Patents Examined by Jennifer Wecker
  • Patent number: 12169192
    Abstract: The present disclosure provides methods for identifying a hydrocarbon fuel, such as the presence and/or amounts of marker compounds having a fluorescence intensity and, through correlation, the presence and/or amounts of additive package(s) within the hydrocarbon fuel. The methods include obtaining a sample of a hydrocarbon fuel including a marker compound having fluorescence, combining the hydrocarbon fuel with water, and subjecting a water phase thereof to light for observing fluorescence.
    Type: Grant
    Filed: November 2, 2020
    Date of Patent: December 17, 2024
    Assignee: AFTON CHEMICAL CORPORATION
    Inventors: Scott D. Schwab, Dana Anderson
  • Patent number: 12168798
    Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: December 17, 2024
    Assignee: INTEGENX. INC.
    Inventors: David Eberhart, Yuan Li, James Ogg, Ezra Van Gelder, Stephen J. Williams, Timothy Woudenberg, Dean S. Burgi, William D. Nielsen
  • Patent number: 12168232
    Abstract: An exemplary embodiment of the present disclosure provides a fluidic device comprising a substrate, an applicator, and a spacer. The substrate can comprise a plurality of wells. The applicator can be used for manipulating a biological substance in at least a portion of the plurality of wells. The spacer can be positioned between the substrate and the applicator. The spacer can be configured to allow the applicator to apply the biological substance to at least a portion of the plurality of wells while maintaining a space between the substrate and the applicator.
    Type: Grant
    Filed: October 12, 2021
    Date of Patent: December 17, 2024
    Assignee: Georgia Tech Research Corporation
    Inventors: Gongchen Sun, Hang Lu
  • Patent number: 12168230
    Abstract: The invention provides a microdroplet- or bubble-producing device that does not require separate through-holes for different liquid droplet/air bubble-producing flow channels. The droplet-producing flow channels are configured in a three-dimensional manner unlike in a conventional device where they are configured in a two-dimensional plane, and therefore the flow channels can be provided in a more high-density configuration than the prior art.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: December 17, 2024
    Assignee: Japan Science and Technology Agency
    Inventors: Takasi Nisisako, Naotomo Tottori
  • Patent number: 12163932
    Abstract: A configurable injector for injecting a fluidic sample in a separation path of a sample separation apparatus includes a sample accommodation volume for accommodating the fluidic sample to be injected into the separation path, a valve arrangement fluidically couplable with the separation path, fluidically coupled with the sample accommodation volume, and being controllable for injecting the fluidic sample into the separation path, an input interface configured for receiving input data indicative of an injection profile of an injector to be emulated by the configurable injector, and a control unit configured for controlling the configurable injector, in particular the valve arrangement, so that the configurable injector is operated in accordance with the injection profile to thereby emulate the injector to be emulated.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: December 10, 2024
    Assignee: Agilent Technologies, Inc.
    Inventor: Thomas Ortmann
  • Patent number: 12163937
    Abstract: An embodiment provides a method for deriving an amount of PFAS substances from a total organic fluoride measurement in a sample, including: removing inorganic fluoride from the sample using one or more of an ion exchange cartridge and an exclusion apparatus; preconcentrating, using a solid phase extraction, at least one PFAS substance in the sample; digesting, using a working electrode and a counter electrode, the at least one PFAS substance to an amount of total organic fluoride; and determining, using an analyzer, the amount of total organic fluoride in the sample. Other aspects are described and claimed.
    Type: Grant
    Filed: January 20, 2022
    Date of Patent: December 10, 2024
    Assignee: HACH COMPANY
    Inventors: Vishnu Vardhanan Rajasekharan, Cary Burton Jackson, Matthew Ryan Salzer, Dan Jonathan Kroll
  • Patent number: 12162008
    Abstract: Methods of partition-based analysis. In an exemplary method, a device having a port fluidically connected to a chamber may be selected. A sample-containing fluid may be placed into the port. The sample-containing fluid may be moved from the port to the chamber. Partitions of the sample-containing fluid may be formed. A monolayer of the partitions in the chamber may be created. At least a portion of the monolayer may be imaged.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: December 10, 2024
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Billy Wayne Colston, Jr., Benjamin Joseph Hindson, Kevin Dean Ness, Donald Arthur Masquelier, Fred Paul Milanovich, Douglas N. Modlin, Vincent Riot, Samuel Burd, Anthony Joseph Makarewicz, Jr., Phillip Belgrader
  • Patent number: 12163171
    Abstract: A method for amplifying nucleic acids by a polymerase chain reaction in a reaction volume heated using electrical energy. In at least one of the passages of the amplification cycle of the polymerase chain reaction, the ratio of the electrical energy used in the denaturation step to heat the reaction volume to the size of the reaction volume is less than 20 Joule per milliliter. Further shown is a method of amplifying nucleic acids in a reaction volume by using a device that includes a reaction vessel and a heating means with at least one heating element in contact with the reaction volume where at least one heating element is conjugated to oligonucleotides. Also shown is a device for the amplification of nucleic acids in a reaction volume including a reaction vessel for receiving the reaction volume and a heating means consisting of at least one heating element contacting the reaction volume.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: December 10, 2024
    Assignee: HP Health Solutions Germany GmbH
    Inventors: Federico Buersgens, Joachim Stehr, Lars Ullerich, Lidiya Osinkina, Eimantas Ruseckas
  • Patent number: 12157124
    Abstract: A sample holder includes a first member featuring a first retaining mechanism configured to retain a first substrate that includes a sample, a second member featuring a second retaining mechanism configured to retain a second substrate that includes a reagent medium, and an alignment mechanism connected to at least one of the first and second members, and configured to align the first and second members such that the sample contacts at least a portion of the reagent medium when the first and second members are aligned.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: December 3, 2024
    Assignee: 10x Genomics, Inc.
    Inventors: David Maurice Cox, Augusto Manuel Tentori, Rajiv Bharadwaj
  • Patent number: 12158409
    Abstract: Disclosed are a blood analysis system, a blood analyzer, a blood analysis method and a storage medium. The blood analysis method includes: acquiring at least two types of optical signals of a test sample derived from a blood sample, wherein red blood cells in the test sample are lysed, blood cells in the test sample are stained by a fluorescence dye, and the at least two types of optical signals include scattered light signals and/or fluorescent signals; generating a scattergram based on the at least two types of optical signals; identifying a preset region in the scattergram based on the at least two types of optical signals; and acquiring detection data of a platelet subpopulation based on the preset region.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: December 3, 2024
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Bo Ye, Huan Qi, Wenbo Zheng, Yi Ye
  • Patent number: 12158478
    Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: December 3, 2024
    Assignee: Meso Scale Technologies, LLC.
    Inventor: Charles M. Clinton
  • Patent number: 12157126
    Abstract: The invention generally relates to systems and methods for synthesizing a reaction product and increasing yield of the same. In certain aspects, the invention provides a multi-mode reaction system in which in a first mode one or more valves of the system are configured to cause reagents to flow from one or more reagent reservoirs of the system through one or more components of the system to generate a reaction product; and in a second mode the one or more valves are configured to change flow within the system such that the one or more reagent reservoirs are isolated from a remainder of the system and the generated reaction product and any remaining reactants are recycled back through the multi-mode reaction system to increase a yield of the reaction product.
    Type: Grant
    Filed: February 24, 2021
    Date of Patent: December 3, 2024
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Zhenwei Wei
  • Patent number: 12151954
    Abstract: This automated analyzer comprises a first system 11 that does not need to use degassed water, a second system 12 for which it is preferable to use degassed water and that comprises a degassing device 21 for producing degassed water and a second pump 19 for delivering the degassed water, and a tank 1 having formed therein a first compartment 4 for storing water to supply to the first system 11 and a second compartment 5 for storing degassed water to supply to the second system 12. The second system 12 comprises a circulation system, which comprises a suction flow path 20 and return flow path 24 for connecting the degassing device 21, the second pump 19, and the second compartment 5 of the tank 1, and a usage system, which comprises a discharge flow path 22 and connection flow path 27 for connecting the degassing device 21 and a usage unit for using the degassed water.
    Type: Grant
    Filed: March 11, 2020
    Date of Patent: November 26, 2024
    Assignee: Hitachi High-Tech Corporation
    Inventors: Akihiro Shimase, Kazumi Kusano
  • Patent number: 12152010
    Abstract: The present invention, belonging to the technical field of biological imaging, discloses a photo-activatable aggregation-induced emission probe with in-situ generation capability, a preparation method therefor and an application thereof. The preparation method is as follows: A bis(2-(2-hydroxybenzylidene)amino)aryl disulfide compound is reacted with thiol to obtain a photo-activatable aggregation-induced emission probe, which has a structure as shown in formula III. In the present invention, the photo-activatable aggregation-induced emission probe is aggregated into a specific organelle, and a 2-(2-hydroxyphenyl)benzothiazole compound having the aggregation-induced emission property is generated through a photo-oxidation reaction.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: November 26, 2024
    Assignee: SOUTH CHINA UNIVERSITY OF TECHNOLOGY
    Inventors: Ben Zhong Tang, Meng Gao, Shiwu Li
  • Patent number: 12151239
    Abstract: The present invention provides methods and devices for simple, low power, automated processing of biological samples through multiple sample preparation and assay steps. The methods and devices described facilitate the point-of-care implementation of complex diagnostic assays in equipment-free, non-laboratory settings.
    Type: Grant
    Filed: May 18, 2022
    Date of Patent: November 26, 2024
    Assignee: NOVEL MICRODEVICES, INC.
    Inventors: Andrea Maria Dominic Pais, Rohan Joseph Alexander Pais
  • Patent number: 12153045
    Abstract: A photonic biosensor including a biological probe disposed on a mid-infrared-transparent waveguide can be used to detect biological analytes in biological samples, using specific binding of the analyte to the probe in conjunction with absorption spectroscopy. In various embodiments, the biosensor is used for molecular diagnostics, e.g., to detect oligonucleotides or proteins associated with a coronavirus.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: November 26, 2024
    Assignee: The Texas A&M University System
    Inventor: Pao Tai Lin
  • Patent number: 12153058
    Abstract: The present invention describes a test kit for the detection of fat-soluble vitamins in serum using a method based on high performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). The internal standard (IS) solution included in the kit is based on methanol, acetonitrile and isopropyl alcohol solvents. Ammonium acetate is added to the IS solution to make it more stable and last for longer storage time. The application of this kit can significantly improve the recovery and detection sensitivity of vitamins A, E, K1 and K2 in serum without additional sample enrichment, make sample preparation process simpler and more efficient, keep processed samples stable for longer time, and lower the overall cost for more accurate and repeatable test results.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: November 26, 2024
    Assignee: Hangzhou Calibra Diagnostics Co., Ltd.
    Inventors: Shanshan Zeng, Qi Zhang, Yuan Wang, Pengyun Liu, Baoyu Han, Huafen Liu
  • Patent number: 12152980
    Abstract: A system and method for isolating and analyzing single cells, including: a substrate having a broad surface; a set of wells defined at the broad surface of the substrate, and a set of channels, defined by the wall, that fluidly couple each well to at least one adjacent well in the set of wells; and fluid delivery module defining an inlet and comprising a plate, removably coupled to the substrate, the plate defining a recessed region fluidly connected to the inlet and facing the broad surface of the substrate, the fluid delivery module comprising a cell capture mode.
    Type: Grant
    Filed: April 11, 2024
    Date of Patent: November 26, 2024
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: Kalyan Handique, Austin Payne, Vishal Sharma, Kyle Gleason, Priyadarshini Gogoi, Karthik Ganesan, Brian Boniface, Will Chow
  • Patent number: 12144905
    Abstract: A kiosk disinfecting system for large walk-up kiosk screens utilizing touchscreens applies a disinfecting fluid to the touchscreen and has a means to move a wiper over the screen to disinfect the touchscreen. A controller may detect the presence of a user and may automatically activate a disinfecting cycle to ensure that the touchscreen is disinfected between users. The disinfecting system may have a disinfecting fluid applicator, such a spray nozzle(s) and a wiper assembly that makes contact with the touchscreen to spread the disinfecting fluid over the touchscreen surface. A wiper may be a wick-wiper that absorbs or wick disinfecting fluid from a reservoir through the wick to the touchscreen. A very small area of the wick may extend out from an applicator opening to reduce the amount of disinfecting fluid that evaporates over time. A disinfection fluid may be non-volatile and may be all natural and food safe.
    Type: Grant
    Filed: December 29, 2021
    Date of Patent: November 19, 2024
    Inventor: Elizabeth T. Zell
  • Patent number: 12145107
    Abstract: An inline filter housing with a biodegradable, hydrophilic material that operates in conjunction with a field sampling apparatus to both concentrate field sampled environmental DNA particles from water samples and to automatically preserve the captured DNA via desiccation, thus avoiding filter membrane transfer steps, chemicals or cold storage preservation requirements. The hydrophilic filter housing is capable of rapidly preserving the field sampled environmental DNA captured on the filter membrane at ambient field temperatures.
    Type: Grant
    Filed: October 17, 2022
    Date of Patent: November 19, 2024
    Assignee: Smith-Root, Inc.
    Inventors: Austen Clouse Thomas, Jesse Andrew Howard