, James L. Hedrick, Victor W. L. Ng, Zhan-Yuin Ong, Jeremy P. K. Tan, Yi Yan Yang
  • Patent number: 9630988
    Abstract: The present invention provides a method for preparing a composition comprising highly concentrated antibodies by ultrafiltration in batch concentration mode having a first constant feed rate step and a second controlled feed rate step.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: April 25, 2017
    Assignees: Chugai Seiyaku Kabushiki Kaisha, Genentech, Inc.
    Inventors: Kelby Lau, Jean Bender, Saeko Tanaka, Rumiko Wakayama, Hidenari Yamada, Tomonori Isoda, Masayoshi Oh-Eda
  • Patent number: 9631008
    Abstract: The current invention reports a method for purifying an immunoglobulin, wherein the method comprises applying an aqueous, buffered solution comprising an immunoglobulin in monomeric, in aggregated, and in fragmented form to an anion exchange chromatography material under conditions whereby the immunoglobulin in monomeric form does not bind to the anion exchange material, and recovering the immunoglobulin in monomeric form in the flow-through from the anion exchange chromatography material, whereby the buffered aqueous solution has a pH value of from 8.0 to 8.5. In one embodiment the anion exchange chromatography material is a membrane anion exchange chromatography material.
    Type: Grant
    Filed: December 18, 2009
    Date of Patent: April 25, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Marc Pompiati, Andreas Schaubmar
  • Patent number: 9623144
    Abstract: Provided herein are in vivo gelling ophthalmic pre-formulations forming a biocompatible retinal patch comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the retinal patch at least partially adheres to the site of a retinal tear. Also provided herein are methods of treating retinal detachment by delivering an in vivo gelling ophthalmic pre-formulation to the site of a retinal tear in human eye, wherein the in vivo gelling ophthalmic pre-formulation forms a retinal patch.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: April 18, 2017
    Inventors: Syed H. Askari, Yeon S. Choi