Abstract: The invention relates to a joint implant for new tissue formation at a joint, the joint implant (1) comprising a pinlike body having a bottom region (11), a top region (12) and a shell region (13), wherein at least the top region (12), of the joint implant (1) has a hydrophobic surface for promoting chondroblastic differentiation of mesenchymal stem cells.

Abstract: Medical implants that include a containment layer surrounding, or surrounded by, a biodegradable medical device provide the benefit that pieces formed during degradation of the medical device are held within a constrained place and thus do not causes injury to a hosts.

Abstract: A lens including a flexible refractive optic having a fixed refractive index, an electro-active element embedded within the flexible refractive optic, wherein the electro-active element has an alterable refractive index, and a controller electrically connected to the electro-active element wherein when power is applied thereto the refractive index of the electro-active element is altered.

Abstract: A system for treating a diseased native valve in a patient includes a valve prosthesis and a delivery device. The prosthesis includes an anchor and a frame. The delivery device includes an outer sheath, an inner shaft, an anchor guide, and a tether. The anchor is shaped to encircle chordae or leaflets of a native valve. The frame is configured to sit within the anchor. The inner shaft is positioned within the outer sheath and translatable and rotatable relative to the outer sheath. The anchor guide is attached to a distal end of the inner shaft and has a curved distal section. The tether is configured to detachably couple to the anchor and to longitudinally translate the anchor within the inner shaft and anchor guide. The anchor is configured to be actuated from a delivery configuration to the deployed configuration when the anchor is translated out of the anchor guide.

Abstract: An intraocular lens is provided that includes a refractive element and a mask. The refractive element has a first power in a first meridian and a second power greater than the first power in a second meridian. A magnitude of the first and second powers and a location of the first and second meridians are configured to correct astigmatism in a human eye. The mask is configured to block a substantial portion of light from passing through an annular region thereof and to permit a substantial portion of light to pass through a central aperture thereof to enhance an astigmatism correction rotational misplacement range and depth of focus.

Abstract: A stent graft system (1) with a first stent graft (2) expandable in respect of a diameter, and with at least a second stent graft (3). The first stent graft (2) at least in some areas has a tubular net structure (4) which, in an expanded mode, has a net structure (4) with substantially round annular meshes (5). The at least second stent graft (3) has, at a distal end (6), outwardly extending barbs (7) via which the at least second stent graft (3) can be coupled to the first stent graft (2) in the expanded mode. The distal end (6) of the at least second stent graft (3) passes through a round annular mesh (5) of corresponding diameter and, with its outwardly extending barbs (7), engages on the round annular mesh (5). Also, a method for coupling stent grafts as a stent graft system.

Abstract: The present invention relates to a stent delivery device having: a first support rod into which a first movable body is inserted; a fixed magnet; and a second support rod into which a second movable body is inserted, wherein a first driving magnet included in the first movable body and a second driving magnet included in the second movable body rotate relative to each other by means of the control of an external magnetic field at a predetermined angle around an axis in a first direction with respect to the fixed magnet, thereby separating a first coupling piece and a second coupling piece from a first coupling groove and a second coupling groove and enabling a stent to unfold.

Abstract: Provided is an intraocular lens including: an optic portion; and a haptic portion extending from the optic portion, wherein a pattern having ridges and grooves is formed on at least one of the optic portion and the haptic portion, and each of the grooves has a nanostructure roughness. Provided also is a method of manufacturing an intraocular lens, the method including: seating an object to be processed including an optic portion and at least one haptic portion extending from the optic portion, processing a predetermined pattern for guiding cells by performing laser irradiation on the haptic portion and the optic portion, forming grooves having a nanostructure surface roughness in the predetermined pattern formed by laser beams, and the surface of each of the grooves has an average roughness Ra less than 200 nm.

Abstract: A graft preparation system that includes a base, a guide extending laterally outward from the base and including a top interface and a bottom interface that removably receives a graft thereon, and a plurality of slots extending through the guide between the top interface and the bottom interface. Each slot of the plurality of slots are sized to receive a needle therethrough such that the plurality of slots form a plurality of channels from the top interface to the bottom interface. The guide is configured to facilitate placement of a suture attached to the needle from the top interface into at least one of the channels formed by the plurality of slots such that the suture is received through the graft at the bottom interface.

Abstract: An implantable prosthetic device can include a frame that is radially expandable and compressible between a radially compressed configuration and a radially expanded configuration. The frame can have a first set of a plurality of struts extending in a first direction, and a second set of a plurality of struts extending in a second direction, and each strut of the first set of struts can be pivotably connected to at least one strut of the second set of struts. Each strut can be curved helically with respect to a first, longitudinal axis of the frame, and each strut can be curved with respect to a second axis that is perpendicular to the first, longitudinal axis of the frame.

Abstract: A heart valve assembly includes an inner frame comprising a graft covering housing a prosthetic heart valve, wherein the graft covering extends around the prosthetic heart valve for providing sealing to the heart valve, an outer frame formed from a metallic material and defining a gridded configuration, and being secured to the graft covering by a plurality of stitches, and a sealing material positioned externally to the outer frame for providing sealing between the outer frame and a patient's anatomical wall to prevent paravalvular leaks. The sealing material includes a plurality of radially extending fibers that extend outwardly of the outer frame. The graft covering is made of polyester, polytetrafluoroethylene, expanded polytetrafluoroethylene, or a polymer.

Abstract: A generally tubular braided flow diverting stent is formed of alternating round and rectangular elongated members, for treatment of aneurysms. The generally tubular braided flow diverting stent maintains a significant wall thickness while increasing area coverage of a vessel wall. Sliding of the round elongated members over the rectangular elongated members allows the stent to be crimped to very low diameters for delivery in narrow portions of the vasculature.

Abstract: A transcatheter valve includes an outer seal made of outwardly extending fibers and is configured for transfemoral delivery within a patient.

Abstract: A prosthetic capsular device configured to be inserted in an eye after removal of a lens, in some embodiments, can comprise a housing structure comprising capable of containing an intraocular device. The housing structure can comprise an anterior portion comprising an anterior opening, a posterior portion comprising a posterior opening, and a continuous lateral portion between the anterior portion and the posterior portion.

Abstract: An intraocular clip comprises a flexible body connected to a plurality of fasteners. The fasteners, at least two of them, are configured on opposite sides of the body in an opposing relationship, and wherein the fasteners are biased to be engaging their respective opposing fasteners on the opposite sides of the body, however manipulation of the body moves the fasteners away from each other until the body is released and the fasteners bias toward each other. The fasteners have a proximal end joined to the body and a distal end on the opposite end of the fastener from the body. The distal ends of the fasteners comprise footpads, and the footpads on opposing fasteners engage each other when the fasteners are biased in their closed positions.

Abstract: The disclosure relates to a vertebral body implant including a flexible main body and at least one pedicle screw joint. The flexible main body is an integrally formed single piece having at least one joint-accommodating hole and at least one opening connected to the at least one joint-accommodating hole. The pedicle screw joint is an integrally formed single piece movably accommodated in the at least one joint-accommodating hole.

Abstract: An intraocular lens includes a base refractive structure having anterior and posterior surfaces that are shaped for producing a first optical power and a diffractive structure formed in one of the surfaces of the base refractive structure including overlapping first and second diffractive patterns over a common aperture for producing second and third optical powers. The second optical power is an uneven division of the third optical power. The first and second diffractive patterns have respective step heights that are separately varied as a function of radial distance from the optical axis over the common aperture.

Abstract: A transcatheter valve assembly replacement device includes an improved paravalvular seal.

Abstract: Apparatuses, systems and methods for providing improved ophthalmic lenses, particularly intraocular lenses (IOLs). Exemplary ophthalmic lenses can include a plurality of echelettes arranged around the optical axis, having a profile in r-squared space. The echelettes may be non-repeating over the optical zone.

Abstract: In various embodiments, disclosed herein is an artificial cornea, comprising an optic zone that is similar in thickness to a natural cornea and a peripheral skirt having a thickness less than the thickness of the optic zone, where the surfaces of the optic zone and peripheral skirt comprise one or more microstructures or nanostructures. In various embodiments, further disclosed herein are methods of manufacturing nanostructures on an artificial cornea, as well as treating a disease by providing an artificial cornea having one or more microstructures and/or nanostructures.