Patents Examined by Jill Warden
  • Patent number: 11982602
    Abstract: The present invention provides a fluidic device in which solutions of different concentrations can be easily obtained.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: May 14, 2024
    Assignee: NIKON CORPORATION
    Inventors: Ryo Kobayashi, Hirofumi Shiono
  • Patent number: 11982680
    Abstract: Platforms for enzymatic assays for biomarkers, including systems, methods, and measuring devices by which a biomarker, such as creatinine, is measured using a small amount of biological fluid, such as blood, plasma, or serum. The measuring device or biosensor can be a test strip including a layered active component assembly positioned between two outer layers which enables multi-step enzymatic reactions operating in kinetic and/or endpoint (in which the reaction is allowed to near completion), and generally includes multiple layers with primary enzyme(s), coupling enzyme(s), and reagents to produce an optical signal correlated to the concentration of a biomarker in the sample. The test strip can be read using a portable optical reader coupled to a smart phone or tablet.
    Type: Grant
    Filed: December 9, 2022
    Date of Patent: May 14, 2024
    Assignee: Jana Care, Inc.
    Inventors: Daniel B. Lookadoo, Ashok A. Kumar, Jeremy E. Schonhorn, Christopher M. Uherek, Michal Depa
  • Patent number: 11982604
    Abstract: Methods and systems of analyzing and quantifying a surface acidity on a low surface area sample are disclosed. The methods include analyzing a quantity of an effluent molecular probe desorption from a temperature programmed desorption (TPD) process and system, by employing a mass spectroscopy (MS) system. The molecular probe is chemically adsorbed on a clean surface of the sample before the TPD process. The sample has a surface area to mass ratio of less than 5 m2/g. In some embodiments, the total surface area analyzed in the method can be as low as 3 m2.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: May 14, 2024
    Assignee: SAINT-GOBAIN CERAMICS & PLASTICS, INC.
    Inventors: Tritti Siengchum, James M Ralph
  • Patent number: 11977088
    Abstract: A method of reducing quality problems associated with patient sample collection and delivery is provided. It is possible that the method can provide a chain of custody process to better track a sample from the initial point of sample collection to the final point of sample testing. Such a method can also include providing an alert to indicate a potential problem with the quality of the diagnostic test result when a measured parameter exceeds a threshold.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: May 7, 2024
    Assignee: Beckman Coulter, Inc.
    Inventors: Wido Menhardt, Matthew Hanson, Anthony Camisa
  • Patent number: 11975322
    Abstract: An optical positioning code disk, device and method for a microfluidic chip are provided. A cross section of an outer contour of the code disk is circular. N light transmissive openings are arranged uniformly around the code disk. The device includes: the code disk, a positioning pin, a rotating shaft, a motor, an internal photoelectric switch and an external photoelectric switch. A positioning surface is provided on the rotating shaft. The motor is fixedly connected with an end of the rotating shaft, and the other end of the rotating shaft passes through a center of the cross section of the code disk. The internal and external photoelectric switches are configured to identify the light transmissive openings on the code disk.
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: May 7, 2024
    Assignee: CAPITALBIO TECHNOLOGY (CHENGDU) CO., LTD.
    Inventors: Chicheng Song, Guanbin Zhang, Yong Huang, Yong Tao, Ruoran Li, Hongcheng Zhou
  • Patent number: 11977057
    Abstract: A method for characterizing a target peptide through a detection approach such as mass spectrometry is provided, including: introducing at least one guard molecule to mix with the target peptide; and applying the detection approach for the characterization of the target peptide. Each guard molecule is configured to have similar characteristics as the target peptide, yet is still distinguishable therefrom by the detection approach, such as having a mass spectrometry-distinguishable different M/z value compared with the target peptide. The method can be used to characterize a neoantigen peptide through mass spectrometry, upstream of which the method can further include steps for tissue sample preparation, HLA molecules enrichment, elution, clean-up, and purification. Some or all of these steps can be configured to be executed in a substantially automatic manner with little or no manual intervention. A system for implementing the neoantigen analysis method is further provided.
    Type: Grant
    Filed: June 13, 2021
    Date of Patent: May 7, 2024
    Assignee: COMPLETE OMICS INTERNATIONAL INC.
    Inventor: Qing Wang
  • Patent number: 11977091
    Abstract: An analyzer having an inner chassis surrounded by a housing includes sample and dilution probes, a mixing housing including first and second mixing chambers, a flow cytometer including a flow cell, and sample and sheath pumps configured to perform first and second pluralities of tasks, respectively. The first plurality of tasks includes: aspirating sample into the sample probe, dispensing sample from the sample probe into the first and second mixing chambers, delivering first sample-dilution fluid mixture to the flow cell, and delivering second sample-dilution fluid mixture to the flow cell. The second plurality of tasks includes: dispensing sheath to the flow cell in cooperation with the delivery of the first sample-dilution fluid mixture to the flow cell, and dispensing sheath to the flow cell in cooperation with the delivery of the second sample-dilution fluid mixture to the flow cell.
    Type: Grant
    Filed: July 9, 2021
    Date of Patent: May 7, 2024
    Assignee: IDEXX LABORATORIES INC.
    Inventors: Jonathan W. Lawrence, Mark R. Dumont, Jason J. Aguiar, John H. McGibbon, Nicholas P. Prince
  • Patent number: 11971426
    Abstract: An automatic analysis device that avoids carryover and prevents deterioration of analysis performance without controlling reaction cell position is provided with: a reaction cell in which a sample and a reagent are mixed and allowed to react; a light source that radiates light onto the mixed liquid of the sample and the reagent; a detector that detects the light radiated from the light source; and a cleaning mechanism that cleans the reaction cell. The cleaning mechanism includes an intake nozzle that draws in liquid from the reaction cell and a discharge nozzle that discharges the liquid into the reaction cell; the intake nozzle and the discharge nozzle can move vertically; and the intake nozzle is cleaned by lowering the intake nozzle into the reaction cell, in which a cleaning liquid or cleaning water have been accumulated, without drawing in the cleaning liquid or the cleaning water.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: April 30, 2024
    Assignee: Hitachi High-Tech Corporation
    Inventors: Rei Konishi, Nobuhiko Sasaki, Masahiko Iijima
  • Patent number: 11971421
    Abstract: A sample analysis system is available that can include a remote sampling system, at least one analyzer, and a controller. The remote sampling system can include a plurality of sample sources for providing a corresponding sample therefrom; and a plurality of sample collection devices selectively coupled to any of the plurality of sample sources for receiving at least one of the samples therefrom. The at least one analyzer can be coupled to the plurality of the sample collection devices for receiving at least one of the samples therefrom. The controller can be coupled with the remote sampling system and the at least one analyzer, the controller configured to control which of the sample sources is actively coupled to a given sample collection device at a given time.
    Type: Grant
    Filed: May 23, 2023
    Date of Patent: April 30, 2024
    Assignee: Elemental Scientific, Inc.
    Inventors: Tyler Yost, Jonathan Hein, Jae Seok Lee, Dong Cherl Park
  • Patent number: 11970727
    Abstract: The present disclosure discloses a pathogenic microorganism sample collection and preservation device with a protection function, including a sampler and a preservation container; the sampler and the preservation container are both packaged by independent aseptic packaging bags. The sampler includes a sample collection mechanism, a holding mechanism, and a protection mechanism arranged between the sample collection mechanism and the holding mechanism. Before sample collection, the preservation container is sealed by an assorted sealing cover. The sample collection and preservation device of the present disclosure is convenient for holding and flexible adjustment of a sample collection angle. The protection mechanism between the holding mechanism and the sample collection mechanism plays a role of shielding, thus avoiding the problem of cross contamination.
    Type: Grant
    Filed: December 30, 2022
    Date of Patent: April 30, 2024
    Inventors: Yanhua Xie, Yansen Xie, Mitchell Brown
  • Patent number: 11971423
    Abstract: An automatic analyzer is capable of transporting a sample at an optimum timing and a method of transporting the sample. An automatic analyzer includes an analysis unit which measures a sample, a transport unit which transports the sample to the analysis unit, and a control unit which controls the analysis unit and the transport unit. A sample is transported to the analysis unit by a time of starting an aspirating operation on the sample by allowing the analysis unit to perform a pre-measurement operation for each measuring method which needs to be performed before aspirating the sample even when the sample is still in the transport unit.
    Type: Grant
    Filed: May 16, 2019
    Date of Patent: April 30, 2024
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Naoto Suzuki, Masashi Akutsu, Akihiro Yasui
  • Patent number: 11965898
    Abstract: An automatic nucleic acid detection system and a method thereof are disclosed. The automatic nucleic acid detection method includes: performing, by an automatic control subsystem, on a nucleic acid extraction machine platform, a nucleic acid extraction on one or more specimens in a sample tray to generate one or more corresponding nucleic acids in the sample tray; distributing, by the automatic control subsystem, on a nucleic acid distribution machine platform, the nucleic acid in each hole of the sample tray and a first reagent into a plurality of holes of a detection tray, wherein the number of holes of the detection tray is greater than that of the sample tray; and performing, by the automatic control subsystem, on a nucleic acid detection machine platform, a nucleic acid detection on the detection tray.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: April 23, 2024
    Assignees: TCI GENE INC, TCI CO., LTD
    Inventors: Yung-Hsiang Lin, Cheng-Hong Hsieh, Ciao-Ting Chen, Tsung-Cheng Chen
  • Patent number: 11965867
    Abstract: A sensing element for a chemiresistor sensor and a method of making such a sensing element is disclosed. The sensing element may include: one or more first type of 3D elements, each comprising a first type of chemiresistor particles; and one or more second type of 3D elements, each comprising a second type of chemiresistor particles. At least one of the one or more first type of 3D elements and at least one of the one or more second type of 3D elements may have one or more joint surface. The first type of chemiresistor particles may differ from the second type of chemiresistor particles by at least one of: a type of nanoparticle core and a type of organic ligands bonded to each nanoparticle core.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: April 23, 2024
    Assignee: NanoScent Ltd.
    Inventor: Yair Paska
  • Patent number: 11959844
    Abstract: There is provided a cool box for use in an automatic analyzer. The cool box has a box body and an air circulator. The box body has a receiving space capable of accommodating therein receptacles for analytes or reagents. The circulator has an intake portion, a fan, and an exhaust portion and operates to circulate air in the receiving space by rotation of the fan. The circulator further includes an inhibitor removing agent retaining portion on which a pouch is set. The pouch contains an analysis inhibitor removing agent for removing components (analysis inhibitor) which adversely affect or inhibit analysis of the analytes.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: April 16, 2024
    Assignee: JEOL Ltd.
    Inventors: Takashi Yaginuma, Kiyohiro Ishikawa, Yusuke Yamanaka
  • Patent number: 11959929
    Abstract: A method of measuring and identifying LSD and its major metabolite O-H-LSD, by obtaining a sample from an individual, and measuring, identifying, and quantifying LSD and O-H-LSD in the sample by performing a LC-MS/MS analysis. A method of treating and monitoring individuals taking LSD, by administering a microdose of LSD, a prodrug of LSD, or an analog of LSD to the individual, monitoring the individual by obtaining a sample from an individual and measuring and identifying the analytes in the sample by performing a LC-MS/MS analysis, and adjusting the microdose based on the amount of LSD quantified in the LC-MS/MS analysis. A method of adjusting dosing of LSD, by administering a microdose of LSD, a prodrug of LSD, or an analog of LSD to the individual, and adjusting the microdose based on blood concentration analytics.
    Type: Grant
    Filed: October 20, 2021
    Date of Patent: April 16, 2024
    Assignee: Universitätsspital Basel
    Inventors: Matthias E. Liechti, Urs Philipp Duthaler
  • Patent number: 11946930
    Abstract: A device for use in the detection of binding affinities comprises a substrate, a planar waveguide arranged thereon and having an outer surface. The device further comprises a grating for coupling coherent light of a predetermined wavelength into the planar waveguide such that the coherent light coupled into the planar waveguide propagates through the planar waveguide in a predetermined propagation direction. An evanescent field of the coherent light propagates along the outer surface of the planar waveguide. The outer surface of the planar waveguide has receptor molecules arranged thereon capable of binding target samples to the receptor molecules such that light of the evanescent field is diffracted by the target samples bound to the receptor molecules. The receptor molecules are arranged along a plurality of straight parallel lines such that a portion of the light of the evanescent field is diffracted by the target samples bound to the receptor molecules.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: April 2, 2024
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventor: Christof Fattinger
  • Patent number: 11940403
    Abstract: A device for the detection of a food allergen includes a sensor having a printed circuit board and a chip comprising a molecularly imprinted polymer (MIP) and a non-imprinted polymer (NIP); a reservoir comprising a liquid; and a chamber for mixing the liquid with a food.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: March 26, 2024
    Assignee: Amulet, Inc.
    Inventors: Srikanth Rao Agnihotra, Madanodaya Sundhoro, Brent Amberger, Abigail Barnes, Joseph Belbruno, Seung Hyuk Noh, Jeanette Numbers, Elizabeth Soucy
  • Patent number: 11938482
    Abstract: A vial cap for a sample vial includes a cylindrical cap body defining a first circular opening at a first end. The vial cap also includes a cap lid extending radially inward from a second end of the cylindrical cap body. The cap lid defines a second circular opening. The vial cap also includes a septum located within the cylindrical cap body and in contact with the cap lid. The septum spans the second circular opening defined by the cap lid portion. The vial cap also includes a number of flexible threads extending from an internal surface of the cylindrical cap body.
    Type: Grant
    Filed: June 1, 2021
    Date of Patent: March 26, 2024
    Assignee: Waters Technologies Corporation
    Inventor: Moon Chul Jung
  • Patent number: 11940457
    Abstract: A robotic arm of an automated pipetting system has a pipetting tip adapter and a slide switch to detect the presence of pipetting tips on the pipetting tip adapter is disclosed. The slide switch has first support member and second support member configured to slide relative to one another between first and second positions along a movement axis, an electrically conducting contact pad arranged on the first support member, an electrically conducting terminal physically attached to second support member in physical contact with the contact pad when support members are in first position, where the terminal is a first resilient wiping member expanding along the movement axis, first wiping member is not in physical contact with the contact pad when support members are in second position, and an electric current can flow between first wiping member and the contact pad when support members are in first position.
    Type: Grant
    Filed: November 11, 2021
    Date of Patent: March 26, 2024
    Assignee: TECAN TRADING AG
    Inventor: Thomas Geiges
  • Patent number: 11940455
    Abstract: A consumable management system comprising a consumable storage cluster with a plurality of storage compartments is presented. Each storage compartment is configured to receive one or more consumables. The consumable management system further comprises storage compartment indicators to provide guidance to a user and a detection unit for validating user action(s).
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: March 26, 2024
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Urs Suter, Riccardo Leone Benedetti, Gregor Hotz, Oliver Rusterholz, Robert Theiler