Patents Examined by Jennifer Wecker
  • Patent number: 11660598
    Abstract: Disclosed herein are microfluidic devices and methods to deliver concentration gradients to biological material such as oocytes and embryos for the purpose of cryopreparation, cryopreservation, or thawing. Cryopreservation methods, such as vitrification, involve the use of cryoprotectants to reduce formation of damaging ice crystals in cells during freezing. Microfluidic devices and methods described herein improve cell viability and efficiency during handling and cryopreservation of biological materials.
    Type: Grant
    Filed: August 6, 2021
    Date of Patent: May 30, 2023
    Assignee: Overture Life, Inc.
    Inventors: Santiago Munne, José Antonio Horcajadas Almansa, Lionel Matthys, Joana Alexandra Sales Fidalgo, Pablo Carasa Ruiz, David Cancio Villalonga, Daniel Garcia Alonso, Cristina Dosda Munuera, Sara Alvarez Arguelles
  • Patent number: 11660600
    Abstract: A microfluidic assembly may include a microfluidic chip operably coupled to a device source pressure port and a device relief pressure port, first and second input reservoirs, an output reservoir, and a reservoir interface. The microfluidic chip may include a microfluidic circuit configured to support a fluid flow that includes a gas flow and a liquid flow within the microfluidic circuit. The reservoir interface may be configured to operably couple the first and second input reservoirs to the microfluidic circuit. The device source pressure port may be configured to receive a source pressure to generate the fluid flow through the microfluidic circuit and cause a mixing of liquids to form an output liquid for delivery to the output reservoir via the fluid flow. The first liquid, the second liquid, and the output liquid need not contact the device source pressure port or the device relief pressure port during the mixing.
    Type: Grant
    Filed: July 28, 2021
    Date of Patent: May 30, 2023
    Assignee: The Johns Hopkins University
    Inventors: Jeffrey S. Lin, Andrew B. Feldman
  • Patent number: 11660602
    Abstract: A microfluidic device includes first and second substrate structures. The first substrate structure has a first substrate surface configured to receive one or more droplets. A plurality of electrodes configured to apply an electric field to the droplets. The second substrate structure has a second substrate surface facing the first substrate surface and spaced apart from the first substrate surface to form a fluid channel. The microfluidic device has a first heating element adjacent to the first substrate structure and disposed on an opposite side of the first substrate surface, and a second heating element adjacent to the second substrate structure and disposed on an opposite side of the second substrate surface. The microfluidic device further includes one or more temperature sensors disposed adjacent to the fluid channel between the first substrate structure and the second substrate structure.
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: May 30, 2023
    Assignee: MGI Holdings Co., Limited
    Inventors: Yan-You Lin, Jian Gong, Frank Zhong
  • Patent number: 11661574
    Abstract: A fluidic device for culturing cells includes a microplate and plate lid. The microplate includes multiple wells and channels, the channels extending between the wells such that the channels interconnect the wells. The plate lid releasably engages the microplate to thereby enclose the wells and the channels. The wells include a culture surface such that a cell culture medium received therein is deposited over the culture surface. At least one channel that extends between adjacent ones of the wells is spaced from the culture surfaces of the adjacent wells defining a gap between the at least one channel and the culture surfaces of the adjacent wells for collection of the cell culture medium.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: May 30, 2023
    Inventors: Gregory Roger Martin, Allison Jean Tanner
  • Patent number: 11662313
    Abstract: A microfluidic device includes a substrate having an electromagnetic wave transmission property, a lid member facing the substrate and being separated from the substrate such that a flow channel is formed between the substrate and the lid member, a light absorption layer which is placed in the flow channel and absorbs an electromagnetic wave, and a microwell array formed on the substrate and having plural microwells that are open to the flow channel to receive a target of analysis.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: May 30, 2023
    Inventors: Yoichi Makino, Keisuke Goto
  • Patent number: 11654436
    Abstract: A microfluidic device for polymerase chain reaction (PCR) processing includes a platform with a microstructure with at least one reaction chamber, and a heating element. The heating element heats at least a part of the at least one reaction chamber. The heating element includes at least one spin torque oscillator (STO) configured to heat the at least a part of the at least one reaction chamber to one or more temperatures for PCR processing.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: May 23, 2023
    Inventors: Tim Rausch, Edward Charles Gage, Walter R. Eppler, Gemma Mendonsa
  • Patent number: 11656213
    Abstract: A detection reagent is disclosed in the form of a dye having the basic structure of a 4-(phenylethynyl)-phenyl-amine, a 4-(phenylethenyl)-phenyl-amine and/or a biphenylamine derivative. The dye can be used as detection reagent for nitroaromatics, nitroalkanes, nitroamines, nitrates, nitric acid, nitrous acid, nitrogen oxides, and additionally for sulphur dioxide (which is produced with the degradation of black powder). The dye can be an asymmetric triphenylamine derivative, which can lead to a fluorescence quenching, which can be used analytically in the case of electron abstraction.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: May 23, 2023
    Assignee: Institut Dr. Foerster GmbH & Co. KG
    Inventors: Mustafa Biyikal, Knut Rurack
  • Patent number: 11650218
    Abstract: An automatic sample injection system (1) includes at least an injector (2). The injector (2) includes a turret (10) comprising a plurality of vial receiving holes (30) that are corresponding to a plurality of types of vials having different sizes, the plurality of vial receiving holes (30) being provided on the same circumference on an upper surface of the turret, the turret being configured to rotate so that the plurality of the vial receiving holes (30) are each moved along a circumferential track, and a controller (22) configured, in a case where a sampler (4) for supplying a vial to the injector (2) is provided, to recognize a size of a target vial to be supplied at the time when the target vial is supplied from the sampler (4) and to arrange the vial receiving hole (30) corresponding to the target vial at a delivery position (P) set on the circumferential track.
    Type: Grant
    Filed: September 10, 2021
    Date of Patent: May 16, 2023
    Inventor: Daiki Fukushima
  • Patent number: 11649496
    Abstract: A method of making an article bonding a layer of deformable material to a surface of a cartridge body having at least one valve body thereon to seal the at least one valve body, the valve body comprising a valve floor and valve walls comprising upper parts, wherein the valve floor is recessed from the surface and the valve walls extend from the surface to the valve floor, and wherein the valve body comprises walls that are curved or sloped in a direction that is non-normal to the plane defined by the surface; and deforming the layer such that upon release of a force causing the deformation, the layer is in contact with the upper parts of the valve walls and is in spaced from the valve floor so as to bias the valve to an open state.
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: May 16, 2023
    Assignee: INTEGENX, INC.
    Inventors: Philip Justus Wunderle, Chungsoo Charles Park, David King, Dennis Lehto
  • Patent number: 11649541
    Abstract: The present invention discloses a PVD coating process for producing a multifunctional coating structure comprising the steps of producing a HEA ceramic matrix on a substrate and the targeted introduction of a controlled precipitate structure into the HEA ceramic matrix to generate a desired specific property of the coating structure.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: May 16, 2023
    Assignee: Oerlikon Surface Solutions AG, Pfäffikon
    Inventor: Siva Phani Kumar Yalamanchili
  • Patent number: 11648562
    Abstract: Method, apparatus, and computer program product are provided for anonymized diagnosis using lateral flow assays. In some embodiments, a test card includes one or more lateral flow assay (LFA) with one or more test patterns (e.g., full line, partial line, dot), one or more dummy patterns, and one or more control patterns. To visually encode LFA results, at manufacture, one or more lines/dots containing true results of the LFA(s) each has a position mixed with other “dummy” lines/dots, in randomized position patterns selected from among a plurality of possible position patterns. An optical machine-readable representation of data (e.g., QR code) is attached to the test card and encodes test card identification information (e.g., lot number, serial number, test type) associated with the test card. In some embodiments, a passcode card having a scrapeable coating that conceals a passcode associated with the test card is removably attached to the test card.
    Type: Grant
    Filed: November 1, 2019
    Date of Patent: May 16, 2023
    Assignee: International Business Machines Corporation
    Inventors: Ricardo L. Ohta, Jaione Tirapu Azpiroz, Ademir F. Silva, Matheus Esteves Ferreira, Mathias B. Steiner
  • Patent number: 11642676
    Abstract: A closure and a container assembly are disclosed. The closure includes a first visual identifier and a second visual identifier, wherein the second visual identifier is different from the first visual identifier. The first visual identifier may be a first color, and the second visual identifier may be a second color. At least one of the first and/or second visual identifier may include a fluorescent compound having a characteristic fluorescent spectra. The first visual identifier and the second visual identifier may be provided on the annular skirt of the closure. The fluorescent compound may be provided on at least one of the closure and the container assembly and can be used to facilitate automated visualization of the fluorescent compound under fluorescence excitation light.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: May 9, 2023
    Assignee: Becton, Dickinson and Company
    Inventors: Ashley Palmer, Kurt Stoeckmann, Craig Owen Russ, Robert S. Ross, Girish Parmar, Craig A. Gelfand
  • Patent number: 11643645
    Abstract: One aspect of the present invention provides a nucleic acid extraction device. The nucleic acid extraction device includes a container which stores each of a cleaning solution and an eluting solution, a water level sensor configured to detect amounts of the cleaning solution and the eluting solution which are stored in the container, a tube sensor configured to sense a sample tube disposed on a sample tube accommodation portion, and an operation initiation portion configured to determine whether the cleaning solution and the eluting solution which are necessary for a nucleic acid extraction operation are provided on the basis of the number of such sample tubes which is sensed by the tube sensor and the amounts of the cleaning solution and the eluting solution which are sensed by the water level sensor.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: May 9, 2023
    Assignee: MICO BIOMED CO., LTD.
    Inventors: Sung Woo Kim, Eun Sub Kim, Song Gyun Jung, Jae Young Byun, Duck Joong Kim, Jin Pyung Kim
  • Patent number: 11644414
    Abstract: The present disclosure relates to a ferrocene-based compound having high selectivity for sulfide ion. The ferrocene-based compound is obtained by reacting a ferrocene starting material with one or more organic compound selected from a nitrile, a methyl ester and an ethyl ester, and a chemical sensor in solution state is prepared by mixing the compound with an organic solvent. The chemical sensor according to the present disclosure has high selectivity and sensitivity for sulfide ion even at low concentration and may be used as a chemical sensor for detecting hydrogen sulfide in solution state by allowing visual inspection of sulfide ion.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: May 9, 2023
    Inventors: Dae-Jun Ahn, Mia Kwon, Jisook Min, Joon-Bae Lee, Dong-Kye Lee, Byeong-Yeol Song
  • Patent number: 11644455
    Abstract: Disclosed herein are methods for the detection of the presence of sperm DNA fragmentation in a semen sample. The methods include embedding of sperm cells of the semen sample in a gel, denaturing DNA of the sperm cells, and lysing the nuclear proteins of the sperm cells. The present method includes an ionic surfactant sodium dodycyl sulfate (SDS) and a chaotropic agent urea in the lysis solution for releasing DNA from protamine of chromosome, which significantly reduces the time required for lysis. A kit for detecting sperm DNA fragmentation in a semen sample is also disclosed.
    Type: Grant
    Filed: December 7, 2021
    Date of Patent: May 9, 2023
    Assignee: Bonraybio Co., Ltd.
    Inventors: Cheng-Teng Hsu, Li-Sheng Chang, Hsiu-Chin Lee
  • Patent number: 11642671
    Abstract: A method and system for performing biomolecule extraction are provided that use liquid-to-liquid extraction (LLE) in combination with an electrowetting on dielectric (EWOD) device to provide a biomolecule extraction solution that has high extraction efficiency and that is less costly and easier to use than current state of the art methods and systems. The system and method are well suited for, but not limited to, extraction of DNA, RNA and protein molecules.
    Type: Grant
    Filed: June 27, 2022
    Date of Patent: May 9, 2023
    Assignee: Board of Regents, The University of Texas System
    Inventors: Hyejin Moon, Shubhodeep Paul
  • Patent number: 11644467
    Abstract: The present disclosure provides a method of treating cancer by immune checkpoint blockade, or selecting patients for treatment with immune checkpoint blockers, by detecting tumors with high levels of T-lymphocytes with low levels of activation and proliferation. In various embodiments the tissue sample may be from a conventional biopsy. In various embodiments the cancer may be non-small cell lung cancer.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: May 9, 2023
    Inventors: David L. Rimm, Kurt Schalper
  • Patent number: 11638919
    Abstract: A sample collection system can include a sample collection vessel having a sample collection chamber with an opening configured to receive a sample into the sample collection chamber. The sample collection system can additionally include a selectively movable sleeve valve configured to associate with the opening of the sample collection chamber. The sample collection system can include a sealing cap that is configured to associate with the selectively movable sleeve valve and with the sample collection vessel. The sealing cap can include a reagent chamber having reagent(s) stored therein, and when the sealing cap is associated with the sample collection vessel, the selectively movable sleeve valve opens, dispensing the reagent(s) into the sample collection chamber. When the selectively moveable sleeve associates with the sample collection chamber, an outer sleeve slides relative to an inner vessel, opening the sleeve and dispensing reagent into the sample collection chamber.
    Type: Grant
    Filed: July 20, 2022
    Date of Patent: May 2, 2023
    Assignee: DNA, LLC
    Inventors: Thomas E. Blair, Tyler Fredric Allan, Bryce Twede, Jeremy Johnson
  • Patent number: 11639938
    Abstract: Bead-based analytical assays suitable for detecting changes in the abundance of target analytes in biological samples are disclosed. In an embodiment, an assay involves incubating a sample with one or several beads that are capable of binding several distinct analytes in an amount sufficient for detection by mass spectrometry from a single bead.
    Type: Grant
    Filed: July 18, 2020
    Date of Patent: May 2, 2023
    Assignee: ADEPTRIX CORP.
    Inventor: Vladislav B. Bergo
  • Patent number: 11639544
    Abstract: A physical vapor deposition (PVD) chamber and a method of operation thereof are disclosed. Chambers and methods are described that provide a chamber comprising an upper shield with two holes that are positioned to permit alternate sputtering from two targets.
    Type: Grant
    Filed: February 26, 2020
    Date of Patent: May 2, 2023
    Assignee: Applied Materials, Inc.
    Inventors: Sanjay Bhat, Vibhu Jindal, Wen Xiao