Patents Examined by Jill Johnston
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Patent number: 5254316Abstract: Improved process to convert in situ conventional reactors with four catalytic beds with axial flow and with intermediate quenching (Kellogg reactor), Third and fourth original beds are combined thus obtaining a reactor with three beds through which the synthesis gas now flows with a substantially radial flow.Type: GrantFiled: April 3, 1992Date of Patent: October 19, 1993Assignees: Ammonia Casale S.A., Umberto ZardiInventors: Umberto Zardi, Giorgio Pagani
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Patent number: 5252486Abstract: A method for flow injection analysis of total inorganic phosphate contained in an aqueous system such a cooling tower or boiler is described which uses a reducing agent and preservative composition therefore as the carrier for the sample to be analyzed, thereby creating a facile process which permits conversion of the various polyphosphates to orthophosphate and development of the molybdenum blue complex color reaction at 60.degree.-95.degree. C. and under 2-10 psi. This method has less stringent pressure and temperature requirements than those employed heretofore, thus permitting the use of more reliable and economic devices for measuring total inorganic phosphate in the field.Type: GrantFiled: August 15, 1991Date of Patent: October 12, 1993Assignee: Calgon CorporationInventors: Christina O'Lear, Keith J. Salamony
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Patent number: 5252459Abstract: An indicator reagent, assay method and test kit for determining the presence or amount of an analyte in a test sample, in which the indicator reagent is formed by attaching an organic polymer latex particle, preferably a colored particle, to a specific binding member. The specific binding member can be adsorbed onto or covalently bound to the organic polymer latex particles. The organic polymer latex particles are readily detected by direct visual observation or can be detected and/or measured by appropriate instrumentation.Type: GrantFiled: September 23, 1988Date of Patent: October 12, 1993Assignee: Abbott LaboratoriesInventors: Peter J. Tarcha, James J. Donovan, Martin Wong
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Patent number: 5250438Abstract: A new method for separation of white cells in differential hematology instruments is described. In the method described, white cell shrinkage is controlled by the use of diazolidinyl urea and accelerated with alcohol thereby providing a reproducible method for easy manipulation of the white cells. In addition, it was found that adsorption of blood platelets and red blood cells in the instruments can be prevented by use of a surfactant such as the polyols.Type: GrantFiled: May 9, 1990Date of Patent: October 5, 1993Assignee: Streck Laboratories, Inc.Inventor: Wayne L. Ryan
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Patent number: 5250260Abstract: A tape for detecting the presence of hydride gases by taking advantage of coloring reactions whose light sensitivity is lowered to a minimum without impairing the inherent mechanical strength of the reagent holder. The detection tape is prepared by impregnating a tape of porous cellulose fibers containing a gas adsorbent such as a powder of silica and a moisture keeper of glycerin with a coloring reagent of silver perchlorate or silver para-toluenesulfonate and a light resistance enhancer of para-toluenesulfonic acid. When the detection tape is exposed to a hydride gas contained in the sampled gas, silver perchlorate or silver para-toluenesulfonate is reduced by the hydride gas to form a colloid of silver that remains as a trace of reaction. As the amount of the colloid of silver is proportional to the concentration of the gas, the concentration of hydride gas can be determined by measuring the optical density of the trace of reaction.Type: GrantFiled: October 30, 1992Date of Patent: October 5, 1993Assignee: Riken Keiki Co., Ltd.Inventors: Nobuo Nakano, Akihiro Yamamoto
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Patent number: 5248616Abstract: A method and apparatus are set forth for enhancing the concentration of oxides of nitrogen in the preferred embodiment. A permeable membrane is formed into a tube placed in a container. A sample containing bound nitrogen in placed in a container in contact with the tube. A carrier gas is swept through the tube in contact with the wall of the tube. This enables hydrophobic gases such as oxides of nitrogen to migrate through the wall of the tube and they are swept into a detection system. If desired, they can be permitted to accumulate in the wall for an interval and the carrier gas can be switched from off to on to achieve peak concentration for delivery to a bound nitrogen analytical device. Other hydrophobic gases such as oxides of sulfur can likewise be identified by sulfur analyzer. This enables an increase in trace concentration.Type: GrantFiled: June 4, 1992Date of Patent: September 28, 1993Inventors: Joseph S. Beckman, Karl A. Conger
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Patent number: 5246669Abstract: Provided is a sampling bottle with easy handling of dejection sample, simple structure, reliable prevention of scattering dejection sample and propagation of offensive smell to nearby environments, and good quantitative precision. The sampling bottle has a bottle main body having an open bottom end and a nozzle unit closed by a thin wall capable of being opened, the bottle main body being capable of containing test liquid, and a sample holding unit insertable into the bottle main body from the open bottom end. The sample holding unit has an inner plug and a sample pickup rod. The sample pickup rod is pierced into sample dejection. The sample pickup rod with attached dejection is inserted into the inner plug. Excessive sample attached to the outer surface of the sample pickup rod is scraped off by the scrape section. The scraped, excessive sample is accommodated and sealed within an excessive sample room between the inner plug and the sample pickup rod.Type: GrantFiled: March 6, 1992Date of Patent: September 21, 1993Assignee: Toyo Seikan Kaisha, Ltd.Inventor: Hiroaki Hayashi
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Patent number: 5246867Abstract: A method for measuring the concentration of a saccharide, conjugated saccharide or polysaccharide of interest using luminescent lifetimes and energy transfer in which an energy transfer donor-acceptor pair is added to a sample to be analyzed, the donor of the donor-acceptor pair being photoluminescent. The acceptor is bound to a carrier, while the donor and any saccharide, conjugated saccharide or polysaccharide of interest present in the sample compete for binding sites on the carrier. The sample is irradiated and the resultant emission detected. Energy transfer occurs between the donors and the acceptors, which produces a detectable lifetime change of the fIuorescence of the donor. The lifetime change is reduced or even eliminated by the competitive binding of a saccharide, conjugated saccharide or polysaccharide of interest to the donor. By measuring the apparent luminescent lifetime, the amount of a saccharide, conjugated saccharide or polysaccharide of interest in the sample can be determined.Type: GrantFiled: January 17, 1992Date of Patent: September 21, 1993Assignees: University of Maryland at Baltimore, Becton Dickinson & CompanyInventors: Joseph R. Lakowicz, Badri P. Maliwal, Peter A. Koen
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Patent number: 5246667Abstract: An analytical furnace includes a pair of generally vertically extending coaxially mounted spaced furnace tubes mounted to a support. The inner tube is made of a material which does not react with the specimen during pyrolysis to produce intereferring byproducts. An analytical sample crucible is supported above the support by a carbonaceous material which in the preferred embodiment comprises a combination of a carbon-felt packing material resting on the support and granular carbon black on which the crucible is placed. The material is selected to position the crucible in the hot zone of the furnace which includes a heater for heating an analytical sample for pyrolysis. The analytical furnace further includes a lance tube extending over and in coaxial alignment with the inner and outer furnace tubes for directing a sample and a carrier gas into the open mouth of the cup-shaped crucible.Type: GrantFiled: February 25, 1991Date of Patent: September 21, 1993Assignee: Leco CorporationInventors: Wayne R. Hemzy, Carlos Guerra
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Patent number: 5246860Abstract: Organic tracers are employed to monitor the movement of subterranean fluids. These organic tracers are (a) stable at elevated temperatures, (b) capable of being detected at low concentrations, and/or (c) not adversely affected by the make-up of at least one subterranean formation. In addition, a plurality of these tracers can be measured by a single analytical technique.Type: GrantFiled: January 31, 1992Date of Patent: September 21, 1993Assignee: Union Oil Company of CaliforniaInventors: Richard D. Hutchins, Dennis L. Saunders
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Patent number: 5244631Abstract: A testing device includes a platelike stick and a detecting function part deposited on said stick. The stick is composed of a water-disintegrable layer, a water-soluble layer superposed on at least one surface of the water-disintegrable layer in the part thereof destined to contact an analyte fluid, and a multiplicity of minute pieces of a water-soluble material superposed on the opposite surfaces of the stick at least in the part thereof destined to contact with analyte fluid.Type: GrantFiled: September 18, 1991Date of Patent: September 14, 1993Assignee: Terumo Kabushiki KaishaInventor: Naoki Morikawa
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Patent number: 5244638Abstract: A high temperature high pressure furnace has a hybrid partially externally heated construction. A metallic vessel fabricated from an alloy having a composition of at least 45% nickel, 15% chrome, and 10% tungsten is utilized (the preferred alloy including 55% nickel, 22% chrome, 14% tungsten, 2% molybdenum, 3% iron (maximum) and 5% cobalt (maximum). The disclosed alloy is fabricated into 11/4 or 2 inch, 32 mm or 50 mm bar stock and has a length of about 22 inches, 56 cm. This bar stock has an aperture formed therein to define a closed high temperature, high pressure oxygen chamber. The opposite and closed end of the vessel is provided with a small blind aperture into which a thermocouple can be inserted. The closed end of the vessel is inserted into an oven, preferably heated by standard nickel chrome electrical elements and having a heavily insulated exterior.Type: GrantFiled: May 17, 1991Date of Patent: September 14, 1993Assignee: The Regents of the University of CaliforniaInventor: Donald E. Morris
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Patent number: 5242833Abstract: A method of separating a first class of lipoprotein in a sample from a second class of lipoprotein in the sample including: precipitating the second class of lipoprotein; contacting the sample with a magnetically responsive particle; and placing the sample in a magnetic field until the magnetically responsive particle has sedimented, thereby causing the precipitated second class of lipoproteins to sediment, leaving the first class of lipoproteins in the supernatant of the sample.Type: GrantFiled: March 20, 1991Date of Patent: September 7, 1993Assignee: Reference Diagnostics, Inc.Inventors: Joseph F. Lawlor, Joseph D. Musto
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Patent number: 5242806Abstract: A method and apparatus for assaying the sensitivity of biopsied tumor cells to chemotherapeutic agents using a predetermined amount of chemotherapeutic agent in an easily deliverable form is disclosed and claimed.Type: GrantFiled: May 15, 1992Date of Patent: September 7, 1993Assignee: Baxter Diagnostics Inc.Inventors: Yu P. Yen-Maguire, Tom Cox, Fred Lewis
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Patent number: 5242665Abstract: The surface of an apparatus made of a Fe base alloy or Ni base alloy containing at least 35 wt. % of Cr is resistant to carbon deposition when the apparatus contacts carburizing/oxidizing atmospheres.Type: GrantFiled: August 28, 1992Date of Patent: September 7, 1993Assignee: JGC CorporationInventors: Keikichi Maeda, Naohiko Kagawa, Kunio Ishii, Takahiro Iijima
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Patent number: 5240679Abstract: Apparatus for the automatic introduction of a pipetting insert through the stopper of a sample vessel sealed by the stopper and containing a sample.To ensure complete introduction of the pipetting insert into the stopper, the apparatus is characterized in that it comprises the following components:(a) an entry device which receives successively individual sample vessels sealed by a stopper, and positions the same in a predetermined position,(b) a feed device which successively brings individual pipetting inserts to a delivery station,(c) a press-in device which is movable by a drive device and which comprises a plunger and guides the plunger so that it takes a pipetting insert from the delivery station of the feed device and presses it against the stopper of the sample vessel and thus introduces it at least partially into the stopper.Type: GrantFiled: July 17, 1991Date of Patent: August 31, 1993Assignee: Hoffmann-La Roche Inc.Inventor: Ueli Stettler
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Patent number: 5238853Abstract: In a blood gas analyzer, a substantially oxygen-free measurement solution is fed through a measuring cell as far as a diffusion cell in which the measurement solution is brought into contact with a blood sample to be tested. The gases dissolved in the blood sample diffuse through a membrane in the diffusion cell into the solution. The measurement solution is then propelled in the reverse direction to feed into the measuring cell. In the measuring cell, the measurement solution is electrochemically measured to determine a value which is related to the partial pressure of oxygen (pO.sub.2) in the sample.Type: GrantFiled: September 11, 1991Date of Patent: August 24, 1993Assignee: Instrumentation Laboratory S.R.L.Inventors: Claudio Calzi, Gabrio Tancredi
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Patent number: 5234835Abstract: A precalibrated sensing system for determining a blood parameter such as the partial pressures of oxygen (pO.sub.2) and carbon dioxide (pCO.sub.2), and the negative logarithm of hydrogen ion activity (pH). A dry sensor is provided which may be calibrated in the factory, packaged, sterilized and stored, without requiring recalibration prior to use.Type: GrantFiled: September 26, 1991Date of Patent: August 10, 1993Assignee: C.R. Bard, Inc.Inventors: James R. Nestor, Bennett L. Hauenstein
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Patent number: 5234836Abstract: The present invention is directed to a method for amino acid sequence analysis comprising either the steps of labeling the sample with a fluorescent reagent and quenching the excess fluorescent reagent remaining after said labeling with an ammonium salt, or the steps of degrading amino acid from the amino terminus of peptides or proteins using a fluorescent Edman reagent and quenching the excess fluorescent Edman reagent remaining after said degrading with an ammonium salt. The method of the present invention makes it possible to eliminate the interference of identification by the chromatographic peak of fluorescent reagent by quenching the excess fluorescent reagent in the sample.Type: GrantFiled: February 26, 1992Date of Patent: August 10, 1993Assignee: Shimadzu CorporationInventors: Kiyoshi Nokihara, Koji Muramoto
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Patent number: 5232858Abstract: A method for the quantitative determination of one or more chemical parameters of a sample medium employs a fluorescent agent which is not responsive to the parameter to be determined and which has an excitation spectrum and an emission spectrum, and a closely adjacent chromogenic agent which responds to the parameter of the sample medium to be determined by a change in its absorption spectrum the emission spectrum of the fluorescent agent at least partically overlapping the absorption spectrum of the chromogenic agent. The absorption maximum of chromogenic agent is shifted in accordance with the parameter to be determined, causing a reduction of fluorescence decay time t in the fluorescent agent, thereby enabling quantitative determination of the chemical parameter with improved long-term stability and infrequent calibrations.Type: GrantFiled: March 4, 1992Date of Patent: August 3, 1993Assignee: AVL Medical Instruments AGInventors: Otto S. Wolfbeis, Marco J. Leiner