Abstract: The present invention generally provides methods and systems for managing a medical gas system by using wireless sensors located at the point of use. In one embodiment, a wireless sensor is fixed to a gas outlet, and is configured to measure gas flow, and to detect whether the gas outlet is connected to a medical device. The gas flow and connection data is included in a wireless signal that is transmitted to a remote server. The data received by the server may be analyzed to determine if any local or system leaks are occurring. In addition, the data may be used to monitor patient therapies, to calculate costs, and to determine replenishment points.