Patents Examined by Jennifer Wecker
  • Patent number: 10981165
    Abstract: A device for visual quantification of an amount of target species in a sample solution. The device includes an inlet, a separator, and a trap. The inlet is arranged to receive the sample solution. The separator in fluid communication with the inlet and arranged to separate one or more species from the sample solution. The trap is arranged downstream of the separator, in fluid communication with the separator, and arranged to trap one or more species of the sample solution. The trap is arranged such that the trapped species is visible for determination of the amount of target species in the sample solution.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: April 20, 2021
    Assignee: City University of Hong Kong
    Inventors: Ting-Hsuan Chen, Zichen Zhao
  • Patent number: 10981950
    Abstract: A compact flow kit for the continuous purification of serums containing therapeutic proteins, manufactured to minimize the risk of leakage or contamination from flexible tubing attachments.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: April 20, 2021
    Inventor: Joanna Pezzini
  • Patent number: 10983108
    Abstract: Methods are described for diagnosing or prognosing insulin resistance in diabetic and pre-diabetic patients, the method comprising determining the amount of insulin and C-peptide in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: April 20, 2021
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Dov Shiffman, Carmen Tong, James J. Devlin, Michael J. McPhaul
  • Patent number: 10983035
    Abstract: Exosomes carry microRNA biomarkers, occur in higher abundance in cancerous patients than in healthy ones, and because they are present in most biofluids, including blood and urine, can be obtained non-invasively. Standard laboratory techniques to isolate exosomes are expensive, time-consuming, provide poor purity, and recover on the order of 25% of the available exosomes. We present a new microfluidic technique to simultaneously isolate exosomes and preconcentrate them by electrophoresis using a high transverse local electric field generated by ion-depleting ion-selective membrane. We use pressure-driven flow to deliver an exosome sample to a microfluidic chip such that the transverse electric field forces them out of the cross flow and into an agarose gel which filters out unwanted cellular debris while the ion-selective membrane concentrates the exosomes through an enrichment effect. We efficiently isolated exosomes from 1×PBS buffer, cell culture media and blood serum.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: April 20, 2021
    Assignee: University of Notre Dame du Lac
    Inventors: Steven Marczak, Zeinab Ramshani, Reginald Hill, David B. Go, Hsueh-Chia Chang, Satyajyoti Senapati
  • Patent number: 10981174
    Abstract: The present invention relates to methods for detecting targets by employing a temperature control system with a microfluidic device. The system allows for non-contact heating by employing an infrared emitter. In some instances, the system can be used in conjunction with a centrifugal microfluidic device. Optionally, a mask can be implemented to provide selective heating of desired assay areas of the device.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: April 20, 2021
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Chung-Yan Koh, Christopher Phaneuf
  • Patent number: 10983127
    Abstract: The present invention relates to a device of diagnosing a colorectal cancer and a method for providing colorectal cancer diagnosis information. A colorectal cancer diagnosing device according to the present invention includes: an input unit which acquires mass spectrometry data measured from a biological sample; a concentration detecting unit which measures a concentration of nudifloramide from the acquired mass spectrometry data; and a diagnosing unit which determines diagnosis information of the colorectal cancer based on a measurement result of the concentration detecting unit.
    Type: Grant
    Filed: September 1, 2017
    Date of Patent: April 20, 2021
    Inventors: Byong Chul Yoo, Kyung Hee Kim, Jun Hwa Lee
  • Patent number: 10983132
    Abstract: A dosage form of glucose and a method of performing an oral glucose tolerance test or challenge test on a patient are disclosed. The dosage form of glucose may be a drinkable gel formulation and include water, a primary gelling agent, and a pH adjuster. The water, the primary gelling agent, and the pH adjuster may be present in amounts which ensure proper hydration and a formation of a firm gel with a bloom grade of at least 100, which can be sheared to make it more fluid, such that it is a drinkable gel.
    Type: Grant
    Filed: November 5, 2016
    Date of Patent: April 20, 2021
    Inventors: Ian Barabash, Nathan Givoni, Felix Meiser, Thomas P. Kralj
  • Patent number: 10974240
    Abstract: A cartridge for collecting sample material may include a cartridge body and a fluid reservoir. The cartridge body may define a capless sample well port configured to receive the sample material and a fluidic channel in fluid communication with the capless sample well port. The fluidic channel may include a sample fluidic channel portion and may be configured such that an effect of gravity on the sample material within the sample fluidic channel portion does not overcome a capillary action of the fluidic channel. The fluidic channel may extend between the capless sample well port and the fluid reservoir. The fluidic channel may be configured to direct the sample material towards the fluid reservoir when a pressure is applied within the fluidic channel.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: April 13, 2021
    Assignee: Qorvo US, Inc.
    Inventor: James Russell Webster
  • Patent number: 10976256
    Abstract: A method for detecting an analyte comprising 2,4,6-trinitrotoluene in a sample comprising: providing an indicator solution, comprising a cation and an anion; bringing in contact and/or interacting the indicator solution and the sample comprising the analyte; photocatalytically induced forming of an anionic TNT sigma complex, comprising the analyte and the anion, by means of exposure of the indicator solution and the sample brought in contact with one another; fluorescence optically detecting the formed anionic TNT sigma complex.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: April 13, 2021
    Assignee: Bundesrepublik Deutschland, Vertreten Durch Den Bundesrepublik Für Wirtschaft Und Energie
    Inventors: Knut Rurack, Mustafa Biyikal
  • Patent number: 10976322
    Abstract: A galactose oral composition having galactose, an antioxidant and a buffer. The galactose oral composition contains 1%-80% by weight of galactose. The antioxidant is selected from Vitamin A, Vitamin C, Vitamin E, Ethylenediaminetetraacetic acid (EDTA), sodium bisulfite, flavonoids, polyphenols, Diethylenetriaminepentaacetic acid (DTPA), and NTA-Nitrilotriacetate acid (NTA). The buffer is selected from ascorbic acid buffer, citrate buffer, phosphate buffer, acetate buffer, carbonate buffer, and triethanolamine buffer. The galactose oral composition can be applied to detect individual galactose metabolic ability to assess liver function.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: April 13, 2021
    Inventors: Oliver Yoa-Pu Hu, Ping Yang, Cheng-Huei Hsiong
  • Patent number: 10968493
    Abstract: Kits and methods are provided for performing multiplex LAMP reactions. These kits and methods are directed to specific and sensitive methods of target nucleic acid detection and more specifically pathogen diagnostics such as detection of Coronavirus. The kits and methods utilize a plurality of sets of oligonucleotide primers for targeting different template sequences in a single nucleic acid target. The kits and methods also include guanidium salts that enhance the sensitivity of the assay.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: April 6, 2021
    Assignee: New England Biolabs, Inc.
    Inventors: Nathan Tanner, Yinhua Zhang, Gregory Patton, Guoping Ren, Zhiru Li, Nicole Nichols
  • Patent number: 10967368
    Abstract: In embodiments there is described a method for reducing false positives and negatives in the detection of SARS-CoV-2 in suspected patients using mass spectroscopy employing the steps of mixing samples of collected saliva and nasopharyngeal secretions in a single sample container; adding universal transport medium to the mixed samples in said single sample container; transporting the single sample container at a temperature above 0° C. to a remote location; deactivation of viral content of the mixed sample; protein digestion of the mixed sample; concomitant separation of peptides, ionization by mass spectroscopy of the separated peptides, and comparison of peptide patterns to known SARS-CoV-2 peptides. Also set forth in an embodiment is a collection container for collecting saliva and/or sputum, as well as a swab member, with universal transport medium and/or virus inactivating agent housed in separate compartment communicable with sample compartment through a one-way valve.
    Type: Grant
    Filed: August 19, 2020
    Date of Patent: April 6, 2021
    Inventors: Timothy S. Moore, Cullen Thomas Moore
  • Patent number: 10968113
    Abstract: The invention relates to a device and method to quantify the lead exposure of an aqueous feed to humans, remove lead from the aqueous feed, and identify the presence of lead service lines. The device includes an inlet to receive a lead-containing aqueous feed; an outlet to discharge a lead-depleted treated aqueous feed; and at least one cartridge containing sampling media positioned so that the lead-containing aqueous feed passes from the inlet and through the cartridge to produce the lead-depleted treated aqueous feed for discharge through the outlet.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: April 6, 2021
    Inventors: Darren Alan Lytle, Michael Reed Schock
  • Patent number: 10962529
    Abstract: A method for detecting a SARS-Cov-2 protease in a biological sample is provided. The method includes contacting the biological sample with a fluorescent probe based sensor, wherein the sensor comprises an L-Histidine-D-aspartic acid peptide substrate, a fluorophore, and a quencher molecule; and detecting the SARS-Cov-2 protease when an increase in fluorescence is observed.
    Type: Grant
    Filed: December 1, 2020
    Date of Patent: March 30, 2021
    Assignee: King Abdulaziz University
    Inventors: Hani A. Alhadrami, Mohammed Zourob
  • Patent number: 10962454
    Abstract: The disclosed methods for preparing cytological samples may include placing a cytological sample in a concave filter in a filtration system, applying a negative pressure to an outer side of the concave filter with a vacuum device to withdraw a liquid from the cytological sample, applying a sectionable matrix material over the filtered cellular material within the concave filter, and removing an assembly including the filtered cellular material and the sectionable matrix material from the filtration system. Various other related methods, systems, and materials are also disclosed.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: March 30, 2021
    Assignee: Leavitt Medical, Inc.
    Inventor: Sorin Musat
  • Patent number: 10962481
    Abstract: A method of analyzing a selected refinery chemical at a low concentration comprises contacting a sample with functionalized metallic nanoparticles that contain metallic nanoparticles functionalized with a functional group comprising a cyano group, a thiol group, a carboxyl group, an amino group, a boronic acid group, an aza group, an ether group, a hydroxyl group, or a combination comprising at least one of the foregoing; radiating the sample contacted with the functionalized metallic nanoparticles with electromagnetic radiation at a selected energy level; measuring a Raman spectrum emitted from the sample; and determining the presence or a concentration of a selected refinery chemical in the sample from the Raman spectrum.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: March 30, 2021
    Inventors: Radhika Suresh, Sankaran Murugesan, Valery N. Khabashesku, Darryl Ventura
  • Patent number: 10962518
    Abstract: A method and apparatus for drug dissolution testing may include an overflow vessel with an overflow outlet port at a predetermined height from a bottom of the overflow vessel, a first water bath submerging the overflow vessel and configured to keep a temperature of the overflow vessel at a first predetermined temperature, a pressurized vessel containing a dissolution medium, a second water bath submerging the pressurized vessel and configured to keep the dissolution medium at a second predetermined temperature, a dissolution medium path with an output end connected in fluid communication with the flow cell and an input end attached in fluid communication to the pressurized vessel, where the dissolution medium path may transfer the dissolution medium from the pressurized vessel into the flow cell, a collection vessel connected to the overflow outlet port of the flow cell, and a third water bath submerging the collection vessel and configured to keep the collection vessel at a third predetermined temperature.
    Type: Grant
    Filed: October 28, 2018
    Date of Patent: March 30, 2021
    Inventors: Hamid Gourabi, Hamid Mobedi, Siyavash Mirzaei, Sakineh Khezli
  • Patent number: 10960002
    Abstract: Methods for diagnosing, treating, and monitoring the treatment of mucormycosis are described. The methods can include detecting the presence of one or more volatile organic compounds (VOCs) in the breath of subjects suspected of having mucormycosis.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: March 30, 2021
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Sophia Koo, Francisco Miguel Marty
  • Patent number: 10962495
    Abstract: To provide a system capable of evaluating a deficiency and/or a lowered function of extrinsic coagulation factors or intrinsic coagulation factors with high sensitivity by adding new procedures and apparatuses to a blood coagulation system analysis procedure, an apparatus, or the like. A blood coagulation system analysis system includes a blood coagulation system measurement apparatus that performs blood coagulation system measurement of a blood sample; and a blood coagulation system analysis apparatus including a coagulation parameter extraction unit that extracts a coagulation parameter from a measurement result by the blood coagulation system measurement apparatus, and a blood coagulation evaluation unit that evaluates a level of blood coagulation of the blood sample on the basis of the coagulation parameter, the measurement by the blood coagulation system measurement apparatus being performed under an extrinsic system acceleration condition and an intrinsic system acceleration condition.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: March 30, 2021
    Assignee: Sony Corporation
    Inventors: Yoshihito Hayashi, Marcaurele Brun, Kenzo Machida, Aya Murata, Shinji Omori, Seungmin Lee, Kaori Kawaguchi
  • Patent number: 10953399
    Abstract: An apparatus for directing fluid into and out of a fluidic device includes two or more fluid prime channels connected to a fluid inlet of the fluidic device, a flow control valve for each fluid prime channel to control flow between the fluid prime channel and the fluid inlet, one or more outlet channels connected to a fluid outlet of the fluidic device, and a flow control valve for each outlet channel to control flow between the fluid outlet and the associated outlet channel. An apparatus for delivering fluids to a fluid inlet includes a plate that is rotatable about an axis of rotation and a plurality of fluid compartments disposed on the plate, each compartment having a fluid exit port disposed at a common radial distance from the axis of rotation and positioned to align with the fluid inlet as the plate rotates about the axis of rotation.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: March 23, 2021
    Inventors: Wesley A. Cox-Muranami, Darren Robert Segale, Oliver Jon Miller, Jennifer Olivia Foley, Tarun Kumar Khurana, Paul Crivelli, Gary Watts