Patents Examined by Jason M. Nolan
  • Imidazolothiazole compounds for the treatment of disease
    Patent number: 7820657
    Abstract: Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: October 26, 2010
    Assignee: Ambit Biosciences Corporation
    Inventors: Shripad Bhagwat, Qi Chao, Robert M. Grotzfeld, Hitesh K. Patel, Kelly G. Sprankle
  • Isoindoline compounds and methods of their use
    Patent number: 7816393
    Abstract: Novel isoindoline compounds are disclosed. Methods of treating, preventing and/or managing cancer, diseases and disorders associated with, or characterized by, undesired angiogenesis, and diseases and disorders mediated by PDE 4, using the compounds are also disclosed.
    Type: Grant
    Filed: August 4, 2009
    Date of Patent: October 19, 2010
    Assignee: Celgene Corporation
    Inventors: George W. Muller, Hon-Wah Man
  • Biotin intermediate and process for preparing the same
    Patent number: 7799929
    Abstract: The present invention is to provide a process for preparing a synthetic intermediate of biotin which is industrially advantageous, and discloses a process for preparing a compound represented by the formula (I): 1 wherein R1 and R2 may be the same or different from each other, and each represents hydrogen atom, a benzyl group which may have a substituent(s) on the benzene ring, a benzhydryl group which may have a substituent(s) on the benzen ring, or a trityl group which may have a substituent(s) on the benzene ring, R3 represents cyano group, carboxyl group, an alkoxycarbonyl group, an alkylthiocarbonyl group, or a carbamoyl group which may have a substituent, or a salt thereof which comprises subjecting a compound represented by the formula (II-a): 2 wherein the symbols have the same meanings as defined above, or a salt thereof to ring transformation.
    Type: Grant
    Filed: January 7, 2008
    Date of Patent: September 21, 2010
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Masahiko Seki, Toshiaki Shimizu, Shin-ichi Yoshida, Masanori Hatsuda
  • 3?-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2?-hydroxy-[1,1?-biphenyl]-3-carboxylic acid bis-(monoethanolamine)
    Patent number: 7795293
    Abstract: An improved thrombopoietin mimetic, the bis-(monoethanolamine) salt of 3?-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazino]-2?-hydroxy-[1,1?-biphenyl]-3-carboxylic acid.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: September 14, 2010
    Assignee: GlaxoSmithKline LLC
    Inventor: Stephen Moore
  • Process for production of optically active PPAR-activating compound and intermediate of the same
    Patent number: 7790903
    Abstract: A process for obtaining a compound (1) and an intermediate thereof in high yield and high optical yield is provided. A process for producing a compound (4), the process including reacting a compound (2) with a compound (3) in the presence of a base; and a process for producing a compound (1), the process including reacting a compound (2) with a compound (3) in the presence of a base to yield a compound (4) and then deesterifying the compound (4). wherein R represents an alkyl group having 1 to 6 carbon atoms or an aralkyl group having 7 to 8 carbon atoms.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: September 7, 2010
    Assignee: Kowa Co., Ltd.
    Inventors: Yukiyoshi Yamazaki, Takaaki Araki, Minoru Koura, Kimiyuki Shibuya
  • Benzoyl-substituted serineamides
    Patent number: 7786046
    Abstract: The present invention relates to benzoyl-substituted serinamides of the formula I in which the variables R1 to R11 are as defined in the description, and to their agriculturally useful salts, to processes and intermediates for their preparation, and to the use of these compounds or of compositions comprising these compounds for controlling unwanted plants.
    Type: Grant
    Filed: March 29, 2006
    Date of Patent: August 31, 2010
    Assignee: BASF Aktiengesellschaft
    Inventors: Matthias Witschel, Cyrill Zagar, Eike Hupe, Toralf Kühn, William Karl Moberg, Liliana Parra Rapado, Frank Stelzer, Andrea Vescovi, Robert Reinhard, Bernd Sievernich, Klaus Groβmann, Thomas Ehrhardt
  • Process for the preparation of substituted indoles
    Patent number: 7781598
    Abstract: The invention relates to a novel process for the preparation of substituted indoles which are useful as therapeutic agents.
    Type: Grant
    Filed: January 9, 2006
    Date of Patent: August 24, 2010
    Assignee: AstraZeneca AB
    Inventors: Philip Keegan, Eric Merifield, Duncan Gill
  • 2-aryl-acetic acids, their derivatives and pharmaceutical compositions containing them
    Patent number: 7776909
    Abstract: Selected 2-arylacetic acids, their derivatives and pharmaceutical compositions that contain these compounds are useful in inhibiting chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2-membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from said activation. In particular, 2(ortho)-substituted arylacetic acids or their derivatives, such as amides and sulfonamides, lack cyclo-oxygenase inhibition activity and are particularly useful in the treatment of neutrophil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.
    Type: Grant
    Filed: February 4, 2004
    Date of Patent: August 17, 2010
    Assignee: Dompe Pha.R.Ma S.p.A.
    Inventors: Alessio Moriconi, Marcello Allegretti, Riccardo Bertini, Cinzia Bizzarri, Maria Candida Cesta, Francesco Colotta
  • Substituted [(phenylethanoyl)amino]benzamides
    Patent number: 7776922
    Abstract: The invention relates to substituted [(phenylethanoyl)amino]benzamides and methods for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of inflammatory disorders such as, for example, cutaneous, respiratory tract and cardiovascular disorders such as, for example, arteriosclerosis and coronary heart disease.
    Type: Grant
    Filed: November 17, 2005
    Date of Patent: August 17, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Ulf Brüggemeier, Petros Gatsios, Mark Meininghaus, Leila Telan, Elisabeth Woltering, Martina Wuttke, Hartmut Beck, Nils Griebenow, Frank Süβmeier, Niels Svenstrup, Axel Kretschmer, Marcus Bauser, Johannes Köbberling, Wahed Moradi, Siegfried Zaiss, Claudia Hirth-Dietrich, Barbara Albrecht
  • Pyrazole analogs
    Patent number: 7772269
    Abstract: The invention relates to the compounds of formula (I): or a pharmaceutically acceptable salt and solvate thereof, wherein R1 is F or H and to processes for the preparation of, intermediates used in the preparation of, compositions containing the uses of, such compounds. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular allergic and respiratory diseases, disorders and conditions.
    Type: Grant
    Filed: November 26, 2007
    Date of Patent: August 10, 2010
    Assignee: Pfizer Inc.
    Inventors: Mathew J. Graneto, Todd M. Maddux, Jaime L. Masferrer
  • Method of preparing sultines
    Patent number: 7772409
    Abstract: A method of preparing a sultine of formula (V) from a dihalogeno compound of formula (IV) is provided. The method comprises reacting the dihalogeno compound (IV) with a hydroxymethanesulfinate salt in a DMSO solvent, wherein: R1, R2, R3 and R4 are each independently selected from hydrogen, hydroxyl, C1-20alkyl, C1-20alkoxy, amino, C1-20alkylamino, di(C1-20alkyl)amino, halogen, cyano, thiol, C1-20alkylthio, nitro, C1-20alkylcarboxy, C1-20alkylcarbonyl, C1-20alkoxycarbonyl, C1-20alkylcarbonyloxy, C1-20alkylcarbonylamino, C5-20aryl, C5-20arylalkyl, C5-20arylalkoxy, C5-20heteroaryl, C5-20heteroaryloxy, C5-20heteroarylalkoxy or C5-20heteroarylalkyl; and X is Cl, Br or I.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: August 10, 2010
    Assignee: Silverbrook Research Pty Ltd
    Inventors: Sutharsiny Indusegaram, Simone Charlotte Vonwiller, Damon Donald Ridley, Kia Silverbrook
  • Synthesis of enone intermediate
    Patent number: 7763735
    Abstract: The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides a more efficient route for preparing the enone intermediate.
    Type: Grant
    Filed: October 11, 2007
    Date of Patent: July 27, 2010
    Assignee: President and Fellows of Harvard College
    Inventors: Andrew G. Myers, Jason D. Brubaker
  • Compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
    Patent number: 7763657
    Abstract: This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salt thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, and heart disease.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: July 27, 2010
    Assignee: Amorepacific Corporation
    Inventors: Hee-Doo Kim, Young-Ger Suh, Hyeung-Geun Park, Uh Taek Oh, Seol Rin Park, Joo Hyun Kim, Mi Jung Jang, Young-Ho Park, Song Seok Shin, Sun-Young Kim, Jin Kwan Kim, Yeon Su Jeong, Ki-Wha Lee, Jin Kyu Choi, Kyung Min Lim, Hyun Ju Koh, Joo Hyun Moh, Sung-Il Kim, Byoung Young Woo
  • Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, process for preparing them, medicaments comprising these compounds, and their use
    Patent number: 7759366
    Abstract: This invention relates to arylaminoaryl-alkyl-substituted imidazolidone-2,4-diones of formula (I) and also to their physiologically tolerated salts: Wherein R, R?, R1 to R10, A, D, E, G, L and p are as defined herein. The invention also relates to processes for preparing them, pharmaceutical compositions comprising them and their therapeutic use. The compounds are suitable, for example, as anti-obesity drugs and for treating cardiometabolic syndrome.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: July 20, 2010
    Assignee: Sanofi-Aventis
    Inventors: Gerhard Jaehne, Siegfried Stengelin, Matthias Gossel, Thomas Klabunde, Irvin Winkler
  • Indol-containing beta-agonists, methods for the preparation thereof and their use as pharmaceutical compositions
    Patent number: 7754756
    Abstract: The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 and R2 have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers, solvates, hydrates, mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, methods of preparing these compounds and their use as pharmaceutical compositions.
    Type: Grant
    Filed: October 19, 2006
    Date of Patent: July 13, 2010
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Rainer Walter, Bradford S. Hamilton, Thomas Trieselmann, Matthew R. Netherton, Marco Santagostino, Ingo Konetzki
  • Indoles are cannabinoid receptor ligands
    Patent number: 7750039
    Abstract: The present invention provides novel compounds of Formula (I) which are CB2 selective ligands useful for the treatment of pain.
    Type: Grant
    Filed: February 13, 2009
    Date of Patent: July 6, 2010
    Assignee: Abbott Laboratories
    Inventors: Jennifer M. Frost, Karin Tietje, Michael J. Dart, Michael D. Meyer
  • Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
    Patent number: 7745444
    Abstract: The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: June 29, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Robert B. Perni, John J. Court, Shawn D. Britt, Janos Pitlik, John H. van Drie
  • 1,5-substituted indol-2-yl amide derivatives
    Patent number: 7745479
    Abstract: The present invention relates to compounds of formula I wherein R1 to R4 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
    Type: Grant
    Filed: November 27, 2006
    Date of Patent: June 29, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Matthias Nettekoven, Jean-Marc Plancher, Hans Richter, Olivier Roche, Valerie Runtz-Schmitt, Sven Taylor
  • Formulations and methods of treating inflammatory bowel disease
    Patent number: 7737133
    Abstract: Methods and formulations for treating inflammatory bowel disease are disclosed. The methods and formulations include, but are not limited to, methods and formulations for delivering effective concentrations of 4-aminosalicylic acid and/or 5-aminosalicylic acid to affected areas of the intestine. The methods and formulations comprise modified-release elements, providing for drug delivery to the affected or desired area. Diseases and conditions treatable with the present invention include Crohn's disease and ulcerative colitis.
    Type: Grant
    Filed: September 1, 2004
    Date of Patent: June 15, 2010
    Assignee: AGI Therapeutics Ltd.
    Inventors: John Devane, Jackie Butler
  • Compound from and the use thereof
    Patent number: 7732482
    Abstract: The present invention relates to novel compounds from Antrodia camphorata and the use thereof.
    Type: Grant
    Filed: May 19, 2008
    Date of Patent: June 8, 2010
    Assignee: Simpson Biotech Co., Ltd.
    Inventors: Masao Hattori, Chia-Chin Sheu, Coolin Yang