Abstract: Systems and methods are provided for evaluating infranodal pacing is applied to a patient. Electrocardiogram (ECG) data representing the pacing is obtained from a set of electrodes as an ECG lead. A predictor value representing a frequency content a portion of the ECG lead is extracted. A fitness parameter is determined for the pacing from at least the predictor value. The fitness parameter represents a likelihood that the applied infranodal pacing will induce left ventricular dysfunction in the patient. The fitness parameter is displayed to a user at an associated display.

Abstract: This disclosure relates to a device for applying a neural stimulus. A battery supplies electrical energy at a battery voltage and an electrode applies the electrical energy to neural tissue. A circuit measures the nervous response of the tissue and a voltage converter receives the electrical energy from the battery and controls a voltage applied to the electrode based on the measured nervous response of the tissue. This direct voltage control is energy efficient because losses across a typical current mirror are avoided. Further, the control based on the measured nervous response leads to automatic compensation of impedance variation due to in-growth or change in posture. As a result, the stimulation results in a desired neural response.

Abstract: A system can utilize interleaving periods or waveforms to stimulate patient tissue and sense signals using the stimulation electrodes. For example, the system can utilize alternating therapeutic periods and sensing periods. As another example, the system can alternate between biphasic waveforms having opposite temporal orders of positive and negative phases. As another example, waveforms that differ in a parameter, such as amplitude or pulse width, can be interleaved to provide different information in the respective sensed signals.

Abstract: An apparatus for assessing user frailty is disclosed. In embodiments, the apparatus includes a housing that defines (or is defined by) a body and a handle coupled to the body. The apparatus includes a force sensor at least partially disposed within the handle. The apparatus further includes an inertial sensor at least partially disposed within the housing. The apparatus may further include a user interface device disposed within a cavity of the body. The user interface device may be coupled to the force sensor and the inertial sensor via one or more signal paths. In embodiments, the user interface device includes a controller with a touchscreen coupled to the controller.

Abstract: A leafless biostimulator, such as a leadless pacemaker, includes a housing sized and configured to be implanted within a heart of a patient and includes both primary and secondary fixation features. The primary fixation feature is adapted to rotate to fix the leadless biostimulator to a wall of the heart during initial implantation. Once the leadless biostimulator is implanted, the secondary fixation feature is adapted to resist counter-rotation of the leadless biostimulator. The primary fixation feature may include a fixation helix configured to affix the housing to the heart by rotating in a screwing direction. The secondary fixation feature may include an apex to engage the heart to resist unscrewing of the primary fixation feature.

Abstract: Devices and methods for the stimulation of neural signaling of an apical splenic nerve, the device having a transducer for placement on or around the apical splenic nerve, and a signal generator to generate a signal that stimulates or inhibits the neural activity of the apical splenic nerve to produce a physiological response. The transducer has at least one electrode, and the signal generator is a voltage or current source. The stimulation electrical signal has a frequency of between 1 Hz and 50 Hz.

Abstract: The present invention relates to an electrode array for neuromodulation, comprising a first electrode section with more than two electrodes being arranged parallel and densely packed in the first electrode section, further comprising a second electrode section with more electrodes than in the first electrode section, the electrodes in the second electrode section being arranged symmetrically with respect to the longitudinal axis and transversal offset to each other. Furthermore, the present invention relates to a lead paddle and a neuromodulation system.

Abstract: Improved stimulation circuitry for controlling the stimulation delivered by an implantable stimulator is disclosed. The stimulation circuitry includes memory circuitry that stores pulse programs that define pulse shapes, steering programs that define electrode configurations, and aggregate programs that link a selected pulse program with a selected steering program. The aggregate programs also include an amplitude modulation factor that modulates the amplitude defined by the pulse program. The inclusion of an amplitude modulation factor in the aggregate program allows complex amplitude-modulated waveforms to be produced. Pulse definition circuits in the stimulation circuitry execute aggregate programs to generate stimulation waveforms, which stimulation waveforms can be generated simultaneously by the different pulse definition circuits.

Abstract: A lead anchor for a neuromodulation lead has an anchor body that receives a portion of the lead. A mesh is arranged so as to at least partially surround the portion of the lead when the portion of the lead is received in the anchor body.

Abstract: An elongate medical device may comprise an elongate tubular body, an electrode, and a trace. The elongate tubular body may comprise a distal end portion and a proximal end portion, the body defining a longitudinal axis. The electrode may comprise electrically-conductive ink extending circumferentially about a portion of the distal end portion. The trace may comprise electrically-conductive ink, electrically coupled with the electrode, extending proximally from the electrode.

Abstract: Methods, apparatus, and systems for medical procedures include a monitoring and processing apparatus that includes a memory configured to store a diagnostic algorithm, a sensor configured to sense a patient data of a first patient, a processor configured to generate a first diagnostic result based on the patient data and the diagnostic algorithm. A local computing device is provided and includes a processor configured to receive the first diagnostic result via a first network, receive a first correction indication that includes a correction of the first diagnostic result and transmit the first correction indication via a second network. A remote computing device may be provided and be configured to generate an updated diagnostic algorithm that is updated based on the first correction indication and transmit the updated diagnostic algorithm via the second network.

Abstract: A biosensor assembly that measures multiple physical parameters is disclosed. The biosensor assembly includes a first implantable probe and a first skin contacting electrode. Wherein a first physiological parameter is measured between the first implantable probe and the first skin contactable electrode.

Abstract: Modulation of neural signaling of a pancreas-related sympathetic nerve is capable of improving glycaemic control by inhibiting T cell activation or migration to the pancreas, and hence providing a way of treating or preventing type 1 diabetes.

Abstract: A method for using a mask-type beauty instrument is provided. The method comprises providing a mask-type beauty instrument comprising a flexible mask and a controller, applying the flexible mask of on a user's face, and turning on the controller and selecting a function button on the controller, inputting a current to a plurality of functional layers in the flexible mask, and stimulating face skin with the current.

Abstract: Implantable medical systems include implantable percutaneous medical leads and/or implantable medical lead extensions that have fewer conductors than distal electrodes, or distal connectors for extensions, by having one or more conductors be electrically coupled to multiple distal electrodes. The multiple distal electrodes may span a general area of a body of a patient that includes a specific point that requires therapy, such as multiple vertebral segments. Because all distal electrodes spanning the general area that are coupled to an active conductor will output the stimulation therapy, the specific point within the general area will receive the therapy even without identifying which electrode is most effective. Bipolar and unipolar stimulation modes may be used. Multiple leads may be used where each lead has more distal electrodes than conductors. Additionally, a single lead may have more distal electrodes than conductors while also carrying multiple stimulation waveforms.

Abstract: Devices, systems, and techniques are described for adjusting therapy parameters defining electrical stimulation therapy delivered by multiple electrodes while maintaining a ratio of a value of a therapy parameter between the multiple electrodes. In one example, a device defines a relationship for multiple electrodes that defines a ratio of a value of a therapy parameter between the multiple electrodes. The device performs a master adjustment that adjusts each value of the therapy parameter for each respective electrode of the multiple electrodes by an amount specified by the relationship to maintain the ratio of the value of the therapy parameter between the multiple electrodes. The device controls delivery of electrical stimulation therapy according to the master adjustment.

Abstract: An exemplary electrode locating system performs an excitation spread measurement by directing a first electrode to generate an electrical pulse and, in response to the generation of the electrical pulse, detecting a voltage between a second electrode and a reference that are both distinct from the first electrode. The first and second electrodes are included in a plurality of electrodes disposed on an electrode lead included within a cochlear implant system and that comprises a proximal portion configured to be coupled with a cochlear implant and a distal portion configured to be inserted into a cochlea of a patient by way of an insertion procedure. Based on the excitation spread measurement, the electrode locating system determines whether at least one of the first electrode and the second electrode is located within the cochlea. Corresponding methods are also described.

Abstract: A percutaneous lead assembly for an active implantable device, the lead assembly comprising a sheath with a plurality of wires extending from a proximal end to a distal end. The wires being adapted to power the active implantable device; the distal end having at least one electrode fixed thereon. The electrodes being in communication with sensor electronics and wherein at least one electrode is on the outer layer of the lead assembly in which the electrode is used to detect at least one of acceleration and electrical signals of an organ.

Abstract: A device and method for rejuvenating skin includes a power supply adapted to generate a voltage and an applicator. The applicator includes a first node and a second node, wherein the first node is adapted to be configurable between a positive electrode or electrically isolated from the power supply, and wherein the second node is adapted to be configurable between a negative electrode or electrically isolated from the power supply. The power supply delivers a current through the first node when the first node is configured as the positive electrode and current returns to the power supply through the second node when the second node is configured to be the negative electrode.

Abstract: A device and method for irradiating a target structure with laser radiation. The device has at least one laser light source and at least one optical element, by means of which the laser radiation is guided through a light outlet opening and focused at a focal point outside the light outlet. The optical element includes an arrangement of a convex mirror inside a hollow mirror, the mirrors being arranged such that laser radiation emitted from the laser light source enters the hollow mirror at least partially through an opening, and the laser radiation that passes through the opening hits the convex mirror, is deflected from the convex mirror to the hollow mirror, and passes through the light outlet opening from the hollow mirror.