Abstract: A device includes a first end portion, a second end portion, an intermediate portion between the first end portion and the second end portion, and a graft material coupled to at least the intermediate portion. The first end portion has a first end diameter. The second end portion has a second end diameter larger than the first end diameter. The intermediate portion tapers between the first end portion and the second end portion. A method of diverting fluid flow from a first passage to a second passage comprising deploying the device in a third passage between the first passage and the second passage, expanding the first end portion against sidewalls of the first passage, and expanding the second end portion against sidewalls of the second passage.

Abstract: A prosthetic heart valve configured to replace a native heart valve and for post-implant expansion and having a valve-type indicator thereon visible from outside the body post-implant. The indicator communicates information about the valve, such as the size or orifice diameter of the valve, and/or that the valve has the capacity for post-implant expansion. The indicator can be an alphanumeric symbol or other symbol or combination of symbols that represent information about the characteristics of the valve such as the valve size. The capacity for post-implant expansion facilitates a valve-in-valve procedure, where the valve-type indicator conveys information to the surgeon about whether the implanted valve is suitable for the procedure and informs the choice of the secondary valve.

Abstract: A two-stage or component-based valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The prosthetic valve comprises a support structure that is deployed at a treatment site. The prosthetic valve further comprises a valve member configured to be quickly connected to the support structure. The support structure may take the form of a stent that is expanded at the site of a native valve. If desired, the native leaflets may remain and the stent may be used to hold the native valve open. In this case, the stent may be balloon expandable and configured to resist the powerful recoil force of the native leaflets. The support structure is provided with a coupling means for attachment to the valve member, thereby fixing the position of the valve member in the body. The valve member may be a non-expandable type, or may be expandable from a compressed state to an expanded state.

Abstract: A fixation device comprises a first clamping member having an adjustable clamping collar and a first curved support portion attached to the adjustable clamping collar. The first clamping member is adapted to receive a digit. The first curved support portion is adapted to support an inferior surface of a proximal phalanx of the digit. A distal member is adjustably attachable to the first clamping member. The distal member has a second curved support surface adapted to support an inferior surface of a distal phalanx of the digit and a curved distal end adapted to apply a compressive force in a proximal direction to a distal end of the distal phalanx.

Abstract: The invention relates to a device for use in the transcatheter treatment of mitral valve regurgitation, specifically a coaptation assistance element for implantation across the valve; a system including the coaptation assistance element and anchors for implantation; a system including the coaptation assistance element and delivery catheter; and a method for transcatheter implantation of a coaptation element across a heart valve.

Abstract: A temporo-mandibular joint prosthesis comprising: a first part for attaching to a temporal bone; a second part for attaching to a mandible bone; and a mechanism linking the first part and the second part. The mechanism defines a range of motion of the first part relative to the second part for when the first and second parts are attached to a temporal bone and a mandible bone, respectively. The mechanism includes a rotary joint providing a rotational range of motion of the first part relative to the second part; and a first slider joint providing a first translational range of motion of the first part relative to the second part.

Abstract: A prosthetic apparatus for implantation in a native mitral valve includes a main body for placement within the native mitral annulus. The main body is compressible to a radially compressed state for delivery into the heart and is self-expandable from the compressed state to a radially expanded state for implantation. A valve structure is mounted within a lumen of the main body and preferably forms three leaflets made of pericardium. An atrial sealing member is disposed along an atrial portion of the main body and ventricular anchors are coupled to a ventricular portion of the main body. The atrial sealing member impedes the flow of blood between the main body and the native annulus. The ventricular anchors are positioned outside the main body for capturing native mitral valve leaflets between the main body and the ventricular anchors.

Abstract: Knee prosthesis includes a femoral component adapted to fit on a distal end of the femur and a tibial insert component. The femoral component includes a measured anterior/posterior dimension defined by the posterior condyle surface and the interior surface of the anterior flange and a distal peg provided on a distal bone facing surface of each of the lateral and medial condylar structures, wherein the distal pegs are positioned at a midpoint of the measured anterior/posterior dimension. The implant system provides two distinct sizing segments and the tibial insert has a medial tibial aspect ratio of 0.74 and a lateral tibial aspect ratio of 0.65 to 0.68 for all sizes.

Abstract: A unitary flexible sheet is folded to define: (i) a panel, defining a plane, and having a first side facing in a first direction away from the plane, (ii) a first tab, disposed on the first side of the panel, and protruding in the first direction away from the panel, and (iii) a second tab, disposed on the first side of the panel, and protruding in the first direction away from the panel. Between the first tab and the second tab are secured (i) a first-leaflet commissural portion of a first prosthetic leaflet, and (ii) a second-leaflet commissural portion of a second prosthetic leaflet. At the first tab, the sheet is folded to define a first cushion at a downstream edge of the first tab. At the second tab, the sheet is folded to define a second cushion at a downstream edge of the second tab.

Abstract: An interphalangeal prosthesis (10) includes a mobile element (12), a proximal fixation element (22), and a distal fixation element (24). The mobile element (12) includes a proximal portion (42, 62, 94) and a distal portion (43, 64, 92), and the proximal portion includes three proximal mobile coupling contiguous surfaces (46, 48, 50) and a proximal mobile coupling protrusion (52), and the distal portion includes a distal coupling mobile surface (54) and a distal mobile coupling protrusion (56), and the proximal portion and the distal portion move relative to each other primarily in an axis of rotation perpendicular to a plane that extends through the proximal mobile coupling protrusion, the three proximal mobile coupling contiguous surfaces, the distal coupling mobile surface, and the distal mobile coupling protrusion in an implanted configuration.

Abstract: The present disclosure is directed to orthopedic implants and methods of rapid manufacturing orthopedic implants using in vivo data specific to an orthopedic implant or orthopedic trial. Specifically, the instant disclosure utilizes permanent orthopedic implants and orthopedic trials (collectively, “implants”) outfitted with kinematic sensors to provide feedback regarding the kinematics of the trial or implant to discern which implant is preferable, and thereafter rapid manufacturing the implant.

Abstract: Stents and methods of using stents are provided. Stents of the invention provide external support structure for a blood vessel segment disposed within, wherein the stents are capable of resilient radial expansion in a manner mimicking the compliance properties of an artery. The stent may be formed of a knitted or braided mesh formed so as to provide the needed compliance properties. A venous graft with the stent and a vein segment disposed within is provided, wherein graft is capable of mimicking the compliance properties of an artery. Methods of selecting stents for downsizing and methods of using the stents of the invention in downsizing and smoothening are provided. Methods of replacing a section of an artery with a venous graft including a stent of the invention are provided. Methods of reducing intimal hyperplasia in implanted vein segment in a venous graft using stents of the invention are provided.

Abstract: An instrument for assembling an implant on a neck. The implant and neck being coupled via a taper having a taper axis. The instrument includes a frame having a distal portion and a proximal portion, the distal portion of the frame including a retaining member adapted to engage a portion of the neck. The instrument also includes a force applier retained in the proximal portion of the frame. The force applier includes a screw having a screw axis that is coaxial with the taper axis, wherein the screw is adapted to engage the implant. As the screw is turned, the force applier applies a force on the implant while the neck is held in place by the frame, thereby causing the tapers of the implant and neck to engage.

Abstract: Devices and methods for treating defects in connective tissue are provided along with methods for making such devices. The devices can include acellular arterial tissue matrices that facilitate regrowth of the damaged tissue.

Abstract: A knee joint prosthesis is disclosed. The knee joint prosthesis can include a tibial baseplate, a tibial insert, and a spine. The tibial baseplate can include a tibial plateau, having a proximal surface and an opposing distal surface, and a tibial stem extending from the distal surface of the tibial plateau. The tibial insert can be located on the proximal surface of the tibial plateau and can include an aperture. The spine can extend through the aperture of the tibial insert and into a cavity of the tibial stem, from the proximal surface of the tibial plateau. The spine can be rotatable with respect to the tibial baseplate and the tibial insert. The knee joint prosthesis can further include a femoral component including a posteriorly-located femoral cam. The posteriorly-located femoral cam can engage the spine during movement of the knee joint prosthesis.

Abstract: In some aspects, graft devices for a mammalian patient can include a tubular member comprising a first end; and a fiber matrix surrounding the tubular member, wherein the fiber matrix is designed and constructed to be substantially continuously tapered at the first end to define a diameter that increases as it approaches the first end.

Abstract: An apparatus for bone cement delivery comprising, a proximal nozzle having a proximal end configured to couple to a bone cement source and a first distal delivery end having a circular cross section, a distal nozzle having a proximal end configured to slideably couple to the first distal delivery end and a second distal delivery end having an oblong cross section, that can be slanted, and an attachment mechanism configured to slideably retain the distal nozzle to the proximal nozzle.

Abstract: An orthopedic implant comprises an articulation head comprising a bearing surface and a reverse surface and a securement disk. The securement disk comprises an attachment surface attached to at least a portion of the reverse surface of the articulation head, a securement surface opposite the attachment surface and adapted for coupling to a fixation plate secured to a bone, and at least one opening formed in the securement surface of the securement disk and adapted to accept fasteners therein. The securement disk comprises a porous material.

Abstract: Various embodiments of stents with radiopaque markers disposed within depots in the stent, are described herein.

Abstract: Apparatus for regulating blood flow of a subject is provided, the apparatus comprising a prosthetic valve (20) that comprises a tubular element (22), shaped to define a lumen (23) therethrough, and a valve member (24), configured to be coupled to the tubular element (22) and to be disposed within the lumen (23). The prosthetic valve (20) has (1) a compressed configuration in which the lumen (23) has a compressed width, the valve member (24) is generally cylindrical, and the prosthetic valve (20) is configured to be percutaneously delivered into the subject, and (2) an expanded configuration in which the lumen (23) has an expanded width that is greater than the compressed width, and the valve member (24) is generally disc-shaped, is coupled to the tubular element (22), and is disposed within the lumen (23). Other embodiments are also described.