Patents Examined by Jill Warden
  • Patent number: 11027272
    Abstract: Disclosed are transfer dispensers for assay devices. These dispensers provide for transfer of a single assay component into a single well in the assay device. This ensures that the assay conducted in each well contains only a single component.
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: June 8, 2021
    Assignee: Plexium, Inc.
    Inventors: Kandaswamy Vijayan, Kapil Mahakalkar, Yi Zhang
  • Patent number: 11027278
    Abstract: A microfluidic device includes a microchannel having an interior bounded by a side wall, an inlet, a switching region, and a plurality of outlet channels downstream of the switching region. The microchannel is formed in a microfluidic chip substrate and configured to accommodate a flow of liquid through the microchannel. The microfluidic device includes a valve operatively coupled to the switching region comprising a sealed reservoir. A side passage extends between the reservoir and the interior of the microchannel via an aperture in the side wall and is configured to accommodate a volume of liquid between the interior of the microchannel and the reservoir. The microfluidic device includes an actuator integrated into the microfluidic chip and configured to increase an internal pressure of the reservoir and move at least a portion of the volume of the liquid from the side passage into the microchannel to deflect a portion of the liquid flowing through the microchannel.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: June 8, 2021
    Assignee: CYTONOME/ST, LLC
    Inventors: John R. Gilbert, Sebastian Böhm, Manish Deshpande
  • Patent number: 11022623
    Abstract: A sample transport method, applied to a test instrument including a conveyor belt, and a loading platform and a grab position sequentially disposed along a transport direction of the conveyor belt, wherein a plurality of sample holder transport positions are disposed on the conveyor belt; the method including: pushing a first sample holder from the loading platform to a sample holder transport position of the conveyor; when a sample position on the first sample holder moves to the grab position, determining whether the sample position moved the grab position is a target sample position; if so, then determining whether all samples positions on the first sample holder before the target sample holder other than a predetermined number of sample positions have completed testing, wherein the predetermined number is sample position number corresponding to a delay time in outputting information indicating whether a sample needs to be retested.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: June 1, 2021
    Inventors: Zhongyi Wu, Bingqiang Zhao, Xiangfeng Shen, Hualong Wang, Huailin Wang
  • Patent number: 11016067
    Abstract: A sorbent tube holder (100) for securing a sorbent tube (10) in position in a fluid-flow system, the sorbent tube holder (100) comprising: an mounting element (126) having first and second opposed ends (126a, 126b) which define a tube mounting axis (A-A); at least one fastener (128) in communication with the mounting element (126) for providing a releasable tube retaining force; at least one sorbent tube (10) engaged with the mounting element (126); and a holder frame (130) to which the mounting element (126) is attached to prevent or limit movement of the mounting element (126) perpendicular to the tube mounting axis. A method of preventing or limiting unintentional damage to a sorbent tube, and a portable tube holder are also provided.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: May 25, 2021
    Inventors: Jeremy Knight, Tom Knight
  • Patent number: 11016027
    Abstract: Methods and systems for detecting and quantifying film forming amines in water systems are described. Water containing a film forming amine is combined with a fluorescent dye, the pH of the water is reduced, and then the fluorescence signal of the fluorescent dye is measured. The fluorescence signal is indicative of the amount of film forming amine in the water, and can be used to quantify the amount of film forming amine and control the amount of film forming amine that is introduced into the water system.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: May 25, 2021
    Assignee: CHEMTREAT, INC
    Inventors: Dale Stuart, Rajendra Prasad Kalakodimi
  • Patent number: 11013230
    Abstract: A vial is described herein that comprises a tubular body which comprises an opened end, a closed end, and a cavity, wherein the opened end is located at one end of the tubular body and the closed end is located at an opposing end of the tubular body. The tubular body further comprises a tear line located therein, wherein the tear line extends across at least a portion of one side of the tubular body, across the closed end, and across at least a portion of another side of the tubular body. In addition, the tubular body further comprises two flanges extending from the closed end, wherein the two flanges are configured to separate from one another outwardly from the tubular body and apply a force to break-open at least a portion of the tear line to open at least the closed end of the tubular body.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: May 25, 2021
    Assignee: Corning Incorporated
    Inventor: Michael Kurt Schaefer
  • Patent number: 11016359
    Abstract: In one aspect of the present invention, a hydrogen occlusion body includes: a hydrogen occlusion layer containing a material whose optical property reversibly changes upon hydrogenation and dehydrogenation; and a catalyst layer containing a palladium-ruthenium alloy.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: May 25, 2021
    Assignee: National Institute of Advanced Industrial Science and Technology
    Inventors: Yasusei Yamada, Kazuki Yoshimura
  • Patent number: 11009518
    Abstract: There is provided an automated analyzer which can eliminate static charge on receptacles storing analytes or reagents to thereby offer improved accuracy of analysis. The automated analyzer comprises: a receptacle carrier mechanism operative to hold a plurality of receptacles storing liquid and to carry the held receptacles in a given direction; a reader device for reading identification information of the receptacles carried by the receptacle carrier mechanism; a static eliminator for eliminating static charge on the receptacles carried by the receptacle carrier mechanism; and an input/output controller for causing the static eliminator to carry out the elimination of the static charge in synchronism with successive reading by the reader device of the identification information of the receptacles carried by the receptacle carrier mechanism.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: May 18, 2021
    Inventor: Takeshi Kitamura
  • Patent number: 11007517
    Abstract: A sub-1 ?L pipette having a small diameter metal tube that is concentrically located within the tip mounting shaft/portion of the pipette and extends from the distal end thereof by some predetermined distance so as to seal against the interior of a pipette tip that is installed to the tip mounting portion. The use of a small diameter metal tube and sealing of the metal tube against the inner surface of the pipette tip near a distal opening of the pipette tip allows for a minimal ullage volume.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: May 18, 2021
    Assignee: Mettler-Toledo Rainin, LLC
    Inventor: James S. Petrek
  • Patent number: 11000851
    Abstract: A method for reconstituting a lyophilized reagent contained within a reagent well comprises the steps of drawing a diluent into a pipette tip attached to an automated pipettor and dispensing the diluent into the reagent well containing the lyophilized reagent. The reagent well has an internal side wall, a bottom wall, and an open upper end and includes one or more retention features disposed about the periphery of the internal side wall and defining a central opening into the well that permits passage of the pipette tip into the reagent well. The one or more retention features are integrally formed with the internal side wall, and each of the one or more retention features extends over a portion of the lyophilized reagent, thereby retaining the lyophilized reagent within the reagent well.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: May 11, 2021
    Inventor: Byron J. Knight
  • Patent number: 11002717
    Abstract: A device for automated characterization of radioactive analytes that provides an integrated system with liquid handling and plate reading components. The device can be further configured to include a chromatographic subsystem. Also provided is a method of using such a device, providing addition of a radioactive sample and a sequence of operations involving the abovementioned components of the system. The system is configured with radiation shielding in such a way that manipulations of radioactive samples do not interfere with concurrent radioactive measurements.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: May 11, 2021
    Assignee: Trace-Ability, Inc.
    Inventors: Arkadij M. Elizarov, Artem Y. Lebedev
  • Patent number: 11001872
    Abstract: The present invention is related to the field of protein chemistry. In particular, mixed buffer compositions are formulated that allow an accurate identification of agent-induced changes in protein melting point temperatures. Such buffer compositions provide for methods that determine the specific effects of exogenous agents on protein stability, cryoprotective effects and/or protein quality control (e.g., synthesis and/or extraction purity validations).
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: May 11, 2021
    Inventor: Shawn Clark
  • Patent number: 11000845
    Abstract: Operability, accuracy, and safety when fitting a glass-made pipette tip to a pipette are improved. A pipette tip fitting adapter includes a hollow body having one end portion configured to serve as a tip inserting portion into which a pipette tip is inserted, and the other end portion configured to serve as a pipette inserting portion into which a pipette is inserted, and at an opening side of an inner circumferential surface of the tip inserting portion, seal portions projecting inward are formed in a circumferential direction. Accordingly, a pipette tip that is long and heavy like a glass tip can be held.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: May 11, 2021
    Assignee: A&D COMPANY, LIMITED
    Inventors: Chika Ariga, Yuji Fukami, Hisanori Oda
  • Patent number: 10989722
    Abstract: There is provided an electrical measuring container of a biological sample in a liquid phase, including at least a biological sample holding section that accommodates a biological sample in a liquid phase and made of a resin, and an electrical conductive section fixed to the biological sample holding section. In a state in which a portion of the electrical conductive section is buried in the biological sample holding section, the biological sample holding section and the electrical conductive section are integrally formed with each other.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: April 27, 2021
    Inventors: Yoichi Katsumoto, Marcaurele Brun, Yoshihito Hayashi
  • Patent number: 10987674
    Abstract: An apparatus includes a substrate, a first heating element, and a second heating element. The substrate includes a first portion, a second portion, and a third portion that is between the first portion and the second portion. The first portion is characterized by a first thermal conductivity, the second portion is characterized by a second thermal conductivity, and the third portion is characterized by a third thermal conductivity. The third thermal conductivity is less than the first thermal conductivity and the second thermal conductivity. The first heating element is coupled to the first portion of the substrate, and is configured to produce a first thermal output. The second heating element is coupled to the second portion of the substrate, and configured to produce a second thermal output. The second thermal output is different from the first thermal output.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: April 27, 2021
    Assignee: Visby Medical, Inc.
    Inventors: Boris Andreyev, Brian Ciopyk, Victor Briones, Jonathan Hong, David Swenson, Gregory Loney, Adam De La Zerda, Steven Chu
  • Patent number: 10989728
    Abstract: A system includes a reagent selector valve controllable to select a reagent flow path from a plurality of reagent flow paths, and a pump coupled to the reagent flow path to draw a liquid through the reagent flow path in accordance with a prescribed test protocol. The system includes a discharge flow path to expel the drawn liquid, and a flow meter to measure liquid displaced by the pump and that outputs data representative of the measured flow. The system also includes a processor to access the data and to determine a volume of the liquid displaced by the pump.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: April 27, 2021
    Assignee: ILLUMINA, INC.
    Inventors: Bradley Kent Drews, Kevin James Cappa
  • Patent number: 10976332
    Abstract: There is provided a receptacle carrier unit and automated analyzer capable of suppressing generation of temperature nonuniformities among liquid aliquots received in plural receptacles without increasing the parts count. The receptacle carrier unit has a turntable, a turntable drive, a cool box, a cooling portion, and a control section. The control section controls the turntable drive, based on the number and installation locations of the receptacles installed in the cool box and on temperature distribution information, to homogenize the effects that the individual receptacles receive from the cool box.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: April 13, 2021
    Assignee: JEOL Ltd.
    Inventor: Hideaki Yamamoto
  • Patent number: 10976260
    Abstract: An electrochemiluminescence immunoassay system and a flow-through cell unit (1) thereof. The flow-through cell unit (1) comprises a working electrode (12), a counter electrode (11) and a reference electrode (13), wherein the working electrode (12) and the counter electrode (11) are vertically provided, and there is a liquid flow path between the two electrodes. When an electrochemical reaction occurs, and when reactants are evenly distributed on the working electrode (12) for a test. After the flow-through cell is cleaned, the liquid flow path is unblocked, so that the cleaning effect is better. A porous structure is provided on a connection surface where the reference electrode (13) is in communication with the liquid flow path, and the porous structure makes the reference electrode (13) have a good electrical conductivity, and prevents the reference electrode (13) from early ageing, and improves the durability of the flow-through cell unit (1).
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: April 13, 2021
    Inventor: Jun Qin
  • Patent number: 10967377
    Abstract: A multi-well plate allows for improvement in accuracy of experiments or tests. The present invention relates to a multi-well plate comprising: a top portion placed in a horizontal direction; a bottom portion opposing the top portion in a direction crossing the horizontal direction; and wells each recessed from the top portion toward the bottom portion, wherein the wells are horizontally arranged in a matrix with rows and columns, and each well has an opening formed at the top portion, and a peripheral wall extending from a periphery of the opening to the bottom portion. In the multi-well plate, at least two wells respectively include marks each containing at least one symbol, and each mark is placed at an opening peripheral wall end portion close to the corresponding opening.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: April 6, 2021
    Inventor: Yoshio Kato
  • Patent number: 10969324
    Abstract: An acoustic separation device for reagent manipulation a standing acoustic including a wave generating device and pairs of perforated pseudo walls comprising a longitudinal standing bulk acoustic wave (LSBAW) channel. The LSBAW channel provides local pressure field amplification to overcome drag forces arising from reagent flow. Further, method for manipulating a reagent under continuous flow conditions microcarrier particles locally confined in an acoustic separation device comprising an inlet and an outlet, a fluid routing layer coupled to a channel, a plurality of loading wells configured to hold a plurality of substances required for a desired synthesis, and a controller configured to distribute the plurality of substances held by the loading wells in a desired sequence. The device for antibody manipulation further comprises an ultrasound actuator, and a channel wherein the channel is separated from the ultrasound actuator.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: April 6, 2021
    Assignee: Washington University
    Inventors: Mikhail Berezin, John Mark Meacham, Michael Binkley