Patents Examined by Jennifer M. H. Tichy
  • Patent number: 10851335
    Abstract: In one embodiment, a flow assembly for cells comprises a first flow path configured to receive a plurality of cells, a second flow path configured to receive a buffer, and a third flow path configured to receive the plurality of cells and the buffer. The plurality of cells are in a single-file orientation and the buffer generally surrounds the single-file orientation of the plurality of cells when in the third flow path.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: December 1, 2020
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Lisa M. Jones, Aimee Rinas
  • Patent number: 10842735
    Abstract: Provided is a hair growth-promoting composition comprising: 100 parts by weight of a stem cell culture solution obtained from a culture medium of mesenchymal stem cells which have been subcultured two or more times; 0.001 to 0.1 parts by weight of zinc; 5 to 50 parts by weight of a panthenol based compound; and 0.0001 to 0.1 parts by weight of a water-soluble vitamin, wherein it is sprayed or applied on the scalp to promote hair growth. Said hair growth-promoting composition may have an excellent effect and improve economical efficiency in treating alopecia due to a simple delivery method of the composition.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: November 24, 2020
    Inventor: Dong Hyun Ahn
  • Patent number: 10837042
    Abstract: Herein is reported a feed mixing device for adding feed solutions with a non-physiologically pH value to a cell cultivation vessel comprising a chamber for mixing the feed solutions prior to their addition to the cell cultivation vessel as well as its use. With the feed mixing device as reported herein feed components can be provided in solution at a pH value at which they have good solubility and/or good stability whereby the pH value can be clearly different from the pH value of the cultivation medium, i.e. different from the physiological pH value. This allows performing the cultivation with more flexibility compared to a cultivation in which the pH value of the feed solution is limited to a small range around the pH value of the cultivation.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: November 17, 2020
    Assignee: Hoffman-La Roche Inc.
    Inventors: Sylvia Baumann, Jens Hoffmann, Alexander Jockwer, Christian Klinger, Thomas Troebs
  • Patent number: 10835562
    Abstract: The present invention relates to a composition for alcohol or acetaldehyde degradation, which comprises probiotics. The composition of the present invention has a significant synergistic effect on the degradation of alcohol or acetaldehyde, when the probiotics are administered alone or in combination or the composition further comprises excipients. In addition, the composition according to the present invention may effectively degrade alcohol and acetaldehyde, thereby not only treating or preventing alcohol-induced diseases, but also effectively relieving hangovers caused by excessive drinking.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: November 17, 2020
    Assignee: CELL BIOTECH CO., LTD.
    Inventor: Myung Jun Chung
  • Patent number: 10828392
    Abstract: A method for preparing a three-dimensional polymer scaffold (3D-PS) for use in tissue-engineering, the method including the subsequent steps of: providing a polymeric precursor scaffold (p-PS) having at least one biodegradable natural polymer (PA); treating the polymeric precursor scaffold (p-PS) with a cross-linking agent having glutaraldehyde to induce cross-linking of the natural polymer (PA), thereby forming a cross-linked polymer scaffold (x-PS) and subjecting the cross-linked polymer scaffold (x-PS) of step b) to low-pressure plasma treatment involving exposure of the polymer scaffold to an ionized oxygen-containing gas plasma at a pressure in the range of 10?3 to 10?6 bar and a temperature below 40° C.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: November 10, 2020
    Inventor: Hans U. Baer
  • Patent number: 10801009
    Abstract: The present invention relates to: a cosmetic composition for improving the condition of the skin, containing, as active ingredients, a cell culture medium, an epidermal growth factor and a bovine serum albumin; a method for improving the condition of the skin by using the same; and a method for preventing or treating skin diseases. According to the present invention, the cosmetic composition can exhibit excellent wrinkle-reducing and wound-healing effects even when only a small amount of EGF is used, and thus can be useful in improving the condition of the skin or in preventing or treating skin diseases.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: October 13, 2020
    Inventors: Chan Wha Kim, Young Joon Kim, Hyun Jung Kim
  • Patent number: 10792315
    Abstract: The present invention provides an intestinal tract protective agent comprising a polyphosphoric acid or a pharmaceutically acceptable salt thereof as an active ingredient.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: October 6, 2020
    Assignees: National University Corporation Asahikawa Medical University, Sapporo Holdings Limited
    Inventors: Yutaka Kohgo, Mikihiro Fujiya, Nobuhiro Ueno, Syuichi Segawa, Naoyuki Kobayashi
  • Patent number: 10792295
    Abstract: Disclosed are compositions containing at least 10% w/w or above of 1-O-galloyl-?-D-glucose (?-glucogallin) which additionally comprising of about 10% w/w to greater than 60% w/w total mucic acid gallates including mucic acid 1,4-lactone 5-O-gallate, mucic acid 2-O-gallate, mucic acid 6-Methyl ester 2-O-gallate, mucic acid 1-Methyl ester 2-O-gallate and ellagic acid, and a probiotic bacteria Bacillus coagulans MTCC 5856, individually or in combination for inhibiting the growth and managing infections of Helicobacter pylori.
    Type: Grant
    Filed: June 6, 2018
    Date of Patent: October 6, 2020
    Inventors: Muhammed Majeed, Kalyanam Nagabhushanam, Sivakumar Arumugam, Furqan Ali, Shaheen Majeed
  • Patent number: 10793819
    Abstract: A liquid injection method for injecting a liquid into a culture vessel includes tilting the culture vessel around a horizontal axis at a tilt angle (X°) of greater than 0° and 50° or less, wherein adherent cells are adhered to the culture vessel; and injecting the liquid into the culture vessel at a predetermined linear velocity (Y mm/s) via a wall surface of the culture vessel tilted at the tilt angle (X°), wherein the tilt angle (X) and the linear velocity (Y) satisfy the following (formula 1): Y?5.075X+123 (formula 1).
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: October 6, 2020
    Inventors: Tomohisa Kato, Kazuya Hamada, Haruhisa Inoue, Takayuki Kondo
  • Patent number: 10787685
    Abstract: The present invention relates to a reaction mixture and a method of producing at least one higher alcohol comprising a reaction mixture comprising a mixed culture of a first and a second microorganism in an aqueous medium comprising carbon monoxide gas, wherein the first microorganism is an acetogenic microorganism capable of converting a carbon source to acetate and/or ethanol; and the second microorganism is selected from the group consisting of Clostridium kluyveri, and C. Carboxidivorans capable of converting the acetate and/or ethanol to form an acid; wherein the first microorganism is further capable of converting the acid to the corresponding higher alcohol and the higher alcohol comprises at least 6 carbon atoms.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: September 29, 2020
    Assignee: Evonik Operations GmbH
    Inventors: Thomas Haas, Thomas Buelter, Martin Demler
  • Patent number: 10781456
    Abstract: The present invention relates to an organism, a tissue, a cell or an organelle expressing enzymes which allow the conversion of 2-phosphoglycolate (2-PG; also known as glycolate 2-phosphate,) into an intermediate compound of the Calvin-Benson-Bassham Cycle (CBBC) without releasing CO2. The organism, tissue, cell or organelle of the invention may be genetically engineered, transgenic and/or transplastomic so as to express at least one enzyme which is involved in this conversion. The present invention further relates to an organism, tissue, cell or organelle which comprises/expresses at least one enzyme which is involved in this conversion. The present invention further relates to a method for producing an organism, tissue, cell or organelle of the invention. The present invention further relates to a method of enzymatically converting 2-PG into an intermediate compound of the CBBC without releasing CO2.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: September 22, 2020
    Inventors: Arren Bar-Even, Tobias Erb, Steffen Lindner, Philippe Marliere, Dan S. Tawfik
  • Patent number: 10780185
    Abstract: A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Photoacoustic emission from the construct correlates with cellular membrane potential.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: September 22, 2020
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: James B. Delehanty, Michael H. Stewart, Okhil Nag, Jeffrey R. Deschamps, Kimihiro Susumu, Eunkeu Oh, Lauren D. Field, Alexander L. Efros, Alan L. Huston, Igor L. Medintz, Philip E. Dawson, Nashaat Rasheed, Parag V. Chitnis, John R. Cressman
  • Patent number: 10774303
    Abstract: This disclosure describes techniques for using a single feedstock of barley to produce a fermented product and a method for filtering a large-particles stream from a liquid stream containing small particles of a process stream using a series of mechanical separation devices to increase yield.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: September 15, 2020
    Assignee: ICM, Inc.
    Inventors: Kurt A. Dieker, Charles C. Gallop, Scott D. Kohl, Keith Tjaden, Justin McMillen
  • Patent number: 10774305
    Abstract: Aspects of the invention relate to compositions comprising one or more live bacterial strains for topical administration to the skin, wherein the one or more live bacterial strains are Propionibacterium acnes (P. acnes) bacterial strains, and methods for use.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: September 15, 2020
    Assignee: S-Biomedic NV
    Inventors: Bernhard Pätzold, Marc Güell
  • Patent number: 10765110
    Abstract: Provided is an agent for preserving a biological component, comprising a hydrogel, the hydrogel comprising a crosslinked product formed from a compound having a plurality of hydroxyl groups and a modified hyaluronic acid having substituents capable of reacting with the hydroxyl groups to form a crosslinked structure.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: September 8, 2020
    Assignees: Denka Company Limited
    Inventors: Yasuhiko Tabata, Kenji Fujii, Masamichi Hashimoto, Akio Ohno
  • Patent number: 10767204
    Abstract: The present disclosure provides methods and systems for generating sugars from biomass. The methods and systems provide increased yields of carbohydrates and fermentable sugars by combining enzyme recycling with removal of saccharification enzyme inhibitors and increased solids loading.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: September 8, 2020
    Assignee: Edeniq, Inc.
    Inventors: James Kacmar, Rich Kleinke, Bernard Cooker, Chris Kalinowski, Jon Van Volkinburg
  • Patent number: 10758577
    Abstract: The present invention is directed to compositions comprising a mixture of microbes and the metabolites produced when the microbes are grown together. The invention is further directed to methods for making and using the compositions.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: September 1, 2020
    Assignee: PURE CULTURES 2020, INC.
    Inventors: Steven K. Kazemi, Naseer Sangwan
  • Patent number: 10744160
    Abstract: Aspects of the invention relate to a novel mesenchymal stem cell line (hb-MSC), a culture medium conditioned by the hb-MSC line, and various hb-MSC compositions. The hb-MSC composition may include a plurality of hb-MSCs, an hb-MSC conditioned medium, or a combination thereof. The hb-MSC composition may also include an appropriate carrier. Also described are methods of use for the hb-MSC cells, the conditioned medium and compositions thereof.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: August 18, 2020
    Assignee: T-Helper Cell Technologies, LLC
    Inventors: Anatoliy Sokolov, Antonina Ivanovna Kolesnikova, Andrei Igorevich Dovgii
  • Patent number: 10736944
    Abstract: The present invention relates to a composition for preventing or treating sepsis or septic shock including a Mycobacterium tuberculosis-derived adenosine kinase (ADK) protein as an active ingredient. The Mycobacterium tuberculosis-derived ADK protein according to one exemplary embodiment of the present invention has an effect of inhibit binding between the LPS and cells by binding to LPS, and also has an excellent therapeutic effect against sepsis by enhancing viability in a sepsis animal model and suppressing inflammatory response in the lung and cell death in the spleen.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: August 11, 2020
    Inventors: Yeong Min Park, In Duk Jung, Sung Jae Shin, Jung Hee Park, Seung Jun Lee, Tae Heung Kang, Byoung Yul Soh
  • Patent number: 10736946
    Abstract: Compositions and methods for treating or preventing S. aureus infections are provided. The compositions can be formulated as pharmaceutical compositions or as disinfectants, sanitizers, detergents or antiseptics, and can be used to eradicate or reduce S. aureus populations and thereby treat or prevent infection by S. aureus. The compositions include one or more digestive enzymes, e.g., one or more protease, lipases, and amylases. Methods of use of the compositions are also provided.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: August 11, 2020
    Assignee: GALENAGEN, LLC
    Inventors: Joan M. Fallon, Matthew Heil, James J. Fallon