Patents Examined by Jennifer M. H. Tichy
  • Patent number: 11225652
    Abstract: Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: January 18, 2022
    Assignee: Omrix Biopharmaceuticals Ltd.
    Inventors: Roberto Meidler, Oleg Belyaev, Liliana Bar, Israel Nur
  • Patent number: 11198891
    Abstract: Provided herein are eukaryotic microorganisms having a simple lipid profile comprising long chain fatty acids (LCFAs). Also provided are compositions and cultures comprising the eukaryotic microorganisms as well as methods of using the eukaryotic microorganisms.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: December 14, 2021
    Inventors: Violeta Ugalde, Zachary Sun, Anthony Windust, Roberto E. Armenta
  • Patent number: 11191792
    Abstract: The present invention relates to a bacterial composition which can be effectively used in the field of sport nutrition, since it is capable of attenuating the decline in sport performance in a subject after a muscle-damaging exercise.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: December 7, 2021
    Assignee: PROBIOTICAL S.P.A.
    Inventor: Giovanni Mogna
  • Patent number: 11193158
    Abstract: Rapid methods that identify sepsis-causing bacteria or yeast aid the physician in critical therapeutic decision-making, thus decreasing patient mortality rates. The methods described herein employ plating microorganisms directly on to a MALDI-MS plate, adding concentrated formic acid, and identifying the microorganism by mass spectrometry. Optionally, an organic solvent may be combined with the formic acid, or added to the sample before or after the concentrated formic acid is added thereto. The methods enable direct extraction of proteins from microorganisms without the need for liquid protein extraction methods and yields positive identification results for gram-positive bacteria, gram-negative bacteria and yeast in minutes.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: December 7, 2021
    Inventors: Liping Feng, William B. Brasso, Susan M. Kircher, Vanda White, Song Shi, Xiao Mo, Tuan-Linh Ngoc Nguyen, Adrien P. Malick, Jon E. Salomon, John D. Mantlo
  • Patent number: 11180788
    Abstract: The present invention discloses a method for preparing lower graft degree GSGs, and belongs to the technical field of biosynthesis of sweeteners. The method uses amylase to catalyze hydrolysis of GSGs with a high graft degree, thereby obtaining GSGs with low graft degree mainly containing GSGs with a low grafting number. The content of mono- and di-glucosyl substituents in the SGs in the product was 60% or more of the total glycosides, and the mass percent of the GSGs with a glucosyl grafting number of 3 or less was higher than 70% of the total glycosides. The mono- and di-substituted GSGs obtained by enzyme catalysis by the present invention were structurally similar to those, belong to a mixture of the isomers thereof, and have good sweetness and a flavoring function.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: November 23, 2021
    Assignees: Jiangnan University, Dongtai Haorui Biotechnology Co., Ltd.
    Inventors: Yongmei Xia, Liping Zhu, Tongtong Zhang, Guoying Du, Xiang Liu, Yun Fang
  • Patent number: 11172678
    Abstract: Methods of controlling agricultural pests are disclosed. An aerated liquid mixture is formed from a composition containing a bacterial nutrient source, a nitrogen-containing compound, a phosphate-containing compound, a magnesium-containing compound, a buffer, a chitinase inducer, and at least one strain of bacteria that produces chitinase. The liquid mixture is administered to soil and plants, and acts as an organic biological pesticide.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: November 16, 2021
    Assignee: TLC Products
    Inventor: John M. Wong
  • Patent number: 11168300
    Abstract: The present invention addresses the issue of providing: a novel microorganism having a high capability to produce urolithins; and a method of producing urolithins using the same, and the issue is solved by a microorganism that belongs to the genus Eggerthella and produces urolithins.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: November 9, 2021
    Inventors: Masatake Kudoh, Takanori Nakajima, Hiroaki Yamamoto
  • Patent number: 11168302
    Abstract: Provided are a method of preparing retinal ganglion cells by differentiation of stem into retinal ganglion cells, retinal ganglion cells differentiated by the method, a method of screening for a death inhibitor or a proliferation promoter of retinal ganglion cells using the retinal ganglion cells differentiated by the method, a kit of screening for the death inhibitor or the proliferation promoter of retinal ganglion cells including the retinal ganglion cells differentiated by the method, a pharmaceutical composition for treating glaucoma or optic neuropathy including the retinal ganglion cells, a method of treating glaucoma or optic neuropathy including the step of administering the retinal ganglion cells to a subject suspected of having glaucoma or optic neuropathy, and a method of preparing a mature retinal ganglion cell line.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: November 9, 2021
    Assignee: ClavisTherapeutics, INC.
    Inventors: Sung Sup Park, Ji Yeon Kim
  • Patent number: 11166986
    Abstract: The present invention is directed to polypeptides and compositions thereof useful for the prevention or treatment of an inflammatory bowel disease in particular Crohn's disease or ulcerative colitis (UC), and of coeliac disease. More particularly, the invention relates to agents and compositions thereof that useful for the prevention and treatment of hypersensitivity and/or hyperirritability of the colon and/or small intestine.
    Type: Grant
    Filed: January 30, 2015
    Date of Patent: November 9, 2021
    Inventors: Anne Mueller, Daniela Engler-Anders
  • Patent number: 11168299
    Abstract: A method for growing probiotic organisms wherein the growth media includes prebiotics especially selected and prepared to be paired with the probiotic organisms being grown. The prebiotic formula is optimized to grow the desired probiotic organisms, as well as important byproducts of the growth process. Specialized freeze-drying buffers may also be paired with certain probiotic organisms for the freeze-drying process.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: November 9, 2021
    Inventors: Shayne Morris, Michael Benson
  • Patent number: 11166989
    Abstract: The present invention relates to Bacillus strains which improves health and performance of production animals. The invention further relates to compositions comprising the Bacillus strains.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: November 9, 2021
    Assignee: Novozymes A/S
    Inventors: Derrick Lewis, Marianne Thorup Cohn, Adam Nelson, Preben Nielsen
  • Patent number: 11160834
    Abstract: Preparations comprising an enriched population of extracellular vesicles (nEVs) having a negatively charged surface, and that are CD81+ and CD9?, are provided. Improved processes and methods for producing an enriched population of nEVs from non-murine cells, especially human origin cells and/or tissues, are disclosed. Therapeutic methods for using the preparations, including for reducing brain inflammation and treatment of various pathologies associated with brain inflammation, such as by intravenous or intranasal administration, are also described. Methods and preparations for reducing brain inflammation associated with traumatic brain injury (TBI) are also disclosed. A method for treating a patient having suffered a mild traumatic injury (mTMI), or concussion, such as a sports-related head injury, is also disclosed. The nEVs are also demonstrated to reduce the expression level of IL-I? in brain tissue of an animal having had traumatic brain injury.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: November 2, 2021
    Inventors: Darwin J. Prockop, Dong-Ki Kim, Hidetaka Nishida, Askok K. Shetty
  • Patent number: 11150253
    Abstract: Disclosed is a method for analyzing a blood specimen, including the steps of: coagulating a blood specimen in the presence of an activating agent for fibrinolytic system to acquire a coagulation waveform; and acquiring information about fibrinolytic capacity of the blood specimen based on the acquired coagulation waveform.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: October 19, 2021
    Inventors: Midori Shima, Keiji Nogami, Tomoko Matsumoto, Sho Shinohara, Nobuo Arai
  • Patent number: 11142668
    Abstract: Processes disclosed are capable of converting biomass into high-crystallinity, hydrophobic cellulose. In some variations, the process includes fractionating biomass with an acid (such as sulfur dioxide), a solvent (such as ethanol), and water, to generate cellulose-rich solids and a liquid containing hemicellulose and lignin; and depositing lignin onto cellulose fibers to produce lignin-coated cellulose materials (such as dissolving pulp). The crystallinity of the cellulose material may be 80% or higher, translating into good reinforcing properties for composites. Optionally, sugars derived from amorphous cellulose and hemicellulose may be separately fermented, such as to monomers for various polymers. These polymers may be combined with the hydrophobic cellulose to form completely renewable composites.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: October 12, 2021
    Assignee: GranBio Intellectual Property Holdings, LLC
    Inventors: Kimberly Nelson, Theodora Retsina, Vesa Pylkkanen, Ryan O'Connor
  • Patent number: 11118198
    Abstract: The disclosure relates to a method for fermentation integrated with separation and purification of acetone, butanol, and ethanol (ABE) or butanol alone, comprising the following steps: 1) obtaining ABE by fermentation using an acetone-butanol-producing bacterium or obtaining butanol using a butanol-producing bacterium; 2) using a “vapor-stripping-vapor-permeation” method (briefly VSVP) for online separation and purification of ABE or purifying butanol from the fermentation broth; wherein the VSVP method comprises the following steps: introducing a gas bubble into the fermentation broth comprising active cells for fermentation to vaporize ABE or Butanol; subjecting the gas along with the vaporized ABE or Butanol to a membrane separation unit to pass through the membrane; recovering ABE or Butanol, or subjecting ABE or Butanol to a next separation device.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: September 14, 2021
    Assignee: Dalian University of Technology
    Inventors: Chuang Xue, Chao Zhu, Lijie Chen
  • Patent number: 11111480
    Abstract: A growth medium for culturing mesenchymal stem cells. The medium comprises a serum, a fibroblast growth factor, and either an L-cysteine, a glutathione, or an N-acetyl cysteine. Optionally, the medium can comprise various quantities of an epidermal growth factor, a hydrocortisone, a calcium chloride, an insulin, a pituitary extract, a selenium, a stromal-derived factor, a sodium pyruvate, a transferrin, and serum-free medium.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: September 7, 2021
    Inventor: Hyeonggeun Park
  • Patent number: 11111509
    Abstract: The present invention relates to a two-stage process for production of drop-in fuels/alcohols (methanol, ethanol or butanol) from volatile fatty acids produced either synthetically from fossil resources or as metabolic intermediates in acidification step of anaerobic digestion process from waste biomass and organic materials.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: September 7, 2021
    Assignee: Indian Oil Corporation Limited
    Inventors: Manoj Kumar, Sandipam Srikanth, Dheer Singh, Suresh Kumar Puri, Sankara Sri Venkata Ramakumar
  • Patent number: 11098341
    Abstract: A method for determining whether a test sample contains a phytopathogenic fungus, which includes (a) putting the test sample on a front surface of a substrate having a through hole; the substrate having a cellulose film on the back surface thereof; the through hole has a cross-sectional area of not less than 7.065 square micrometers and not more than 19.625 square micrometers; and the cellulose film has a thickness of not less than 0.5 micrometers and not more than 3.7 micrometers; (b) leaving the test sample at rest after the step (a); (c) irradiating the cellulose film with ultraviolet light after the step (b); (d) bringing a back surface of the cellulose film into contact with a fungus color reaction reagent after the step (c); and (e) determining that the test sample contains the phytopathogenic fungus, if a color is given to the fungus color reaction reagent.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: August 24, 2021
    Inventors: Yuki Kushida, Yoshitsugu Uriu, Yosifumi Kariatumari
  • Patent number: 11096984
    Abstract: This invention relates generally to products and methods using lunasin-enriched soy extract combined with Reliv Now® to reduce free fatty acid levels and increase leptin levels and adiponectin levels in plasma for the control of obesity, type 2 diabetes and metabolic syndrome. More specifically, the present invention relates to novel compositions comprising lunasin enriched soy extract and Reliv Now® formulations, methods of using these compositions in individuals for the control of obesity, type 2 diabetes and metabolic syndrome, and methods of making compositions comprising them.
    Type: Grant
    Filed: March 10, 2019
    Date of Patent: August 24, 2021
    Assignee: SL Technology, Inc.
    Inventors: Alfredo Flores Galvez, Ryan Schmidt, Carl Hastings
  • Patent number: 11078500
    Abstract: The invention relates to a method for the simultaneous production of a fermented, solid product and ethanol comprising the following steps: 1) providing a mixture of milled or flaked or otherwise disintegrated biomass, comprising oligosaccharides and/or polysaccharides and live yeast in a dry matter ratio of from 2:1 to 100:1, and water; 2) fermenting the mixture resulting from step (1) under conditions where the water content in the initial mixture does not exceed 65% by weight, for 1-36 hours at a temperature of about 25-60° C. under anaerobic conditions; 3) incubating the fermented mixture resulting from step (2) for 0.5-240 minutes at a temperature of about 70-150° C.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: August 3, 2021
    Assignee: HAMLET PROTEIN A/S
    Inventors: Ole Kaae Hansen, Katrine Hvid Ellegård, Karl Kristian Thomsen