Abstract: The invention is a method for conducting an electrochemiluminescent assay that includes contacting a sample containing an analyte of interest with a first electrical waveform, followed by contacting the sample with a second electrical waveform that has been modulated in an amount derived from a pre-determined gain extension factor.
Type:
Grant
Filed:
December 8, 1997
Date of Patent:
August 31, 1999
Assignee:
Igen International, Inc.
Inventors:
Stephanie A. Hayes, Jonathan K. Leland, David B. Talley
Abstract: A polymeric gas sensor utilizes a variety of electrode geometries to generate varied responses to selective gases. The characteristic response to various gases of each electrode geometry permits the construction of a gas sensor having desirable and reproducible characteristic responses to specific gases. The gas sensor array of the invention produces characteristic responses from a plurality of sensors. These responses collectively produce a characteristic response pattern that can be used for the identification of specific gases with pattern recognition techniques.
Abstract: A vessel useful for the collection of body fluid samples includes a first elongate tube defining an axis. The first tube has an open end with an inside diameter and a closed end section with an outside diameter. The first tube includes a receptacle therein for receiving a fluid sample that is accessible from open end. The vessel includes a second elongate tubes substantially identical to the first tube. The closed end section outside diameter is less than the inside diameter of the open end. The first tube closed end section is conjugately disposed in the open end of the second tube so that the first tube and the second tube are substantially axially aligned thereby forming a single article.
Abstract: An apparatus for cleaning a disposal chute in a building, the chute having a chute wall, includes a crane and cable assembly; a cleaning fluid spraying assembly suspended from the crane and cable assembly for lowering and raising within the chute; a flexible fluid delivery line suspended from the spraying assembly; and a fluid pump assembly connected to the flexible fluid delivery line. The spraying assembly preferably additionally includes a guide cage having resilient and outwardly bowed vertical support ribs interconnected by lateral support hoops extending substantially parallel to the mounting plate. The apparatus preferably additionally includes at least one cage wheel having an axial wheel port and being rotatably mounted on at least one support hoop for rolling against the chute wall as the spraying assembly is raised and lowered within the chute.
Abstract: A microplate assembly for use in analyzing samples captured on a filter medium comprises a holding tray and a collimator having multiple sample wells. These elements are generally rectangular in shape and are sized to stack on top of one another. The filter medium is positioned within the holding tray and the holding tray is positioned within the collimator with the filter medium positioned beneath the collimator. To prepare samples in the microplate assembly for analysis, the samples are captured on the filter medium and the filter medium is placed in the holding tray. After adding scintillation cocktail or luminescent substrate to the filter medium, the collimator is placed over the holding tray with the filter medium positioned between the collimator and the holding tray and the samples disposed in the sample wells. The holding tray, the filter medium and the collimator are provided with complementary keyed corners to facilitate alignment of these elements relative to one another.
Abstract: A chemical switch device comprising a film which irreversibly reacts upon exposure to specific chemical components in the environment under the conditions of measurement. The reactions can lead to large changes in the physical and chemical properties of the film which are measurable electrically, optically or by other methods.
Type:
Grant
Filed:
June 1, 1995
Date of Patent:
August 17, 1999
Assignee:
The Arizona Board of Regents, A Body Corporate of the State of Arizona, Acting for and On Behalf of Arizona State University
Inventors:
William Glaunsinger, Ian Sorensen, Qingcheng Bao, Michael J. McKelvy
Abstract: The present invention provides a selective fluorescent chemosensor, sensitive to nanomolar concentrations of zinc(II) and selective for this ion over Na.sup.+, Mg.sup.2+, Co.sup.2+.
Abstract: A reagent and a method for classifying leukocytes with a flow cytometer by means of optical measurements on fluorochrome-stained blood cells are included.The reagent and the method are useful in the practice of clinical testing.
Abstract: A method and a reagent for highly accurate measuring of trace amount of metals in a sample of living body. The method and the reagent for measuring metals in a sample of living body includes:(1) a method for measuring metals in sample of living body, in which metals other than the objective metals of measurement are added to the measurement system to release the objective metals bonding to co-existing substances in the sample from the co-existing substances; and(2) a reagent for the measurement, in which metals other than the objective metals of the measurement are contained in a reagent for measuring metals in a sample of living body in order to release the objective metals bonding to the co-existing substances in the sample from the co-existing substances.
Type:
Grant
Filed:
June 30, 1997
Date of Patent:
July 20, 1999
Assignee:
Iatron Laboratories, Inc.
Inventors:
Kazuyoshi Nishidate, Hiroshi Suzuki, Youko Suzuki, Youko Koga
Abstract: An integrated biochemical sensor (200) for detecting the presence of one or more specific samples (240) having a device platform (355) with a light absorbing upper surface and input/output pins (375) is disclosed. An encapsulating housing (357) provides an optical transmissive enclosure which covers the platform (355) and has a layer of fluorescence chemistry on its outer surface (360). The fluorophore is chosen for its molecular properties in the presence of the sample analyte (240). The detector (370), light sources (365, 367, 407, 409) are all coupled to the platform (355) and encapsulated within the housing (357). A filter (375) element is used to block out unwanted light and increase the detector's (370) ability to resolve wanted emission light.
Type:
Grant
Filed:
October 1, 1997
Date of Patent:
July 13, 1999
Assignee:
Texas Instruments Incorporated
Inventors:
Jose Melendez, Richard A. Carr, Diane L. Arbuthnot
Abstract: Compositions containing a stable, liquid, ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
Type:
Grant
Filed:
May 30, 1997
Date of Patent:
July 6, 1999
Assignee:
Alcon Laboratories, Inc.
Inventors:
Bahram Asgharian, Ronald P. Quintana, Bor-Shyue Hong
Abstract: The concentration of the active ingredient in a rolling oil emulsion can be rapidly determined, and correction of the concentration of the active ingredient can be undertaken by measuring the measuring the amount of light reflected from the emulsion at the peak absorbing wavelength of the dye to obtain a first reflectance value and measuring the amount of light reflected from said emulsion at a wavelength other than the peak absorbing wavelength of the dye to obtain a second reflectance value for at least two different concentrations of the rolling oil in the rolling oil emulsion, establishing a calibration curve, and then monitoring the rolling oil emulsion in like manner. The results may be utilized to feed additional additive to the emulsion, or may be used to feed water into the emulsion system.
Abstract: A method of assessing glycated blood protein in a sample which comprises separating glycated and non-glycated protein using a liquid phase precipitation reagent, contacting the sample with a signal forming agent capable of binding preferentially to the glycated protein, and assessing the signal forming agents.
Abstract: A method for the quantitative determination of dissolved oxygen in a liquid fuel includes the steps of doping a sample of the fuel with a preselected concentration of a probe material including a luminophor which exhibits luminescence of wavelength which is quenched by oxygen dissolved in the fuel, illuminating the fuel with light from a coherent light source, such as a laser, of a wavelength which induces the luminescence in the luminophor, and thereafter measuring the change with time of the luminescence from the luminophor in the fuel and determing from the change with time of the luminescence the concentration of oxygen in the fuel.
Type:
Grant
Filed:
July 16, 1997
Date of Patent:
July 6, 1999
Assignee:
The United States of America as represented by the Secretary of the Air Force
Inventors:
James R. Gord, Steven W. Buckner, William L. Weaver, Keith D. Grinstead, Jr.
Abstract: A plurality of light emission molecules, having different light emission lifetimes, are irradiated with excitation light so that the light emission molecules emit light. The emitted light is divided into at least two different wavelength regions. Temporal changes in each of the at least two wavelength regions of the light emission is measured over at least two different time periods. Information on energy transfer generated between the plurality of light emission molecules is determined based on the measured results in each of the wavelength regions over each of the time periods.
Abstract: Biologic molecules and pathogens in a sample substance are detected by utilizing the multiplicity of mirrors in a digital micromirror device as test sites to which molecular probes are attached and to which the sample substance is applied. A molecule or pathogen bonded on the surface of a micromirror activated with an appropriate molecular probe can be detected by optical projection or software interrogation of the array of micromirrors.
Abstract: Paint applied to a wheel electrostatically in the dry state is removed subsequently from the hub by a method of which the first step is to block the hub from one side with a plate, offered to a first face of the wheel and of shape such that it combines with the substantially cylindrical bore of the hub to create a chamber which remains accessible from the opposite face of the wheel. A jet of air is then generated close to the hub and introduced into the chamber, investing the cylindrical surface directly or indirectly or obliquely and creating a turbulence sufficient to remove the unwanted layer of paint; at the same time, suction is generated at least in the part of the chamber flooded with air, in such a way as to aspirate and recover the particles of paint removed from the hub and held in suspension by the resulting swirl.
Abstract: The process of this invention comprises providing a membrane for separating CO.sub.2 into a first CO.sub.2 sample phase and a second CO.sub.2 analyte phase. CO.sub.2 is then transported through the membrane thereby separating the CO.sub.2 with the membrane into a first CO.sub.2 sample phase and a second CO.sub.2 analyte liquid phase including an ionized, conductive, dissociated CO.sub.2 species. Next, the concentration of the ionized, conductive, dissociated CO.sub.2 species in the second CO.sub.2 analyte liquid phase is chemically amplified using a water-soluble chemical reagent which reversibly reacts with undissociated CO.sub.2 to produce conductivity changes therein corresponding to fluctuations in the partial pressure of CO.sub.2 in the first CO.sub.2 sample phase. Finally, the chemically amplified, ionized, conductive, dissociated CO.sub.2 species is introduced to a conductivity measuring instrument. Conductivity changes in the chemically amplified, ionized, conductive, dissociated CO.sub.
Type:
Grant
Filed:
April 4, 1997
Date of Patent:
June 8, 1999
Assignee:
Umpqua Research Company
Inventors:
James E. Atwater, James R. Akse, Jeffrey DeHart
Abstract: A system for cleaning vessels that have been contaminated with oil field drilling and production waste materials such as oil well drilling fluid or hazardous waste using recycled wash water. As dirty wash water accumulates in a vessel during cleaning, it is transferred to a settlement section of the waste receiving barge. A cationic polymer is injected into the suction side of a waste water pump during transfer of dirty fluid from the vessel to the receiving barge. The polymers react with fluids to begin an initial settling process within the waste receiving barge. Decant water is subjected to secondary settlement and secondary chemical treatment after it leaves the primary settling section of the waste receiving barge. The laundered water is returned to the wash water storage facility for reusing and cleaning the same vessel or additional vessels. In this fashion, waste is continuously concentrated in the receiving vessel for ultimate disposal at a remote site and wash water is recycled for reuse.