Patents Examined by Jeffrey Edwin Russel
  • Patent number: 7449547
    Abstract: A process for the total synthesis of Distamycin, and synthetic poly-(4 aminopyrrole-2-carboxamide) congeners thereof, using 1-methyl-4-forinylamino-2-pyrrolecarbonyl chloride iteratively as an intermediate, is provided. The process finds application for both in solution and solid support synthetic technologies.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: November 11, 2008
    Assignee: Naxopharma S.r.l.
    Inventor: Paolo Lombardi
  • Patent number: 7417024
    Abstract: Template-fixed ?-hairpin peptidomimetics of the general formulae (I), wherein Z is a template-fixed chain of 7 to 11 ?-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formulae, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases. These ?-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: August 26, 2008
    Assignees: Polyphor Ltd., Universität Zürich
    Inventors: Daniel Obrecht, John Anthony Robinson, Anne Descours
  • Patent number: 7390875
    Abstract: The invention concerns a method for binding, in solution, at least a peptide composition and at least a lipophilic vector bearing an aldehyde function, the coupling comprising a step which consists in producing a hydrazone bond between the peptide compound and the lipophilic vector. The invention also concerns lipophilic vectors for use in this method, lipopeptides obtained by this method, uses of the lipopeptides for cell screening, and the applications of the invention, in particular for preparing targeting of an active principle of the peptide kind (for example hormone or neuropeptide) through physiological barriers such as cell membranes.
    Type: Grant
    Filed: September 7, 2001
    Date of Patent: June 24, 2008
    Assignee: Institut Pasteur de Lille
    Inventors: Dominique Bonnet, Line Bourel, Oleg Melnyk, Hélène Gras-Masse
  • Patent number: 7387996
    Abstract: Stable insulin formulations can be prepared by mixing a monomeric insulin and a soluble acylated insulin analog.
    Type: Grant
    Filed: July 29, 2005
    Date of Patent: June 17, 2008
    Assignee: Novo Nordisk A/S
    Inventor: Liselotte Langkjaer
  • Patent number: 7381706
    Abstract: A novel peptide found as gonadotropin-releasing hormone (GnRH) in octopuses, a member of mollusks. The structure and the activities of the peptide have been unraveled. The peptide finds use as a reagent used in the studies of correlations between the structure and the activities of GnRH and the information processing mechanisms of the nervous systems in higher animals. It can also serve as a base compound in the development of pesticides and drugs. The peptide has the GnRH activity and has the following amino acid sequence (I): <Glu-Zaa-Zaa-His-Zaa-Ser-Zaa-Zaa-Zaa-Zaa-Pro-Gly-NH2 (SEQ ID NO: 7) ??(I) wherein <Glu represents pyroglutamic acid and Zaa represents any amino acid. Specifically, the peptide has the following amino acid sequence (1): <Glu-Asn-Tyr-His-Phe-Ser-Asn-Gly-Trp-His-Pro-Gly-NH2 (SEQ ID NO: 1) ??(1) wherein <Glu represents pyroglutamic acid.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: June 3, 2008
    Assignee: Suntory Limited
    Inventors: Hiroyuki Minakata, Eiko Iwakoshi, Kyoko Kuroda
  • Patent number: 7381703
    Abstract: Aplidine and aplidine analogues are used in the manufacture of a medicament for treating multiple myeloma.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: June 3, 2008
    Assignees: Dana-Faber Cancer Institute, Inc., Pharma Mar, S.A.
    Inventors: Joseph R. Bertino, Daniel Medina, Glynn Thomas Faircloth, Constantine S. Mitsiades, Kenneth Anderson, Nicholas Mitsiades
  • Patent number: 7381416
    Abstract: The purpose of this invention is: new selenohydroxy acid compounds and their derivatives; their process for the preparation; use of the new compounds as precursors of L(+)-selenomethionine and/or source of selenium in human or animal nutrition, in cosmetics and pharmaceutics; and nutritional, cosmetic and pharmaceutical compositions containing them.
    Type: Grant
    Filed: July 22, 2005
    Date of Patent: June 3, 2008
    Assignee: Tetrahedron SAS
    Inventors: Irène Erdelmeir, Jean-Claude Michel, Marc Moutet, Jean-Claude Yadan
  • Patent number: 7378396
    Abstract: The present invention provides methods and agents for treating subjects who have or are at risk of developing or having cardiovascular disease. Such agents inhibit binding of myeloperoxidase (MPO) to a molecule comprising the MPO binding site of apolipoprotein A-1 (apoA-1) and include a peptide fragment of apoA-1 comprising at least 4 contiguous amino acids in SEQ ID. NO: 2, a modified form of the apo-1 fragment comprising one or more D amino acids, a retro-inverso form of the apoA-1 peptide fragment, an organo-mimetic of the apoA-1 peptide fragment, a peptide-mimetic of the apoA1 peptide fragment, or a nucleic acid encoding the apo A-1 peptide fragment. The present invention also provides methods of identifying or screening test agents for treating subjects having or at risk of having or developing CVD.
    Type: Grant
    Filed: August 5, 2005
    Date of Patent: May 27, 2008
    Assignee: The Cleveland Clinic Foundation
    Inventors: Stanley L. Hazen, Marc S. Penn
  • Patent number: 7375080
    Abstract: Disclosed is a composition of matter comprising a defined dispersion of lactoferria immobilized on a naturally occuring substrate via the N-terminus region of the lactoferrin. Compositions comprising immobilized lactoferrin (Im-LF) are used in a method for reducing the microbial contamination of a composition subject to microbial contamination, which is also disclosed, and which encompasses a method for reducing the microbial contamination of a foodstuff, such as a meat product. Foodstuffs treated by the method are disclosed, including meat products. A method of inhibiting the growth and/or adhesion of a microbial species on a food-contacting surface f a material for food packaging or food handling with Im-LF is also disclosed. Food containers and food-handling implements so treated are also disclosed, as are antimicrobial cleansers, polishes, paints, sprays, soaps, or detergents containing Im-LF for applying to an inanimate surface.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: May 20, 2008
    Inventor: A. Satyanarayan Naidu
  • Patent number: 7371411
    Abstract: The present invention relates to a composite for the treatment of a variety of medical conditions, the composite comprising an oxidized glutathione-based compound, which has a disulfide bond, and a metal material, in particular where the metal is either platinum or palladium. The oxidized glutathione-based compound and metal material can be present in a ratio of 3000 to 1 and preferably 1000 to 1. The oxidized glutathione-based compound can be oxidized glutathione itself or salts or derivatives. A feature of the invention is that the composite has a more stabilized disulfide bond than the oxidized glutathione-based compound itself. Methods for preparing the composite are provided, such methods being beneficial in that the composite is provided in high yields and at high purity. Methods for treating various medical conditions with the composites of the present invention are also disclosed.
    Type: Grant
    Filed: December 27, 2006
    Date of Patent: May 13, 2008
    Assignee: Novelos Therapeutics, Inc.
    Inventors: Leonid A. Kozhemyakin, Mark B. Balasovski
  • Patent number: 7371579
    Abstract: The invention relates to a compound comprising a labeled nickel complex (FIG. 1) that is used to detect and purify nucleic acid sequences by forming an adduct between a specific nucleic acid base and the labeled nickel complex.
    Type: Grant
    Filed: July 3, 2000
    Date of Patent: May 13, 2008
    Assignee: The University of Maryland
    Inventors: Steven E. Rokita, Cynthia J. Burrows
  • Patent number: 7368425
    Abstract: The present disclosure teaches analogs of human chemokines and methods of using them in the prevention, treatment, and ameliorization of diseases that can benefit from therapeutic angiogenesis. The teachings are generally directed to compositions comprising SDF-1 mimetics, as well as methods that include the use of SDF-1 mimetics to induce neo-vessel formation. The disclosure also teaches articles of manufacture that can be useful in practicing the methods taught herein.
    Type: Grant
    Filed: March 24, 2006
    Date of Patent: May 6, 2008
    Assignee: Chemokine Therapeutics Corp.
    Inventors: Ahmed Merzouk, Carolina Abramovich, Hassan Salari
  • Patent number: 7368433
    Abstract: The subject invention provides novel peptides for use in treating mammals to control appetite and obesity. Disclosed is a peptide derivative having the formula: X1-Z-Q-arg-trp-NH2 wherein: X1 is an acyl group, Z is amino-2-naphthyl-carboxylic acid or histidine, Q is (D)phenylalanine or p-iodo-(D)phenylalanine, or a pharmacologically acceptable salt, complex or derivative thereof, the peptide derivative having melanocortin-4 receptor agonist activity.
    Type: Grant
    Filed: November 8, 2005
    Date of Patent: May 6, 2008
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Carrie Haskell-Luevano, Jerry Ryan Holder
  • Patent number: 7364752
    Abstract: A pharmaceutical composition is disclosed which comprises a solid dispersion of an HIV protease inhibitor in a water soluble carrier, such as PEG, having enhanced bioavailability and improved dissolution properties. The solid dispersion may optionally be encapsulated in hard gelatin capsules, compressed into a tablet, or may be granulated with a pharmaceutically acceptable granulating agent. Also disclosed are methods of making said solid dispersion and methods of treating an HIV infection employing said solid dispersion.
    Type: Grant
    Filed: November 10, 2000
    Date of Patent: April 29, 2008
    Assignee: Abbott Laboratories
    Inventors: James J. Fort, Steven L. Krill, Devalina Law, Yihong Qiu, William R. Porter, Eric A. Schmitt
  • Patent number: 7358077
    Abstract: Described are methods for electrical treatment of biological cells, in particular using electrical field pulses, involving the steps: arrangement of the cells (1) on apertures (2) of a solid planar carrier element (3) which divides a measuring chamber (10) into two compartments (11, 12); and temporary formation of an electrical treatment field which permeates the cells, wherein an alternating-current impedance measurement takes place on the carrier element (3), and from the result of the alternating-current impedance measurement, a degree of coverage of the carrier element and/or healing of the cells after electrical treatment are/is acquired. Also described are devices for implementing the methods.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: April 15, 2008
    Assignee: Eppendorf AG
    Inventors: Ulrich Zimmermann, Vladimir Sukhorukov, Kurt Lucas
  • Patent number: 7351693
    Abstract: The invention relates to anti-microbial and immunostimulatory molecules of the cathelicidin family derived from fish. The invention provides a novel cathelicidin molecule, fragments, derivatives and uses thereof, and nucleic acids encoding the same.
    Type: Grant
    Filed: January 27, 2003
    Date of Patent: April 1, 2008
    Assignee: University Court of the University of Aberdeen
    Inventors: Christopher John Secombes, Olga Pleguezuelos
  • Patent number: 7351691
    Abstract: Disclosed are glycopeptides that are substituted with one or more substituents each comprising one or more phosphono groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
    Type: Grant
    Filed: October 23, 2006
    Date of Patent: April 1, 2008
    Assignee: Theravance, Inc.
    Inventors: Michael R. Leadbetter, Martin S. Linsell
  • Patent number: 7348310
    Abstract: The invention relates to aplidine derivatives of the general formula: which are useful for the treatment of tumors.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: March 25, 2008
    Assignee: Pharma Mar, S.A.
    Inventors: Ignacio Rodriguez, Concepción Polanco, Felix Cuevas, Paloma Mendez, Carmen Cuevas, Pilar Gallego, Simon Munt, Ignacio Manzanares
  • Patent number: 7348307
    Abstract: The present invention provides methods of treating a lymphoma (e.g.
    Type: Grant
    Filed: May 3, 2006
    Date of Patent: March 25, 2008
    Assignee: Praecis Pharmaceuticals Incorporated
    Inventors: Gary L. Olson, Christopher Self, Lily Lee, Charles M. Cook, Jens Birktoft, Barry Morgan, Christopher C. Arico-Muendel
  • Patent number: 7348308
    Abstract: Peptide inhibitors of glycogen synthase kinase-3 (GSK-3) having an amino acid sequence motif of XZXXXS(p)X, wherein S(p)=phosphorylated serine or phosphorylated threonine, X=any amino acid, and Z=any amino acid except serine or threonine. These inhibitors, which are about 7 to 20 amino acids long, are specific for GSK-3 and strongly inhibit the enzyme with an IC50 of about 150 ?M. Also provided are methods of treating biological conditions mediated by GSK-3 activity, such as potentiating insulin signaling in a subject, treating or preventing type 2 diabetes in a patient, and treating Alzheimer's Disease by administering peptide inhibitors. Compositions of these peptide inhibitors and pharmaceutically acceptable carriers are also provided, as is a method for identifying inhibitors of GSK-3. The invention further relates to a computer-assisted method of structure based drug design of GSK-3 inhibitors using a three-dimensional structure of a peptide substrate of GSK-3.
    Type: Grant
    Filed: November 21, 2006
    Date of Patent: March 25, 2008
    Assignee: Tel Aviv University Future Technology Development L.P.
    Inventor: Hagit Eldar-Finkelman