Patents Examined by Jeannette M Lieb
  • Uses of cyclic peptides for treating and preventing atherosclerosis
    Patent number: 10092620
    Abstract: The present invention provides cyclic compounds that are useful in preventing or treating atherosclerosis or related disorders. The invention also provides therapeutic methods for treating or preventing various diseases or disorders associated with or mediated by atherosclerosis. Further provided in the invention are methods of screening for anti-atherosclerotic cyclic peptides with improved properties.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: October 9, 2018
    Assignee: The Scripps Research Institute
    Inventors: M. Reza Ghadiri, Luke J. Leman, Yannan Zhao, Bruce E. Maryanoff
  • Protease triggered release of molecules from hydrogels
    Patent number: 10046053
    Abstract: The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a cross-linker comprising a peptide sequence that is capable of being degraded by an enzyme; the therapeutic agent being effective as a treatment of a condition related to the presence of the enzyme.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: August 14, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Brendan Patrick Purcell, Jason Alan Burdick