Abstract: An analysis device employs an analysis kit including a chip provided with a capillary through which a sample flows and a cartridge superimposed on the chip and provided with a liquid reservoir. The analysis device includes a guide-in section into which the analysis kit is guided, a placement section on which the analysis kit placed so as to be supported, a pusher member that pushes the analysis kit from one side face of the analysis kit, contact members that oppose another side face on an opposite side in the horizontal direction to the one side face of the analysis kit placed on the placement section, and contact the other side face of the analysis kit being pushed in by the pusher member so as to position the analysis kit in the horizontal direction, and a measurement member that measures a component present in the sample in the analysis kit.

Abstract: A container carrier for carrying a sample container along a track is presented. The container carrier comprises a holding portion for receiving and holding a sample container and a base portion. A radio frequency identification (RFID) tag containing identifying information is provided with an antenna for wireless communication of the RFID tag with a reader device of the diagnostics system to read the identifying information. The RFID tag is on the holding portion. An arrangement for a diagnostics system is provided comprising container carriers and a track with a transport mechanism for moving the container carriers along a transportation lane. The transport mechanism defines a transport plane along which the container carriers move. A reader device reads the identifying information from the RFID tags. The reader device comprising a reader antenna above the transport plane to generate and emit a reader field for wireless communication with the RFID tag's antenna.

Abstract: Antibody-free processes are disclosed that provide accurate quantification of a wide variety of low-abundance target analytes in complex samples. The processes can employ high-pressure, high-resolution chromatographic separations for analyte enrichment. Intelligent selection of target fractions may be performed via on-line Selected Reaction Monitoring (SRM) or off-line rapid screening of internal standards. Quantification may be performed on individual or multiplexed fractions. Applications include analyses of, e.g., very low abundance proteins or candidate biomarkers in plasma, cell, or tissue samples without the need for affinity-specific reagents.

Abstract: The invention discloses a reaction incubation device, an immunity analyzer and a reaction incubation method. The reaction incubation device comprises a reaction unit (10), which is used for bearing and incubating a reaction container; and a transfer unit (20), which is used for removing the reaction container in and out of the reaction unit (10). The reaction unit (10) comprises a rotating device (11). The rotating device (11) is provided with an incubation position which increases a predetermined angle ? at an interval of fixed time T along with the rotating device (11). The transfer unit (20) removes the reaction container out of the incubation position according to variable incubation time ti. With the device, flexible and variable incubation time can be achieved, and the problem of complicated control, low reliability and that high-speed automation is not easy to achieve in the prior art can be solved.

Abstract: An applicator or applicator system used for handling samples in an analytical laboratory setting. In particular, the invention the applicator or applicator system is capable of capping an analytical sample tube by applying a capping material to an opening of an analytical sample vessel, the applicator or applicator system including g a dispenser configured to dispense a substantially continuous length of a capping material, such that a region of the substantially continuous length of capping material is located on or about an opening of an analytical sample vessel held in a predetermined orientation.

Abstract: A device and a method of using the device for improving sensitivity, speed, and easy-to-use of a colorimetric assay of a liquid sample are provided. The device includes a first plate and a second plate, spacers, and a textured surface. The two plates each have a sample contact surface and are movable relative to each other into an open configuration or a closed configuration. The sample is deposited on one or both plates in the open configuration. Thereafter, the closed configuration is formed where the plates compress at least part of the deposited sample into a continuous layer. The textured surface is disposed on the sample contact surface of the second plate and has a textured structure that scatters light, from which an optical signal such as a colorimetric or fluorescent signal can be obtained for analyzing the sample.

Abstract: Disclosed is a specimen analyzer configured to perform analysis on a specimen for a plurality of measurement items, the specimen analyzer including a measurement section configured to perform a specimen measurement for measuring a measurement sample prepared from a specimen and a reagent corresponding to a measurement item, and configured to perform a quality control measurement for measuring a measurement sample prepared from a quality control substance and a reagent corresponding to a measurement item; and a controller programmed to set a quality control for each measurement item, from a quality control group that includes at least two types of quality controls selected from a first quality control in which the quality control measurement is performed at a predetermined time, a second quality control in which the quality control measurement is performed every time the specimen measurement is performed a predetermined number of times of measurement, and a third quality control in which the quality control me

Abstract: A pretreatment device for performing pretreatment using a liquid sucked by a probe from an inside of a septum-attached container includes: a container holding unit which has a space for accommodating the septum-attached container and is provided with a hole into which the probe is inserted with respect to a septum of the septum-attached container to be stored; an installation unit in which the container holding unit is detachably installed; and a fixing unit which fixes the container holding unit to the installation unit in a state where the container holding unit is detachably installed in the installation unit, to solve the above-described problem.

Abstract: A cryostat chuck is disclosed. The disclosed chuck may be configured for use in a frozen-sectioning device, such as a cryostat, or other suitable host equipment. The disclosed chuck may include a tab portion configured, in accordance with some embodiments, to provide a means for gripping the chuck by hand (e.g., human or robotic) or by a tool or other desired interfacing element. The tab portion may serve to distance a user's hand or piece of gripping equipment from the sharp microtome of the host cryostat, reducing the opportunity of sustaining bodily injury or equipment damage. Moreover, the tab portion may provide a means by which the cryostat chuck may be manipulated when inserting, adjusting, or removing the chuck prior to, during, or after engagement by the cryostat (or other suitable host equipment).

Abstract: Provided herein is a method for isolating high molecular weight (HMW) DNA using beads that are at least 200 ?m in diameter that utilizes a device for retaining the beads and where the purified DNA eluant exits the device without shearing the HMW DNA. In some embodiments, the method comprises precipitating the DNA onto the beads, washing the beads in the device, and then eluting the DNA from the beads therein while substantially avoiding shear. Compositions and kits for practicing the method are also provided.

Abstract: The present disclosure provides systems and methods for characterizing the interaction of free radicals with various materials and the use of known interactions to isolate free radical generation from free radical interaction with a target molecule.

Abstract: A device for aggregating cells includes a cavity. The cavity includes a plurality of microwells for receiving at least one cell. Each of the microwells includes a vertical sidewall and a curved bottom. The microwells are made in a hydrogel layer. Each of said microwells has a diameter and an interwell distance between one microwell and another microwell, wherein a ratio for the interwell distance to the diameter is less than or equal to 1/10.

Abstract: Aspects of the present disclosure include methods and systems for automated analysis of clinical fluid samples, such as urine, blood, or cerebral spinal fluid, where the number of fluid samples in increased or optimized without negatively impacting the accuracy of the analysis of a given fluid sample.

Abstract: A method to provide control samples for validating a diagnostic test within a laboratory system is presented. The laboratory system comprises an aliquoting device, a storage, a transport system, at least two analyzers, and a control unit. A total number of control sample aliquots and an aliquot volume for each control sample aliquot is determined based on a validation time schedule. A provided total control sample volume is aliquoted into the determined total number of control sample aliquots with the determined aliquot volumes. The generated control sample aliquots are transported to one or more of the at least two analyzers according to the validation time schedule.

Abstract: A system for detecting mold includes a housing defining a chamber and an opening through a surface. The system includes a movable grate for selectively covering the opening. The system includes a substrate treated to promote mold growth. The system includes a mechanism for moving the substrate to move previously unexposed portions into the chamber. The system includes a thermal control system to maintain predetermined environmental conditions in the chamber. The system includes a sensor configured to detect mold growth in the chamber. The system includes a mold suppressor to kill mold in the chamber when activated. The system includes a controller to coordinate operation of the components to detect mold growth in an environment.

Abstract: A method for evaluating and controlling roasting and degree (level) of roast in food items including but not limited to: coffee, cocoa, beans, nuts, grains and seeds, involves collecting spectra of the gases (including water vapor) emitted during roasting in the mid-infrared region using either mid-infrared source or visible light to include Raman scattering. The changes in the spectra, due to absorption by molecular vibrations in the gases emitted during roasting are evaluated in real time during roasting. These data may be processed in frequency or time domain. The spectra and change in spectra are correlated with a roasting profile to mark the inception of roasting, progress of roasting and maturity/achievement of degree of a roast. The information can be transmitted to the roaster or controller to monitor the roasting progress and can be used to adjust parameters as desired during roasting.

Abstract: A system for second lab testing of genetic materials is presented. The system includes a computing device configured to receive a specimen from a human subject and perform a smart test on the specimen. The smart test includes a first lab test configured to generate a first lab test identifying a first disease agent and a second lab test configured to generate a second lab test identifying a second disease agent, wherein identifying the second disease agent includes generating a second lab machine-learning model, training the second lab machine-learning model as a function of a second lab test training set, and outputting, as a function of the second lab machine-learning model, the second lab test result using specimen data as an input. The computing device is further configured to generate a smart test result as a function of the smart test.

Abstract: A sensor for detecting a target pathogen (e.g., a virus or a bacterium) in a specimen is disclosed, which includes at least two sensing units one of which is configured to detect at least one protein (such as a structural protein) associated with the target pathogen and another one is configured to detect at least one genetic component (e.g., an RNA or a DNA segment) associated with that pathogen (e.g., an RNA segment that is unique to that pathogen).

Abstract: A fully integrated miniaturized optical biosensor and methods of making the same are disclosed. The biosensor may include a fluid transport system and an optical system.

Abstract: The automatic analysis system comprises an analysis device which introduces sample containers which have been placed at a predetermined placement location into an analysis unit to perform analysis on the samples, and a management device which has a function of transmitting identification information for a sample to said analysis device when an analysis request has been made for that sample. The analysis device comprises a sample information management unit which retains sample identification information transmitted from the management device as analysis-requested sample information and retains identification information for samples which have been analyzed by the analysis unit as analysis-completed sample information.