Patents Examined by Jennifer H. Tieu
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Patent number: 11940443Abstract: Among other things, the present invention is related to bio/chemical sampling, sensing, assays and applications.Type: GrantFiled: January 25, 2019Date of Patent: March 26, 2024Assignee: Essenlix CorporationInventors: Stephen Y. Chou, Wei Ding, Ji Li, Yufan Zhang
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Patent number: 11913949Abstract: The present invention relates to a multiparameter lateral flow strip (1), comprising a microporous membrane layer (2) supported on a liquid-impermeable support layer (3), for lateral flow of a liquid through the microporous membrane layer (2), wherein the microporous membrane layer (2) has two or more flow lanes (4) in the direction of lateral flow, wherein said two or more flow lanes (4) are separated by hydrophobic separation channels (5), and wherein each of said two or more flow lanes (4) comprises a detection spot (6) including a binding agent, wherein said two or more flow lanes (4) are isomorphic lanes. Furthermore, the present invention relates to a multiparameter lateral flow immunoassay device comprising said multiparameter lateral flow membrane (1), the use of said multiparameter configured lateral flow membrane (1) in an immunological test, as well as to a method for the manufacture of said multiparameter configured lateral flow membrane (1).Type: GrantFiled: April 28, 2015Date of Patent: February 27, 2024Assignee: Sartorius Stedim Biotech GmbHInventors: Denise Van Rossum, Eric Jallérat, Susanne Drebing, Dieter Melzner
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Patent number: 11846633Abstract: Seroprotection analysis systems, kits, and techniques are described for testing oral fluid for the presence of protective levels of antibodies of interest. In one aspect, the presence of protective levels of target antibodies indicates a test subject has achieved a target seroprotection level, such as but not limited to a target seroprotection level following vaccination. A collection kit can include a swab that enables collection of oral fluid containing antibodies from both dentulous and edentulous individuals, a container that can be pre-filled with an extraction solution, and a nozzle that can be coupled to the container to form a fluid-tight device. A user can use the nozzle to seal the swab in the container and to compress the swab within the container.Type: GrantFiled: December 23, 2019Date of Patent: December 19, 2023Assignees: Becton, Dickinson and Company, University of Maryland, BaltimoreInventors: Michael D. Fiechtner, Francis R. Go, Myron Levine, Scott Castanon
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Patent number: 11808764Abstract: Provided is a membrane carrier for a liquid sample test kit (3) that detects a substance to be detected in a liquid sample, the liquid sample test kit including at least one flow path (2) capable of transporting the liquid sample, in which a microstructure that causes a capillary action for transporting the liquid sample is provided on a bottom surface of the flow path (2), and a level difference at which a height level of the bottom surface changes, is provided in the flow path (2). The membrane carrier preferably has a detection zone for detecting a substance to be detected in the liquid sample.Type: GrantFiled: December 10, 2018Date of Patent: November 7, 2023Assignee: DENKA COMPANY LIMITEDInventors: Yuto Akiyama, Kenji Monden
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Patent number: 11747331Abstract: Provided is a membrane carrier for a liquid sample test kit (3) that detects a substance to be detected in a liquid sample, the liquid sample test kit including at least one flow path (2) capable of transporting the liquid sample, in which a microstructure that causes a capillary action for transporting the liquid sample is provided on a bottom surface of the flow path (2), and a level difference at which a height level of the bottom surface changes, is provided in the flow path (2). The membrane carrier preferably has a detection zone for detecting a substance to be detected in the liquid sample.Type: GrantFiled: December 10, 2018Date of Patent: September 5, 2023Assignee: DENKA COMPANY LIMITEDInventors: Yuto Akiyama, Kenji Monden
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Patent number: 11738342Abstract: A method of detecting a target biological entity in a biofluid using a sensor, wherein the biofluid comprises a plurality of the target biological entities and nanoparticles, the sensor comprising a substrate bearing a pair of electrodes having an affinity with the nanoparticles, and wherein a region between the electrodes defines a sensing region.Type: GrantFiled: October 30, 2020Date of Patent: August 29, 2023Assignee: MURSLA LIMITEDInventors: Tomas Miguel De Freitas Dias, Pierre Arsène
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Patent number: 11684921Abstract: The pocket detection platform (PDP) detects pathogens, toxins and chemicals of interest simultaneously by way of a multi-channeled, soft see-through plastic pouch design that consists of inner and outer compartments that promote compartmentalization and/or unidirectional sample flow. The platform enables the concurrent running of multiple detection assay techniques such as lateral flow immunoassays (LFI), Isothermal molecular assays (i.e., Recombinase Polymerase Amplification, or RPA) and/or paper-based chemical assays (i.e., M8, pH paper) from a single wet or dry sample with minimal sample processing. The PDP reduces soldier overburden by decreasing size weight, and power (SWaP) as well as training time, electronic burden, while providing a flexible, customizable assay platform that can be rapidly produced, assembled, sustained, and when contaminated, easily to dispose of.Type: GrantFiled: August 7, 2020Date of Patent: June 27, 2023Assignees: Leidos, Inc., The United States of America as Represented by the Secretary of the ArmyInventors: Kelley D. Betts, Jennifer W. Sekowski
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Patent number: 11673134Abstract: Provided herein are devices that facilitate the magnetic separation of an analyte from a sample, and methods of use thereof. In particular embodiments, devices and methods are provided for the trans-interfacial magnetic separation (TIMS) of analytes from a sample.Type: GrantFiled: June 6, 2018Date of Patent: June 13, 2023Assignee: Northwestern UniversityInventors: David M. Kelso, Abhishek K. Agarwal, Sally M. McFall, Tom Westberg, Matthew Austin Butzler, Jennifer L. Reed
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Patent number: 11668676Abstract: The present disclosure provides methods, microfluidic devices, and systems for isolating target particles from a sample containing or suspected of containing the target particles. The methods, microfluidic devices, and systems disclosed herein facilitate affinity-based isolation of target particles in a microfluidic channel by translating the target particles to the side walls of the microfluidic channel where capture agents that bind to the target particles are immobilized.Type: GrantFiled: May 28, 2020Date of Patent: June 6, 2023Assignee: The Regents of the University of CaliforniaInventors: Ahmet Ali Yanik, Xiangchao Zhu, Evan Peterson, Yixiang Li
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Patent number: 11635428Abstract: According to one embodiment, a molecule detecting device includes a capturing section, a releasing section, and a detecting section. The capturing section is configured to, by combining a target molecule and a solubilizing agent with each other and thereby creating a composite body, capture the target molecule in a carrier liquid. The releasing section is configured to make the composite body release the target molecule therefrom in the carrier liquid. The detecting section is configured to carry out detection of the target molecule in the carrier liquid.Type: GrantFiled: September 10, 2020Date of Patent: April 25, 2023Assignee: Kabushiki Kaisha ToshibaInventors: Hiroko Miki, Atsunobu Isobayashi, Yoshiaki Sugizaki
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Patent number: 11630106Abstract: There is disclosed herein a device for determining the smoking status of a subject, wherein said device comprises a plurality of different specific binding molecules deposited to a solid phase to detect specifically the presence of two or three tobacco smoke exposure biomarkers in a biological sample, said biomarkers consisting of: (i) cotinine and total 4-(methylnitrosamino)-1-(3-, pyridyl)-1-butanol (NNAL); (ii) cotinine and N-acetyl-S-[2-carboxyethyl]-L-cysteine (CEMA); or (iii) cotinine and NNAL and CEMA.Type: GrantFiled: May 18, 2018Date of Patent: April 18, 2023Assignee: Philip Morris Products S.A.Inventors: Frank Luedicke, Manuel C. Peitsch
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Patent number: 11609229Abstract: The present invention relates to a system capable of performing simple and rapid inspection of an antigen equivalent to the immune chromatographic method with accuracy good as a PCR method. An embodiment relates to a novel fluorescence counting system for quantifying viruses or antibodies in an analyte which comprises an unit of providing an antigen or antibody phase solidified substrate by an aggregation method with quantum crystals, an unit for making a labeling liquor and labeling a virus or an antibody to be measured in the analyte by an antigen-antibody method, an unit of exciting the fluorescently labeled virus or antibody by a surface plasmon excitation method, and an unit of counting fluorescent points in an excited fluorescent screen to quantify the virus or antibody in the analyte.Type: GrantFiled: November 12, 2020Date of Patent: March 21, 2023Assignee: MYTECH CO. LTD.Inventors: Yuki Hasegawa, Katsuyuki Hasegawa
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Patent number: 11583856Abstract: A bio-information detection substrate and a gene chip are provided. The substrate includes a first main surface, the first main surface includes a test region and a dummy region located around the test region, at least one accommodation region is disposed on the first main surface, and the accommodation region is located in the dummy region.Type: GrantFiled: April 2, 2019Date of Patent: February 21, 2023Assignees: BEIJING BOE OPTOELECTRONICS TECHNOLOGY CO., LTD., BOE TECHNOLOGY GROUP CO., LTD.Inventors: Shenkang Wu, Dongsheng Huang, Tingze Dong, Jianxing Shang, Yizhe Li, Yue Geng, Jian Li, Guowei Chen, Hongliang Xu, Kuohai Wang, Chang Dai, Na Wei, Xin Li, Xiao Xin, Chao Sun
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Patent number: 11585808Abstract: Devices, methods, and kits for detecting at least two analytes present within a small volume single fluid sample obtained from patient for the creation of a multiplexed panel of the various analytes present within the single fluid sample are disclosed.Type: GrantFiled: February 12, 2021Date of Patent: February 21, 2023Assignee: Siemens Healthcare Diagnostics Inc.Inventor: David Ledden
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Patent number: 11559807Abstract: A method for detecting biomarkers with shortened test time and maximized precision. A sample from the body fluid is made to flow over a sensor surface coated with a capture antibody to allow binding of a biomarker in the sample to the capture body. An optical method detects and counts the individual binding events along the sensor surface with single molecule resolution, and difference in the binding events along the sensor surface is detected in real time and analyzed to determine the biomarker concentration.Type: GrantFiled: November 20, 2019Date of Patent: January 24, 2023Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITYInventors: Nongjian Tao, Wenwen Jing
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Patent number: 11549938Abstract: An analysis unit for quantitating detection target substances bound to antibodies includes wells and inclination parts. The wells each have a hole-like shape defined by an opening, an inner circumferential surface, and a bottom. The inclination parts each have an inclined surface connected to the inner circumferential surface and inclined downward such that whose height with respect to the bottom decreases as a distance from an outer circumferential side of the well increases.Type: GrantFiled: February 21, 2020Date of Patent: January 10, 2023Assignee: JVCKENWOOD CORPORATIONInventors: Shigehiko Iwama, Yuichi Hasegawa, Koji Tsujita, Masayuki Ono, Katsue Horikoshi, Atsushi Saito
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Patent number: 11402377Abstract: A membrane carrier for a liquid sample test kit that detects a substance to be detected in a liquid sample, the membrane carrier including at least one integrally-molded flow path capable of transporting the liquid sample, in which a microstructure that causes a capillary action for transporting the liquid sample is provided on a bottom surface of the flow path, and the microstructure has two or more peak positions at which a height becomes maximum per one repeating unit structure.Type: GrantFiled: December 10, 2018Date of Patent: August 2, 2022Assignee: DENKA COMPANY LIMITEDInventors: Yuto Akiyama, Kenji Monden
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Patent number: 11275085Abstract: A problem of the present invention is to provide an immunochromatographic test strip avoiding agglutination of colloidal gold while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a hemagglutinating agent and the colloidal gold conjugates as a detection reagent, and to provide immunochromatography using the test strip. To solve the problem, the present inventors reviewed the composition of the existing reagent itself from a completely different viewpoint rather than the selection of type or amount of polyanions, and as a result of extensive study on each element, the inventors surprisingly found that agglutination of colloidal gold may be suppressed by using a particular additive without neutralization by polyanions.Type: GrantFiled: August 13, 2019Date of Patent: March 15, 2022Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Keigo Kohno, Mayumi Yoshida, Mitsuaki Yamamoto, Shinya Yokokawa, Marie Asami