Abstract: Introducing one or more stimulating drugs to the vagus nerve and/or one or more branches of the vagus nerve to treat movement disorders uses at least one implantable system control unit (SCU) with an implantable pump with at least one infusion outlet. Optional electrical stimulation may additionally be supplied by an implantable signal/pulse generator (IPG) with one or more electrodes. In certain embodiments, a single SCU provides one or more stimulating drugs and the optional electrical stimulation. In some embodiments, one or more sensed conditions are used to adjust stimulation parameters.

Abstract: Techniques are provided for distinguishing Cheyne-Stokes Respiration (CSR) caused by central sleep apnea (CSA) from CSR caused by congestive heart failure (CHF) and for evaluating the severity of CHF, if present, based up CSR. A time period associated with the CSR is determined based upon separate evaluation of apnea and hyperpnea periods during CSR and then the time period is compared against a time-varying discrimination threshold derived from integrated thoracic impedance signals. If the time period exceeds the threshold, the CSR of the patient is caused by CHF; otherwise, the CSR is caused by CSA. Thereafter, the course of therapy delivered to the patient is controlled based upon the type of CSR. In addition, if the CSR is caused by CHF, the time period associated with CSR is employed to determine the severity of CHF—with longer time periods being associated with more severe CHF.

Abstract: Methods and systems for computing epicardial surface electric potentials based on measured body surface electric potentials, where the methods and systems include representing at least one geometric relationship between at least one body surface electric potential measuring system and the epicardial surface as a multidimensional matrix, estimating an inverse of the multidimensional matrix based on a Generalized Minimum Residual (GMRes) method, and, based on the inverse matrix and the measured body surface potentials, determining the epicardial surface electric potentials.

Abstract: A conductive layer is made of a carbon fiber. A conductive lead wire is connected to the conductive layer to lead an electric signal. A conductive gel layer is attached to a first face of the conductive layer and adapted to be adhered on a living body. The conductive gel layer is formed from at least water, polymeric monomer, aminoalcohol as a pH adjuster, and a cross-linking agent so as to have a pH in a range from 8 to 13.