Patents Examined by Jehanne Sitton
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Patent number: 9863002Abstract: Described are methods of determining if a subject has a genetic predisposition to developing prostate cancer (PCa), e.g., an American or Caribbean subject of African descent and of reducing their risk.Type: GrantFiled: May 31, 2013Date of Patent: January 9, 2018Assignees: North Carolina Central University, University of Louisville Research FoundationInventors: La Creis Renee Kidd, Kevin Sean Kimbro
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Patent number: 9828638Abstract: Described are methods and kits for identifying a subject at risk of, or having, a sensory neuropathy related disease, such as sensory neuropathies. In particular, the disclosure is based on the determination of mutations in the SPTLC2 gene causing sensory neuropathies.Type: GrantFiled: September 19, 2011Date of Patent: November 28, 2017Assignees: VIB VZW, Universiteit Antwerpen, University of Zurich, Medical University of GrazInventors: Annelies Rotthier, Vincent Timmerman, Michaela Auer-Grumbach, Thorsten Hornemann
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Patent number: 9797015Abstract: Described herein is a method of determining lithium responsiveness in a bipolar disorder patient. The method includes obtaining a sample from a patient having bipolar disorder, and assaying the sample for the presence or absence of one or more glutamate decarboxylase-like 1 (GADL1) gene variants selected from the group consisting of a T allele of the single nucleotide polymorphism (SNP) rs17026688, a G allele of the SNP rs17026651, and GADL1 1VS8+48delG. The presence of one or more of the GADL1 gene variants indicates that the patient is responsive to lithium treatment.Type: GrantFiled: January 29, 2014Date of Patent: October 24, 2017Assignee: Academia SinicaInventors: Andrew Tai-Ann Cheng, Yuan-Tsong Chen, Chien-Hsiun Chen, Chau-Shoun Lee, Ming Ta Michael Lee
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Patent number: 9771616Abstract: The present invention relates to a nucleic acid molecule comprising an annexin A5 (ANXA5) gene regulation element which comprises at least one point mutation corresponding to nucleotide 186 (G to A), 203 (A to C), 229 (T to C), and 276 (G to A) of SEQ ID NO: 2, a vector comprising the nucleic acid molecule, and a host transformed with the vector. The invention also relates to specific uses, in particular diagnostic uses of the nucleic acid molecules described herein. The invention also relates to haplotyping an ANXA5 gene regulation element from a nucleic acid from an individual which involves determining nucleotides present at positions 186, 203, 229 and 276 of the individual's copy of the ANXA5 gene regulation element by comparison to SEQ ID NO: 2.Type: GrantFiled: January 13, 2012Date of Patent: September 26, 2017Assignee: Universitätsklinikum MünsterInventors: Nadja Bogdanova, Arseni Markoff, Jürgen Horst, Volker Gerke
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Patent number: 9758836Abstract: The present invention provides compositions and methods for detecting Candidatus Liberibacter infection and Huanglongbing disease in a citrus plant by detecting the expression of small RNAs such as miRNA and siRNA. The invention also provides methods for treating Huanglongbing disease in a citrus plant by contacting the plant with a phosphorus containing solution.Type: GrantFiled: March 7, 2012Date of Patent: September 12, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventor: Hailing Jin
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Patent number: 9745634Abstract: This invention identifies and provides a recurrent translocation t(4;8) (p16.2; p23.1) associated with certain cancers and other abnormal cell growth disorders and diagnostic methods using the translocation by FISH hybridization or PCR based assays.Type: GrantFiled: November 20, 2014Date of Patent: August 29, 2017Assignee: The Translational Genomics Research InstituteInventors: Kimberly Bussey, Michael J. Demeure
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Patent number: 9714450Abstract: Genetic markers of schizophrenia (SCZ) are presented herein, as are methods for using same for assessing risk of developing SCZ and diagnosing SCZ. Methods for choosing a therapeutic regimen and predicting and/or determining efficacy of a therapeutic regimen based on these genetic markers are also encompassed herein.Type: GrantFiled: September 3, 2013Date of Patent: July 25, 2017Assignee: New York UniversityInventor: Dolores Malaspina
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Patent number: 9650678Abstract: Methods of identifying a subject having an increased risk of developing anthracycline-related cardiotoxicity are provided. Such methods may include isolating a DNA sample from a biological specimen from the subject; genotyping the DNA sample to determine a copy number of a variant allele that increases the risk of developing chemotherapy-induced cardiotoxicity; and identifying the subject as having an increased risk of developing anthracycline-related cardiotoxicity when the copy number is at least one. In some embodiments, the methods may include optimally administering a therapeutically effective dose of a chemotherapy agent or an alternative non-cardiotoxic chemotherapeutic agent to the subject.Type: GrantFiled: December 9, 2013Date of Patent: May 16, 2017Assignee: CITY OF HOPEInventor: Smita Bhatia
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Patent number: 9637788Abstract: The present invention provides a method for detecting the presence or absence of, or for discriminating between, blood type variants, including RHD*r?s, RHD*DIIIa, RHD*DIVa-2, RHCE*css and RHCE*ce733G. The method comprises genotyping a sample obtained from a human subject at one or more positions in intron 7 of the RHD gene and/or in intron 7 of the RHCE gene. The invention also provides products, in particular, probes, primers and kits for use in the method of the invention.Type: GrantFiled: June 14, 2012Date of Patent: May 2, 2017Assignee: Progenika Biopharma, S.A.Inventors: Jorge Ochoa, Monica Lopez, Sergio Escorza, Diego Tejedor, Antonio Martinez, Laureano Simon
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Patent number: 9605320Abstract: Predictive biomarkers identify those patients suffering from immunoglobulin positive (Ig+) B lineage malignancies that are responsive to active immunotherapy, where the active immunotherapy comprises vaccination with a tumor-specific idiotype-immunogen. It is shown herein that patient responsiveness to the idiotype-immunogen is dependent upon the sequence of the immunogen, where an immunogen having a low number of tyrosine residues in the CDR1 (herein termed CDR1-Y10) regions of one or both of the immunogen heavy and light chains is predictive of a positive anti-tumor response, while a high number of CDR1 tyrosine residues (herein termed CDR1-Yhi) is predictive of a low anti tumor response.Type: GrantFiled: January 10, 2012Date of Patent: March 28, 2017Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Arash Ash Alizadeh, Dan Denney, Ronald Levy
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Patent number: 9556486Abstract: The present invention relates, in general, to perioperative bleeding and, in particular, to methods of identifying individuals at risk of perioperative bleeding. The present invention relates, in general, to perioperative renal dysfunction and, in particular, to methods of identifying individuals at risk of perioperative renal dysfunction. The present invention relates, in general, to perioperative stroke and, in particular, to methods of identifying individuals at risk of perioperative stroke.Type: GrantFiled: December 6, 2013Date of Patent: January 31, 2017Assignee: Duke UniversityInventors: Debra A. Schwinn, Ian Welsby, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Hilary P. Grocott, William D. White, Richard W. Morris, Joseph P. Mathew
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Patent number: 9556488Abstract: The present invention provides an isolated nucleic acid molecule containing a repeat region of an isolated spinocerebellar ataxia type 8 (SCA8) coding sequence, the coding sequence located within the long arm of chromosome 13, and the complement of the nucleic acid molecule. Diagnostic methods based on identification of this repeat region are also provided.Type: GrantFiled: April 28, 2014Date of Patent: January 31, 2017Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Laura P. W. Ranum, Michael D. Koob, Kellie A. Benzow, Melinda L. Moseley-Alldredge
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Patent number: 9556484Abstract: The present invention relates to a method, in particular an in vitro method for identifying IL-17 expressing T cells in a blood and/or tissue sample derived from a mammal, comprising analysing the methylation status of at least one CpG position in the gene IL-17A, wherein a demethylation of said at least one CpG position in said sample when compared to an analogous position in a non IL-17 blood cell is indicative for a IL-17 positive CD4 positive T cell. The analyses according to the invention can identify IL-17 positive T cells and distinguish them from all other cells in complex samples, such as, for example, other blood cells. The present invention furthermore provides an improved method for quantifying IL-17 positive T cells in complex samples based on a comparison of the IL-17A methylation with a methylation of at least one marker selected from the group of CD3, FOXP3, and/or GAPDH.Type: GrantFiled: October 18, 2012Date of Patent: January 31, 2017Assignee: EPIONTIS GMBHInventors: Sven Olek, Udo Baron
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Patent number: 9539242Abstract: Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotonin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes.Type: GrantFiled: April 30, 2014Date of Patent: January 10, 2017Assignee: University of Virginia Patent FoundationInventor: Bankole A. Johnson
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Patent number: 9534256Abstract: The present invention provides a method of identifying a subject as having an increased risk of having or developing aggressive prostate cancer, comprising detecting in the subject the presence of various polymorphisms associated with an increased risk of having or developing aggressive prostate cancer.Type: GrantFiled: January 6, 2012Date of Patent: January 3, 2017Assignees: Wake Forest University Health Sciences, The Johns Hopkins UniversityInventors: Jianfeng Xu, William B. Isaacs, Henrik Grönberg
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Patent number: 9518994Abstract: The present invention provides methods and kits for diagnosing or monitoring conditions such as schizophrenia and tauopathies in a patient by determining the level of ADNP1 or ADNP2 in a sample from the patient.Type: GrantFiled: January 4, 2011Date of Patent: December 13, 2016Assignee: Ramot at Tel Aviv UniversityInventors: Illana Gozes, Efrat Dresner
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Patent number: 9512482Abstract: The present invention provides compositions, methods, and kits for discriminating sequence variation between different alleles. More specifically, in some embodiments, the present invention provides compositions, methods, and kits for determining the presence and/or level (e.g., quantitating) of rare (e.g., mutant) allelic variants, such as single nucleotide polymorphisms (SNPs) or nucleotide insertions or deletions, in samples comprising abundant (e.g., wild-type) allelic variants with high sensitivity and/or specificity. As such, in certain embodiments, the present invention provides a highly selective method for the detection of somatic mutations, e.g., in samples containing abundant levels of a wild-type allele compared to very low levels of a mutant allele.Type: GrantFiled: February 18, 2014Date of Patent: December 6, 2016Assignee: Nestec S.A.Inventors: Fred Princen, Fabiyola Selvaraj, Sharat Singh
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Patent number: 9488656Abstract: Truncation variants of BCR-ABL mRNA that produces BCR-ABL proteins with a truncated C-terminus and its role in resistance to treatment with kinase inhibitors is described. Vectors for expressing the truncated gene products are described as well as recombinant cells that express the truncated gene products from cDNA constructs. Also provided are methods compositions and kits for detecting the BCR-ABL truncation variants. Also provided are methods for determining the prognosis of a patient diagnosed as having myeloproliferative disease, and methods for predicting the likelihood for resistance to a treatment with tyrosine kinase inhibitor in a patient diagnosed as having myeloproliferative disease. Additionally, methods for screening BCR-ABL tyrosine kinase domain inhibitors which rely on the recombinant cells are also disclosed.Type: GrantFiled: September 28, 2010Date of Patent: November 8, 2016Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATEDInventors: Maher Albitar, Wanlong Ma
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Patent number: 9469877Abstract: A method of detecting high-grade dysplasia, pancreatobiliary cancer, or metastatic cancer to the pancreatobiliary tract or inferring an increased risk thereof, comprising obtaining a sample of pancreatobiliary cells from a patient with a set of detectably labeled probes comprising a locus-specific probe for MCL1 (myeloid cell leukemia sequence 1), a locus-specific probe for EGFR (epidermal growth factor receptor), a locus-specific probe for MYC, and a locus-specific probe for P16 under hybridization conditions and determining the presence of chromosomal abnormalities; a set of probes comprising a locus-specific probe for MCL1, a locus-specific probe for EGFR, a locus-specific probe for MYC, and a locus-specific probe for P16; and a kit comprising the set of probes and instructions for detecting high-grade dysplasia, pancreatobiliary cancer, or metastatic cancer to the pancreatobiliary tract, or inferring an increased risk thereof, in a patient.Type: GrantFiled: December 20, 2012Date of Patent: October 18, 2016Assignees: Abbott Molecular Inc., Mayo Foundation For Medical Education and ResearchInventors: Irina Sokolova, Larry Morrison, Ekaterina Pestova, Emily Barr Fritcher, Lewis Roberts, Gregory Gores, Kevin Halling, Benjamin Kipp
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Patent number: 9458507Abstract: The present invention relates to the prediction of antipsychotic treatment efficacy based on a patient's genotype at one or more single nucleotide polymorphism (SNP) loci and to the treatment of a patient based on such prediction.Type: GrantFiled: March 30, 2016Date of Patent: October 4, 2016Assignee: Vanda Pharmaceuticals, Inc.Inventors: Christian Lavedan, Simona Volpi, Louis Licamele, Mihael H. Polymeropoulos