Patents Examined by Jasmine C. Chambers
  • Transgenic non-human animals depleted in a mature lymphocytic cell-type
    Patent number: 6023010
    Abstract: Transgenic mice having a phenotype characterized by the substantial depletion of a mature lymphocytic cell type otherwise naturally occurring in the species from which the transgenic mouse is derived. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell of the lymphocytic cell type which is depleted. The transgene comprised is a DNA sequence encoding a lymphatic polypeptide variant which inhibits maturation of the lymphocytic cell type.
    Type: Grant
    Filed: December 5, 1996
    Date of Patent: February 8, 2000
    Assignee: GenPharm International
    Inventors: Paulus Jacobus Angelinus Krimpenfort, Antonius Johannes Maria Berns
  • Transgenic mouse containing an IGF-1 transgene
    Patent number: 5837875
    Abstract: A transgenic mouse containing an IGF-1 transgene which is operably linked to a promoter sequence and is expressed in the pancreas of the mouse.
    Type: Grant
    Filed: December 26, 1995
    Date of Patent: November 17, 1998
    Assignee: The Autonomous University of Barcelona
    Inventors: Fatima Bosch, Alfons Valera