Patents Examined by Jeremy C Flinders
  • Patent number: 10444144
    Abstract: We disclose a method of tagging nutritional or drug compositions using chemical entities which are known to be safely consumed and which are detectable using known techniques, including near IR spectroscopy. The chemical entities used as tags may be detected in easily obtainable biological samples, including urine and feces. The biological sample may be deposited into a medical toilet which may analyze the biological sample using an analytical device associated with the medical toilet. The tag may be identified and quantified to then identify and quantify the nutritional or drug composition the subject consumed along with the tag. This system may be used to track the source of a food or drug, confirm compliance to a prescribed diet or drug treatment, confirm drug consumption in clinical trials, identify the source of contaminated food, and identify the food substances used to produce food products.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: October 15, 2019
    Assignee: Hall Labs LLC
    Inventors: David R. Hall, Dan Allen, Daniel Hendricks, Andrew Nguyen, Conrad Rosenbrock, Travis Niederhauser, Joe Fox, Terrece Pearman, Steven J. M. Butala
  • Patent number: 10436778
    Abstract: Disclosed herein are compositions comprising beads with unique identifiers for storing information about a multiplex assay as well as methods for using the same in multiplex chemical and biological assays.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 8, 2019
    Assignee: PLEXBIO CO., LTD.
    Inventors: Dean Tsao, Chin-Shiou Huang
  • Patent number: 10407442
    Abstract: The present disclosure relates to novel macrocyclic compounds and libraries thereof containing heteroaryl moieties that are useful as research tools for drug discovery efforts. The present disclosure also relates to methods of preparing these compounds and libraries and methods of using these libraries, such as in high throughput screening. In particular, these libraries are useful for evaluation of bioactivity at existing and newly identified pharmacologically relevant targets, including G protein-coupled receptors, nuclear receptors, enzymes, ion channels, transporters, transcription factors, protein-protein interactions and nucleic acid-protein interactions. As such, these libraries can be applied to the search for new pharmaceutical agents for the treatment and prevention of a range of medical conditions.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: September 10, 2019
    Assignee: CYCLENIUM PHARMA INC.
    Inventors: Amal Wahhab, Helmut Thomas, Luc Richard, Mark L. Peterson, Dwight Macdonald, Daniel Dubé
  • Patent number: 10392726
    Abstract: Methods and compositions for determining and/or monitoring the immune state of an individual are provided.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: August 27, 2019
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Francois Vigneault, Uri Laserson, Ido Bachelet
  • Patent number: 10385476
    Abstract: Methods for selecting tag-oligonucleotide sequences for use in an in vitro nucleic acid assay. The selected tag sequences are useful for nucleic acid assay wherein interference between the nucleic acid sequences is the assay is to be controlled. Selected tag sequences are incorporated into nucleic acid assay to improve the performance of and/or minimize any interference between nucleic acids in the assay compared to untagged assays.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: August 20, 2019
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Norman C. Nelson, Jijumon Chelliserry
  • Patent number: 10386378
    Abstract: A method of diagnosing a prostate condition in a subject comprises determining, in a sample obtained from a subject, levels of a plurality of constituents selected from the group consisting of Ca, K, Mg, Zn, Ag, Al, Au, B, Ba, Bi, Br, Cd, Ce, Co, Cr, Cs, Cu, Dy, Er, Fe, Gd, Hg, Ho, La, Li, Mn, Na, Nd, Ni, P, Pb, Pr, Rb, S, Sb, Sc, Se, Si, Sm, Sr, Tb, Th, Tl, U, Y, and Zr. A combination of the levels of the plurality of constituents in the sample is compared with a combination of control levels of the same plurality of constituents. A difference between the combinations is indicative of the prostate condition.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: August 20, 2019
    Assignee: CAMBRIDGE ONCOMETRIX LIMITED
    Inventors: Sofia Zaichik, Maxim Rossmann, Dmitry Solovyev, Mikhail Lomonosov, Vladimir Zaychik
  • Patent number: 10379126
    Abstract: Provided herein are compositions and methods for proteomic analysis. In particular, provided herein are compositions and methods for performing mass spectrometry-based protein quantitation analysis.
    Type: Grant
    Filed: October 26, 2016
    Date of Patent: August 13, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventor: Haojie Zhu
  • Patent number: 10370776
    Abstract: A general method and recombinant nucleic acid sequences, by means which the method selects a recombinant protein containing an FHA domain for binding a target molecule from a library proteins with a high-throughput method of creating protein variations within the FHA domain in non-conserved or non-structural sequences of the FHA scaffold, and the library may also be in the form of a phagemid or phage library wherein the ALP nucleic acid sequence is inserted into a vector capable of allowing the vector and expressed ALP protein from being virally packaged, and the recombinant nucleic acid sequences which are randomly mutated at varying non-conserved or non-structural FHA domain sequences.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: August 6, 2019
    Assignee: IDEA ORCHARD, LLC
    Inventors: Michael Longo, Rajika Perera
  • Patent number: 10365265
    Abstract: The present teachings describe a method for testing a biological sample, including (a) obtaining a biological sample from a mammal, (b) acquiring at least two extracellular endogenous metabolic products from the biological sample, (c) detecting the at least two extracellular endogenous metabolic products from the extract, (d) determining a pattern on the basis of the presence or the mass ratio of the at least two extracellular endogenous metabolic products, (e) comparing the pattern with the pattern from a retention sample.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: July 30, 2019
    Inventor: Eberhard Wieland
  • Patent number: 10351848
    Abstract: Provided are a method for constructing a nucleic acid single-stranded cyclic library and the reagents used therein. By the combination of interruption via a transposase with a restricted nick translation reaction, the method realizes a simple and rapid nucleic acid single-stranded cyclic library construction.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: July 16, 2019
    Assignee: MGI TECH CO., LTD.
    Inventors: Chunyu Geng, Ruoying Chen, Yuan Jiang, Xia Zhao, Rongrong Guo, Lingyu He, Yaqiao Li, Wenwei Zhang, Hui Jiang, Radoje Drmanac
  • Patent number: 10337057
    Abstract: A system for performing quality control for nucleic acid sample sequencing is disclosed. The system comprises a set of solid supports, each solid support having attached thereto a plurality of nucleic acid sequences, wherein the set comprises plural groups of solid supports and each group contains solid supports having the same nucleic acid sequences attached thereto. The nucleic acid sequences of each group differ from each other. The nucleic acid sequences are synthetically derived, and the nucleic acids sequences are designed such that the nucleic acid sequences produce a predefined pattern of detectable signals during a sequencing run. A method of preparing a quality control for performing nucleic acid sample sequencing, a method of validating a nucleic acid sequencing instrument during a nucleic acid sequencing experiment, and a method of processing nucleic acid sequencing data during a nucleic acid sequencing experiment are also disclosed.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: July 2, 2019
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Min-Yi Shen, Douglas Greiner
  • Patent number: 10337058
    Abstract: A system for performing quality control for nucleic acid sample sequencing is disclosed. The system comprises a set of solid supports, each solid support having attached thereto a plurality of nucleic acid sequences, wherein the set comprises plural groups of solid supports and each group contains solid supports having the same nucleic acid sequences attached thereto. The nucleic acid sequences of each group differ from each other. The nucleic acid sequences are synthetically derived, and the nucleic acids sequences are designed such that the nucleic acid sequences produce a predefined pattern of detectable signals during a sequencing run. A method of preparing a quality control for performing nucleic acid sample sequencing, a method of validating a nucleic acid sequencing instrument during a nucleic acid sequencing experiment, and a method of processing nucleic acid sequencing data during a nucleic acid sequencing experiment are also disclosed.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: July 2, 2019
    Assignee: LIFE TECH NOLOGIES CORPORATION
    Inventors: Min-Yi Shen, Douglas Greiner
  • Patent number: 10316356
    Abstract: Provided is a method of constructing a sequencing library using an adaptor element in a bubble shape. The bubble-shaped adaptor is ligated to a DNA fragment respectively at the 3?-terminal and the 5?-terminal i.e., two bubble-shaped adaptors with same sequences are ligated in one step. The bubble-shaped adaptor-ligated product is then amplified with a primer complementary to the 3?-terminal of the long-chain nucleic acid of the bubble-shaped adaptor, so as to replace the non-paired sequence in the short-chain nucleic acid.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: June 11, 2019
    Assignee: MGI TECH CO., LTD.
    Inventors: Yuan Jiang, Kai Tian, Xia Zhao, Wenwei Zhang, Huaiqian Xu, Hui Jiang, Radoje Drmanac, Chunyu Geng
  • Patent number: 10301605
    Abstract: Methods, kits, and compositions of matter relating to poly(UG) polymerases are disclosed. In one embodiment, a method includes: contacting an RNA substrate with a poly(UG) polymerase; and allowing the poly(UG) polymerase to add a poly(UG) sequence to the end of the RNA substrate by retaining contact between the RNA substrate and the poly(UG) polymerase for a period of time from about 1 second to about 28 days. The poly(UG) polymerase can be Caenorhabditis elegans RDE-3.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: May 28, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Marvin P. Wickens, Melanie A. Preston
  • Patent number: 10300452
    Abstract: The present invention provides methods, compositions, and systems for distributing single polymerase molecules into array regions. In particular, the methods, compositions, and systems of the present invention result in a distribution of single polymerase molecules into array regions at a percentage that is larger than the percentage expected to be occupied under a Poisson distribution.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: May 28, 2019
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Lei Sun, Natasha Popovich, Gene Shen, Thang Pham, Stephen Turner
  • Patent number: 10302663
    Abstract: Biomarkers relating to pancreatic Beta-cell function, pancreatic Beta-cell glucose sensitivity, insulin resistance, and/or pancreatic Beta-cell-related disorders are provided. Methods based on the same biomarkers are also provided.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: May 28, 2019
    Assignee: METABOLON, INC.
    Inventors: Walter Gall, Kay A. Lawton
  • Patent number: 10302650
    Abstract: The present disclosure provides a high-throughput fluorescence polarization microorganism screening assay for a metabolite produced by a microorganism. The metabolite is detected using competition with a fluorescent reporter for a receptor that binds both the metabolite and the reporter. The present disclosure further provides materials used in such an assay, a kit for such an assay, an isolated microorganism identified using such an assay, and culture conditions identified using such an assay.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: May 28, 2019
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Yao Zong Ng, Pedro Alexis Baldera Aguayo, Virginia W. Cornish, Ehud Herbst
  • Patent number: 10302614
    Abstract: Food distributed to consumers through a distribution chain may be traced by tagging the food with DNA tags that identify the origin of the food, such as the grower, packer and other points of distribution, and their attributes. This makes it much quicker and easier to trace the food in case of food contamination or adulteration. Preferably these attributes indicate the field, location, crew and machine used to grow and process the food, and the dates of the various steps of food harvesting, processing and distribution. Natural or synthetic DNA pieces may be used to tag items, including food items. Multidigit binary or other types of bar codes may be represented by multiple types of DNA. Each digit of the bar code may be represented by one, two or more unique DNA pieces.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: May 28, 2019
    Assignees: SafeTraces, Inc., Lawrence Livermore National Security, LLC
    Inventors: Antonios Zografos, George Roy Farquar
  • Patent number: 10286376
    Abstract: Disclosed herein are formulations, substrates, and arrays. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays, including porous arrays. Also disclosed herein are formulations and methods for one-step coupling, e.g., for synthesis of peptides in an N->C orientation. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: May 14, 2019
    Assignee: Vibrant Holdings, LLC
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Kang Bei, Hari Krishnan Krishnamurthy, Punitha Vedantham
  • Patent number: 10281459
    Abstract: The present invention is directed to fluorescent protein biosensors based on oligonucleotide cross reactive sensor arrays including a selective and a non-selective protein surface binding domain for protein detection. Interaction of different protein isoforms with the sensors of this invention yields a unique optical signature for each protein. The unique optical signature allows differentiating between closely related protein isoforms and diagnosing diseases and disorders associated with the proteins also in biofluids.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: May 7, 2019
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: David Margulies, Leila Motiei, Zohar Pode