Patents Examined by Jerome D. Goldberg
  • Method of treating a patient having precancerous lesions with phenyl purinone derivatives
    Patent number: 6200980
    Abstract: Derivatives of Phenyl Purinone are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.
    Type: Grant
    Filed: April 17, 1997
    Date of Patent: March 13, 2001
    Assignee: Cell Pathways, Inc.
    Inventors: Gary A. Piazza, Rifat Pamukcu
  • Composition and method of treating cancer with tannic acid and tannin complexes
    Patent number: 6200568
    Abstract: A pharmaceutical composition including tannic acid and tannin complexes, and a method of treating cancer with tannic acid and tannin complexes.
    Type: Grant
    Filed: August 8, 1997
    Date of Patent: March 13, 2001
    Assignee: Atajje, Inc.
    Inventor: Juan Falcon
  • Anticancer composition comprising a diaminotrifluoromethylpyridine derivative
    Patent number: 6197796
    Abstract: An anticancer composition comprising a diaminotrifluoromethylpyridine derivative of the formula (I) or its pharmaceutically acceptable salt, as an active ingredient: wherein X is a cycloalkylcarbonyl group, a furancarbonyl group or a benzoyl group which may be substituted by a halogen atom, and Y is an alkylsulfonyl group.
    Type: Grant
    Filed: August 17, 1999
    Date of Patent: March 6, 2001
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventor: Yoshifumi Ogura
  • Benzamide therapeutics for the treatment of inflammatory bowel disease
    Patent number: 6194465
    Abstract: Benzamides are disclosed to be useful for treating and preventing inflammatory bowel disease.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: February 27, 2001
    Assignee: Centaur Pharmaceuticals, Inc.
    Inventors: William D. Flitter, William A. Garland, Ian Irwin
  • Combination therapy including 9-nitro-20(S)-camptothecin
    Patent number: 6191119
    Abstract: A method for treating a patient having a disease associated with undesirable or uncontrolled cell proliferation such as cancer and restenosis is provided. The method comprises: delivering to the patient a therapeutically effective amount of 9-nitro-20(S)-camptothecin in combination with an effective amount of an antibiotic agent such as doxorubicin.
    Type: Grant
    Filed: October 15, 1999
    Date of Patent: February 20, 2001
    Assignee: SuperGen, Inc.
    Inventor: Joseph Rubinfeld
  • Therapeutic use of d-methionine to reduce the toxicity of platinum-containing anti-tumor compounds
    Patent number: 6187817
    Abstract: Methods of preventing or reducing hearing or balance loss, damage to ear cells, weight loss, gastrointestinal toxicity, neurotoxicity, alopecia, and prolonging survival in patients undergoing treatment with therapeutically effective amounts of platinum-containing chemotherapeutic agents such as cisplatin are provided. These methods comprise administering an effective amount of a methionine protective agent, such as D-methionine, prior to, simultaneously with, or subsequently to administration of the platinum-containing chemotherapeutic agent. Combinations of these time periods can also be employed.
    Type: Grant
    Filed: October 2, 1997
    Date of Patent: February 13, 2001
    Assignee: Southern Illinois University School of Medicine
    Inventor: Kathleen C. M. Campbell
  • Compositions and methods of treating cancer with tannin complexes
    Patent number: 6187315
    Abstract: A pharmaceutical composition including tannic acid and tannin complexes, a method of treating cancer with tannic acid and tannin complexes, and a method of making a medicament for treating cancer is disclosed.
    Type: Grant
    Filed: August 7, 1998
    Date of Patent: February 13, 2001
    Assignee: Atajje, Inc.
    Inventor: Juan Falcon
  • Use of K-252a derivative
    Patent number: 6184217
    Abstract: Disclosed herein are therapeutic methologies utilizing a ring substituted derivative of the indolocarbazole K-252a, the derivative represented by the formula:
    Type: Grant
    Filed: June 24, 1997
    Date of Patent: February 6, 2001
    Assignee: Cephalon, Inc.
    Inventors: Thomas M Engber, Forrest A. Haun, Michael S. Saporito, Lisa D. Aimone, Matthew S. Miller, Ernest Knight, Jr.
  • Drug resistance and multidrug resistance modulators
    Patent number: 6180633
    Abstract: Drug and multidrug resistant modulators of the formula: where R1 and R2 are independently hydrogen or halo; A is —CH2—CH2—, —CH2—CHR4—CH2—, or —CH2—CHR5—CHR6—CH2—, where R4 is —H, —OH, or acyloxy; one of R5 or R6 is —H, —OH, or acyloxy, and the other is —H; R3 is a polyaryl; and pharmaceutically acceptable salts and solvates thereof, are described and claimed. Use of the new compounds in the preparation of pharmaceutical compositions is described and claimed. In addition, methods for treating drug and multidrug resistance in various diseases using a compound, or pharmaceutically acceptable salt or solvate thereof, of this invention are described and claimed.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: January 30, 2001
    Assignee: Eli Lilly and Company
    Inventors: Julian Stanley Kroin, Bryan Hurst Norman
  • Method of treatment for cancer or viral infections
    Patent number: 6177460
    Abstract: Methods for the treatment of cancers or viral infections in mammals are disclosed that include administration of an N-chlorophenylcarbamate, or an N-chlorophenylthiocarbamate, or a salt thereof. Such compounds may be used in combination with a chemotherapeutic agent and/or a potentiator.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: January 23, 2001
    Assignee: The Procter & Gamble Company
    Inventor: James Berger Camden
  • Naphthoquinone antitumor compound and method
    Patent number: 6174918
    Abstract: The invention provides 1,4-naphthoquinone compounds and a method for inhibiting tumor cell growth in a subject by administering such compounds. The compounds are represented by the structures: where R1 is lower alkyl, halogenated lower alkyl, phenyl, benzyl, phenethyl, or —(CH2)mCOOX, where m is 2 or 3 and X is H, methyl, or ethyl; R2 is halo or NHY, where Y is hydrogen, loweralkyl, halogenated lower alkyl, hydroxylated lower alkyl, lower dialkylaminoalkyl, phenyl, benzyl, or phenethyl; R3 is lower alkyl, halogenated lower alkyl, phenyl, benzyl, phenethyl, or —(CH2)mCOOX, where m and X are as defined for R1 above; and R4 is hydrogen, lower alkyl, lower aminoalkyl, halogenated lower alkyl, phenyl, benzyl, or phenethyl.
    Type: Grant
    Filed: July 30, 1998
    Date of Patent: January 16, 2001
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Kuo-Hsiung Lee, Sheng-Chu Kuo, Toshiro Ibuka
  • Method of enhancing the efficacy of anti-tumor agents
    Patent number: 6171620
    Abstract: A method for enhancing the effect of anti-tumor agents on solid tumors is provided. The method comprises administering to an individual an anti-tumor agent and a hematocrit elevator. The hematocrit elevator may be administered before or concurrently with the anti-tumor agent.
    Type: Grant
    Filed: April 27, 1999
    Date of Patent: January 9, 2001
    Assignee: Health Research, Inc.
    Inventors: M. Steven Piver, David F. Silver
  • Method for treating cancer with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
    Patent number: 6166029
    Abstract: A method of treating specific forms of cancer with water-insoluble 20(S)-camptothecin compounds with the closed-lactone ring intact and/or derivatives thereof is disclosed. The method includes administering the compounds intramuscularly, orally and transdermally.
    Type: Grant
    Filed: May 21, 1998
    Date of Patent: December 26, 2000
    Assignee: The Stehlin Foundation for Cancer Research
    Inventors: Beppino C. Giovanella, Hellmuth R. Hinz, Anthony J. Kozielski, John S. Stehlin
  • Use of spiramycin for treating gastrointestinal disorders caused by H. pylori
    Patent number: 6162792
    Abstract: Gastrointestinal disorders involving Helicobacter pylorid are treated by administering spiramycin or spiramycin/metronidazole combinations. In addition, administration of anti-ulcer agents may be carried out before, during or after such administration of spiramycin or spiramycin/metronidazole combinations. Pharmaceutical compositions for such administrations are also disclosed.
    Type: Grant
    Filed: October 22, 1996
    Date of Patent: December 19, 2000
    Assignee: Aventis Pharma S.A.
    Inventors: Erik T. Forfang, Sven-Erik Larssen
  • Herbal supplement for increased muscle strength and endurance for athletes
    Patent number: 6159476
    Abstract: Athletic performance may be improved by administering a composition comprising galanthamine as an active ingredient to an athlete before and during sports activities. Also provided is an herbal sports performance composition comprising whole plant extract of Leucojum aestivum.
    Type: Grant
    Filed: January 10, 2000
    Date of Patent: December 12, 2000
    Assignee: Herbaceuticals
    Inventors: Atanas Russinov Djananov, Tricia Grose
  • Prophylactic composition and method for alzheimer's Disease
    Patent number: 6160018
    Abstract: A method of preventing or delaying the onset of symptoms of Alzheimer's Disease includes the step of administering to a patient in need of such treatment a composition having an effective Alzheimer's Disease prophylactic amount of an enantiomerically stable R-NSAID or a pharmaceutically acceptable salt thereof, the composition being substantially free of the S-enantiomer of the selected R-NSAID.
    Type: Grant
    Filed: March 10, 1997
    Date of Patent: December 12, 2000
    Assignee: Loma Linda University Medical Center
    Inventors: William J. Wechter, John D. McCracken
  • Method for treating abnormal cell proliferation in the brain
    Patent number: 6156789
    Abstract: This invention relates to a method for treating abnormal cell proliferation in the brain by administering a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof: ##STR1## in which R represents a hydrogen atom or an acetyl, alkoxyacetyl or alkyl radical, R.sub.1 represents a benzoyl radical or a radical R.sub.2 --O--CO-- wherein R.sub.2 represents an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclylic radical, and Ar represents an aryl radical.
    Type: Grant
    Filed: March 17, 1998
    Date of Patent: December 5, 2000
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Marie-Christine Bissery, Alain Renard
  • Use of pyrimidine derivatives for the prevention of cancer, on their own or in combination with other therapeutic measures
    Patent number: 6156755
    Abstract: Use of pyrimidine derivatives for the prevention of cancer, on their own or in combination with other therapeutic measures.The present invention is concerned with the use of pyrimidine derivatives as agents for the prevention of carcinomatous disorders.The pyrimidine derivatives used are active compounds of the formula I ##STR1## in which R.sup.1 to R.sup.7 have the meaning indicated, and their physiologically tolerable salts.
    Type: Grant
    Filed: March 11, 1998
    Date of Patent: December 5, 2000
    Assignee: Aventis Pharma Deutschland GmbH
    Inventor: Karl Geisen
  • Method of treating angiogenesis in tumor tissue
    Patent number: 6153603
    Abstract: The present invention relates to a method of treating angiogenesis in tumor tissue, such as glioma and glioblastama tissue. The method comprises administering to a mammal, including, man an effective amount at an isomer of inositol trisphosphate, such as D-myo-inositol-1,2,6-trisphosphate, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 22, 1998
    Date of Patent: November 28, 2000
    Assignee: Perstorp AB
    Inventor: Matti Siren
  • 1,2,4-benzotriazine oxides formulations
    Patent number: 6153610
    Abstract: Disclosed are: aqueous parenteral formulations for the treatment of cancer tumors comprising 1,2,4-benzotriazine 1,4-dioxides in a citrate buffer; and method of cancer tumor treatment.
    Type: Grant
    Filed: September 21, 1998
    Date of Patent: November 28, 2000
    Assignee: Sanofi-Synthelabo Inc.
    Inventors: Stephen Brown, Edward Baker