Patents Examined by Jerry Lin
  • Patent number: 10304567
    Abstract: There are provided a medical assistance device, an operation method of a medical assistance device, a non-transitory computer-readable recording medium, and a medical assistance system capable of improving work efficiency by reducing the burden on a user. When a request receiving unit has not received an input of a designated data range or when there is a difference between the designated data range and a first recommended data range, an automatic data range setting unit reads a second recommended data range of the latest event from a second recommended data range list. The medical data acquisition unit extracts medical data corresponding to the second recommended data range from the medical data in the entire course of treatment for the patient. The program control unit executes a diagnostic assistance program by giving medical data corresponding to the second recommended data range as input data, and outputs diagnostic assistance information.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: May 28, 2019
    Assignee: FUJIFILM Corporation
    Inventors: Yusuke Kitagawa, Akinari Tsugo
  • Patent number: 10295543
    Abstract: Therapeutic compositions for treating diseased cells such as cancer cells in a patient, formulated from a plurality of therapeutic agents selected from radiopharmaceuticals, chemotherapeutic agents and radionuclide labeled antibodies. Methods for predicting the response of an individual patient's cells to therapeutic intervention are also disclosed.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: May 21, 2019
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Roger W. Howell, John M. Akudugu, Jordan B. Pasternack, Venkata S. Neti
  • Patent number: 10289800
    Abstract: The present invention provides processes for calculating phased genomic sequences of the fetal genome using fetal DNA obtained from a maternal sample. The processes and systems of the present invention utilize novel technological and computational approaches to detect fetal genomic sequences and determine the phased heritable genomic sequences. The invention could be used, e.g., to identify in utero deleterious mutations carried by the parents and inherited by a fetus within a particular heritable genomic region.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: May 14, 2019
    Inventors: John Stuelpnagel, Craig Struble, Eric Wang
  • Patent number: 10278640
    Abstract: A portable system is provided for measuring a ketone, such as an acetone, in the breath or other bodily fluid of a user. The system includes a portable measurement device that analyzes fluid samples and generates corresponding ketone measurements. The portable measurement device communicates with an application which runs on a smartphone or other mobile device of the user. The application tracks, and generates graphs of, the ketone measurements, and may include various features for facilitating the analysis of the measurements.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: May 7, 2019
    Assignee: Invoy Holdings, LLC
    Inventors: Lubna M. Ahmad, Salman A. Ahmad, Zachary Smith
  • Patent number: 10264983
    Abstract: In a medical monitoring system, one or more biometric monitors collect data of a plurality of monitored biometric parameters. An expression evaluator evaluates a user-defined expression incorporating one or more of the monitored biometric parameters to generate data for a user-defined biometric parameter. A further processing component performs processing and display of data of at least one parameter selected from the monitored biometric parameters and the user-defined biometric parameter. The further processing component operates in the same way regardless of whether the at least one parameter is selected from the monitored biometric parameters or the user-defined biometric parameter.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: April 23, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Larry Nielsen, Mohammed Saeed
  • Patent number: 10241075
    Abstract: A method for nucleic acid sequencing includes receiving a plurality of signals indicative of a parameter measured for a plurality of defined spaces, at least some of the defined spaces including one or more sample nucleic acids, the signals being responsive to a plurality of nucleotide flows introducing nucleotides to the defined spaces; determining, for at least some of the defined spaces, whether the defined space includes a sample nucleic acid; processing, for at least some of the defined spaces determined to include a sample nucleic acid, the received signals to improve a quality of the received signals; and predicting a plurality of nucleotide sequences corresponding to respective sample nucleic acids for the defined spaces based on the processed signals and the nucleotide flows.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: March 26, 2019
    Assignee: Life Technologies Corporation
    Inventors: Melville Davey, Simon Cawley, Alan Williams
  • Patent number: 10240209
    Abstract: Embodiments are related to the accurate detection of somatic mutations in the plasma (or other samples containing cell-free DNA) of cancer patients and for subjects being screened for cancer. The detection of these molecular markers would be useful for the screening, detection, monitoring, management, and prognostication of cancer patients. For example, a mutational load can be determined from the identified somatic mutations, and the mutational load can be used to screen for any or various types of cancers, where no prior knowledge about a tumor or possible cancer of the subject may be required. Embodiments can be useful for guiding the use of therapies (e.g. targeted therapy, immunotherapy, genome editing, surgery, chemotherapy, embolization therapy, anti-angiogenesis therapy) for cancers. Embodiments are also directed to identifying de novo mutations in a fetus by analyzing a maternal sample having cell-free DNA from the fetus.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: March 26, 2019
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang
  • Patent number: 10234469
    Abstract: A blood state analysis device (1) that analyzes a state of a blood sample, as used for clotting time testing, said blood sample comprising a plasma and at least one reagent, including a correction unit (11) configured to correct a measured blood coagulation evaluation result of the blood sample based on a relation between reference concentrations of the at least one reagent in plasma and reference blood coagulation evaluation results, the at least one reagent is an anticoagulation treatment releasing agent, a coagulation activator, an anticoagulant, a platelet activator, an antiplatelet drug, or a combination thereof and is present in the blood sample. For instance, such device (1) allows to correct blood clotting time results with respect to concentrations of an anti-coagulant drug present in the blood sample.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: March 19, 2019
    Assignee: Sony Corporation
    Inventors: Yoshihito Hayashi, Marcaurele Brun, Kenzo Machida
  • Patent number: 10216895
    Abstract: Accurate variant calling methods for low frequency variants are provided. Sequence reads of targeted ultra-deep sequencing are received and aligned to a reference sequence. Read depths and variant counts for variants of the same class at each location where the reference allele exists on the reference sequence are determined for each sample-amplicon. Based on the read depths and variant counts, a probability value indicating the confidence level that a specific variant at a specific location is a true positive is calculated using methods such as a statistical model based method and a localized method using a reference sample. The probability value is then compared with a threshold level to determine whether the detected variants are true positives.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: February 26, 2019
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Wei-Min Liu
  • Patent number: 10213155
    Abstract: A method and apparatus for receiving, from a wearable sensor, current lactate level information of a user; setting, by the user, a target fatigue value; determining target lactate level information based on the target fatigue value; receiving characteristics of a physical exercise including information of an end of the physical exercise; determining adjusted characteristics of the physical exercise in order to match the current user lactate level information in the end of the physical exercise with the target lactate level information, based on the current lactate level information of the user, the target lactate level information and the characteristics for the physical exercise; and providing feedback to the user based on the adjusted characteristics of the physical exercise.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: February 26, 2019
    Assignee: Nokia Technologies Oy
    Inventors: Miikka Vilermo, Jussi Leppänen, Lasse Laaksonen, Pasi Saari
  • Patent number: 10217219
    Abstract: Systems and methods for rapidly analyzing cell containing samples, for example to identify morphology or to localize and quantitate biomarkers are disclosed.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: February 26, 2019
    Assignee: YALE UNIVERSITY
    Inventors: David Rimm, Robert Camp
  • Patent number: 10216898
    Abstract: A system, method and apparatus for executing a sequence analysis pipeline on genetic sequence data includes a structured ASIC formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the structured ASIC connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits are arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the sequence analysis pipeline on the reads of genomic data. Each subset of the hardwired digital logic circuits is formed in a wired configuration to perform the one or more steps in the sequence analysis pipeline.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: February 26, 2019
    Assignee: Edico Genome Corporation
    Inventors: Robert J. McMillen, Pieter van Rooyen, Michael Ruehle
  • Patent number: 10216897
    Abstract: The present invention concerns the design and construction of diverse peptide and polypeptide libraries. In particular, the invention concerns methods of analytical database design for creating datasets using multiple relevant parameters as filters, and methods for generating sequence diversity by directed multisyntheses oligonucleotide synthesis. The present methods enable the reduction of large complex annotated databases to simpler datasets of related sequences, based upon relevant single or multiple key parameters that can be individually directly defined. The methods further enable the creation of diverse libraries based on this approach, using multisynthetic collections of discrete and degenerate oligonucleotides to capture the diverse collection of sequences, or portions thereof.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: February 26, 2019
    Assignee: I2 PHARMACEUTICALS, INC.
    Inventors: Lawrence Horowitz, Ramesh Bhatt, Aaron L. Kurtzman
  • Patent number: 10203277
    Abstract: There is provided a technique for automatically determining or predicting a line range specific to a sample that appears in a reaction curve in an automated analyzer for mixing a specimen and a reagent and measuring a change in a mixture of the specimen and the reagent with time. This invention approximates reaction curve data by a function and automatically determines a curve part at an early stage or a second stage of a reaction. The invention determines a line range not including a curve part for each sample and calculates a laboratory test value using absorbance data within the determined line range. This invention also automatically determines a start time of line at the early stage of the reaction on the basis of absorbance data obtained up to a point halfway through the reaction curve, predicts a line range on the basis of the end time of line and a planned end time of line, and calculates a predictive value on the basis of a result of the prediction.
    Type: Grant
    Filed: April 5, 2011
    Date of Patent: February 12, 2019
    Assignee: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Chihiro Manri, Satoshi Mitsuyama, Tomonori Mimura, Kumiko Kamihara
  • Patent number: 10194844
    Abstract: Provided are methods and apparatus for receiving sensor data from an analyte sensor of a sensor monitoring system, processing the received sensor data with time corresponding calibration data, outputting the processed sensor data, detecting one or more adverse conditions associated with the sensor monitoring system, disabling the output of the sensor data during the adverse condition time period, determining that the one or more detected adverse conditions is no longer present in the sensor monitoring system, retrieving the sensor data during the adverse condition time period, processing the retrieved sensor data during the adverse condition time period, and outputting the processed retrieved sensor data.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: February 5, 2019
    Assignee: ABBOTT DIABETES CARE INC.
    Inventor: Wesley Scott Harper
  • Patent number: 10184940
    Abstract: The present invention provides methods for aiding in the diagnosis of irritable bowel syndrome (IBS) in an individual. In particular, the present invention is useful for determining whether a sample from an individual is an IBS sample or a healthy control sample using a statistical algorithm. Thus, the present invention provides an accurate diagnostic prediction of IBS and is useful for guiding treatment decisions.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: January 22, 2019
    Assignee: Nestec S.A.
    Inventors: Sharat Singh, Nicholas Chi-Kwan Ling, Shui-Long Wang, Fred Princen, Stefan Westin, Steven Lockton
  • Patent number: 10162800
    Abstract: The present invention generally relates to systems and methods for determining the probability of a pregnancy at a selected point in time. Systems and methods of the invention employ an algorithm that has been trained on a reference set of data from a plurality of women for whom at least one of fertility-associated phenotypic traits, fertility-associated medical interventions, or pregnancy outcomes are known, in which the algorithm accounts for any woman who ceases pregnancy attempts prior to reaching a live birth outcome.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: December 25, 2018
    Assignee: Celmatix Inc.
    Inventors: Michael Elashoff, Hrishikesh Karvir, Piraye Yurttas Beim
  • Patent number: 10127351
    Abstract: Accurate and fast mapping of sequencing reads obtained from a targeted sequencing procedure can be provided. Once a target region is selected, alternate regions of the genome that are sufficiently similar to the target region can be identified. If a sequencing read is more similar to the target region than to an alternate region, then the read can be determined as aligning to the target region. The reads aligning to the target region can then be analyzed to determine whether a mutation exists in the target region. Accordingly, a sequencing read can be compared to the target region and the corresponding alternate regions, and not to the entire genome, thereby providing computational efficiency.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: November 13, 2018
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Xiaoying Chen, Yan Li, Wei-Min Liu, Xiaoju (Max) Ma, Sim-Jasmine Truong
  • Patent number: 10095836
    Abstract: Methods, apparatuses, computer program products, devices and systems are described that are configured for accepting an input identifying at least one treatment target in search of an agent; accessing at least one dataset containing at least one agent for use in the context of the at least one treatment target; applying at least one filter criterion to at least one dataset to identify a subset of the at least one dataset, the subset of the at least one dataset associated with a defined level of at least one adverse event associated with administration of the at least one agent; and presenting the at least one agent in response to the subset of the at least one dataset.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: October 9, 2018
    Assignee: GEARBOX LLC
    Inventors: Edward K. Y. Jung, Royce A. Levien, Robert W. Lord, Mark A. Malamud, Lowell L. Wood, Jr.
  • Patent number: 10086072
    Abstract: The present invention provides methods for personalized therapeutic management of a disease in order to optimize therapy and/or monitor therapeutic efficacy. In particular, the present invention comprises measuring an array of one or a plurality of biomarkers at a plurality of time points over the course of therapy with a therapeutic agent to determine a mucosal healing index for selecting therapy, optimizing therapy, reducing toxicity, and/or monitoring the efficacy of therapeutic treatment. In certain instances, the therapeutic agent is a TNF? inhibitor for the treatment of a TNF?-mediated disease or disorder.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: October 2, 2018
    Assignee: Nestec S.A.
    Inventors: Sharat Singh, Nicholas Hoe, Steve Lockton, Scott Hauenstein, Linda Ohrmund