Patents Examined by Jennifer E. Graser
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Patent number: 12290540Abstract: Microorganisms for lowering blood ammonia level and composition for protecting neuronal cells containing the same, particularly relates to microbes or a symbiotic pair that has a neuroprotective function by lowering blood ammonia levels or reducing ammonia levels in the body and composition for protecting neuronal cells comprising the microbes. The microorganisms having a neuroprotective function by lowering the blood ammonia level can be selected from the group that include, but not limited to, a Lactobacillus sp. strain and a Streptococcus sp. strain. The ammonia removal strains and the composition have a neuroprotective effect by their excellent ability to remove neurotoxic ammonia, and thus can be widely used as a preventive or therapeutic agent for hyperammonemia and neurological diseases caused thereby.Type: GrantFiled: November 19, 2020Date of Patent: May 6, 2025Assignee: JINIS CO., LTDInventors: Hyeon Jin Kim, Sang Woo Kim, Seong Tshool Hong
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Patent number: 12285475Abstract: The result of orally administering saliva derived from a Crohn's disease patient or an ulcerative colitis patient to germ-free mice has revealed that Th1 cells markedly increased in the colons. Further, from the bacterial microbiota in the intestines of the mice in which such an increase in Th1 cells were observed, bacteria have been successfully isolated which caused strong Th1 cell induction in the colon upon intestinal colonization.Type: GrantFiled: November 1, 2017Date of Patent: April 29, 2025Assignee: KEIO UNIVERSITYInventors: Kenya Honda, Koji Atarashi, Seiko Narushima, Wataru Suda, Masahira Hattori
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Patent number: 12286616Abstract: Provided is an alga belonging to Cyanidiophyceae having a diploid cell and a haploid cell form. Also provided is a nutrient composition containing an alga belonging to Cyanidiophyceae or an extract thereof.Type: GrantFiled: November 28, 2018Date of Patent: April 29, 2025Assignee: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Shin-ya Miyagishima, Shunsuke Hirooka
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Patent number: 12274718Abstract: The present invention relates to a composition for preventing, alleviating or treating liver injury, for example, nonalcoholic fatty liver, and more specifically, it relates to a composition for preventing or treating liver injury comprising a Ruminococcus spp. strain.Type: GrantFiled: July 30, 2020Date of Patent: April 15, 2025Assignee: KOBIOLABS, INC.Inventors: Gwang Pyo Ko, Won Kim, Hyun Ju You, Giljae Lee, Bo-Ram Cho
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Patent number: 12274741Abstract: The invention relates to antigenic polypeptides derived from a naturally occurring R. microplus protein, and nucleic acids encoding such polypeptides. The polypeptides elicit an immune response which, in turn, produces detrimental effects in R. microplus feeding on vaccinated cattle. Thus, the present disclosure provides novel vaccines to protect cattle from R. microplus infestation.Type: GrantFiled: February 15, 2024Date of Patent: April 15, 2025Assignee: The United States of America as Represented by the Secretary of AgricultureInventors: Felicito Guerrero, Kylie G Bendele, Luisa N Domingues
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Patent number: 12268719Abstract: The present invention provides new bacteriophages, their selection, compositions, cocktails and formulations thereof, and their administration for the prevention of opportunistic infections in livestock, such as Avian Pathogenic E. Coli (APEC) infections in poultry.Type: GrantFiled: October 24, 2023Date of Patent: April 8, 2025Assignee: SYNTBIOLAB INC.Inventors: Rodrigue Dubar, Simon Labrie
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Patent number: 12264194Abstract: The present disclosure is directed to methods of treating subjects colonized with S aureus with an anti-alpha toxin antibody or antigen-binding fragment thereof. The methods can decrease the incidence of infection attendant to the presence of S. aureus in the subject.Type: GrantFiled: March 12, 2020Date of Patent: April 1, 2025Assignee: MedImmune, LLCInventors: Mark Esser, Alexey Ruzin, Hasan Jafri, Kathryn Shoemaker, Bret Sellman, Li Yu
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Patent number: 12263211Abstract: Provided are compositions and methods that include a K. pneumoniae yidR protein or an antigenic segment of the protein, and homologous of the protein, and antigenic segments of the homologs. The compositions can be provided as vaccine formulations for use with humans and non-human animals, including but not limited to dairy cows. The compositions and methods are useful for prophylaxis and/or therapy of conditions associated with Gram negative bacteria that include K. pneumonia, E. coli, and other pathogenic Gram negative bacteria. The conditions include such bacterial infections generally, and include specifically mastitis and metritis. The compositions and methods can also improve fertility and milk production. Administration of the compositions can improve the likelihood of a first service conception.Type: GrantFiled: April 27, 2020Date of Patent: April 1, 2025Assignee: Cornell UniversityInventor: Rodrigo Bicalho
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Patent number: 12265087Abstract: Provided are an odorant receptor marker of microglia and a use thereof, and according to the odorant receptor marker of microglia and a use thereof according to one aspect, microglia may be detected by measuring an activity or expression level of a protein of an odorant receptor (OR) Olfr110 or Olfr111, and OR ligands of microglia may be selected using them, and an inhibitor or activator against the interaction between the OR and 2-pentylfuran is effectively used in treatment of a neuroinflammatory disease or meningitis.Type: GrantFiled: June 26, 2020Date of Patent: April 1, 2025Assignee: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Jae Hyung Koo, Na Hye Lee, Yoon Gyu Jae
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Patent number: 12256742Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one further biological control agent selected from particular microorganisms disclosed herein and/or a mutant of a specific strain of a microorganism disclosed herein having all identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.Type: GrantFiled: October 16, 2023Date of Patent: March 25, 2025Assignee: BASF CORPORATIONInventors: Damian Curtis, Brian Thompson
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Patent number: 12259387Abstract: A system, method, apparatus and diagnostic test for Plasmodium vivax, to determine a likelihood of a specific timing of infection by P. vivax in a subject, and hence identify individuals with a high probability of being infected with otherwise undetectable liver-stage hypnozoites. The system, method, apparatus and diagnostic test relate to the identification of hypnozoites (“dormant” liver-stages), or at least of the likelihood of the subject being so infected. Optionally and preferably, the specific timing relates to recent infections, for example within the last 9 months.Type: GrantFiled: October 11, 2023Date of Patent: March 25, 2025Assignee: The Walter and Eliza Hall Institute of Medical ResearchInventors: Ivo Mueller, Takafumi Tsuboi, Michael White, Rhea Longley
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Patent number: 12258373Abstract: Disclosed herein is a panel comprising one or more MHC multimers; and a panel comprising one or more pools of MHC multimers, wherein each pool comprises one or more MHC multimers; wherein said MHC multimers comprise an antigenic peptide P derived from a Borrelia antigenic polypeptide selected from the group consisting of OppA, DbpA, FlhF, FlaB and P37-42; as well as uses thereof in the detection of Borrelia-specific T cells and the diagnosis, treatment and monitoring of Borrelia disease in an individual.Type: GrantFiled: December 17, 2019Date of Patent: March 25, 2025Assignee: Immudex ApSInventors: Liselotte Brix, Kivin Jacobsen, Amir Ameri
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Patent number: 12233120Abstract: The present invention provides isolated proteins isolatable from a Pasteurella spp. such as P. multocida. Also provided by the present invention are compositions that include one or more of the proteins, and methods for making and methods for using the proteins.Type: GrantFiled: May 31, 2023Date of Patent: February 25, 2025Assignee: Vaxxinova US, Inc.Inventors: Charles Nelson Carver, III, Daryll Emery
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Patent number: 12226470Abstract: Methods of immunizing older adult subjects against Streptococcus pneumoniae infection are provided. Provided methods comprise immunization of naïve adult subjects with a conjugated pneumococcal polysaccharide vaccine. Optionally, initial immunization may be followed by additional immunization doses comprising conjugated pneumococcal polysaccharide vaccine or unconjugated pneumococcal polysaccharide vaccine composition.Type: GrantFiled: October 5, 2021Date of Patent: February 18, 2025Assignee: WYETH LLCInventors: George Rainer Siber, Peter R. Paradiso, Jill Hackell, Stephen Paul Lockhart, William P. Hausdorff
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Patent number: 12227545Abstract: The present invention discloses a Acinetobacter baumannii immunogenic protein and its composition and application. This invention provides a protein, comprising 39 amino acids of the N-terminal ?-helix part of the Ata protein transport functional domain of Acinetobacter baumannii and an adjuvant protein; amino acid sequence of said 39 amino acids of the N-terminal ?-helix part of the Ata protein transport functional domain of Acinetobacter baumannii is shown as the 127th-165th amino acid residues of SEQ ID NO:2. In present invention the 39 amino acids of the N-terminal ?-helix part of surface protein Ata (Acinetobacter trimeric autotransporter) of Acinetobacter baumannii, was took to fuse with CTB, and express in BL21. The protein was purified by a nickel column, and used to intraperitoneally immunize mouses by 2.5 ?g/mouse. Its immunogenicity and immunoprotection was verified through the animal experiments, which proves it has a good effect of anti-infection of Acinetobacter baumannii.Type: GrantFiled: May 23, 2019Date of Patent: February 18, 2025Assignee: CHENGDU OLYMVAX BIOPHARMACEUTICALS INC.Inventors: Hengliang Wang, Li Zhu, Chao Pan, Zhicheng Liu, Xin Li, Jun Wu, Peng Sun, Ming Zeng, Bin Wang, Xiankai Liu, Dongshu Wang, Erling Feng
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Patent number: 12227800Abstract: The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterisation using CsgG.Type: GrantFiled: January 26, 2023Date of Patent: February 18, 2025Assignee: Oxford Nanopore Technologies PLCInventors: Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace
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Patent number: 12226430Abstract: The invention relates to methods, uses, systems, arrays, engineered nucleotide sequences and vectors for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for treatment of microbes such as for environmental, medical, food and beverage use. The invention relates inter alia to methods of controlling microbiologically influenced corrosion (MIC) or biofouling of a substrate or fluid in an industrial or domestic system.Type: GrantFiled: November 3, 2023Date of Patent: February 18, 2025Assignee: SNIPR TECHNOLOGIES LIMITEDInventors: Jasper Clube, Morten Sommer, Christian Grøndahl, Eric Van Der Helm, Ruben Vazquez-Uribe
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Patent number: 12221611Abstract: The present specification relates to an astrocyte-specific nucleic acid aptamer and a use thereof. The astrocyte-specific nucleic acid aptamer, according to the disclosure in the present specification, is a DNA aptamer.Type: GrantFiled: October 15, 2019Date of Patent: February 11, 2025Assignee: IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY)Inventors: Eun-Song Lee, Miso Kim, Jin Saem Lee, Chang-Hwan Park, Young-Pil Kim, Eun Hye Lee
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Patent number: 12222353Abstract: A diagnostic kit for a confirmatory assay using the indirect ELISA method that measures the levels of anti-Native Hapten antibodies produced during a real infection, thereby preventing large financial losses to livestock farm, by discerning “false positives” that present anti-LPS antibodies due to cross-reactions with enterobacteria and post-vaccinal antibodies for the diagnosis of bovine brucellosis in blood serum and individual milk (per animal) and bulk milk (tank), characterised by using the crude Native Hapten antigen, extracted from B.Type: GrantFiled: April 5, 2018Date of Patent: February 11, 2025Inventor: Victoria Maroun Cortez
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Patent number: 12214028Abstract: Disclosed is an immunogenic formulation that induces protection against Shiga Toxin-Producing Escherichia coli (STEC), the formulation comprising: one or more chimeric proteins derived wholly or in part from OmpT and Hes proteins of STEC; and at least one physiologically or pharmaceutically acceptable excipient, carrier and/or diluent.Type: GrantFiled: May 31, 2019Date of Patent: February 4, 2025Assignee: UNIVERSIDAD DE CHILEInventors: Roberto Mauricio Vidal Alvarez, Felipe Antonio Del Canto Fuentes, David Arturo Montero Forero, Juan Carlos Salazar Garrido