Patents Examined by Jennifer Wecker
  • Patent number: 11326057
    Abstract: The invention relates to the identification of polymer materials on the basis of the fluorescence decay time of the intrinsic fluorescence of the polymer materials for definite sorting in a completely separated manner. The invention further relates to marking with fluorescent dyes, which, because of the specific fluorescence decay times of the fluorescent dyes, can further increase the sorting reliability by means of redundancy and can be used to identify particular batches.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: May 10, 2022
    Inventors: Heinz Langhals, Thorben Schlücker, Dominik Zgela
  • Patent number: 11325119
    Abstract: A fluidic device includes a fluidic layer, a capture material, and an electronics layer, the fluidic layer includes a main channel and a pair of sample channels fluidly coupled to the main channel. The pair of sample channels is configured to receive and introduce a sample material into the device. The sample material includes an analyte. The capture material is positioned in a portion of the main channel that is spaced from the pair of sample channels. The capture material has a three-dimensional matrix of receptors therein configured to bond with the analyte. The capture material has a length that is associated with a dynamic range of the fluidic device and a cross-sectional area that is associated with a sensitivity of the fluidic device. The electronics layer includes electrodes configured to measure an electrical resistance through a portion of the capture material.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: May 10, 2022
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Carlos Francisco NG Pitti, Ulri Nicole Lee, Richard Novak, Olivier Yves Frederic Henry, Remco Van Erp, Donald E. Ingber
  • Patent number: 11327085
    Abstract: A method for rapid and quantitative determination of sildenafil in cocktail includes the exemplary steps of: Step 1, assigning a Raman spectrum of sildenafil; Step 2, weighing and dissolving a sildenafil standard in methanol to obtain a 1,000 mg/L sildenafil standard solution, and mixing cocktails with the sildenafil standard solution, to prepare test solutions; Step 3, mixing 100 ?L each of test solutions with 500 ?L of surface enhancer OTR 202 to acquire Raman spectra; and Step 4, establishing a linear regression model, with a formula of y=4035.1 x+503.26, where y is the content of sildenafil in cocktail, in mg/L, and x is intensity of Raman characteristic peaks at 1584 cm?1. Rapid determination of sildenafil by SERS is feasible and reliable, serving as a novel, rapid, and accurate method for quantitative determination of sildenafil in cocktail. The method meets the requirements of analysis and detection of sildenafil in other alcoholic beverages.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: May 10, 2022
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Yong He, Lei Lin, Pengcheng Nie
  • Patent number: 11325123
    Abstract: Control of fluid flow in a fluidic network is provided by controlling phase transitions of a phase-change material between a liquid phase and a non-fluid phase. The phase-change material is disposed at ports of the fluidic network where the fluidic network is in communication with an ambient. This advantageously provides control of pressure-driven flow within the fluidic network without altering properties of fluids within the fluidic network.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: May 10, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Anita Rogacs, Juan G. Santiago
  • Patent number: 11327059
    Abstract: The present invention relates to a dianhydride analysis method. The method can stably analyze a dianhydride which has high reactivity and low solubility. Furthermore, the method can minimize the problem that a reaction product disturbs an analysis result, thereby improving accuracy of the analysis result.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: May 10, 2022
    Inventors: So Yeon Kim, Joon Seok Lee, Bumgyu Choi, Byoung Hyoun Kim
  • Patent number: 11327075
    Abstract: It was discovered that hydrogel scaffolds can be used to induce phase separation as aqueous two-phase systems (ATPSs) pass through and/or rehydrate the scaffolds, allowing for concentration of target analyte(s) (e.g., biomolecule(s)) into a particular phase of the ATPS or into a leading front. Accordingly, in various embodiments methods and devices are provided that utilize aqueous two-phase systems and hydrogel scaffolds to improve the sensitivity of assays (e.g., of point-of-care assays) without sacrificing cost or ease of use.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: May 10, 2022
    Assignee: The Regents of the University of California
    Inventors: Daniel Takashi Kamei, Benjamin Ming Wu, David Yuan Pereira, Chloe Michelle Wu, Matthew Foosing Yee, Joshua Anthony Keefe, Christina Caroline Pearce, Amir Adam Dailamy, Vincent K. Wong, Nguyen Khoi Le
  • Patent number: 11328913
    Abstract: The purpose of the present invention is to improve uniformity of film deposition by a plasma-based sputtering device. Provided is a sputtering device 100 for depositing a film on a substrate W through sputtering of targets T by using plasma P, said sputtering device being provided with a vacuum chamber 2 which can be evacuated to a vacuum and into which a gas is to be introduced; a substrate holding part 3 for holding the substrate W inside the vacuum chamber 2; target holding parts 4 for holding the targets T inside the vacuum chamber 2; multiple antennas 5 which are arranged along a surface of the substrate W held by the substrate holding part 3 and generate plasma P; and a reciprocal scanning mechanism 14 for scanning back and forth the substrate holding part 3 along the arrangement direction X of the multiple antennas 5.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: May 10, 2022
    Assignee: NISSIN ELECTRIC CO., LTD.
    Inventors: Shigeaki Kishida, Daisuke Matsuo
  • Patent number: 11318458
    Abstract: A cassette may include a substrate and a die coupled to the substrate wherein the substrate is made of modified polyetherimide (PEI). A system for ejecting a fluid into an assay may include at least one dispense head, the at least one dispense head including a substrate and a die coupled to the substrate wherein the substrate is made of modified polyetherimide (PEI).
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: May 3, 2022
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Gary G. Lutnesky, Paul Schweitzer, Michael W. Cumbie
  • Patent number: 11320350
    Abstract: Methods of agglutinating and separating erythrocytes, by which erythrocytes can be instantaneously agglutinated into a sufficient size in a blood sample and completely separated from the blood sample; and a hemagglutination reagent are provided. The method of agglutinating erythrocytes according to the present invention includes adding a solution containing a cholic acid-based surfactant and an acid to a blood sample. The method of separating erythrocytes according to the present invention includes separating the erythrocytes agglutinated by the above-described method of the present invention. The hemagglutination reagent according to the present invention contains a cholic acid-based surfactant and an acid.
    Type: Grant
    Filed: October 4, 2017
    Date of Patent: May 3, 2022
    Assignee: DENKA COMPANY LIMITED
    Inventors: Shino Muramatsu, Daisuke Kato, Tomohiro Hattori
  • Patent number: 11320344
    Abstract: An aseptic sampling flow path kit to be applied to an isolator having a liquid delivery port includes a sampling section, a first flow path that communicates with the sampling section, and that connects an inside of the isolator to an outside of the isolator through the liquid delivery port, and at least one one-way valve which is disposed in the first flow path, and that limits flow of fluid in the first flow path to a direction from the sampling section toward the liquid delivery port. In the kit, at least a part of the first flow path is a germicidal flow path to which a germicidal unit is applicable.
    Type: Grant
    Filed: January 2, 2019
    Date of Patent: May 3, 2022
    Assignees: NIHON KOHDEN CORPORATION, OSAKA UNIVERSITY
    Inventors: Hodaka Makino, Hirotsugu Kubo, Masahiro Kinooka
  • Patent number: 11320383
    Abstract: The present invention relates to a method for the determination of the film forming amines on surfaces by the detection of a colored complex. The invention also relates to the use of the absorber material for the detection of the film forming amines. The invention also relates to a kit of parts comprising the components capable of the determination of film forming amines.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: May 3, 2022
    Assignee: KURITA WATER INDUSTRIES LTD.
    Inventors: Julia Jasper, Kirstin Zimmer, Andre De Bache, Wolfgang Hater
  • Patent number: 11320438
    Abstract: Tryptophan degradation is a key metabolic pathway controlling immune reactions and evidence suggests that during cancer progression generation of tryptophan metabolites may be fundamental for immune escape promoting the malignant phenotype of cancer cells in an autocrine fashion. The present invention relates to methods of measuring mass tag labelled tryptophan and metabolites thereof and methods using the labelled molecules for monitoring in a subject the effectiveness of a treatment and of disease recurrence after treatment, for stratifying patients and for diagnosing suppression of an immune response in a subject.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: May 3, 2022
    Assignees: ELECTROPHORETICS LIMITED, RUPRECHT-KARLS-UNIVERSITAT, DKFZ DEUTSCHES KREBSFORSCHUNGSZENTRUM
    Inventors: Sasa Koncarevic, Karsten Kuhn, Peter Schulz-Knappe, Ian Hugo Pike, Christiane Opitz, Michael Platten
  • Patent number: 11318469
    Abstract: An example system includes a microfluidic cavity; a retaining feature within the microfluidic cavity, and a releasing feature. The retaining feature is to position capsules at a predetermined location in the microfluidic cavity. The capsules have a thermally degradable shell enclosing a material therein. The releasing feature is to selectively cause degradation of the shell to release the material into the microfluidic opening. The releasing feature is to generate heat to facilitate degradation of the shell. In some examples, the retaining feature is a physical barrier sized to prevent flow of the capsule and to allow flow of the released materials through the microfluidic cavity.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: May 3, 2022
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Viktor Shkolnikov, Chien-Hua Chen
  • Patent number: 11320428
    Abstract: The present subject matter relates to compounds that have aggregation-induced emission (AIE) characteristics and are capable of generating Raman signals in the Raman cell-silent region (1800 cm?1-2800 cm?1). The compounds can be used in dual-mode cell imaging by fluorescence and Raman microscopes.
    Type: Grant
    Filed: April 18, 2018
    Date of Patent: May 3, 2022
    Assignee: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Benzhong Tang, Meijuan Jiang, Xuesong Li, Jianan Qu
  • Patent number: 11318466
    Abstract: One example includes a device that may include a heating element and a molecular binding site. The heating element may heat a fluid volume, interfaced with the heating element, in response to a voltage being applied to the heating element, the heat transforming the fluid volume from a liquid state into a vaporized state to generate fluid motion within the fluid volume. The molecular binding site may be disposed proximate to the heating element, in which a portion of the fluid volume expands when the fluid volume transforms from the liquid state into the vaporized state, the vaporized state of the fluid volume generating the fluid motion within a target fluid that is disposed within the molecular binding site.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: May 3, 2022
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: David P. Markel, Erik D Torniainen, Alexander Govyadinov, Pavel Kornilovich
  • Patent number: 11318471
    Abstract: A method for stretching a plurality of sample isolates, including: trapping the plurality of sample isolates away from a wall of at least one microfluidic channel of a microfluidic flow system; generating a microfluidic flow to stretch the plurality of trapped sample isolates; determining deformation characteristics of the plurality of stretched samples isolates based on one or more frames from an image processing system; and outputting information corresponding to the deformation characteristics.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: May 3, 2022
    Assignee: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Zhanshi Yao, Ching Chi Kwan, Andrew Wing-On Poon
  • Patent number: 11311880
    Abstract: A microchip controlling system comprises a microchip which is configured by adhesion of an elastic sheet and a plate/sheet member, and on which a flow path is provided as an inadhesive section between the elastic sheet and the plate/sheet member; and a microchip controlling apparatus comprising a valve mechanism which is inflated or deflated so as to control the flow path to be opened or closed.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: April 26, 2022
    Assignee: NEC CORPORATION
    Inventor: Yasuo Iimura
  • Patent number: 11311883
    Abstract: Aniosotropic Ratchet Conveyor (“ARC”)-based biomolecule processing devices and related methods are described. The ARC-based biomolecule processing devices include (i) a substrate having an ARC track defined on or within the substrate and including a biomolecule receiving area, which is designed to receive biomolecule, and a reconstituting area, which is designed to contain dry reagents and is designed to receive a transport solution such that at the reconstituting area, dry reagents are reconstituted with transport solution; and (ii) a microheater area disposed at or near the biomolecule receiving area, fitted with a microheater, which is designed to heat biomolecule that is received through the biomolecule receiving area and designed to process heated biomolecule and dry reagents reconstituted with transport solution.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: April 26, 2022
    Assignees: CONSERVATION X LABS, INC., NATIONAL SCIENCE FOUNDATION
    Inventors: David Baisch, Hallie Ray Holmes, Karl F. Bohringer
  • Patent number: 11315771
    Abstract: Methods and apparatus for processing a substrate are provided herein. A method, for example, includes igniting a plasma at a first pressure within a processing volume of a process chamber; depositing sputter material from a target disposed within the processing volume while decreasing the first pressure to a second pressure within a first time frame while maintaining the plasma; continuing to deposit sputter material from the target while decreasing the second pressure to a third pressure within a second time frame less than the first time frame while maintaining the plasma; and continuing to deposit sputter material from the target while maintaining the third pressure for a third time frame that is greater than or equal to the second time frame while maintaining the plasma.
    Type: Grant
    Filed: July 14, 2020
    Date of Patent: April 26, 2022
    Assignee: APPLIED MATERIALS, INC.
    Inventors: Xiangjin Xie, Fuhong Zhang, Shirish A. Pethe, Martin Lee Riker, Lewis Yuan Tse Lo, Lanlan Zhong, Xianmin Tang, Paul Dennis Connors
  • Patent number: 11311884
    Abstract: A biological sample collection system can include a sample collection vessel having a sample collection chamber with an opening configured to receive a biological sample into the sample collection chamber. The biological sample collection system can additionally include a selectively movable sleeve valve configured to associate with the opening of the sample collection chamber. The biological sample collection system can additionally include a sealing cap that is configured to associate with the selectively movable sleeve valve and with the sample collection vessel. The sealing cap can include a reagent chamber having reagent(s) stored therein, and when the sealing cap is associated with the sample collection vessel, the selectively movable sleeve valve opens, dispensing the reagent(s) into the sample collection chamber.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: April 26, 2022
    Assignee: Ancestry.com DNA, LLC
    Inventors: Kevin Gregg Williams, Jeremy Johnson, Bryce Twede, Michael Andersen, Michael S. Horito, Collin Sorensen