Abstract: Therapeutic amounts of DHEA are administered to human patients for the treatment and prevention of such disorders as atherosclerosis, angina, diabetes, obesity and congestive heart failure. Administering therapeutic quantities of DHEA to human patients has been found to reduce body fat mass and increase muscle mass, lower serum LDL cholesterol levels, lower serum apoB levels, and not affect tissue sensitivity to insulin.

Abstract: A pharmaceutical composition is provided for oral administration. The composition comprises estradiol dissolved in an oil vehicle containing a suspension of micronized progesterone. The oil vehicle is high in glycerides of polyunsaturated fatty acids. The estradiol and micronized progesterone contained in the oil are more readily absorbable in the blood stream and achieve enhanced estradiol and progesterone blood serum levels. The pharmaceutical composition according to the invention can be readily formulated into capsules and administered for the treatment of menopausal symptoms.

Abstract: The present invention provides novel compounds for controlling mammalian obesity by simultaneous action upon caloric intake and caloric expenditure. This is accomplished by the administration of pharmaceutically acceptable and therapeutically active analogs of .alpha.-HET and .beta.-HET, having a methyl group at the 3.beta. position to avoid metabolically induced conjugation of the molecule to an inactive species while retaining the structural integrity of the molecule.

Abstract: A solid base which is obtainable by reacting alumina with an alkali metal hydroxide and an alkali metal hydride or reacting water-containing alumina with an alkali metal hydride in an amount more than the molar equivalent of water container in the water-containing alumina, at a temperature of 200.degree. to 500.degree. C. in an inert gas atmosphere can effectively catalyze various reactions, particularly isomerization of olefins.

Abstract: A hemorrhoidal treatment compound includes pharmaceutically effective amounts of a hydrocortisone compound, pramoxine hydrogen chloride, and ephedrine sulfate. The compound may further contain witch hazel, glycerin, vitamin A, and propylene glycol. The compound is provided in a disposable application kit that includes an absorbent pad with the improved compound absorbed therein for use as a swab or compress. The absorbent pad is further sealed in a wrapping, all of which may be disposed of after a single use.

Abstract: The invention relates to 4-substituted 6-alkylidenandrostene-3,17-dione derivatives of the following formula ##STR1## wherein each of R.sub.1, R.sub.2 and R.sub.3 is, independently, hydrogen or C.sub.1 -C.sub.6 alkyl; R.sub.4 is hydrogen of fluorine; (x) represents a single or double bond; and R is, especially, a hydroxy or mercapto or amino group or a functional derivative thereof. The compounds of the invention show aromatase inhibitory activity and may be useful, for instance, in the treatment of hormone-dependent tumors and of prostatic hyperplasia.

Abstract: 11 .beta.-(4-isopropenylphenyl)-estra-4,9-dienes of general Formula I ##STR1## wherein X is an oxygen atom or a hydroxyimino grouping N OH,R.sup.1 is a hydrogen atom or a methyl group,R.sup.2 is a hydrogen atom or an acyl residue of 1-10 carbon atoms,R.sup.3 is a hydrogen atom, the cyanomethyl group, --(CH.sub.2).sub.n --, CH.sub.2 Z, --CH.dbd.CH--(CH.sub.2).sub.m Z or --C.tbd.C--Y wherein n=0 to 5 and m=1 to 4, Z meaning a hydrogen atom or the OR.sup.4 group with R.sup.4 meaning a hydrogen atom, an alkyl or alkanoyl group each of 1-4 carbon atoms, and Y meaning a hydrogen, chlorine, fluorine, iodine or bromine atom, an alkyl, hydroxyalkyl, alkoxyalkyl or acyloxyalkyl group each of 1-4 carbon atoms in the alkyl or acyl residue, possess antiprogestational activity.