Patents Examined by Jill Warden
  • Patent number: 10989722
    Abstract: There is provided an electrical measuring container of a biological sample in a liquid phase, including at least a biological sample holding section that accommodates a biological sample in a liquid phase and made of a resin, and an electrical conductive section fixed to the biological sample holding section. In a state in which a portion of the electrical conductive section is buried in the biological sample holding section, the biological sample holding section and the electrical conductive section are integrally formed with each other.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: April 27, 2021
    Assignee: SONY CORPORATION
    Inventors: Yoichi Katsumoto, Marcaurele Brun, Yoshihito Hayashi
  • Patent number: 10976332
    Abstract: There is provided a receptacle carrier unit and automated analyzer capable of suppressing generation of temperature nonuniformities among liquid aliquots received in plural receptacles without increasing the parts count. The receptacle carrier unit has a turntable, a turntable drive, a cool box, a cooling portion, and a control section. The control section controls the turntable drive, based on the number and installation locations of the receptacles installed in the cool box and on temperature distribution information, to homogenize the effects that the individual receptacles receive from the cool box.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: April 13, 2021
    Assignee: JEOL Ltd.
    Inventor: Hideaki Yamamoto
  • Patent number: 10976260
    Abstract: An electrochemiluminescence immunoassay system and a flow-through cell unit (1) thereof. The flow-through cell unit (1) comprises a working electrode (12), a counter electrode (11) and a reference electrode (13), wherein the working electrode (12) and the counter electrode (11) are vertically provided, and there is a liquid flow path between the two electrodes. When an electrochemical reaction occurs, and when reactants are evenly distributed on the working electrode (12) for a test. After the flow-through cell is cleaned, the liquid flow path is unblocked, so that the cleaning effect is better. A porous structure is provided on a connection surface where the reference electrode (13) is in communication with the liquid flow path, and the porous structure makes the reference electrode (13) have a good electrical conductivity, and prevents the reference electrode (13) from early ageing, and improves the durability of the flow-through cell unit (1).
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: April 13, 2021
    Assignee: BEIJING UNIDIAG TECHNOLOGY INC
    Inventor: Jun Qin
  • Patent number: 10969324
    Abstract: An acoustic separation device for reagent manipulation a standing acoustic including a wave generating device and pairs of perforated pseudo walls comprising a longitudinal standing bulk acoustic wave (LSBAW) channel. The LSBAW channel provides local pressure field amplification to overcome drag forces arising from reagent flow. Further, method for manipulating a reagent under continuous flow conditions microcarrier particles locally confined in an acoustic separation device comprising an inlet and an outlet, a fluid routing layer coupled to a channel, a plurality of loading wells configured to hold a plurality of substances required for a desired synthesis, and a controller configured to distribute the plurality of substances held by the loading wells in a desired sequence. The device for antibody manipulation further comprises an ultrasound actuator, and a channel wherein the channel is separated from the ultrasound actuator.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: April 6, 2021
    Assignee: Washington University
    Inventors: Mikhail Berezin, John Mark Meacham, Michael Binkley
  • Patent number: 10967377
    Abstract: A multi-well plate allows for improvement in accuracy of experiments or tests. The present invention relates to a multi-well plate comprising: a top portion placed in a horizontal direction; a bottom portion opposing the top portion in a direction crossing the horizontal direction; and wells each recessed from the top portion toward the bottom portion, wherein the wells are horizontally arranged in a matrix with rows and columns, and each well has an opening formed at the top portion, and a peripheral wall extending from a periphery of the opening to the bottom portion. In the multi-well plate, at least two wells respectively include marks each containing at least one symbol, and each mark is placed at an opening peripheral wall end portion close to the corresponding opening.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: April 6, 2021
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventor: Yoshio Kato
  • Patent number: 10962560
    Abstract: A pipetting arrangement includes at least two sets of pipettes (9a; 9b; 9c; 9d). Each set of pipettes (9a; 9b; 9c; 9d) is operationally connected, via a controllable ON/OFF valve (11a; 11b; 11e; 11d) to a common aspiration port (7). Latter is connectable to a pumping arrangement. The valves (11a; 11b; 11e; 11d) are controlled by a timing-control unit (15) conceived to establish, by control of the valves (11a; 11b; 11e; 11d), the operational connections of the at least two sets of pipettes (9a; 9b; 9c; 9d) to the aspiration port (7) in a time-multiplexed manner.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: March 30, 2021
    Assignee: Tecan Trading AG
    Inventor: Pius Fink
  • Patent number: 10953445
    Abstract: Disclosed herein are single use indicators and methods for employing the same. Such indicators and their uses are directed towards identifying the discharge status of single procedure devices, which are typically, but not limited to, medical devices.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: March 23, 2021
    Assignee: VIANT AS&O HOLDINGS LLC
    Inventors: Biswa P. Das, Ashish Shah
  • Patent number: 10946374
    Abstract: Provided herein are pipette tips having a proximal region with grooves and panels configured to facilitate wall expansion or wall compression when a pipette tip is mounted onto and sealingly engages with an appropriately designed liquid dispensing device.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: March 16, 2021
    Assignee: BIOTIX, INC.
    Inventors: Peter Paul Blaszcak, Arta Motadel
  • Patent number: 10947578
    Abstract: An air sampling device is disclosed which includes one or more air sampling cassettes, with each cassette having a cassette internal diameter and a sample collection media disposed within the cassette internal diameter. The sum of the interior diameters of the air sampling cassettes is from about 2.5 mm to about 65 mm. The device also includes a sampling device casing having one or more air inlet orifices, an air outlet orifice, and an interior passageway in flow communication with both air inlet orifices and the air outlet orifice. One air sampling cassette is attached to each air inlet orifice. The device also includes a fan for drawing air through the air sampling cassettes and the interior passageway at an air flow rate. The device produces a noise level of less than 40 dBA, measured at a distance of 1 foot from the air outlet orifice, when the air flow rate is from about 0.5 to about 2.0 liters per minute. A method for air sampling is also disclosed.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: March 16, 2021
    Inventor: Edward Sobek
  • Patent number: 10945448
    Abstract: Described are methods of removing phospholipids and other off-flavor-causing compounds from edible proteins using a cyclodextrin treatment. The methods include treating soy protein with cyclodextrins such as ?-cyclodextrin to form cyclodextrin-compound complexes and then separating the resulting complexes from the protein. Optionally, prior to treating the protein with cyclodextrin, the protein is sonicated and then treated with a phospholipase, such as phospholipase A2. Versions of the methods described herein are capable of removing more than 99% of phospholipids from soy protein.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: March 16, 2021
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Srinivasan Damodaran, Akshay Arora
  • Patent number: 10935559
    Abstract: In some embodiments, the invention provides a container adapted for detecting hyperfibrinolysis or fibrinolysis in a blood sample using viscoelastic analysis comprising an interior having a coating comprises an inhibitor of fibrinolysis.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: March 2, 2021
    Assignees: Haemonetics Corporation, The Regents of the University of Colorado, a body corporate
    Inventors: Michael P. Chapman, Ernest E. Moore, Katherine M. Norem
  • Patent number: 10935485
    Abstract: In one aspect, a system for performing flow cytometry is disclosed, which comprises a laser for generating laser radiation for illuminating a sample, at least one detector for detecting at least a portion of a radiation emanating from the sample in response to said illumination so as to generate a temporal signal corresponding to said detected radiation, and an analysis module for receiving said temporal signal and performing a statistical analysis of said signal based on a forward model to reconstruct an image of said sample.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: March 2, 2021
    Assignee: BD BIOSCIENCES
    Inventors: Eric Diebold, Keegan Owsley, Jonathan Lin, Matthew Bahr
  • Patent number: 10928406
    Abstract: This invention relates to a cartridge assembly tray for conducting automated biochemical tests, such as immunoassay tests. The tray comprises a base member, a hinged frame and a locking mechanism. The base member includes a plurality of slots within the base member. Each of the plurality of slots is to receive a test cartridge. The hinged frame is coupled to the base member. The hinged frame is capable to rotate to an opened position or a closed position. The hinged frame includes a horizontal push bar configured to apply a downward force to test cartridges received in the plurality of slots when the hinged frame is in the closed position. The locking mechanism is to lock the hinged frame in the closed position when the hinged frame rotates to the closed position.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: February 23, 2021
    Assignee: Access Medical Systems, LTD.
    Inventors: Hong Tan, Yongli Ren, Ming Xia, Genqian Li
  • Patent number: 10921340
    Abstract: A detection chip comprises a flow path and a liquid injection unit connected to one end of the flow path, and by means of a pipette chip inserted into the liquid injection unit of the detection chip, the liquid in the liquid injection unit is aspirated to remove the liquid in the flow path. Subsequently, the pipette chip is made to carry out a reciprocating motion two or more times along the axial direction of the pipette chip, and at least one of those times, the fluid in the liquid injection unit is aspirated by the pipette chip. Subsequently, a liquid is injected from the pipette chip into the liquid injection unit, and the liquid is introduced into the flow path.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: February 16, 2021
    Assignee: KONICA MINOLTA, INC.
    Inventors: Youichi Aoki, Atsuo Iwashita
  • Patent number: 10919019
    Abstract: The present disclosure relates to an apparatus for the synthesis of chemical compounds, e.g., radiopharmaceutical compounds. In one implementation, the apparatus may include a synthesis module and a loading module configured to receive multiple chemical cassettes having reagents and a transfer mechanism. The apparatus may further include a shifter configured to move the cassettes from a location on the loading module to a location connected to the synthesis module on an interface configured to connect to the cassette.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: February 16, 2021
    Assignee: Ion Beam Applications S.A.
    Inventors: Michel Guyette, Jozef Comor
  • Patent number: 10906035
    Abstract: A sample processing tubule is provided including, from a proximate to a distal end, an opening through which a sample is introducible, at least three segments, and an extraction port operatively connected to a distal segment of the at least three segments. The extraction port enables extraction of a reaction mixture in the distal segment of the tubule without piercing the tubule or one or more seals separating each of the segments in the tubule.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: February 2, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventor: Thomas Drechsler
  • Patent number: 10906020
    Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceuti
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: February 2, 2021
    Assignee: CARDINAL HEALTH 414, LLC
    Inventors: Dennis Eshima, Mehmet Husnu, James Stone, Derrick Alcaide, Joseph E. Zambanini, Thomas A. Klausing, Chad E. Bouton, Henry Padgett, Brian C. Kelley, Scott N. Danhof, David A. Holley, Jeffrey T. Stroup, James B. Gleeson, Eric Hassenpflug, James A. Prescott, Herman Benecke, Daniel B. Garbark
  • Patent number: 10894270
    Abstract: A liquid jet discharge device includes: a narrow tube having a tube shaped body that is open at both ends, and in which a discharge liquid being disposed therein, the discharge liquid contacting at least at an inner face of the narrow tube at a contact angle of less than 90 degrees; a container in which a transmission medium being disposed at a base side thereof where one end of the narrow tube is disposed, so as to enable pressure to be transmitted to the discharge liquid; an adjustment mechanism that causes a liquid surface of the discharge liquid inside the narrow tube and an interface of the transmission medium outside the narrow tube and inside the container to be staggered in position along an axial direction of the narrow tube; and a generation mechanism that generates a pressure wave in the transmission medium such that a liquid jet is discharged from the discharge liquid inside the narrow tube.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: January 19, 2021
    Assignee: NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY
    Inventors: Yoshiyuki Tagawa, Hajime Onuki
  • Patent number: 10888261
    Abstract: A specimen transfer device adapted to receive a blood sample is disclosed. The specimen transfer device includes a housing and an actuation member. A deformable material is disposed within the housing and is deformable from an initial position in which the material is adapted to hold the sample to a deformed position in which at least a portion of the sample is released from the material. A viscoelastic member is disposed within the housing between the material and the housing and between the material and the actuation member. The viscoelastic member is engaged with the actuation member and the material such that movement of the actuation member from a first position to a second position deforms the material from the initial position to the deformed position.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: January 12, 2021
    Assignee: Becton, Dickinson and Company
    Inventors: Milan Ivosevic, Bradley M. Wilkinson, C. Mark Newby, Kishore K. Bokka Srinivasa Rao
  • Patent number: 10888260
    Abstract: A biological fluid collection device that allows a blood sample to be collected anaerobically is disclosed.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: January 12, 2021
    Assignee: Becton, Dickinson and Company
    Inventors: Adam Edelhauser, Anthony V. Torris, Robert G. Ellis, Bradley M. Wilkinson, Joseph Nathan Pratt, Bartosz Marek Korec