Patents Examined by Jennifer Wecker
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Patent number: 12228482Abstract: A device is described that overlays a first fluid, such as blood or a cellular suspension onto a base material, such as a density gradient. In some embodiments, the fluid layering device includes a cylindrical reservoir, a fluid barrier, a coupling extension, a plunger, and an exhaust vent. The fluid layering device can be coupled through its coupling extension to an open end of a container, such as a conical centrifuge tube, including the density gradient. Once attached, the plunger may be lowered to a position above the surface of the density gradient. A first fluid may flow from the reservoir into the conical tube across the plunger, so that a suitable overlay is formed without substantially disturbing a surface of the density gradient.Type: GrantFiled: August 17, 2021Date of Patent: February 18, 2025Inventor: Jae Go Kwon
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Patent number: 12226772Abstract: A biochip and a method for manufacturing the same are provided. The biochip includes: a guide layer; a channel layer on the guide layer, wherein the channel layer has therein a plurality of first channels extending in a first direction; a plurality of second channels extending in a second direction, wherein each of the plurality of second channels is in communication with the plurality of first channels, the plurality of second channels are in a layer where the channel layer is located, or in a layer where the channel layer and the guide layer are located; an encapsulation cover plate on a side of the channel layer distal to the guide layer; and a driving unit configured to drive biomolecules to move.Type: GrantFiled: January 22, 2021Date of Patent: February 18, 2025Assignee: BOE TECHNOLOGY GROUP CO., LTD.Inventors: Xiaochen Ma, Ce Ning, Guangcai Yuan, Xin Gu, Zhengliang Li
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Patent number: 12228514Abstract: A system for virus detection, and related method, employ a fluorescence detection device to capture an image of processed samples irradiated by fluorescence excitation light. A system includes a fluorescence detection device and a computing device. The fluorescence detection device includes an image capture device that captures an image of fluorescence emitted by samples in response to incidence of the excitation light onto the samples. The computing device processes the image to determine one or more detection results for the presence of one or more viruses in the samples.Type: GrantFiled: April 7, 2021Date of Patent: February 18, 2025Assignee: A9.com, Inc.Inventor: Carlos Roberto Resquin
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Patent number: 12227789Abstract: Provided herein are structures and methods for isolating cellular components from at least one region of interest in a planar tissue section. Structures and methods as described can allow for isolation and tagging of tissue regions.Type: GrantFiled: September 2, 2020Date of Patent: February 18, 2025Assignee: QUANTUMCYTE, INC.Inventors: John Butler, Bidhan Chaudhuri
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Patent number: 12225955Abstract: Disclosed herein is a molecular imprinted protective face mask comprising a supportive structure, a surface material that receives and retains a molecular imprint and that is positioned to contact airborne molecules during use, a molecular imprint of a bioactive molecule wherein an imprinted cavity is at least one of a bioactive molecule with a molecular configuration that captures a specific airborne and/or microdroplet-borne molecule and a protein with a binding site that captures a specific molecule.Type: GrantFiled: June 30, 2020Date of Patent: February 18, 2025Assignee: Utah Valley UniversityInventor: Timothy Edwin Doyle
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Patent number: 12226775Abstract: An embodiment of the present disclosure provides a microfluidic chip, including: a first substrate; wherein the first substrate includes a first base, a first electrode layer on the first base; the first electrode layer includes a plurality of first electrodes at intervals along a first direction, wherein a cross-sectional shape of the first electrode parallel to the first base is a centrosymmetric shape, and the cross-sectional shape includes: a first boundary and a second boundary opposite to each other in the first direction; a shape of the first boundary is a centrosymmetric curve, a distance between two end points of the first boundary in a second direction perpendicular to the first direction is less than a length of the first boundary; the second boundary has a same shape and length as the first boundary, and the first and second boundaries are parallel to each other in the first direction.Type: GrantFiled: September 25, 2020Date of Patent: February 18, 2025Assignee: BOE TECHNOLOGY GROUP CO., LTD.Inventors: Qiuxu Wei, Yingying Zhao, Wenliang Yao, Bolin Fan, Le Gu, Yongjia Gao
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Patent number: 12226777Abstract: A well plate cover includes a base defining a base plane, and a plurality of insertion elements. At least a portion of each of the insertion elements is transparent. Each of the insertion elements is coupled to the base, and extends, in a direction orthogonal to the base plane, from the base to a distal end surface of the insertion element. The distal end surface of each of the insertion elements includes an apex that, when the respective insertion element is inserted into a well of a well plate, extends further into the well than any other portion of the distal end surface. The apex is a point, a line, or a plane having a diameter that is less than one half of a maximum diameter of the distal end surface.Type: GrantFiled: December 16, 2019Date of Patent: February 18, 2025Assignee: AMGEN INC.Inventors: Graham F. Milne, Tony Y. Wang
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Patent number: 12222284Abstract: The present invention provides a method for measuring a content of a polycyclic aromatic hydrocarbon in a carbon black, comprising the following steps: extracting a carbon black to be measured using an organic solvent to obtain a sample to be tested; testing the sample to be tested by ultraviolet-visible spectrometer to obtain an absorbance; and using the absorbance and a calibration curve to obtain a content of a polycyclic aromatic hydrocarbon in the sample to be tested, wherein the calibration curve shows relationship between the absorbance of the polycyclic aromatic hydrocarbon and the content of the polycyclic aromatic hydrocarbon. The measurement method of the present invention benefits reduction of detection time.Type: GrantFiled: April 7, 2022Date of Patent: February 11, 2025Assignee: Linyuan Advanced Materials Technology Co., Ltd.Inventors: Hong-Zhang Chen, Jheng-Guang Li
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Patent number: 12222340Abstract: A preparative liquid chromatograph for separating and extracting components in a sample, the preparative liquid chromatograph including a separation channel (2) through which a mobile phase flows, an injector (6) that injects the sample into the mobile phase, a separation column (8) for separating components in the sample injected into the mobile phase, the separation column (8) being provided downstream of the injector (6) on the separation channel (2), a detector (10) for detecting peaks of the components separated by the separation column (8), a fraction collector (12) configured to collect an eluate from the separation column (8) into a plurality of collection containers (20:22) at a downstream of the detector (10) while fractionating the eluate, and a controller (14) for controlling operation of the fraction collector (12), wherein the fraction collector (12) is provided with peak collection containers (20) and waste liquid collection containers (22), each peak collection container (20) is used for colleType: GrantFiled: February 20, 2022Date of Patent: February 11, 2025Assignee: SHIMADZU CORPORATIONInventors: Shiori Ueda, Tomohiro Shagawa, Soichiro Tamaoki, Tomoyuki Yamazaki, Shohei Sato
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Patent number: 12222357Abstract: Provided is an automatic analyzer in which a linear movement unit and a rotational movement unit that access to a same location can be arranged in a same plane. The automatic analyzer includes a linear movement unit configured to access to an access point by a linear movement, a rotational movement unit configured to access to the access point by a rotational movement, and a control unit configured to control an operation of the linear movement unit and the rotational movement unit so that the linear movement unit and the rotational movement unit do not interfere with each other.Type: GrantFiled: February 25, 2020Date of Patent: February 11, 2025Assignee: Hitachi High-Tech CorporationInventors: Tsukasa Suenari, Takenori Okusa
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Patent number: 12220697Abstract: Microfluidic devices having a circuit substrate with a control unit, a switching mechanism associated with a dielectrophoresis (DEP) electrode, and a memory unit are described. Switching instructions may be received, stored, and retrieved by the control unit and used to control the DEP electrode via the switching mechanism. Systems comprising the described microfluidic devices and methods of controlling the described microfluidic devices are included herein.Type: GrantFiled: May 17, 2021Date of Patent: February 11, 2025Assignee: Bruker Cellular AnalysisInventors: Keith J. Breinlinger, Johannes Paul Sluis
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Patent number: 12223753Abstract: The invention relates to a method for classifying selected marker signals from cytometric measurements comprising a first measurement and a second measurement, wherein the first measurement comprises a cytometric measurement acquired from a first sample of particles, and the second measurement comprises a cytometric measurement acquired from a second sample of N2 particles, being the number of particles in the first sample and N2 being the number of particles in the second sample. Each particle njN 1 of the N1 particles of the first sample is labelled with a number of L1 fluorescent, mass or oligo markers ljN 1. Each particle n1N 2 of the N2 particles of second sample is labelled with a number of L2 fluorescent, mass or oligo markers ljN2? With the acquired data a machine learning method is trained such that the marker combinations showing the most significant differences for two distinct populations are selected and displayed to a user in a novel fashion.Type: GrantFiled: April 2, 2020Date of Patent: February 11, 2025Assignee: DEUTSCHES RHEUMA-FORSCHUNGSZENTRUM BERLINInventors: Ria Baumgrass, Yen Hoang
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Patent number: 12220700Abstract: A fluidic network for carrying out, in parallel, a plurality of analyses of biological samples is disclosed. The network has a flow cell array with a plurality of reaction chambers. The reaction chambers each have a first channel connection and a second channel connection. The first channel connections are connected to a first supply channel and the second channel connections are connected to a second supply channel. The first supply channel and the second channel connection are interconnected by a circulation line. At least one component is connected to the circulation line so that component test reagents can be introduced into the reaction chambers of the flow cell array.Type: GrantFiled: February 12, 2020Date of Patent: February 11, 2025Assignee: Robert Bosch GmbHInventor: Jochen Hoffmann
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Patent number: 12216133Abstract: A sample handling system for handling samples is disclosed. The sample handling system comprises sample holders, each receives a sample container; a sample transport device for moving the sample holders; a control unit for controlling functionality of the sample handling system, and a monitoring system for monitoring the samples during movement. The monitoring system comprises a camera module for continuously capturing images of a part of the sample transport device, wherein the camera module is at a distance from the sample transport device such that the camera module has a free field of view to the sample transport device, and a processor for processing the captured images and determining an item of information about the sample transport device and/or the sample container and/or the sample from the captured images. The control unit retrieves the item of information from the processor. The controlling is based on the retrieved item of information.Type: GrantFiled: March 31, 2021Date of Patent: February 4, 2025Assignee: ROCHE DIAGNOSTICS OPERATIONS, INC.Inventors: Christopher Espy, Yin Cai
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Patent number: 12215858Abstract: A soot-suppression flame-separation combustion device for combustion calorimetry and in-situ free radicals monitoring is mainly composed of a premixed combustion gas guide tube, an inner flame generating seat, an oxidation flame separation guide, and a sample combustion chamber. The inner flame generating seat is arranged in the premixed combustion gas guide tube, the oxidation flame separation guide is arranged on the premixed combustion gas guide outlet end of the premixed combustion gas guide tube, the sample combustion chamber is a cavity arranged inside the oxidation flame separation guide, and the oxidation flame separation guide is evenly arranged with at least 4 oxidation flame separation guide paths in a manner of surrounding the sample combustion chamber. The combustion device utilizes the special structure of the oxidation flame separation guide to suppress the generation of smoke and limit the smoke particles to a specific combustion area.Type: GrantFiled: July 4, 2024Date of Patent: February 4, 2025Assignee: Sichuan UniversityInventors: Yuzhong Wang, Teng Fu, Xuan Song, Ran Wang, Yajie Yang, Yahan Kuang
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Patent number: 12216054Abstract: An embodiment provides a method for measuring total chlorine in a solution, including: preparing a thiocarbamate indicator; introducing the thiocarbamate indicator to a solution, wherein the solution contains an amount of monochloramine; adding an additive to the solution, wherein the additive accelerates the reaction rate between the thiocarbamate indicator and monochloramine and causes a change in fluorescence of the solution; and measuring the amount of monochloramine in the solution by measuring an intensity of the fluorescence. Other aspects are described and claimed.Type: GrantFiled: October 14, 2020Date of Patent: February 4, 2025Assignee: HACH COMPANYInventor: Amit Das
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Patent number: 12216118Abstract: A system, a sensor and a control unit for determining validity of a result of a lateral flow test, whereby a lateral flow stick that has a sample pad, a conjugate pad having antibody treated gold particles, and a porous membrane for receiving a capillary flow of a milk sample. The porous membrane has a test line treated with a progesterone reference which binds antibody treated gold particles of the milk sample and thereby brings the test line to change colour tint when exposed for milk comprising a progesterone level lower than a threshold limit, and a control line treated with an antibody reference which binds antibody, and thereby brings the control line to change colour tint when exposed for milk comprising antibody treated gold particles.Type: GrantFiled: June 9, 2020Date of Patent: February 4, 2025Assignee: DeLaval Holding ABInventors: Claus Dallerup Rasmussen, Jonas Trier Hald
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Patent number: 12209257Abstract: A viral inactivation device including at least one experimental continuous viral inactivation reactor having at least an inlet, an outlet, and a tubular flow path and a computer system that, based on the experimental continuous viral inactivation reactor can design, select, make, and/or manufacture a scaled actual reactor. The tubular flow path includes a set of alternating turns that form a serpentine or an interwoven pattern between the inlet and the outlet.Type: GrantFiled: October 2, 2019Date of Patent: January 28, 2025Assignee: Boehringer Ingelheim International GmbHInventors: Matthew R. Brown, Jonathan Coffman, Raquel Orozco
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Patent number: 12208173Abstract: In the COP treatment and the SOP treatment of the interior of a chamber of an aseptic filler, any cleaning liquid or aseptic water remaining in the chamber is quickly removed before spray of a sterilizer containing peracetic acid or hydrogen peroxide. A transfer device for transferring a container in the chamber of the aseptic filler is driven to remove the cleaning liquid sued for the COP treatment or the aseptic water used for the SOP treatment.Type: GrantFiled: November 13, 2023Date of Patent: January 28, 2025Assignee: Dai Nippon Printing Co., Ltd.Inventor: Atsushi Hayakawa
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Patent number: 12203175Abstract: A process for preventing the formation of white rust on a steel surface at least partially coated with zinc includes a) bringing said surface, preferably under thermal load, into contact with an aqueous composition, the pH of which is between 6.5 and 8.5 comprising at least one organic acid of formula: R—X—OH??(I) wherein X represents C(O) or S(O)2, and R represents an organic chain. A composition and also to a cooling tower treated by the process are provided.Type: GrantFiled: March 29, 2019Date of Patent: January 21, 2025Assignee: SUEZ GROUPEInventors: Stéphanie Mourier, Eric Toledo