Abstract: Systems and methods for analysis of a whole blood sample from an individual to determine the platelet function and coagulation status of the individual in a substantially automated and efficient matter. Also provided here are systems, reagent kits, and methods for concurrent assessment of platelet function and coagulation as they interact during hemostasis.

Abstract: Disinfecting apparatus and method. The apparatus may include an enclosure configured to receive a device to be at least partially disinfected; an inlet port operably positioned with respect to the enclosure and configured to receive a disinfectant agent from a source and guide the disinfectant agent to at least partially disinfect the device, and an outlet port including a filter portion to at least minimize an amount of disinfectant agent that exits the enclosure.

Abstract: The invention relates to a method and system for performing VPD-DC on wafer surfaces, wherein the pipette substitutes for the function of the scan tube and is operated such that a bulge of scanning liquid protrudes from the pipette channel and contacts the wafer surface for scanning.

Abstract: Provided is photoactivated selective release (or PHASR) of droplets from a microwell array enabled by a photoresponsive polymer layer integrated into the microfluidic device. This photoresponsive layer is placed in between a microwell array that traps a large number of droplets and a monolithic flow chamber that can be used for recovery. By using focused light, the photoresponsive layer can either be punctured or induced to create local heating to selectively release droplets. The type of photoacoustic dye and the physical properties of the photoresponsive layer can be engineered to induce either puncture of the membrane or pushing of droplets out of the microwells with low thermal impact on the droplets. This approach has broad application in the field of soft lithography-based microfluidic devices for various applications including photoresponsive valves as well as high throughput single cell sequencing.

Abstract: A detection system for an electronic nose which allows a physicochemical classification of odors, that is to say a classification as a function of the physicochemical properties of the volatile compounds, or odorous molecules, making up these odors. This detection system comprises sensors with cross-reactivity with respect to volatile compounds, each sensor comprising a sensitive part functionalized by a receptor comprising a sequence formed by the repetition of an ?-amino acid. The ?-amino acid of the receptor of a sensor of a first series of sensors is hydrophilic, while the ?-amino acid of the receptor of another sensor of the first series is hydrophobic, and the ?-amino acids of the receptors of two sensors of a second series of sensors have isoelectric points which differ from one another by at least one pH unit.

Abstract: Method of assaying for an analyte in a sample, and kits for performing the assay.

Abstract: The present inventors discovered that compounds containing an amino group protected with a protecting group having an Fmoc skeleton can be quantitatively determined accurately by removing the protecting group having the Fmoc skeleton from the compounds and measuring the contents of dibenzofulvene or its derivative thereby produced.

Abstract: An apparatus and method for detecting one or more target molecules includes a hydrophobic substrate, and a sensor. The sensor includes two or more electrodes disposed on the hydrophobic substrate and separated from one another by a gap, a plurality of nanostructures formed on or within an upper surface of each electrode, a plurality of binding molecules attached to the plurality of nanostructures, wherein the plurality of binding molecules are configured to bind with the one or more target molecules, and wherein the upper surface of each electrode and the plurality of nanostructures are hydrophilic, and may further detect two or more analytes with two or more sensors that detect two or more different modalities, such as, electrical, optical fluorescence, optical resonance, magnetic detection, or acoustic waves.

Abstract: A 3D nanopore device for characterizing biopolymer molecules includes a first selecting layer having a first axis of selection. The device also includes a second selecting layer disposed adjacent the first selecting layer and having a second axis of selection orthogonal to the first axis of selection. The device further includes an third electrode layer disposed adjacent the second selecting layer, such that the first selecting layer, the second selecting layer, and the third electrode layer form a stack of layers along a Z axis and define a plurality of nanopore pillars.

Abstract: A module for an automated biology laboratory system includes a housing and a storage device located within the housing. The storage device has a plurality of plate slots for receiving microplates or lab-ware with a microplate footprint or containers. The laboratory system further includes a transfer slot to transfer the microplates or containers between an inside of the module and an outside of the module; indexing means to facilitate alignment of the transfer slot with a microplate transfer interface comprising an aperture of the housing; and connection means for fixedly connecting the transfer interface of the module to a transfer interface of an adjacent module.

Abstract: The present disclosure relates to a method for detecting TCEP content in ADC by LC-MS/MS. The ADC samples are derivatized by Ellman reaction, and then the TCEP content is measured by LC-MS/MS. This method can exclude the interference caused by the substances that may react with Ellman in complex ADC samples, which provides with no need for sample pretreatment, and with strong specificity.

Abstract: Sub-millimeter scale three-dimensional (3D) structures are disclosed with customizable chemical properties and/or functionality. The 3D structures are referred to as drop-carrier particles. The drop-carrier particles allow the selective association of one solution (i.e., a dispersed phased) with an interior portion of each of the drop-carrier particles, while a second non-miscible solution (i.e., a continuous phase) associates with an exterior portion of each of the drop-carrier particles due to the specific chemical and/or physical properties of the interior and exterior regions of the drop-carrier particles. The combined drop-carrier particle with the dispersed phase contained therein is referred to as a particle-drop. The selective association results in compartmentalization of the dispersed phase solution into sub-microliter-sized volumes contained in the drop-carrier particles. The compartmentalized volumes can be used for single-molecule assays as well as single-cell, and other single-entity assays.

Abstract: It is an object of the present invention to provide improved lateral flow test devices that can provide sensitive and accurate quantitative test results, and methods for the manufacture thereof.

Abstract: Methods and systems for identifying and/or treating urinary disorders are provided. The methods and systems generally operate by obtaining a urine sample from a subject, identifying (such as by using nucleic acid sequencing) an abundance of a first set of one or more microbes (such as one or more bacteria or viruses) in the urine sample, and determining whether the subject suffers from a urinary disorder based on the abundance of the first set of one or more microbes. In some cases, the methods and systems further operate by identifying a second set of microbes to supplement a microbiome in the urinary tract of the subject. In some instances, the methods and systems further operate by treating the urinary disorder using the second set of microbes. In some instances a preservation solution is utilized.

Abstract: A method for determining an amount of metallic impurities within silicon. The method includes the steps of (a) providing a rodlike silicon sample and a rodlike seed crystal in a zone melting apparatus, (b) zone melting to form a single silicon crystal having a conical end region with a droplike melt forming at the end of the single silicon crystal in a separation step, (c) cooling of the droplike melt to form a solidified silicon drop, (d) partial or complete dissolution of the silicon drop in an acid, and analyzing the solution obtained in step (d) by a trace analysis technique. Wherein the separation step further includes a remelting step for the silicon sample to reduce its diameter, forming a droplike melting zone, and separation of the seed crystal and the silicon sample by moving the seed crystal and the silicon sample apart from one another.

Abstract: A fluid line part for a microfluidic device includes a first substrate having a first surface in which at least one depression is provided, the depression forming a channel for conducting a fluid along a main flow direction. At least one support web extends lengthwise inside the channel along the main flow direction. The support web is configured and positioned such that fluid flows freely around it.

Abstract: Compositions, systems, and methods for detecting events are provided. A composition can include a nanopore including a first side, a second side, and an aperture extending through the first and second sides; and a permanent tether including head and tail regions and an elongated body disposed there between. The head region can be anchored to or adjacent to the first or second side of the nanopore. The elongated body including a reporter region can be movable within the aperture responsive to a first event occurring adjacent to the first side of the nanopore. For example, the reporter region is translationally movable toward the first side responsive to the first event, then toward the second side, then toward the first side responsive to a second event. The first event can include adding a first nucleotide to a polynucleotide. The second event can include adding a second nucleotide to the polynucleotide.

Abstract: A method of evaluating suitability of lighting conditions for detecting an analyte in a sample using a mobile device camera. A test strip is provided for detecting the analyte. A first image of the test strip is captured while an illumination source of the mobile device is turned off and a second image of the test strip is captured while the illumination source is turned on. A sample is applied to the test strip and the first and second images are compared to thereby determine the difference in lighting conditions between the first image and the second image. The comparison is used to derive information on suitability of the lighting conditions for analyte detection. The lighting conditions are indicated as suitable when a predetermined threshold amount of light intensity used for illumination of the test strip originates from the illumination source.

Abstract: A gas sensor device including a housing, a porous member through which the analyte gas is transportable in operative connection with the a of the housing to separate an inner chamber of the housing from the ambient environment, a gas sensor responsive to the analyte gas within the inner chamber, a source of pressure waves positioned within the inner chamber and spaced from the porous member so that any pressure waves emitted from the source of pressure waves that are transmitted out of the inner chamber are transmitted through the porous member, a sensor responsive to pressure waves, and circuitry in operative connection with the sensor responsive to pressure waves to relate a phase of a measured response of the sensor responsive to pressure waves to a state of blockage in the porous member.

Abstract: A gas sensor device to detect an analyte gas in an ambient environment includes a housing including an inner chamber and a port, a porous member through which the analyte gas transports in operative connection with the port to separate the inner chamber from the ambient environment, a sensor responsive to the analyte positioned within the inner chamber, a source of pressure waves positioned within the inner chamber, a sensor responsive to pressure waves positioned within the inner chamber; and circuitry in operative connection with the sensor responsive to pressure waves to relate a response of the sensor responsive to pressure waves to a state of blockage in the porous member.