Patents Examined by Jeoyuh Lin
  • Patent number: 6858007
    Abstract: A method of characterizing an adnexal mass is disclosed, the method is effected by (a) obtaining a cross-sectional or projectional image of an examined adnex including the adnexal mass; (b) extracting boundaries of the adnexal mass; and (c) using a first algorithm for quantifying at least one morphological feature of the adnexal mass, thereby providing quantification of the at least one morphological feature.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: February 22, 2005
    Assignee: Ramot University Authority For Applied Research and Industrial Development Ltd.
    Inventors: Solange Akselrod, Ron Tepper, Yair Zimmer
  • Patent number: 6816743
    Abstract: Methods and apparatus for analyzing the chemical composition of vulnerable plaques with an intravascular catheter having a near-infrared light source, a fiber-optic probe, a mechanism for directing the light from the light source into a blood vessel, and detectors for detecting light reflected or scattered by the tissue. The light source may be a tunable laser, and may transmit an incident beam having a wavelength ranging from 1400 to 4100 nm. A computer may be included to receive and process the spectral data in the analysis of the vulnerable plaques. A catheter system may be configured to provide near-IR spectrometric imaging of arteries to non-destructively locate and determine lipid pool and fibrous cap size and composition. Additionally, mediators and cellular components may be also determined that are typically associated with vulnerable plaques which have an increased risk of rupture.
    Type: Grant
    Filed: January 24, 2001
    Date of Patent: November 9, 2004
    Assignee: University of Kentucky Research Foundation
    Inventors: Pedro Moreno, Robert A. Lodder, William O'Connor, James E. Muller
  • Patent number: 6748259
    Abstract: A method for detecting and localizing a target tissue within the body in the presence of ambient light in which an optical contrast agent is administered and allowed to become functionally localized within a contrast-labeled target tissue to be diagnosed. A light source is optically coupled to a tissue region potentially containing the contrast-labeled target tissue. A gated light detector is optically coupled to the tissue region and arranged to detect light substantially enriched in target signal as compared to ambient light, where the target signal is light that has passed into the contrast-labeled tissue region and been modified by the contrast agent. A computer receives signals from the detector, and passes these signals to memory for accumulation and storage, and to then to image processing engine for determination of the localization and distribution of the contrast agent.
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: June 8, 2004
    Assignee: Spectros Corporation
    Inventors: David A. Benaron, Yair Talmi, Ilian H. Parachikov
  • Patent number: 6748258
    Abstract: Various methods and devices for treating a patient who has lost, or is at risk of losing cardiac function by cardiac ischemia are disclosed. Treatment includes first imaging a patient's heart, or a portion thereof, to identify underperfused regions of cardiac muscle, and a source of oxygenated blood that is proximate to the underperfused region. Between the underperfused regions and the oxygenated blood source, a target area is selected where thermal or mechanical injury is introduced, and optionally reintroduced, to convert initial capillary blush, resulting from the injury.
    Type: Grant
    Filed: November 3, 2000
    Date of Patent: June 8, 2004
    Assignee: SciMed Life Systems, Inc.
    Inventors: Richard L. Mueller, U. Hiram Chee
  • Patent number: 6735460
    Abstract: A biomagnetic field measuring apparatus has a plurality of fluxmeters disposed externally of a living body and each including a superconducting quantum interference device (SQUID) for detecting a biomagnetic field generated from the living body, the plurality of fluxmeters being operative to detect a temporal change of a component of the biomagnetic field in a first direction which is vertical to the surface of the living body, an operation processor for performing computation for determining a temporal change of a value proportional to a root of square sum of differential value of the first-direction magnetic field component in second and third directions which cross the first direction and computation for integrating the temporal change of the value over a predetermined interval to determine an integral value, and a display for displaying the determined integral value. Distribution of magnetic fields generated from the heart is determined with a small number of fluxmeters.
    Type: Grant
    Filed: July 5, 2002
    Date of Patent: May 11, 2004
    Assignee: Hitachi, Ltd.
    Inventors: Keiji Tsukada, Akihiko Kandori, Kenichi Okajima, Hitoshi Sasabuchi, Hiroyuki Suzuki, Shoji Kondo, Yasuaki Komiyama
  • Patent number: 6719694
    Abstract: Ultrasound applicators able to both image a treatment site and administer ultrasound therapy include an array of transducer elements that can be focused. In several embodiments, an electronically phased array is used for controlling the focal point of an ultrasound beam. The ultrasound beam produced thereby can also be electronically steered. To reduce the quality factor or Q of the array when the array is used for imaging, an electronic switch is selectively closed, placing a resistance in parallel with each of the array elements. A flexible array is employed in several embodiments and is selectively bent or flexed to vary its radius of curvature and thus control the focal point and/or a direction of focus of the array. In another embodiment, each of the transducer elements comprising the array are individually mechanically pivotable to steer the ultrasonic beam produced by the transducer elements.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: April 13, 2004
    Assignee: Therus Corporation
    Inventors: Lee Weng, David M. Perozek, Jimin Zhang
  • Patent number: 6714807
    Abstract: A method for performing MRI, including imposing N sets of steady-state free precession (SSFP) sequences on an object to be imaged, the sequences including respective initial radio-frequency (RF) excitation pulses, each initial RF excitation pulse having a predetermined phase shift relative to the other initial RF excitation pulses. N is a whole number larger than one and less than six. The method further includes setting the phase shift of the RF pulse of the sequences so that the phase shift of the RF pulse of an Mth sequence is substantially equal to 2 ⁢ π ⁡ ( M - 1 ) N radians, wherein M is a whole number larger than 0 and less than or equal to N, receiving a respective set of image signals from the object responsive to the N sets of SSFP sequences, and processing the set of received image signals to generate an image of the object.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: March 30, 2004
    Assignee: GE Medical Systems Global Technology Co., LLC
    Inventor: Yuval Zur
  • Patent number: 6699198
    Abstract: An ocular blood-flow meter includes an optical system for applying measuring light to a blood vessel of a subject eye, and for receiving light scattered by the blood vessel of the subject eye. A mechanism is provided for changing a direction in which the measuring light is applied and a direction in which the scattered light is received so as to enable a plurality of measurements in different directions. A controller performs the plurality of measurements in the different directions by using the optical system and the mechanism so as to obtain information concerning a blood flow. An output device provides a received-light signal obtained by the optical system or the information concerning the blood flow. An input device enables an operator to select a re-measurement operation in a desired direction from the different directions and to instruct the selected re-measurement operation.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: March 2, 2004
    Assignee: Canon Kabushiki Kaisha
    Inventor: Yasuyuki Numajiri
  • Patent number: 6701174
    Abstract: A computer assisted orthopedic surgery planner software for generation of 3D (three dimensional) solid bone models from two or more 2D (two dimensional) X-ray images of a patient's bone. The computer assisted orthopedic surgery planner software reconstructs the bone contours by starting with a 3D template bone and deforming the 3D template bone to substantially match the geometry of the patient's bone. A surgical planner and simulator module of the computer assisted orthopedic surgery planner software generates a simulated surgery plan showing the animation of the bone distraction process, the type and the size of the fixator frame to be mounted on the patient's bone, the frame mounting plan, the osteotomy/coricotomy site location and the day-by-day length adjustment schedule for each fixator strut. All bone models and surgery plans are shown as 3D graphics on a computer screen to provide realistic, pre-surgery guidance to the surgeon.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: March 2, 2004
    Assignee: Carnegie Mellon University
    Inventors: Norman Krause, Robert W. Mendicino, Kenji Shimada, Lee Weiss, Takeo Kanade
  • Patent number: 6701181
    Abstract: First and second optical-redirectors mounted on a catheter couple radiation to a target along separate first and second paths. Either the first or second optical-redirectors, or both, can include a steering mechanism for selecting the first and/or second path.
    Type: Grant
    Filed: May 31, 2001
    Date of Patent: March 2, 2004
    Assignee: InfraReDx, Inc.
    Inventors: Jing Tang, Guillermo J. Tearney, Brett E. Bouma, S. Eric Ryan, Simon Furnish, Andres Zuluaga
  • Patent number: 6694166
    Abstract: A magnetic resonance method is described for forming a fast dynamic image with an automatically generated grid of essentially orthogonally arranged grid lines by a saturation information induced over the object to be imaged. Therefore a first set of parallel saturation planes is obtained by applying a first nonselective RF pulse with a flip angle of 90°, an intermediate magnetic field gradient pulse in direction of the spatial modulation, and a second nonselective RF pulse with a flip angle of 90°. A subsequent spoiler gradient pulse is applied in the direction of the magnetic field gradient for slice selection. Subsequently a second set of parallel saturation planes is obtained in the same manner by inverting one second RF pulse with respect to the first RF pulse. Further the first and the sets of saturation planes are subtracted from each other to obtain a grid free of any contribution of relaxation components of magnetization.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: February 17, 2004
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Ryf Salome, Marcus Alexander Spiegel, Oliver Michael Weber, Peter Boesiger
  • Patent number: 6675033
    Abstract: The invention describes a system, method, and means for an MRI guidewire that can be visible on an MRI, can act as an antenna and receive MRI signals from surrounding subject matter, and can allow the use of multiple interventional tools without removal of the guidewire from a subject.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: January 6, 2004
    Assignees: Johns Hopkins University School of Medicine, Surgi-Vision, Inc.
    Inventors: Albert C. Lardo, Xiaoming Yang, Ergin Atalar, Parag Karmarkar, Elliott R. McVeigh, Henry R. Halperin, Christine Enger McNamara, Paul A. Bottomley
  • Patent number: 6671536
    Abstract: A 3D projection reconstruction pulse sequence is employed to acquire CEMRA data as the subject is continuously moved through the field of view of the MRI system. The acquired k-space data is phase corrected to offset the table motion and the corrected data is used to reconstruct an image over a field of view that far exceeds the size of the MRI system field of view. In one embodiment the image is formed as a set of anatomic subregion images which are concatenated to form a single image and in another embodiment a series of images of each anatomic subregion are produced to depict the dynamic inflow of contrast agent.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: December 30, 2003
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Charles A. Mistretta
  • Patent number: 6665555
    Abstract: A system for delivery of high dosage of radiation to a targeted spinal area is provided. This is accomplished by a system which provides for precise immobilization and positioning of the treated spinal area during dose planning and treatment via stereotactic radiosurgery. Advantages of the system include convenience to the patient, enhanced efficacy, and reduced risk of radiotoxicity to non-target tissues.
    Type: Grant
    Filed: April 5, 2001
    Date of Patent: December 16, 2003
    Assignee: Georgetown University School of Medicine
    Inventors: Fraser C. Henderson, James Rodgers, Azam Niroomand-Rad, Kevin Cleary, Anatoly Dritschilo, Leon Der
  • Patent number: 6662040
    Abstract: The invention relates to a method of generating an image of an animate human or non-human animal body or part thereof. The method comprises administering to said body a physiologically tolerable contrast agent comprising a radiation absorbing component and/or a pressure inducing component, exposing said body to radiation, detecting pressure waves generated in said body by said radiation and generating an optoacoustic image therefrom of at least a part of said body containing the administered contrast agent.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: December 9, 2003
    Assignee: Amersham Health AS
    Inventors: Paul Mark Henrichs, Marten Eriksen, Pal Rongved, Wolfgang Hans Heinrich Gunther, Robert Allen Snow, Kenneth Robert Hollister, Gregory Lynn McIntire, Steven Blair Coffey
  • Patent number: 6647285
    Abstract: An optical probe for tissue identification includes an elongated body. Optical fibers are located within the elongated body for transmitting light to and from the tissue. Light fluctuation protection is associated with the optical fibers. In one embodiment the light fluctuation protection includes a reflective coating on the optical fibers to reduce stray light. In another embodiment the light fluctuation protection includes a filler with very high absorption located within the elongated body between the optical fibers.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: November 11, 2003
    Assignee: The Regents of the University of California
    Inventors: Luiz B. Da Silva, Charles L. Chase
  • Patent number: 6647283
    Abstract: In a method for examining a living subject with an imaging method making use of the concentration of a contrast agent having a physical property that is identifiable with the imaging method in a region of interest (ROI) of the subject presented in time-successive images acquired with the imaging method representing quantitative values of the physical property, a histogram of the quantitative values of the physical property in the ROI is produced for each of the individual images, and the contrast agent concentration in the ROI is determined on the basis of the frequency of occurrence of the quantitative values of the physical property in the ROI.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: November 11, 2003
    Assignee: Siemens Aktiengesellschaft
    Inventor: Ernst Klotz
  • Patent number: 6643537
    Abstract: A fluid injection arrangement, particularly involving a systematic fluid injection programming capability, in the context of patient imaging systems, in which phases of contrast medium infection and flushing medium injection can be freely and selectably ordered so as to make available to the operator and patient a vast array of possible protocols than has hitherto been essentially unattainable. Also contemplated is the use of a “hold” phase, involving an indefinite pause between phases of a protocol, in connection with such imaging systems. Further contemplated is the use of a “pause” phase in which a pause of fixed duration is pre-programmed into the protocols of MRI Injector systems.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: November 4, 2003
    Assignee: Medrad, Inc.
    Inventors: Douglas M. Zatezalo, Jeffrey John Thompson, Steven C. Rygg, Scott R. Griffith, John Gardner, Ronald J. Barbati
  • Patent number: 6643538
    Abstract: An introperative surgical probe incorporating both a fiber optic imaging system and multi-element beta/gamma radiation directional indicating system is described.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: November 4, 2003
    Assignee: Southeastern Universities Research Assn.
    Inventors: Stanislaw Majewski, Vladimir Popov, Georgii Loutts
  • Patent number: 6640129
    Abstract: A method and a device for determining liver function are described. Liver function is determined after injection of an indicator dye into the bloodstream, optical measurement of the resulting concentration of indicator dye in the bloodstream and calculation of a plasma elimination rate from the dye concentration-time curve of the indicator dye. An average circulation transit time mttcirc is calculated from the measurement of the dye concentration c(t). In addition, a parameter k representing a fractional reentry rate of the indicator dye after each pass through the circulation is determined. The plasma elimination rate PER is calculated according to the equation: PER=(1−k)/(k·mttcirc).
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: October 28, 2003
    Inventor: Andreas Hoeft