Patents Examined by Jerry Lin
  • Method and system for testing of active molecules using molecular simulation of skin membrane
    Patent number: 10720228
    Abstract: A system and method for testing of active molecules using simulation of skin membrane have been provided. The present disclosure provides a molecular level model of the skins upper protective layer Stratum-Corneum. The systems consist of a molecular model of the skins upper layer stratum corneum and permeate molecules. A protocol have been developed to perform molecular dynamics simulations which can be automated. The system predicts the permeability, partition coefficient and diffusivity of different active molecules like drugs and cosmetics through mentioned skin model using multiple molecule in single window constrained molecular dynamics simulations.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: July 21, 2020
    Assignee: Tata Consultancy Services Limited
    Inventors: Rakesh Gupta, Balarama Sridhar Dwadasi, Beena Rai
  • Blood pressure estimation by wearable computing device
    Patent number: 10716518
    Abstract: According to one aspect of the present disclosure, a method for estimating blood pressure is provided, comprising training a machine learning model on a cohort data set. The cohort data set may include subject-specific contextual data, time-varying features, and blood pressure measurements for a plurality of subjects. The method may include receiving contextual data for a specific subject, wherein the contextual data includes medical history data of the subject. The method may further include personalizing the machine learning model to the subject based on the contextual data. The method may include calibrating the machine learning model to the subject based on a set of time-varying features and blood pressure measurements of the subject. In addition, the method may include using the machine learning model and the time-varying features for the subject to generate a blood pressure estimate.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: July 21, 2020
    Assignee: MICROSOFT TECHNOLOGY LICENSING, LLC
    Inventors: Sumit Basu, Daniel Morris, Jeremiah Wander
  • Methods and devices for assessing in vivo toxic levels of bilirubin and diagnosing increased risk of bilirubin neurotoxicity
    Patent number: 10712352
    Abstract: In alternative embodiments are provided methods, devices and systems that use clinical data to determine whether bilirubin binding is normal in a newborn infant with hyperbilirubinemia in order to detect in vivo neurologically toxic levels of bilirubin and to determine whether treatment is needed to prevent a bilirubin-induced neurological injury (e.g. encephalopathy). In alternative embodiments, also provided are devices and systems comprising automated micro-fluid handling technologies such as zone fluidics systems to obtain a bilirubin binding panel. In alternative embodiments, also provided are methods for using the bilirubin binding panel to determine if treatments are needed to ameliorate, reverse, or prevent a bilirubin-induced neurological injury (e.g. encephalopathy) in an individual in need thereof such as a newborn with hyperbilirubinemia (jaundice), and for commencing the treatment, if needed.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: July 14, 2020
    Assignee: NEOMETRIX DX
    Inventor: Charles Ahlfors
  • Computer systems for treating diseases
    Patent number: 10714208
    Abstract: The present invention relates to computer-implemented methods and system for analysing a biomarker which cycles in a subject. In some other aspects, the present invention relates to analysing a biomarker which at least initially increases or decreases in amount in a subject following a treatment for a disease. In further aspects, the present invention relates to computer-implemented methods and systems for determining a preferred time to administer a therapy to treat a disease in a subject. The present invention also relates to computer program product to implement the methods. Further, the present invention relates to methods of determining the timing of treating a disease in a subject in which the immune system is cycling.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: July 14, 2020
    Assignee: BIOTEMPUS PTY LTD
    Inventors: Martin Leonard Ashdown, Andrew Robinson
  • System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
    Patent number: 10711309
    Abstract: A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, are disclosed. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. In accordance with one embodiment of the invention, incomplete genetic data is acquired from embryonic cells, fetal cells, or cell-free fetal DNA isolated from the mother's blood, and the incomplete genetic data is reconstructed using the more complete genetic data from a larger sample diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and/or genetic data taken from other related individuals.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: July 14, 2020
    Assignee: Natera, Inc.
    Inventors: Matthew Rabinowitz, Milena Banjevic, Zachary Demko, David Johnson
  • System and method for providing patient-specific dosing as a function of mathematical models updated to account for an observed patient response
    Patent number: 10706364
    Abstract: A system and method for predicting, proposing and/or evaluating suitable medication dosing regimens for a specific individual as a function of individual-specific characteristics and observed responses of the specific individual. Mathematical models of observed patient responses are used in determining an initial dose. The system and method use the patient's observed response to the initial dose to refine the model for use to forecast expected responses to proposed dosing regimens more accurately for a specific patient.
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: July 7, 2020
    Inventor: Diane R. Mould
  • Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform
    Patent number: 10691775
    Abstract: A system, method and apparatus for executing a bioinformatics analysis on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit that may be connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits may be arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the bioinformatics analysis on the reads of genomic data. Each subset of the hardwired digital logic circuits may be formed in a wired configuration to perform the one or more steps in the bioinformatics analysis.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: June 23, 2020
    Assignee: EDICO GENOME, CORP.
    Inventors: Pieter van Rooyen, Michael Ruehle, Rami Mehio, Mark Hahm
  • Adaptive brain-machine interface system for anesthesia delivery
    Patent number: 10675406
    Abstract: A system for controlling a state of anesthesia of a patient. The system includes a neural sensor configured to be coupled to a patient and generate an output signal indicative of neural activity of the patient; and an electronic processor. The electronic processor is coupled to the neural sensor and to an infusion pump, and is configured to receive the output signal from the neural sensor, estimate a drug concentration of the patient based on a model including a first model parameter, and estimate a second model parameter based on the output signal from the neural sensor. The electronic processor is also configured to update the model for estimating the drug concentration of the patient with the second model parameter, and output control signals to the infusion pump to deliver a drug, the output signals being based on the estimated drug concentration for the patient and estimates of the parameters.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: June 9, 2020
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventor: Maryam M. Shanechi
  • System and method for sample collection, transport and analysis
    Patent number: 10677807
    Abstract: A system and method for collecting, transporting, and analyzing dried bodily fluid samples using a sample collection device incorporating extraction markers, an imaging device to take images of dried samples on the collection device, and a computing device to analyze data points from the images so as to measure various properties of the collected sample such as the volume of blood initially collected, and the portion of that volume containing plasma and erythrocytes.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: June 9, 2020
    Inventor: Edward L Mamenta
  • System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
    Patent number: 10655181
    Abstract: A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, are disclosed. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. In accordance with one embodiment of the invention, incomplete genetic data is acquired from embryonic cells, fetal cells, or cell-free fetal DNA isolated from the mother's blood, and the incomplete genetic data is reconstructed using the more complete genetic data from a larger sample diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and/or genetic data taken from other related individuals.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: May 19, 2020
    Assignee: Natera, Inc.
    Inventors: Matthew Rabinowitz, Milena Banjevic, Zachary Demko, David Johnson
  • Multivariable artificial pancreas method and system
    Patent number: 10646650
    Abstract: Methods and modules for using physiological (biometric) variables to advance the state of the artificial pancreas. The method and system includes one or more modules for recursive model identification, hypoglycemia early alert and alarm, adaptive control, hyperglycemia early alert and alarm, plasma insulin concentration estimation, assessment of physical activity (e.g., presence, type, duration, expected effects on insulin sensitivity and GC), detection of acute stress and assessment of its impact on insulin sensitivity, detection of sleep and its stages and assessment of sleep stages on GC, sensor fault detection and diagnosis, software and controller performance evaluation and adjustment and/or pump fault detection and diagnosis.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: May 12, 2020
    Assignee: ILLINOIS INSTITUTE OF TECHNOLOGY
    Inventors: Ali Cinar, Kamuran Turksoy, Iman Hajizadeh
  • Methods of assessing cellular breast samples and compositions for use in practicing the same
    Patent number: 10627389
    Abstract: Methods are provided for assessing a cellular breast sample. Aspects of the methods include flow cytometrically obtaining sample data, cellular data, and combinations thereof, and then assessing the cellular breast sample based on the obtained data. In addition, compositions, e.g., kits, systems and programming, useful in practicing various embodiments of the methods are provided.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: April 21, 2020
    Assignee: IncellDx, Inc.
    Inventors: Keith Shults, Amanda Noel Chargin, Seyedhamed Jafarianmohamady
  • Systems, devices, and methods for alleviating glucotoxicity and restoring pancreatic beta-cell function in advanced diabetes mellitus
    Patent number: 10624577
    Abstract: Systems, methods and/or devices for treating diabetes mellitus by alleviating glucotoxicity and restoring pancreatic beta-cell function, comprising at least a first memory for storing data inputs corresponding at least to one or more components in a patient's present insulin dosage regimen, and data inputs corresponding at least to the patient's blood-glucose-level measurements determined at a plurality of times, and a processor operatively connected to the at least first memory. The processor is programmed at least to determine from the data inputs corresponding to the patient's blood-glucose-level measurements determined at a plurality of times whether and by how much to vary at least one of the components of the patient's present insulin dosage regimen.
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: April 21, 2020
    Assignee: Hygieia, Inc.
    Inventors: Eran Bashan, Israel Hodish
  • Bioinformatics systems, apparatuses, and methods executed on an integrated circuit processing platform
    Patent number: 10622096
    Abstract: A system, method and apparatus for executing a bioinformatics analysis on genetic sequence data includes an integrated circuit formed of a set of hardwired digital logic circuits that are interconnected by physical electrical interconnects. One of the physical electrical interconnects forms an input to the integrated circuit that may be connected with an electronic data source for receiving reads of genomic data. The hardwired digital logic circuits may be arranged as a set of processing engines, each processing engine being formed of a subset of the hardwired digital logic circuits to perform one or more steps in the bioinformatics analysis on the reads of genomic data. Each subset of the hardwired digital logic circuits may be formed in a wired configuration to perform the one or more steps in the bioinformatics analysis.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: April 14, 2020
    Assignee: Edico Genome Corporation
    Inventors: Pieter van Rooyen, Michael Ruehle, Rami Mehio
  • Detecting genetic aberrations associated with cancer using genomic sequencing
    Patent number: 10619214
    Abstract: Methods, systems, and apparatus determine whether a first chromosomal region exhibits a deletion or an amplification associated with cancer in a sample from a subject (e.g., where the sample includes a mixture of cell-free DNA from tumor cells and non-malignant cells. Nucleic acid molecules of the biological sample are sequenced. Respective amounts of a clinically-relevant chromosomal region and of background chromosomal region(s) are determined from results of the sequencing. A parameter derived from these amounts (e.g. a ratio) is compared to one or more cutoff values, thereby determining a classification of whether first chromosomal region exhibits a deletion or an amplification associated with cancer.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: April 14, 2020
    Assignee: The Chinese University of Hong Kong
    Inventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan
  • High-throughput, multi-omics approach to determine and validate de novo global mechanisms of action for drugs and toxins
    Patent number: 10607721
    Abstract: The present disclosure provides for rapid identification of mechanism of action (MOA) for drugs and toxins, and does so in a rapid (30 days or less) fashion. The methods use a combination of high throughput bioinformatics and pathway analysis that examine a wide variety of biological parametics.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: March 31, 2020
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Richard Caprioli, John Wikswo, John McLean, Eric Skaar, Jeremy L. Norris, Dana Borden Lacy, Stacy Sherrod, James Pino, Danielle Gutierrez, Nicole D. Muszynski, Melissa Farrow
  • System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
    Patent number: 10597724
    Abstract: A system and method for determining the genetic data for one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available, are disclosed. Genetic data for the target individual is acquired and amplified using known methods, and poorly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related subjects. In accordance with one embodiment of the invention, incomplete genetic data is acquired from embryonic cells, fetal cells, or cell-free fetal DNA isolated from the mother's blood, and the incomplete genetic data is reconstructed using the more complete genetic data from a larger sample diploid cells from one or both parents, with or without genetic data from haploid cells from one or both parents, and/or genetic data taken from other related individuals.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: March 24, 2020
    Assignee: Natera, Inc.
    Inventors: Matthew Rabinowitz, Milena Banjevic, Zachary Demko, David Johnson
  • Sperm inspection method and device
    Patent number: 10593036
    Abstract: The present invention addresses the problem of developing a simple sperm inspection method and device for reflecting fertility. In the present invention, a simple sperm inspection method and device having a high correlation with fertility can be provided by suspending a sperm population in an inspection liquid and measuring a quality indicator value for each sperm, stratifying the sperm population on the basis of the sperm quality indicator value, and evaluating the quality of the sperm on the basis of the quality indicator value of one or a plurality of groups in the stratified population. This standard can predict fertility with higher precision through use of a graph in which the quality indicator values for individual sperm of the sperm population are arranged in sequence. Sperm motility is preferably used as a sperm quality indicator.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: March 17, 2020
    Assignee: Livestock Improvement Association of Japan, Inc.
    Inventors: Masashi Kinukawa, Kyoko Uchiyama
  • System, apparatus, method, and graphical user interface for screening
    Patent number: 10592637
    Abstract: Disclosed is a computer-implemented method of screening a patient for end organ damage due to infection. The method entails receiving patient data relating to an identified patient in a computing system including a processor and memory coupled to the processor, wherein the memory stores programmable instructions executable by the processor. The presence of Systematic Inflammatory Response Syndrome is determined and then the presence or absence of a high probability of end organ damage due to infection. Each of the determining steps includes receiving, on a graphical user interface, one or more user selections presented on the graphical user interface and executing programmable instructions based on received user selections.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: March 17, 2020
    Assignee: Luminare Incorporated
    Inventors: Narasimheswara Sarma Velamuri, Marcus Joel Christian Persson Rydberg
  • Method of predicting phenotypic instability in a cell
    Patent number: 10591463
    Abstract: A method for predicting the phenotypic stability of a cell line comprises the steps of culturing the cell line over an assay period, and generating an environmental response fingerprint for the cell line at a plurality of different time points over the assay period, wherein each environmental response fingerprint is generated by determining the environmental response of the cells in the presence of each of a plurality of chemical cell stressors. The plurality of environmental response fingerprints are compared to detect change in the environmental response fingerprint over the assay period. The level of change in the environmental response fingerprint over the assay period is indicative of the level of predicted phenotypic instability in the cell line. The environmental response may be growth response, productivity response, or another detectable environmental response.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: March 17, 2020
    Assignee: Valitacell Limited
    Inventors: Ben Thompson, David James, Jerry Clifford