Abstract: Novel TF-2 substances having antitumor and immunostimulating activity, which are obtained from a culture or its supernatant fluid prepared by culturing bacteria belonging to Fusobacterium genus. Said substances are useful for the treatment of cancerous diseases of the mammals including human beings. This disclosure concerns such substances and a process for preparing the same and an antitumor agent containing the same.

Abstract: Fermentation of a culture of Nocardia sp. ATCC 39043 produces an antibiotic complex comprising erythromycin D, 3",4"-di-O-acetylerythromycin D, 3"-O-acetyl-4"-O-propionylerythromycin D and 4"-O-acetylerythromycin D. The components are separated and are each useful in vitro and in vivo as antibacterial agents. If erythromycin D is the desired product, the esters can be hydrolyzed prior to the separation of the erythromycin D.

Abstract: A medium for the rapid cultivation of mycobacteria, in particular leprosy and tubercle bacilli, comprises amino acids, sugars, phospholipids, muscle metabolism compounds, vitamins, inorganic salts and trace minerals.

Abstract: A novel antibiotic complex designated BBM-2478 is produced by fermentation of an actinomycete strain J907-21 (ATCC 39417). The complex may be separated chromatographically into two bioactive components designated BBM-2478A and BBM-2478B. The BBM-2478A component displays both antibacterial and antitumor activity while the BBM-2478B component has antibacterial activity.

Abstract: A yeast culture containing at least 10% by weight, based on the dry cell, of S-adenosyl methionine; and a process for producing S-adenosyl methionine, which comprises cultivating a yeast having the ability to produce S-adenosyl methionine in a liquid culture medium containing methionine to accumulate at least 10% by weight, based on the dry yeast cells, of S-adenosyl methionine in the yeast cells, separating the yeast cells from the culture medium, and thereafter obtaining S-adenosyl methionine in a stable form from the yeast cells.

Abstract: An improved process for the production of butanol by fermentation of carbon-containing compounds with C. acetobutylicum is disclosed. The fermentation is conducted in an aqueous medium containing a sufficient concentration of dissolved carbon monoxide to give increased yields of butanol while suppressing the formation of hydrogen and acetone. This fermentation also gives increased conversion of butyric acid to solvents.

Abstract: A substratum for cell culture which comprises a chemically modified collagen rich in either positive or negative charges when under culture conditions. The substratum is prepared by modifying the amino groups or carboxyl groups of collagen. The chemically modified collagen enhances the adherence and proliferation of animal cells much more actively than unmodified collagen in the presence or absence of bovine fetus serum. The cultured animal cells can be detached efficiently from the chemically modified collagen. This allows for highly selective isolation and recovery of the cultured animal cells which can be accomplished without incurring any injury from the chemically modified collagen.

Abstract: A new acidic polycyclic ether antibiotic, CP-63,517, having the formula: ##STR1## and cationic salts thereof produced by submerged aerobic propagation of Streptomyces endus subsp. aureus, ATCC-39574, a new strain of microorganism isolated from a soil sample in Japan, a process for producing this antibiotic and methods for its use to improve feed utilization, promote growth of cattle and swine and to control coccidiosis.

Abstract: A biologically pure culture of Actinomadura Sp. Strain H710-49 (ATCC 39144) is provided. The antibiotic designated BBM-1644 may be produced by fermentation of the subject culture.

Abstract: Disclosed is a process for preparation of the water-soluble peptide antibiotic designated Bu-2517 by fermentation of Empedobacter sp. strain G393-B445 (ATCC 31962).

Abstract: A novel asporogenic strain of Clostridium acetobutylicum is produced by growing a spore-forming strain in a continuous culturing reactor. Culturing is conducted at a dilution rate which prevents accumulation of butanol and acetone in the medium. Culturing at this dilution rate is continued until the asporogenic strain is obtained.