Abstract: Systems and devices with enhanced stability to kinetic impact for the containment of cryogenically preserved material. A device comprising a vessel with increased surface to volume ratio when compared to cylindrical vessels of like capacity, and further comprising a material that remains resistant to shock and impact at cryogenic temperatures while providing a continuous barrier of a single material surrounding the vessel contents. The device further comprising a design that may be readily modified to include internalized sensors, enhanced interfacing to external instruments, provide optimized thaw rate, and post-thawing sample processing capabilities.

Abstract: A compact sorting flow cytometer system includes a fluidics system having a flow cell and a deflection chamber in communication with the flow cell and a droplet deposition unit (DDU) system in communication with the deflection chamber. The defection chamber receives drops in a stream of a sample biological fluid with one or more biological cells or particles and selectively deflect the drops in the stream. The DDU system is in communication with the deflection chamber to receive the selectively deflected drops into one or more containers. The DDU system includes a case forming a portion of a containment chamber. When closed, one or more doors seal and close off the containment chamber from an external environment. Air can be evacuated from the containment chamber by one or more fans in one or more tunnels. Air can be conditioned by a thermoelectric cooling array between the containment chamber and an air conditioning chamber that is moved by one or more fans.

Abstract: An article of manufacture includes an array of distinct and separate regions with respective pharmaceutical compounds located thereon. The array of distinct and separate regions includes a first region with a first set of one or more pharmaceutical compounds located thereon; a second region, that is distinct and separate from the first region, with a second set of one or more pharmaceutical compounds, that is distinct from the first set of one or more pharmaceutical compounds, located thereon; and a third region, that is distinct and separate from the first region and the second region, with a third set of one or more pharmaceutical compounds, that is distinct from the first set of one or more pharmaceutical compounds and the second set of one or more pharmaceutical compounds, located thereon.

Abstract: A substrate holder includes a base configured to receive a substrate; a cover configured to mateably engage with the base, the cover defining an opening formed by inner sidewalls; and a removable insert defining a surface, the removable insert being configured to be received within the opening of the cover. The removable insert includes a gasket; a projection coupled to the gasket; and at least two insert tabs extending from opposite sides of the removable insert, each insert tab being configured to engage with at least one of the inner sidewalls forming the opening of the cover.

Abstract: There is provided methods and systems for disaggregation and deagglomeration of small scale materials such as carbon nanotubes by cavitation of a treatment substance. The treatment substance may be a substance such as CO2 which is capable of undergoing phase changes. Systems must be capable of withstanding high pressures, and cavitation may be done by ultrasound, mechanical agitation, injection of a jet stream, or other methods. Materials treated via the methods of the invention may be removed without the use of chemical surfactants or other chemical modification means, and may be further used in a battery.

Abstract: The disclosure provides cartridges that are pre-loaded with reagents for performing antimicrobial susceptibility testing (AST) and FISH testing. Cartridges of the disclosure include various incubation wells loaded with different antimicrobial agents for differential growth analysis. Imaging wells with species-specific microbial probes, fluorescent tags, magnetic particles and dye-cushion layers allow for tagging and imaging of target microbes for differential growth analysis.

Abstract: A milking system with a milking device, a milk line, and a sampling and analysis device to sample and analyse the milk are disclosed. The sampling and analysis device includes a control unit, a tape wound on a tape reel, and including a base material with a series of reagent pads arranged to provide a detectable response in the presence of a substance in the sample, a tape mover to move and unwind the tape, a dosing device to provide a part of the sample onto one of the reagent pads, and an optical sensor device to detect optical radiation from said reagent pad with said sample, and to analyse the detected optical radiation to provide an indication of a presence or concentration of said substance. The dosing device includes a displaceable nozzle with a supply line for supplying the sample to the nozzle. The nozzle is arranged for supplying the sample upwardly to the reagent pad.

Abstract: Provided herein are systems, devices, and methods for performing optical multianalyte detection in a sample, such as a human blood sample. The system processes sample in a single-use support pack that holds the blood sample and contains pipette tips, buffers, reagent preparation wells and a monolayer. Sample is transferred from the sample pack to a single-use disc consumable that contains microwells pre-filled with dried chemistries, plasma separation features, and a hematocrit channel. The instrument comprises a cell imager, an absorbance module comprising a spectrophotometer, a fluorescent laser scanning module, and a camera. The system uses only a small amount of blood from a single heparinized sample, to simultaneously provide results for a full panel of routine blood tests spanning elecochemistry, clinical chemistry, hematology, immunoassays and combinations thereof.

Abstract: A surface bio-contamination assay kit (1) comprising a disposable swab cartridge (2) comprising a swab (29); a sampler (3) designed to removably receive the cartridge (2) and to wipe the cartridge swab (29) on a surface to be collect a sampled, along a predetermined sampling path (4) designed to cover a predetermined surface area; and a bio-contamination meter (5) designed to removably receive the cartridge (2) after sampling and to measure bio-contamination of the collected sample on the cartridge (2).

Abstract: A cover member for use in the treatment of a sample on a substrate is disclosed. The cover member has fluid flow features and is adapted for use in an instrument, such as a laboratory instrument. The cover member comprises at least one orientation feature detectable by the instrument for ascertaining an orientation of the cover member. An automated method for detecting orientation of a cover member in a sample treatment assembly is also disclosed, in which a processor compares data corresponding to one or more images collected from the sample treatment assembly, with data representing a reference image to determine if a cover member is in the sample treatment assembly.

Abstract: A cell manipulation panel includes a pixel array defining multiple pixels, an insulating layer forming multiple vias, and a cell gap provided with a fluid medium having cells therein. Each pixel has a TFT and corresponds to a corresponding via. The TFT includes a gate electrode, a first electrode, and a second electrode partially exposed to the fluid medium through the corresponding via. For each pixel, in an operational mode, when the gate electrode is provided with an OFF signal and the first electrode is not grounded, the TFT is turned off, allowing one of the cells in the fluid medium to be captured in the corresponding via by a dielectrophoresis (DEP) force. When the gate electrode is provided with an ON signal and the first electrode is grounded, the TFT is turned on, and the second electrode is grounded to release the captured cell to the fluid medium.

Abstract: A method for indicating a sanitation status of a surface may comprise contacting a coating on a surface with a cleaning composition, wherein the coating comprises a chromic material and exhibits a baseline optical state under illumination with light having a first wavelength prior to contact with the cleaning composition and an altered optical state under illumination with light having a second wavelength after contact with the cleaning composition, the cleaning composition configured to induce a switch from the baseline optical state to the altered optical state; and illuminating the coating with the first wavelength of light, the second wavelength of light, or both, to reveal a sanitation status of the surface. Systems for indicating a sanitation status of a surface are also provided.

Abstract: A multi-chamber saliva-collection device is configured to segregate a saliva sample into at least two aliquots, each of the at least two aliquots being contained within a distinct chamber of the multi-chamber device, wherein the multi-chamber device is useful for performing an instant analyte test and a subsequent DNA confirmation to validate the identity of the tested individual. Related methods for using the device to obtain each of: an analyte test result, and a DNA confirmation of the identity of the individual from which the tested saliva sample, are also disclosed.

Abstract: A method and device are provided for detecting a target in a biological sample. The target binds to a solid phase substrate. First and second cavities in a plate are filled with an oil. The first and second cavities are in fluid communication with each other. The solid phase substrate is magnetically drawn sequentially from a drop of the biological sample in the first cavity, through the oil, into a drop of the reaction solution in the second cavity. A change in a parameter of the drop of the reaction solution indicates the presence of the target.

Abstract: A vented dual port centrifuge tube includes a tubular receptacle having upper and lower ends. A first common inlet and outlet port is formed in the upper end and a second common inlet and outlet port is formed in the lower end. A piston is sealably and slidably mounted within a chamber of the receptacle. A vent is supported in the upper end of the receptacle and a flexible vent pipe attached to the piston is communicably interconnected between the vent and a lower region of the chamber between the piston and the lower end of the receptacle. Air pressure in the lower region of the receptacle is equalized or neutralized as biological fluids and separated constituent components are introduced into and aspirated from the receptacle through the common inlet ports.

Abstract: There is provided a biological specimen separation instrument with which a biological specimen can be stably separated into a predetermined component.

Abstract: A filter insert, a sample vial incorporating a filter insert, a method of using a sample vial containing a filter insert for chemical analysis, and a sample vial kit including a filter insert. The filter insert includes a cylindrical body having a proximal end, a protrusion extending radially from the proximal end of the cylindrical body and configured to set on the open end of a sample vial, a distal end, a cavity extending longitudinally through the cylindrical body from the proximal end to the distal end, and a filter assembly coupled with the distal end of the cylindrical body.

Abstract: Apparatuses and methods for monitoring curing of photocurable material are disclosed. The methods generally include directing an ultraviolet cure light into a photocurable material, wherein the ultraviolet cure light causes the photocurable material to cure; directing a probe light into the photocurable material through an optical fiber during the cure; collecting a back reflection signal from the photocurable material with the optical fiber; and determining a refractive index change of the photocurable material during the cure.

Abstract: Reagent delivery systems, which can include a reagent trough and a pump system, are useful for delivering liquids to a laboratory workbench. Processing samples on the laboratory workbench can result in a large amount of liquid waste. Described herein are reagent troughs, pump systems, reagent delivery systems, waste management systems, and methods of using the same.

Abstract: Since a few kilovolts of an application voltage is necessary to take in a biological sample, an EWOD electrode, for example, is destroyed, and the electrode becomes non-reusable for moving a droplet. Therefore, an object of the present invention is to provide a biochemical cartridge usable for multiple times for taking in a biological sample by a capillary array, for example, and a biochemical analysis device using the biochemical cartridge. In order to solve the problem, the biochemical cartridge according to the present invention includes a passage through which a sample is transported, a plurality of electrodes disposed on the passage along a direction in which a sample is transported, the plurality of electrodes being provided to transport a sample, and an opening provided opposite to the plurality of electrodes disposed on a downstream side of the passage.