Abstract: A hemodialysis catheter including a catheter tube and a bolus tip, the bolus having a radially extending main side port. The catheter also has second and third side ports axially spaced from said main side port. The second and third side ports are each axially elongated, with an edge which is semi-circular in cross-section. The second side port is displaced 180° from the main side port. The third side port is axially aligned with the main port. The catheter is thickened in an arch opposite each of the second and third side ports.

Abstract: The apparatus includes a flexible, elongated tubular member and is comprised of a tube of superlastic metal which in response to changing temperatures resists to a greater or less degree the bending moment imposed by a biasing element, thereby altering the shape of the tubular member as a function of temperature and producing a broad range of shapes.

Abstract: Adapters for use with an angiographic injector. A face plate adapter includes a channel for receiving a rearward end of a syringe. First and second mounting flanges on the adapter overlay a portion of the channel, to cooperate with mounting flanges on a rearward end of the syringe, so that the syringe mounting flanges may be inserted between the adapter mounting flanges, and then rotated in the channel behind the adapter mounting flanges, to thereby lock the syringe to the adapter. The adapter further includes one or more locking pins, which in a locked position extend across the channel, to block the syringe from rotating in the channel and thereby prevent a syringe from being dismounted from the adapter. A collar incorporated in the adapter interacts with a drive ram of the injector to move the locking pins into their locked position whenever the ram is forward of a rearwardmost position.

Abstract: The present invention provides a catheter device/method for enhancing local administration of pharmaceutical compounds. Such device/method is used for various situations which require high concentrations of drugs that are delivered locally.

Abstract: A catheter (200) includes a spear shaped tip (130). In one embodiment, the spear shaped tip (130) is part of a spear shaped tip assembly (100) that includes a swivel assembly. The swivel assembly provides for improved trackability of the catheter (200) over a guide wire. The spear shaped tip catheter of the present invention can be designed in numerous configurations including over-the-wire and rapid exchange versions.

Abstract: Catheter systems and methods for their use in enhancing fluid flow through a vascular site occupied by a vascular occlusion are provided. The subject catheter systems include at least an aspiration catheter and at least one of a total occlusion insert catheter and a partial occlusion insert catheter, where the insert catheters are capable of being slidably moved in the lumen of the aspiration catheter. In practicing the subject methods, a surface of the vascular occlusion is flushed with an acidic dissolution fluid using the subject catheter systems for a period of time sufficient for fluid flow through the vascular site to be enhanced, e.g. increased or established. The subject catheter systems and methods find use in the treatment of a variety of different vascular diseases characterized by the presence of calcified vascular occlusions, including peripheral and coronary vascular diseases.

Abstract: An improved medication infusion set is provided of the type having a soft cannula for subcutaneous delivery of a selected medication to a patient. The infusion set comprises a cannula housing having a soft cannula protruding therefrom and a self-sealing septum mounted at an upstream end of the cannula. The cannula housing is initially assembled with an insertion hub having an elongated insertion needle extending through the septum and cannula for transcutaneously placing the cannula followed by separation of the insertion hub from the cannula housing. An infusion hub is then assembled with the cannula housing and includes a short infusion needle for coupling the cannula with the selected medication supplied from a source via a length of infusion tubing.

Abstract: A catheter and a method of using the catheter are disclosed that serve to create an efficient and rapid controlled manner of regulating a patient's body temperature. The catheter is a heat exchange catheter insertable into a blood vessel of a patient, circulating a heat exchange fluid therein, and including a spiral-shaped inflatable balloon that mixes laminar layers of the heat exchange fluid flowing inside the balloon.

Abstract: A combined arterial and venous blood tubing set is provided for transport of blood between a patient and a blood processing unit. The set comprises an arterial set component comprising arterial tubing having an arterial patient connector at one end and an arterial unit connector at the other. A venous set component has venous tubing with a venous patient connector at one end and a venous unit connector at the other end. The arterial and venous patient connectors, and the arterial and venous unit connectors, are respectively, substantially, and releasably directly connected to each other. As a result of this, the arterial, and venous set components cooperate to form a loop. Other features of improved sets are also disclosed.

Abstract: A hemodialysis catheter comprising a lumen tube with a bolus at its distal end. A main venous port is formed in one side of the bolus adjacent the bullet nose of the bolus. Second and third venous ports are formed in either the bolus or the tube. The second port is circumferentially displaced 180° around the catheter from the main venous port. An arterial port is formed in either the bolus or the tube, in axial alignment with the main venous port and circumferentially displaced 180° around the catheter from the second venous port.

Abstract: A method and apparatus for treating Alzheimer's disease is disclosed. The method comprises delivering indomethacin or nonsteroidal anti-inflammatory agents having cyclooxygenase inhibitor action directly to the hippocampus or the lateral ventricle through an implanted catheter. The catheter has a flexible distal end that is implanted directly in the hippocampus or lateral ventricle as the preferred embodiment. The distal end has either a porous tip or a closed end. Where the distal end is closed, or a plurality of elution holes are present indomethacin is delivered to the hippocampus or lateral ventricle through either the porous tip or the elution holes.

Abstract: The present invention relates generally to improved cathodes (24) for use in an electrotransport device (10) for transdermally or transmucosally delivering a beneficial agent (e.g., a drug) to, or extracting a body analyte (e.g., glucose) from, the body surface of a patient. Most particularly, the present invention relates to a cathodic electrode (24) in the form of a silver halide foil which can be made, e.g., by forging particulate silver chloride. The cathode (24) does not absorb agent (e.g., drug), eliminates the need for binders, solvents and processing aids during the manufacturing process, and increases dimensional freedom of design.

Abstract: A device for maintaining antisepsis of embedded devices with a body is provided. The device comprises a housing having a first active surface and a second active surface with the housing being sized and shaped for being received within the body. The first active surface and the second active surface are contactable with the tissue and bodily fluids. A metal antimicrobial substance is attached to at least a portion of the first active surface and the second active surface. A control system is electrically connected to the first active surface and the second active surface of the housing for creating an electric field between the first active surface and the second active surface through the body with the electric field ionizing the antimicrobial substance thereby profusing the substance into the tissue.

Abstract: A surgical device for endoscopic surgical procedures capable of preventing injuries to internal organs during insertion. The surgical device can include one or more of the following: a multiple system of sharp blade edges, a mechanical tissue protection device that includes a series of thin plastic guards sliding along the sides of the planar knives and having an angle between their edges smaller than that of the cutting knife edges, one or more fixed conical deflectors to expand the cut tissue passage leaving the guards to contact tissue contact only at their tips, an insufflation passage configured to transport fluid into the body cavity during penetration, a locking system for the guards that prevents accidental reuse of the cutting features, and/or an ergonomic design which facilitates handling.

Abstract: An apparatus for treating a patient. The apparatus includes a catheter having a distal end and a proximal end. The distal end has an orifice through which a fluid can flow. The distal end has a port through which the fluid can flow. The port is adjacent to but apart from the orifice. The apparatus includes a mechanism for controlling the size of the port that is open. The controlling mechanism is disposed over the port and able to close the port. An apparatus for treating a patient. The apparatus includes a catheter having a proximal end and a distal end having an orifice through which a fluid can flow. The distal end has an end marker disposed about the orifice which appears in an image of an imaging device. An apparatus for treating a patient. The apparatus includes a catheter having a proximal end and a distal end having an orifice through which fluid can flow. The catheter has an axis.

Abstract: A thrombolysis catheter system having a fixed length infusion zone is disclosed. The invention contemplates apparatus, method and kit aspects. The apparatus, which has the capability to track a guidewire, uses a multilumen catheter to deliver radially thrombolytic agent to an infusion zone defined by one or more balloon means. In one aspect, with an occluder means, a primary lumen of the catheter is used both for catheter placement and delivery of fluid. The method discloses utilization of radiopaque indicia to place the catheter in proximity to the occlusion or diseased tissue to be treated. The kit includes a catheter of the invention in conjunction with a steerable guidewire and a tip occluder wire, either or both of the tip occluder wire and the guidewire having an enlargement on their distal tip which cooperates with a reduced diameter portion of the catheter lumen.

Abstract: The present invention comprises homeopathic dilutions of growth factors and methods for their use. Disorders which may be effectively treated with the compositions of the present invention include chronic viral disorders, such as HIV, AIDS, chronic fatigue syndrome and Epstein-Barr viral infections, cancer, diabetes and depression. Homeopathic dilutions of growth factors are preferably administered orally. In an alternative embodiment, patients are treated with radio frequency signals corresponding to homeopathic dilutions of growth factors.

Abstract: A disposable device is provided which accurately and reliably delivers an infusable liquid to a patient. The infusion device includes a housing which defines a bladder chamber. A compressible bladder is disposed in the bladder chamber and is compressed by the housing upon filling the bladder with an infusable liquid to create a pressurized bladder. The infusion devices further includes a delivery system for subcutaneously delivering the infusable liquid to a body. The delivery system includes a collapsible member that supports an injection needle and a cannula. The injection needle is used to insert the cannula into the skin of the body being treated. The cannula is in communication with the bladder during delivery of the infusable liquid. The housing includes microfluidic passageways that allow communication between fluid in the bladder and the cannula.

Abstract: Implantable ports and other devices are cleansed by the injection of a washing solution into a region in the device or in a tissue pocket surrounding the device. In a first embodiment, the washing solution is injected through an aperture in the device to flush internal regions of the device before infusing the tissue pocket and flushing outwardly through a tissue tract leading to the device. In other embodiments, the washing solution is injected directly to a target site on the exterior of the device. Implantable devices may include special, usually hardened, target regions for receiving the sharpened end of a needle used to inject the washing solution. Kits will include devices, syringes, access devices, and instructions for cleansing according to the methods of the present invention.

Abstract: A brain lead anchoring system is described which allows for installation of a brain stimulation lead or a drug delivery catheter without the lead or catheter ever being unsupported during installation so that the lead or catheter does not move during the anchoring procedure. An anchor assembly contains an anchoring mechanism that is biased in the closed or anchoring position and is only open to allow installation of a lead when it is mated to an introducer instrument, which has prongs that open the anchoring mechanism. Once the lead is appropriately positioned within the brain and while the lead is still supported by the installation guiding device, the introducer instrument is withdrawn from the anchoring mechanism, which thus allows the anchoring mechanism to return to its closed position. A locking cap covers the aperture through the anchor assembly into the skull and mechanically ensures that the anchoring mechanism remains in the closed position.