Abstract: Method and apparatus for optimizing analyte sensor calibration including receiving a current blood glucose measurement, retrieving a time information for an upcoming scheduled calibration event for calibrating an analyte sensor, determining temporal proximity between the current blood glucose measurement and the retrieved time information for the upcoming calibration event, initiating a calibration routine to calibrate the analyte sensor when the determined temporal proximity is within a predetermined time period, and overriding the upcoming scheduled calibration event using the current blood glucose measurement are provided.

Abstract: A system, device and methods for quantitatively monitoring and evaluating changes in water and hemoglobin content in the brain in a non-invasive manner are provided. The system may be used for real-time detection and monitoring of brain edema and/or for an assessment of cerebral autoregulation.

Abstract: An information processing device, an information processing method, a recording medium storing a program, and a biomedical-signal measuring system. The information processing device includes circuitry to obtain specific information of a first intensity distribution of a biomedical signal from a source, the specific information being displayed on a display, and extract, based on the specific information, a specified area of the first intensity distribution to obtain second intensity distribution of the biomedical signal to be superimposed on an image indicative of the source. The information processing method includes obtaining specific information of a first intensity distribution of a biomedical signal from a prescribed source, the specific information being displayed on a display, and extracting, based on the specific information, a specified area of the first intensity distribution to obtain second intensity distribution of the biomedical signal to be superimposed on an image indicative of the source.

Abstract: An analyte monitoring system includes an analyte sensor, a transceiver, and a display device. The analyte sensor may include an analyte indicator that exhibits one or more detectable properties based on an amount or concentration of an analyte in proximity to the analyte indicator. The transceiver may receive first sensor data directly from the analyte sensor and may calculate first analyte information using at least the received first sensor data. The display device may receive second sensor data directly from the analyte sensor and calculates second analyte information using at least the received second sensor data. The transceiver may convey the first analyte information, and the display device may receive the first analyte information conveyed by the transceiver and display the first and second analyte information.

Abstract: Methods for capturing and transmitting images by an in-vivo device comprise operating a pixel array in a superpixel readout mode to capture probe image, for example, according to a time interval. Concurrently to capturing of each probe image, the probe image is evaluated alone or in conjunction with other probe image(s), and if it is determined that no event of interest is detected by the last probe image, or by the last few probe images, the pixel array is operated in the superpixel readout mode and a subsequent probe image is captured. However, if it is determined that the last probe image, or the last few probe images, detected an event of interest, the pixel array is operated in a single pixel readout mode and a single normal image, or a series of normal image, is captured and transmitted, for example, to an external receiver.

Abstract: A continuous glucose monitoring system may utilize externally sourced information regarding the physiological state and ambient environment of its user for externally calibrating sensor glucose measurements. Externally sourced factory calibration information may be utilized, where the information is generated by comparing metrics obtained from the data used to generate the sensor's glucose sensing algorithm to similar data obtained from each batch of sensors to be used with the algorithm in the future. The output sensor glucose value of a glucose sensor may also be estimated by analytically optimizing input sensor signals to accurately correct for changes in sensitivity, run-in time, glucose current dips, and other variable sensor wear effects.

Abstract: The present invention relates to the acquisition, processing, and monitoring of signals, and particularly to the acquisition, processing, and monitoring of electrophysiological signals. More particularly, the present invention relates to the acquisition, processing, and monitoring electroencephalography (EEG) signals representing cortical/brain activity. Further, the present invention relates to a method and apparatus for acquiring such signals in the presence of electrical interference and noise. More particularly, the present invention relates to systems and methods for filtering out and rejecting electrical interference and noise while maintaining or improving the quality of the underlying physiological signal and preventing perturbation or introduction of artifacts into the physiological signal.

Abstract: A functional medical package is disclosed having a disposable package and a sterile container removably received inside the disposable package. A subsystem is received in the sterile container and is configured to be at least partially inserted into a host. The sterile container has an insertion exit opening for the subsystem and a liner closes the insertion exit opening. The liner is attached to the disposable package and automatically peels off the insertion exit opening when the sterile container is removed from the disposable package. Also disclosed are a method of manufacturing the medical package and a method of using the medical package with an inserter.

Abstract: In some examples, a device includes processing circuitry configured to receive first and second signals indicative of first and second physiological parameters and determine a trendline function based on values of first and second physiological parameters. The processing circuitry is further configured to determine transformed values of the first physiological parameter based on the trendline function. The processing circuitry is configured to determine correlation coefficient values for the transformed values of the first physiological parameter and the values of the second physiological parameter. The processing circuitry is further configured to determine a limit of autoregulation of the patient based on the correlation coefficient values. The processing circuitry is configured to determine an autoregulation status based on the estimate of the limit of autoregulation and output, for display, an indication of the autoregulation status.

Abstract: A wearable security device includes a strap and watch face base attached to the strap with a heart rate monitor on the backside of the watch face base that is placed on the vital signs of a user and records the vital signs of the user. Within the wearable security device is a memory for storage and at least one program configured to track and store the vital signs of the user. Also, an internal system is programmed to send a wireless alert signal in response to a vital sign of the user that indicates that the user is in danger.

Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into a host's peripheral vein or artery.

Abstract: Described is an apparatus for inline urine analysis comprising a control unit and at least one image capture unit comprising an image sensor and an optical assembly. The apparatus is configured to be coupled with an indwelling urinary catheter or conduit leading from the catheter. Embodiments of the apparatus comprise a dispenser configured to dispense inert or reactive matter into the urine stream to aid in the analysis of properties of the urine and an illumination device configured to illuminate the urine stream. Also described is a system comprising at least one of these apparatuses and at least one image analyzer unit operatively connected to it. The image analyzer unit comprises a processor and software adapted to analyze the captured images to derive information therefrom relating to identification of properties of the urine and/or objects of interest in the urine stream. Embodiments of the system may comprise other peripheral devices.

Abstract: A continuous glucose monitoring system may utilize externally sourced information regarding the physiological state and ambient environment of its user for externally calibrating sensor glucose measurements. Externally sourced factory calibration information may be utilized, where the information is generated by comparing metrics obtained from the data used to generate the sensor's glucose sensing algorithm to similar data obtained from each batch of sensors to be used with the algorithm in the future. The output sensor glucose value of a glucose sensor may also be estimated by analytically optimizing input sensor signals to accurately correct for changes in sensitivity, run-in time, glucose current dips, and other variable sensor wear effects.

Abstract: A sleep monitoring system includes an ECG device (2) and a respiration inductance plethysmogram (3) which monitor cardiac activity and physical (ribcage) respiration respectively and feed representative signals to a digital data processor. Operations (5-9) process the beat interval data, while in a second thread, operations (20-24) independently process the amplitude modulation of the ECG data caused by the respiratory motion of the subject. The inductance plethysmogram device (3) provides an input to the processor which represents respiration as directly monitored independently of the ECG. Operations (30-34) process this direct respiration data independently and in parallel, in a third thread. All extracted features are fed to a classifier which in step (10) combines selected combinations of features to make decisions in real time.

Abstract: Systems, architectures, and methods of neurophysiological monitoring are described. In a particular example, an architecture may include a monitoring system and display system including two or more display devices. The monitoring system may manage the monitoring of some aspect of a patient's nervous system. A first display device is positioned adjacent the patient and viewable by a first user. A second display device is positioned apart from the patient and viewable by a second user and obscured from the first user. The first display device and the second display device may be used to display monitoring data collected by the monitoring system.

Abstract: Provided are systems and methods for determining a subject's physiological parameters such as heart rate, blood glucose level, variation in heart rate and/or oxygen saturation in a non-contact manner. A photoplethysmography (PPG) signal representing physiological parameter is obtained from a subject by a sensor that generates non-contact PPG signal in red, blue, green (RBG) components. The method further includes a step of analyzing the RBG components for simultaneously measuring the oxygen saturation level and any of the heart rate, blood glucose level or variation in heart rate of the subject.

Abstract: Techniques are disclosed for detecting knowledge based on brainwave response to external stimulation. A subject can be exposed to stimuli and brainwave responses indicating a p-300 signal can be detected. Further stimuli or sequences of stimuli can be selected be presented to the subject based on the category correlated with the stimuli that indicate a p-300 response.

Abstract: An exemplary monitoring system 1) monitors evoked responses that occur in response to acoustic stimulation during an insertion procedure in which a lead that is communicatively coupled to a cochlear implant is inserted into a cochlea of a patient, the monitoring comprising using an intracochlear electrode disposed on the lead to measure a first and a second evoked response at a first and a second insertion depth within the cochlea, the second insertion depth nearer to an apex of the cochlea than the first insertion depth, 2) determines that a change between the first evoked response measured at the first insertion depth and the second evoked response measured at the second insertion depth is greater than a predetermined threshold, and 3) determines, based on the determination that the change is greater than the predetermined threshold, that cochlear trauma has likely occurred at the second insertion depth.

Abstract: A semi-rigid foot orthotic can have 3-axis accelerometers, gyroscopes, magnetometers, and strain gauges embedded in one or more flexible regions along with a microprocessor and wireless transmitter. Data from the sensors can be used to track the gait cycle. Data on the flexing, bending, or rotating of portions of the orthotic are processed and compared to ideal or data from other runs to rate the effectiveness of the orthotic. The orthotic and the sole of the shoe have relative freedom of motion between them. By doing a 3D comparing of the location, motion and orientation of the shoe from the same information for at least one orthotic region; determining shoe-to-orthotic relative motion. Modifications or adjustments can be made to improve the user-experience. The computation can involve either or both of a cloud based server and an external hand-held device in wireless communication with the orthotic.

Abstract: A method and device for detection of drowsiness of a person, based on a relationship between distal temperature and heart rate and on a balance between body heat loss and body heat production, wherein the distal temperature in a predetermined distal region of the person is monitored as a measure for body heat loss, and the heart rate of the person is monitored as a measure for body heat production, wherein drowsiness in the immediate future is concluded when a change of distal temperature passes a first threshold and, subsequently, a change of the heart rate passes a second threshold or, subsequently, the change of the distal temperature is larger than the change of the heart rate.