Patents Examined by James W. Rogers
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Patent number: 10232062Abstract: The invention relates to a radiolabelled material comprising a polymer, a radioactive isotope, and an immobilizing agent, wherein the immobilizing agent is capable of immobilizing the radioactive isotope on or in the polymer, and wherein the immobilizing agent is a macromolecule comprising electron donating groups. The invention also relates to a process for making a radiolabelled material, to use of a radiolabelled material for the preparation of medicaments for treating cancer and/or for radiation imaging, and to use of a radiolabelled material in the treatment of cancer. There is further described use of an immobilizing agent to immobilize a radioactive isotope on or in a polymer.Type: GrantFiled: December 20, 2013Date of Patent: March 19, 2019Assignee: The Australian National UniversityInventors: Ross Wentworth Stephens, Jessica Louise Bell
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Patent number: 10220075Abstract: Examples include a method of making a protein-PEG conjugate. The method may include providing an aqueous protein solution. The aqueous protein solution may include a protein, a pH buffer, and a chelating agent. The chelating agent may be chosen from the group consisting of an aminopolycarboxylic acid, a hydroxyaminocarboxylic acid, an N-substituted glycine, 2-(2-amino-2-oxocthyl) aminoethane sulfonic acid (BES), and deferoxamine (DEF). The method may also include introducing sodium cyanoborohydride and a methoxy polyethylene glycol aldehyde to the aqueous protein solution. The sodium cyanoborohydride in the methoxy polyethylene glycol aldehyde may have a molar ratio ranging from about 5:1 to about 1.5:1. The method may further include reacting the methoxy polyethylene glycol aldehyde with the protein to form the protein-PEG conjugate. The pH buffer may maintain a pH of the aqueous protein solution ranging from 4.0 to 4.4 during the reaction.Type: GrantFiled: May 19, 2016Date of Patent: March 5, 2019Assignee: REZOLUTE, INC.Inventors: Mary S. Rosendahl, Sankaram B. Mantripragada
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Patent number: 10189815Abstract: Provided is a compound represented by general formula (1) or a salt thereof as well as a medicine containing the compound or the salt. In the formula, R1, R2, R3, R4, R5, X1, X2, and X3 are defined.Type: GrantFiled: June 25, 2015Date of Patent: January 29, 2019Assignees: NIHON MEDI-PHYSICS CO., LTD., KYOTO UNIVERSITY, NATIONAL HOSPITAL ORGANIZATIONInventors: Akihiro Izawa, Kei Akama, Yuki Okumura, Yurie Fukui, Nobuya Kobashi, Tsutomu Abe, Yoshihiro Doi, Miho Ikenaga, Hideo Saji, Hiroyuki Kimura, Mitsuhide Naruse
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Patent number: 10182986Abstract: Described herein are methods of delivering a nanoparticle across the blood brain barrier to the brain of a subject by administering to the subject a nanoparticle having a nanoparticle core and a targeting agent. A variety of targeting agents may serve to promote delivery of the described nanoparticle.Type: GrantFiled: November 22, 2016Date of Patent: January 22, 2019Assignee: California Institute of TechnologyInventors: Devin Wiley, Andrew Clark, Mark E. Davis
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Patent number: 10166178Abstract: The present invention relates to a fat-soluble depilatory wax composition which includes hydrophilic cosmetic active agents adding cosmetic properties to treatment for the purpose for which this composition is used. In other words, the present invention relates to the method for obtaining said composition and to the use thereof for simultaneously depilating and treating skin.Type: GrantFiled: March 24, 2014Date of Patent: January 1, 2019Assignee: GRUPO DRV PHYTOLAB, S.L.Inventors: Raúl Vidal Esmoris, Gema García De Miguel
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Patent number: 10124075Abstract: A bionanofluid includes a carbon-based nanomaterial substantially mono-dispersed in a fluid. The carbon-based nanomaterial is surface modified with a polar group when the fluid is polar or with a non-polar group when the fluid is non-polar, and functionalized with a biological targeting moiety to allow specific association of the carbon-based nanomaterial to a targeted entity. A hybrid bionanofluid includes the bionanofluid, with the carbon-based nanomaterial further modified with a hybrid nanoparticle which includes an alloy, transition metal, semi-conductor, semi-metal or polymer based nanoparticle with biological targeting moiety. A hydrogel, foam, cream, spray or dried product includes the bionanofluid or hybrid bionanofluid. The bionanofluid or hybrid bionanofluid are useful in multimodal imaging (photo-luminescence, luminescence, photo-acoustic, MRI, ultrasound) and/or cellular targeting.Type: GrantFiled: November 14, 2014Date of Patent: November 13, 2018Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MC GILL UNIVERSITYInventors: Mark Trifiro, Miltiadis Paliouras, Philip Roche, Idit Dotan, Lenore Beitel, Carlos Alvarado, Matthew Carnevale, Elliot Jonathan Mitmaker
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Patent number: 10124090Abstract: Described herein are apparatus, compositions, systems and methods for occluding vascular structures and vascular malformations with radiopaque hydrogel filaments. The filaments can contain no support members and can be CT and MR compatible. Methods of forming such filaments are also disclosed.Type: GrantFiled: April 3, 2015Date of Patent: November 13, 2018Assignee: Terumo CorporationInventors: Michael Constant, Edward Michael Keeley, Joshua Garretson, Gregory M. Cruise, Wendy Graczyk
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Patent number: 10124007Abstract: The present invention relates to combinations of at least two components, component A and component B, component A being an inhibitor of PI3K kinase, and component B being a pharmaceutically acceptable salt of radium 223. Another aspect of the present invention relates to the use of such combinations as described supra for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly for the treatment of cancer with bone metastases.Type: GrantFiled: December 1, 2014Date of Patent: November 13, 2018Assignee: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Ningshu Liu, Arne Scholz, Andrea Hägebarth
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Patent number: 10117874Abstract: The present invention relates to combinations of at least two components, component A and component B, component A being an inhibitor of PI3K kinase, and component B being radium 223, particularly a pharmaceutically acceptable salt of radium-223. Another aspect of the present invention relates to the use of such combinations as described herein for the preparation of a medicament for the treatment or prophylaxis of a disease, particularly for the treatment of breast and prostate cancer as well as their bone metatases.Type: GrantFiled: November 28, 2014Date of Patent: November 6, 2018Assignee: BAYER PHARMA AKTIENGESELLSCHAFTInventor: Ningshu Liu
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Patent number: 10098972Abstract: This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres comprising the polymers. The microspheres are imageable during embolization procedures and can be loaded with drugs or other therapeutic agents to provide an imageable drug delivery system.Type: GrantFiled: September 5, 2014Date of Patent: October 16, 2018Assignee: BIOCOMPATIBLES UK LTD.Inventors: Stéphane Hohn, Andrew Lennard Lewis
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Patent number: 10098882Abstract: A risperidone sustained release microsphere formulation is provided. The microsphere formulation includes risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release micro sphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.Type: GrantFiled: November 9, 2016Date of Patent: October 16, 2018Assignees: Shandong Luye Pharmaceutical Co., Ltd., Nanjing Luye Pharmaceutical Co., Ltd.Inventors: Kaoxiang Sun, Rongcai Liang, Qilin Wang, Wenyan Wang, Wanhui Liu, Youxin Li
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Patent number: 10092663Abstract: Polymers are described herein comprising: a reaction product of a prepolymer solution including at least one macromer, at least one flexomer, and at least one visualization agent. Methods of making and using these polymers are also described.Type: GrantFiled: April 3, 2015Date of Patent: October 9, 2018Assignee: Terumo CorporationInventors: Michael Constant, Gregory M. Cruise, Samuel Chen
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Patent number: 10066052Abstract: A docetaxel nano-polymer micelle lyophilized preparation is disclosed including methoxypolyethylene glycol-polylactic acid block copolymer carrier material and docetaxel, the docetaxel being is encapsulated in the carrier material. A mass ratio of the docetaxel to the carrier material is 0.01-0.15. The methoxypolyethylene glycol-polylactic acid block copolymer is formed by ring opening polymerization of D,L-lactide and methoxypolyethylene glycol. A mass ratio of the methoxypolyethylene glycol to the D,L-lactide is 1:0.55-0.65 or 1:0.73-0.89 or 1:0.91-0.99. The mass ratio of the docetaxel to the carrier is further optimized by adjusting a mass ratio of polyester to polyether in the methoxypolyethylene glycol polylactide block copolymer. The encapsulation efficiency of a docetaxel micelle prepared by the block copolymer after being re-dissolved by water can be greater than 90% at 12 hours.Type: GrantFiled: July 16, 2014Date of Patent: September 4, 2018Assignee: Suzhou High-Tech Biosciense Co., Ltd.Inventors: Junshan Ruan, Pengfei Du, Limian Wang, Huan Zhou
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Patent number: 10067139Abstract: Polymer nanoparticles and related methods include polymer dots having a coating including a polyelectrolyte polymer. The polymer dots can have a polyelectrolyte coating that can improve colloidal stability of the particles as compared to polymer dots not having the coating. A method of preparing a population of nanoparticles. The methods can include, e.g., providing the population of nanoparticles having a condensed semiconducting polymer; and combining, in a first aqueous solution comprising polyelectrolytes, the population of nanoparticles having the condensed semiconducting polymer to form a population of nanoparticles having a polyelectrolyte coating surrounding the condensed semiconducting polymer of each of the nanoparticles in the population. The methods can include a step of forming the condensed semiconducting polymer using nanoprecipitation or miniemulsion techniques. The polyelectrolyte coating can completely surround the condensed semiconducting polymer.Type: GrantFiled: February 1, 2013Date of Patent: September 4, 2018Assignee: University of Washington through its Center for CommercializationInventors: Daniel T. Chiu, Yuhui Jin, Fangmao Ye, Changfeng Wu, Yang-Hsiang Chan
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Patent number: 10058554Abstract: An injectable depot formulation includes a biocompatible polymer, an organic solvent combined with the biocompatible polymer to form a viscous gel, and a small molecule drug incorporated in the viscous gel such that the formulation exhibits an in vivo release profile having Cmax to Cmin ratio less than 200 and lag time less than 0.2.Type: GrantFiled: February 2, 2017Date of Patent: August 28, 2018Assignee: Indivior UK LimitedInventors: Andrew S. Luk, Gunjan H. Junnarkar, Guohua Chen
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Patent number: 10052321Abstract: The present invention relates to storage stable nanoparticulate compositions of piperazine compounds. The pharmaceutical compositions comprising the nanoparticulate compositions that are useful for the treatment and prevention of proliferative diseases including cancer are also described.Type: GrantFiled: July 26, 2017Date of Patent: August 21, 2018Assignee: REXAHN PHARMACEUTICALS, INC.Inventors: Young Bok Lee, Chang-Ho Ahn, Deog Joong Kim
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Patent number: 10052267Abstract: Individually packaged topical formulations comprising about 0.25 to about 6% w/w of glycopyrrolate for the treatment of hyperhidrosis, wherein said wipe is contained within a pouch resistant to leakage. The formulations may further comprise ethanol, a buffering agent and water. In addition, the formulations may further comprise a polymer system comprising a hydrophobic polymer in combination with a hydrophilic polymer.Type: GrantFiled: July 27, 2017Date of Patent: August 21, 2018Assignee: ROSE U, LLCInventors: Michael Johnston, Robert James Houlden
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Patent number: 10046068Abstract: This invention relates to compounds comprising a saccharide conjugated to an imaging agent or a reporter group, compositions comprising them and methods of using them. Specifically BLM-disaccharide and BLM-monosaccharide conjugates containing different linker groups and an imaging agent or a reporter group are provided for the targeting and imaging of tumors.Type: GrantFiled: March 14, 2014Date of Patent: August 14, 2018Assignee: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Sidney Hecht, Manikandadas Mathilakathu Madathil, Chandrabali Bhattacharya, Trevor Bozeman, Rakesh Paul, Zhiqiang Yu, Michael J. Rishel
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Patent number: 10039699Abstract: Disclosed are petrolatum-like compositions that include metathesized unsaturated polyol esters. Also disclosed are emulsions that include metathesized unsaturated polyol esters. The petrolatum-like compositions may be used as substitutes for petroleum-based petrolatum. The emulsions may be water-in-oil or oil-in-water emulsions and may be suitable for a variety of end uses.Type: GrantFiled: May 3, 2017Date of Patent: August 7, 2018Assignee: Elevance Renewable Sciences, Inc.Inventors: Diza Pearl Braksmayer, Timothy A. Murphy, Stephen E. Russell, Michael John Tupy, Scott A. Walters
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Patent number: 10016454Abstract: A tissue sealant that includes the reaction product of (a) a polyol; (b) a polyisocyanate; and (c) an alkoxy silane having the formula: (R1R2R3)—Si—CH2—Z where (i) Z is an —OH, —SH, —NCO, or —NHR4 group, where R4 is hydrogen, an alkyl group, or an aryl group; and (ii) each R1, R2, and R3, independently, is H, an alkoxy group, an alkyl group, a heteroalkyl group other than an alkoxy group, an aryl group, or a heteroaryl group, with the proviso that at least two of R1, R2, and R3 are alkoxy groups, the relative amounts of the polyol, polyisocyanate, and alkoxy silane being selected such that the reaction product comprises free isocyanate groups. The tissue sealant is moisture-curable and biodegradable in a physiological environment.Type: GrantFiled: December 4, 2012Date of Patent: July 10, 2018Assignee: Cohera Medical, Inc.Inventors: Dottie Clower, Despina Dobbins, Stephanie Kladakis