Patents Examined by Jerome Goldberg
  • Ascorbyl esters for the treatment of cancer
    Patent number: 6638974
    Abstract: There is provided a method of treating cancer by treating the cancer cells with a lipophilic derivative of ascorbic acid. Also provided is a method of inhibiting the Ras pathway by administering a lipophilic derivative of ascorbic acid. A method of inducing apoptosis in cancer cells is also provided by treating cancer cells with a lipophilic derivative of ascorbic acid. A pharmaceutical composition for the treatment of cancer comprising a lipophilic derivative of ascorbic acid in a pharmaceutically acceptable carrier is also provided.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: October 28, 2003
    Assignee: University of South Florida
    Inventor: Kamatham A. Naidu
  • Methods and compositions for inhibition of angiogenesis with EM-138
    Patent number: 6518298
    Abstract: The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, the invention comprises the compound EM-138 and its use in the inhibition of angiogenesis and treatment of angiogenesis associate diseases, including the inhibition of tumor growth and metastasis.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: February 11, 2003
    Assignee: Entremed, Inc.
    Inventors: Shawn J. Green, Glenn M. Swartz, Jr., Jamshed H. Shah, John Madsen, Robert J. D'Amato
  • Anticancer property of dithiolopyrrolones
    Patent number: 6020360
    Abstract: The invention is drawn to a novel use of a group of known compounds with the formula shown below, ##STR1## wherein R.sub.1, R.sub.2 =hydrogen, substituted or unsubstituted alkyl, cycloalkyl, acyl, aryl, aralkyl, or heterocyclic group; R.sub.3 =hydrogen, alkyl, cycloalkyl, aralkyl, aryl or heterocyclic group, the salts thereof, the compositions thereof and their use as medicaments, particularly in the treatment of human and animal cancers.
    Type: Grant
    Filed: September 18, 1996
    Date of Patent: February 1, 2000
    Inventors: John M. Webster, Jianxiong Li, Genhui Chen
  • Method for the treatment of coccidioidomycosis in warm-blooded animals
    Patent number: 5837734
    Abstract: This invention relates to the use of acyl urea compounds for the treatment or prophylaxis of Coccidioides immitis infections in warm-blooded animals. The invention has particular application in the treatment, prophylaxis or reduction of coccidioidomycosis.
    Type: Grant
    Filed: May 1, 1996
    Date of Patent: November 17, 1998
    Assignee: Novartis Corporation
    Inventors: Robert C. Bartsch, Russell T. Greene
  • Carcinostatic for hormonotherapy containing dienogest as effective component
    Patent number: 5652231
    Abstract: A carcinostatic for a hormonotherapy containing dienogest or its solvate, which is expected to exert therapeutic effects for a broad range of cancer cases at a far lower dose than that of conventional hormonotherapeutic agents and utterly free from side effects that the conventional high-dose hormonotherapy had suffered.
    Type: Grant
    Filed: November 16, 1994
    Date of Patent: July 29, 1997
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Yasunori Shibutani, Masaomi Obata, Masami Sato, Yukio Katsuki
  • Method for treating toxoplasmosis
    Patent number: 5486535
    Abstract: This invention provides a method of treating toxoplasmosis in a mammal by administering to the mammal a therapeutically effective dose of an alkyl derivative of qinghaosu. In another embodiment, this invention provides a method for inhibiting the growth of parasites of the suborder Eimeriorina, particularly members of the genus Toxoplasma, by administration of a growth inhibitory level of an alkyl derivative of ginghaosu.
    Type: Grant
    Filed: September 7, 1993
    Date of Patent: January 23, 1996
    Assignee: Regents of the University of Colorado
    Inventors: J. Joesph Marr, Edward C. Krug, Randolph L. Berens, Ou-Yang Ke
  • Use of bezafibrate for treating diabetes
    Patent number: 5304575
    Abstract: Bezafibrate is used for the treatment of normolipidaemic diabetes mellitus type II.
    Type: Grant
    Filed: December 17, 1992
    Date of Patent: April 19, 1994
    Assignee: Boehringer Mannheim GmbH
    Inventor: Walter Beck
  • Win 49596-finasteride method of use and compositions
    Patent number: 5175155
    Abstract: The method of use of a combination of the antiandrogen (5.alpha.,17.alpha.)-1'-(methylsulfonyl)-1'H-pregn-20-yno[3,2-c]pyrazol-17 -ol (Win 49596) and the 5.alpha.-reductase inhibitor (5.alpha.,17.beta.)-N-(1,1-dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carb oxamide (finasteride) for treating prostate disease in a male mammal and pharmaceutical compositions thereof are disclosed.
    Type: Grant
    Filed: October 7, 1991
    Date of Patent: December 29, 1992
    Assignee: Sterling Winthrop Inc.
    Inventors: Paul E. Juniewicz, Bruce M. Berger
  • Method of treating cancer and cancer metastasis
    Patent number: 4963559
    Abstract: The present invention relates to an agent for treating cancer and preventing cancer metastasis consisting of a compound selected from 5-(2-chlorobenzyl)-4,5,6,7-tetrahydro-thieneo[3,2-c]pyridine and its therapeutically acceptable acid addition salts.The therapeutically acceptable acid addition salt is in particular the hydrochloride named Ticlopidine.
    Type: Grant
    Filed: October 27, 1982
    Date of Patent: October 16, 1990
    Assignee: Sanofi
    Inventor: Tadao Suzuki