Abstract: The present invention generally relates to a microcolumn capable of separating an analyte from a sample in the millisecond time domain. The microcolumn is capable of such rapid separation by employing small column volumes that can tolerate medium to high flow rates. The invention also relates to a method of loading a microcolumn capable of separating an analyte from a sample in the millisecond time domain using plural injections of the packing material.

Abstract: The invention relates to equipment for pretreatment of catalysts and/or catalytic testing that makes it possible to establish the material balance of a chemical reaction in the presence of very small amounts of solid catalyst under operating conditions of industrial use.

Abstract: A high-performance liquid chromatography apparatus and a process for conversion of mobile phase, enabling a trace amount of sample for NMR analysis to be efficiently separated and prepared, includes steps of separating a target ingredient from the sample by the high-performance liquid chromatography, trapping the target ingredient in a trapping column using a different mobile phase, replacing water by deuterium oxide and eluting this target ingredient from the trapping column using deuterated solvent other than deuterium oxide.

Abstract: A sample inlet liner includes a novel matrix that serves to retain an injected sample. The preferred inert matrix is polytetrafluoroethylene (PTFE) that serves to retain an injected sample and is provided in lieu of a conventional packing material. The contemplated inert matrix may be selected from a range of configurations of PTFE so as to provide a supporting material capable of retaining an ample quantity of injected sample in the sample inlet liner. The contemplated matrix nonetheless provides a tortuous path for the retained quantity of injected sample so as to facilitate known injection techniques such as split/splitless injection and large volume injections.

Abstract: For anion analysis, the method includes: (a) flowing an aqueous liquid sample stream containing anions to be detected and cation hydroxide through a separator bed, (b) flowing the aqueous effluent from the separator bed through a flow-through suppressor, (c) flowing the effluent liquid from the suppressor past a detector, (d) recycling said liquid effluent from the detector through a cathode chamber proximate to the suppressor bed and separated by a first barrier, and (e) applying an electrical potential between the cathode and the anode. Water is electrolyzed at the anode to cause cations on the cation exchange resin to electromigrate toward the barrier and to be transported across the barrier toward the cathode while water in the cathode chamber is electrolyzed to generate hydroxide ions which combine with the transported cations to form cation hydroxide in the cathode chamber.

Abstract: A system and method for applying one or more chemicals to a tissue sample is provided. The system preferably includes a cassette for housing a slide device, a film, and an injection system. The slide device preferably includes a specimen slide for containing the tissue sample and a cover plate connected to the specimen slide. The film is preferably moveable through the cassette along guide rollers and preferably contains a plurality of containers containing one or more chemicals. The injection system may include a piston for displacing the chemicals from the containers through an injection port to the tissue sample. The cassette may be placed on a cassette driver that contains a motor-driven shaft for driving the piston and moving the film.

Abstract: The invention relates to a thin-layer chromatography apparatus (1) having a plurality of optical light guides to inject light from a light source (2) onto a thin-layer plate (4) and to feed light from the thin-layer plate to an optical examining device (6). To obtain a robust, compact thin-layer chromatography apparatus having a high spectral and spatial resolution, with which there are only minimal disturbances, if any, caused by ambient light and which is nonetheless economical to produce, the invention provides for the emitted-light guides (3) and or received-light guides (5) to be positioned in a regular geometrical pattern in relation to each other either towards or away from the plate, as represented by the rows (11 and 14). The light spots emitted by the emitted-light guides and the field of vision of the received-light guide overlap in an adjustable manner (linear movements 12b, pivoting movements 12a), as regards spatial resolution and light yield.

Abstract: An apparatus and method of manufacture for a pipette tip having a membrane filter includes a pipette tip having an interior annulus for receiving an exterior perimeter of the membrane filter. A shear plate overlying the pipette tip defines an aperture having a dimension equal to the exterior perimeter of the membrane filter. A cylindrical punch has a path of motion for passing through the aperture in the shear plate to the interior annulus of the pipette tip. Membrane filter material is placed over the shear plate in the path of motion of the cylindrical punch. By the expedient of moving the cylindrical punch through the membrane filter material, the aperture in the shear plate, to the interior annulus of the pipette tip to place sheared filter material over the annulus of the pipette tip. Specific embodiments of pipette tips are illustrated including tips having a first filter for filtering material drawn into the pipette tip and second filters from preventing contamination of the pipette.

Abstract: One of a pair of temperature sensor sections in a combustible gas sensor is covered with porous oxidizing catalytic layers (23, 24) for oxidizing a combustible gas, and the other is not covered with the oxidizing catalyst layers. The temperature sensor sections each have temperature sensitive portions (13, 14) made of a dense ceramic material, resistors (21, 22) buried therein and having a positive resistance temperature coefficient, current leads (31, 32, 41, 42) and voltage leads (33, 34, 43, 44). A method for detecting the deterioration of a catalyst which intends to eliminate the combustible gas, by the use of this combustible gas sensor is further disclosed. When a difference between temperatures of the pair of resistors or a difference between powers fed to the pair of resistors is in excess of a predetermined value, it is judged that the catalyst has been deteriorated.

Abstract: A sample pre-separation and concentration system for detecting low levels of analytes in highly complex mixtures includes a plurality of trapping columns having a high selectivity for classes of compounds of interest, upstream of a standard separation column. The system may be used, for example, to measure urinary 8 hydroxy 2′ deoxyguanoisine.

Abstract: A gas detector having a sealed sensor assembly is only exposed to the ambient atmosphere when the detector is to be placed in the service. The detector is placed in the service by removing an elongated planar adhesive backed sealing member. The gas sensor also incorporates a replaceable biomemetic sensing material which is carried within a housing within the detector. The housing contains an internal region wherein the gas sensing material is located. The internal region is sealed where the housing is attached to a printed circuit board on one hand and by the removable sealing planar member on the other hand so as to protect the gas sensitive material from contamination or exposure to the atmosphere until the unit is placed into service.

Abstract: The invention relates to a method and device for preparing samples for gas chromatography, the sample material being guided through a liquid chromatograph (1) by a solvent and being monitored by a detector (2), and, on the basis of the detector (2) recognizing a chromatographic region of interest, the sample material of this region being removed from the stream of sample material leaving the liquid chromatograph (1) and being analyzed by gas chromatography. In this case, the stream of sample material leaving the liquid chromatograph (1) is guided through a flow-through cuvette (4), and the removal is carried out, until the end of the chromatographic region of interest, via a syringe (18) which, when the sample material of the region of interest reaches the flow-through cuvette (4), is introduced into the stream of sample material guided through the flow-through cuvette (4) and is drawn upwards at a predetermined ratio to the transport rate of the stream of sample material.

Abstract: A method for directly monitoring and controlling a continuous process stream for dechlorination residual is provided. A sample stream to which a dechlorination agent has been added to completely eliminate a residual disinfectant is continuously drawn off. An analyzing agent of iodine is provided by introducing an iodide solution, a chloramine-T solution, and an acetic acid buffer into the sample stream. The reagents quickly react to produce iodine that reacts with any residual disinfectant removal agent residual that may be present. Thereafter, the sample stream is continuously analyzed to determine the amount of unreacted iodine remaining in the process sample. Based on the amount of iodine added to the process sample and the amount of unreacted iodine remaining in the sample after reaction, the amount of dechlorination residual is continuously determined.

Abstract: Whether or not there remains a frameless chemical analysis film in a cartridge in which a plurality of the frameless chemical analysis films are stacked is judged by a film presence detector disposed in a second position different from a position where a film takeout mechanism takes out the frameless chemical analysis films from the cartridge so that the film presence detector does not interfere with the film takeout mechanism.

Abstract: A device and method for separating heavier and lighter phases of a fluid sample is described. The fluid separation device includes an elongate collection tube accommodating the fluids, and a deformable separator including a deformable bladder having a flowable substance contained therein. The deformable bladder is reconfigurable upon centrifugation to a toroidal shape allowing fluid flow therethrough. The bladder is movable along the tube during centrifugation to a position between the separated blood phase.

Abstract: The present invention generally provides microfluidic devices (200) and systems that utilize electrokinetic material transport systems to selectively control and direct the transport of materials through and among complex arrangements of integrated microscale channels (for example, 202 and 208+2n, where n=0, 1, . . . 8) disposed within integrated body structures.

Abstract: A corner cube array device (20) is disclosed having a silicon substrate (30) with a generally cubic crystal lattice. A number of silicon crystal projections (62a, 62b, 62c, 62d, 62e, 62f, 62g) extend from the substrate (30). The projections (62a, 62b, 62c, 62d, 62e, 62f, 62g) each have three generally planar surfaces, as exemplified by surfaces (70, 72, 74) of projection (62a), to provide a cube corner shape. Projections (62a, 62b, 62c, 62d, 62e, 62f, 62g) are spaced apart from each other in accordance with a predetermined spatial pattern to define a cube corner array (60) suitable for optical device applications and the mass production of articles having a substantially similar corner cube array shape.

Abstract: A method for preserving cytological specimens for histological or histopathological use. A cytological sample from a biological tissue such as a tumor or a tumor cell line is dehydrated, disbursed and evenly distributed throughout a volume of molten material. The molten material is then drawn into a tubular member such as a pipette and allowed to solidify. Upon solidification, the cylindrical specimen is partially or completely extruded from the tube for further processing, including fixation, dehydration and molten paraffin infiltration and embedding as required for presentation to a sectioning device such as a microtome. Thin circular slices of the cylindrical specimen are removed from the cylindrical specimen and transferred to a slide, fixed and stained as desired. The device and method enable the production of a slide bearing a spatially homogeneous distribution of cytological material for microscopic examination.

Abstract: A method for the chemical analysis of molecules bound and bonded to solid surfaces is presented. The method includes the steps desorbing absorbate molecules or structurally significant fragments of these molecules by selective cleavage of a bond in an absorbate/substrate system using resonant excitation processes and detection of the absorbate species or its characteristic fragments using mass spectrometry techniques.

Abstract: The present invention generally provides microfluidic devices and systems that utilize electrokinetic material transport systems to selectively control and direct the transport of materials through and among complex arrangements of integrated, interconnected microscale channels disposed within integrated body structures.