Patents Examined by Jennifer E. Graser
  • Whole cell vaccines
    Patent number: 11179454
    Abstract: The disclosure relates to attenuated bacterial cells expressing glycans and glycoconjugate antigens and their use in the manufacture of whole cell vaccines effective at preventing or treating bacterial infections in non-human species.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: November 23, 2021
    Assignee: London School of Hygiene and Tropical Medicine
    Inventors: Jon Cuccui, Brendan Wren, Alexandra Faulds-Pain
  • Vaccine delivery systems using yeast cell wall particles
    Patent number: 11179343
    Abstract: The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.
    Type: Grant
    Filed: June 5, 2020
    Date of Patent: November 23, 2021
    Assignee: Orbis Health Solutions, LLC
    Inventor: Thomas E. Wagner
  • Regulated expression of antigen and/or regulated attenuation to enhance vaccine immunogenicity and/or safety
    Patent number: 11180765
    Abstract: The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
    Type: Grant
    Filed: August 11, 2020
    Date of Patent: November 23, 2021
    Assignees: The Arizona Board of Regents for and on behalf of Arizona State University, The Washington University
    Inventors: Roy Curtiss, III, Shifeng Wang, Soo-Young Wanda, Wei Kong
  • Immunogenic proteins against
    Patent number: 11173198
    Abstract: Described are immunogenic proteins against Clostridium difficile. Also described are compositions comprising the immunogenic proteins. Further described are methods of preventing or treating a Clostridium difficile infection in a subject in need thereof.
    Type: Grant
    Filed: February 10, 2020
    Date of Patent: November 16, 2021
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventor: Xingmin Sun
  • Production of steviol glycosides in recombinant hosts
    Patent number: 11168343
    Abstract: The invention relates to recombinant microorganisms and methods for producing steviol glycosides and steviol glycoside precursors.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: November 9, 2021
    Assignee: EVOLVA SA
    Inventors: Veronique Douchin, Micheael Dalgaard Mikkelsen, Iben Møller-Hansen
  • Genetic control of cell size
    Patent number: 11168329
    Abstract: Described herein are mutant cyanobacterial cell populations that have a smaller mean cell length than wild type cyanobacterial cell populations of the same species.
    Type: Grant
    Filed: February 6, 2020
    Date of Patent: November 9, 2021
    Assignee: Board of Trustees of Michigan State University
    Inventors: Daniel Christopher Ducat, Katherine Osteryoung, Joshua Scott MacCready
  • Immunostimulatory preparation exhibiting antitumor activity
    Patent number: 11160854
    Abstract: The proposed preparation and methods relate to medicinal microbiology and pharmacology, and relate to preparations exhibiting an immunostimulatory effect, which may be used for the prevention and treatment of oncological diseases. The essence of the preparation and methods consists in a primary component of the preparation including a polyvalent corpuscular antigen, prepared on the basis of Treponema pallidum culture strains. The proposed preparation exhibits an immunostimulatory effect, with a primary influence on components of T-cell immunity. The proposed preparation, in a preventative therapeutic application, is effective with regard to tumors of various histogenesis.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: November 2, 2021
    Assignee: Limited Liability Company “Cancernet”
    Inventors: Eduard Isaakovich Mordukhovich, David Borisovich Zhukov, Ilya Vladimirovich Darmov, Veronika Yuryevna Okhapkina
  • Vaccine comprising toxoids
    Patent number: 11154605
    Abstract: The present invention relates to an immunogenic composition comprising one or more C. difficile toxoid for use in a medicament for animals. The invention also encompasses an immunogenic composition comprising one or more C. difficile A toxoid and one or more C. difficile B toxoid and one or more C. perfringens Type A toxoid. The invention also encompasses vaccines comprising said immunogenic compositions, vaccines for use in the treatment and/or prevention of disease caused by C. difficile and C. perfringens, and kits thereof.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: October 26, 2021
    Assignee: HIPRA SCIENTIFIC, S.L.U.
    Inventors: Xavier Gibert Pérez, Marta Sitjà Arnau
  • Multivalent pneumococcal conjugate vaccine
    Patent number: 11147863
    Abstract: The present invention relates to a multivalent Pneumococcal conjugate vaccine (PCV) composition comprising: 1) at least 12 capsular polysaccharides selected from serotypes 1, 3, 4, 5, 6B, 7F, 9N, 9V, 15B, 14, 18C, 19A, 19F, 22F, 23F and 33F of S. pneumoniae activated with CDAP and conjugated to carrier protein selected from CRM197, pneumococcal surface protein A (PspA), pneumococcal adhesin protein (PsaA) or combination thereof and 2) a pharmaceutically acceptable carrier, wherein the composition does not contain capsular polysaccharide from serotype 6A.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: October 19, 2021
    Inventors: Ramesh Venkat Matur, Nagarajan Thirumeni, Rajendar Burki, Narender Dev Mantena, Mahima Datla
  • Apparatus and method for detecting microbial contamination
    Patent number: 11150244
    Abstract: Provided are novel methods for screening and testing for pathogens in food, water, and bodily fluids using methods that are faster to complete than conventional methods of culturing and plating that require lengthy times in properly equipped labs. The invention utilizes specific, rapid and sensitive optical detection to capture small concentrations of the target bacteria and render them amenable for detection with various specific synthesis binding agents approaches. The technique merges capture and detection steps with quantification unit suitable to provide results in a relatively shorter time current detection methods.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: October 19, 2021
    Assignee: S D SYSTEMS, INC.
    Inventor: Majed El-Dweik
  • Compositions and methods for long-term in vitro culture of the syphilis spirochete
    Patent number: 11130937
    Abstract: Presented herein are compositions and methods for the long-term in vitro culturing of Treponema species such as T. pallidum. Culture media and systems for Treponema culture are also provided.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: September 28, 2021
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Steven J. Norris, Diane G. Edmondson
  • Antibodies against microorganisms and uses thereof
    Patent number: 11130800
    Abstract: Described herein are methods and antibodies useful for reducing, eliminating, or preventing infection with a bacterial population in domestic animals or humans. Also described herein are antigens useful for targeting by heavy chain antibodies and VHH fragments for reducing a bacterial population in domestic animals or humans.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: September 28, 2021
    Assignee: NOVOBIND LIVESTOCK THERAPEUTICS INC.
    Inventor: Hamlet Abnousi
  • SLAM polynucleotides and polypeptides and uses thereof
    Patent number: 11123418
    Abstract: The present disclosure relates to methods for exporting target proteins (e.g., surface lipoproteins) from the cytosol to the extracellular surface of bacterial cells using surface lipoprotein assembly modulator (SLAM) polypeptides. The use of SLAM polypeptides in a method of preparing vaccines useful in the prevention of bacterial infectious diseases is also taught.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: September 21, 2021
    Assignee: Engineered Antigens Inc.
    Inventors: Trevor F. Moraes, Christine Chieh-Lin Lai, Yogesh Hooda, Andrew Judd, Anthony B. Schryvers, Scott D. Gray-Owen
  • Glycoconjugation processes and compositions
    Patent number: 11110160
    Abstract: The invention provides eTEC linked glycoconjugates comprising a saccharide covalently conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, immunogenic compositions comprising such glycoconjugates, and methods for the preparation and use of such glycoconjugates and immunogenic compositions.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: September 7, 2021
    Assignee: Pfizer Inc.
    Inventors: Jianxin Gu, Jin-hwan Kim, Avvari Krishna Prasad, Yu-ying Yang
  • Anti HLA-G specific antibodies
    Patent number: 11111302
    Abstract: The present invention relates to antibodies, or antigen-binding fragments thereof, directed against human leukocyte antigen-G (HLA-G) protein and raised against an immunogenic peptide derived from the ?3 domain of HLA-G protein. The invention further relates to the immunogenic peptide, and methods for producing said anti-HLA-G specific antibodies.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: September 7, 2021
    Assignee: Invectys SA
    Inventors: Pierre Langlade Demoyen, Thierry Huet, Julien Caumartin, Maria Loustau, Maria Wehbe
  • Systems and compositions for diagnosing pathogenic fungal infection and methods of using the same
    Patent number: 11112409
    Abstract: The present disclosure relates generally to detection of contamination of a sample or diagnosis of subject based upon detection or quantification of amino acid sequences in a sample, specifically to the identification and use of molecular biomarkers for Candida albicans biofilm infections.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: September 7, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Clarissa Nobile, Michael Winter, Charles Craik, Alexander Johnson, Anthony O'Donoghue
  • Nanoparticles for treatment of allergy
    Patent number: 11071776
    Abstract: The present invention encompasses the surprising finding that nanoparticle compositions can have beneficial effects on allergy even when prepared without a known specific allergy therapeutic. The present invention provides such nanoparticle compositions. In some embodiments, provided nanoparticles are associated with functional elements that cause the nanoparticles to mimic bacterial cells. The present invention encompasses the surprising finding that provided nanoparticles may be useful for treatment and/or prevention of multiple different allergies in a single patient. The present invention encompasses the recognition that provided empty nanoparticles may be useful as a “pan-allergy” therapeutic and/or vaccine.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: July 27, 2021
    Assignee: N-Fold LLC
    Inventor: Michael J. Caplan
  • Methods of modulating immune and inflammatory responses via administration of an algal biomass
    Patent number: 11065287
    Abstract: An algal biomass and supernatant derived from at least one species of algae exhibits anti-inflammatory and immune response modulating properties. Methods of reducing the symptoms of or treating a condition or disease in an animal, including bovine mastitis and Bovine Respiratory Disease Complex, and the pain and discomfort caused by osteoarthritis, injury or overexertion or muscle and connective tissue strains, comprises administering to the animal in need thereof an algal biomass or supernatant derived from at least one species of algae, or an extract, derivative or biologically active compound derived from the algae species, biomass or supernatant, or compositions thereof.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: July 20, 2021
    Assignee: ZIVO BIOSCIENCE, INC.
    Inventors: Andrew A. Dahl, Amy E. Steffek
  • Immunomodulatory compositions and methods of use thereof
    Patent number: 11065283
    Abstract: The present disclosure provides immunomodulatory compositions comprising live Caulobacter crescentus (CC). Immunomodulatory compositions of the present disclosure are useful for modulating an immune response in an individual. The present disclosure thus provides methods of modulating an immune response in an individual, involving administering an immunomodulatory composition comprising live CC to the individual.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: July 20, 2021
    Inventors: Babita Agrawal, Rakesh Kumar, Nancy Gupta
  • Methods of determining colorectal cancer status in an individual
    Patent number: 11061029
    Abstract: A method of determining colorectal cancer status in an individual, which comprises abundance profiling of the individual's microbiome.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: July 13, 2021
    Assignee: UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
    Inventors: Paul O'Toole, Burkhardt Flemer, Fergus Shanahan, Ian Jeffery, Katryna Cisek