Abstract: Lancet assemblies for puncturing the skin and creating an incision. Upon activation, the disclosed assemblies are configured to move through a firing sequence in which a puncturing instrument extends through an aperture in the device and then is retracted back into a housing of the device and cannot be re-fired. The assemblies are designed so that the aperture in contact with the incision site does not move relative to the incision site during the firing sequence. Accordingly, the tolerance of the assembly is reduced and the reliability of the incisions created by the assembly, including the depth and width of such incisions, is increased.

Abstract: A method of producing a modified acellular tissue matrix (mATM) from an acellular tissue matrix (ATM), where the mATM has a reduced stretchiness relative to the ATM, without substantially compromising its associated structural or functional integrity. The method includes providing an acellular tissue matrix (ATM) and exposing the ATM to elastase for a period of time.

Abstract: A method of treating a sinus cavity of a subject includes advancing a distal portion of a light source through a drainage pathway of a sinus cavity and into the sinus cavity and visually observing a transdermal light emitted from the light source. A distal portion of a substantially rigid inner guide member of a balloon dilation catheter is advanced into the drainage pathway, the balloon dilation catheter including a movable shaft including a balloon that is slidably mounted on the substantially rigid inner guide member. The movable shaft and balloon are advanced distally over the substantially rigid inner guide member to place a portion of the balloon in the drainage pathway whereby the balloon is inflated.

Abstract: An insertion system for inserting an implantable electrode carrier includes an insertion instrument having a housing with a proximal end and a distal end, and a vibration generator coupled adjacent to the housing. The proximal end is configured to hold the implantable electrode carrier. The vibration generator is configured to generate vibrations in at least a portion of the electrode carrier.

Abstract: A minimally invasive surgical instrument is provided, comprising a shaft and an end effector connected to the shaft, wherein the end effector operates in the pitch or yaw direction against the shaft when a first wire and a second wire conveyed through the shaft operate cooperatively according to a first aspect; and the end effector operates in the roll direction against the shaft when the first wire and the second wire operate cooperatively according to a second aspect, wherein the first wire and the second wire operate in the same direction when the cooperative operation is according to one aspect of the first aspect and the second aspect; and the first wire and the second wire operate in the opposite directions when the cooperative operation is according to the other aspect of the first aspect and the second aspect.

Abstract: A balloon-expandable shunt is disclosed for shunting a vessel which has a graft with two ends and at least one expandable support element supporting the graft from within along a length at or near at least one of its ends. The shunt is bifurcated at an aperture that leads to a side-channel and which has a closed configuration and an open configuration such that when the aperture is in the closed configuration it defines a clot-resistant inner graft surface and when the aperture is in the open configuration it is configured to provide access to the shunt for a balloon that actuates the expandable support element. A balloon configured for actuating the shunt is also disclosed. A kit has a bifurcated graft with at least one expandable support element and a balloon for actuating the at least one expandable support element.

Abstract: A laparoscopic scalpel includes a shaft and a recess disposed in a surface of the shaft proximal to a distal end of the shaft. A blade is attached to the shaft. The blade includes a cutting edge having a portion exposed by the recess and oriented outwardly from the recess. A proximal end of the portion of the cutting edge exposed by the recess is disposed further from the surface than is a distal end of the portion of the cutting edge exposed by the recess.

Abstract: An apparatus enables concurrent restoration of a gastroesophageal valve and tightening of the lower esophageal sphincter. The apparatus comprises a longitudinal member having a distal end arranged to be received within a stomach, a tissue shaper at the distal end of the longitudinal member that forms a gastroesophageal valve from stomach tissue, and a tissue gatherer that gathers fundus tissue at or aboral to the gastroesophageal junction to reduce an esophageal opening into the stomach and tighten the lower esophageal sphincter. A fastener deployer then deploys at least one fastener pair to maintain both the restored gastroesophageal valve and the tightened lower esophageal sphincter.

Abstract: An ultrasonic surgical instrument includes a shaft, a first jaw having a proximal end at the distal end of the shaft, a second jaw and an ultrasonic waveguide. The first jaw has an internal trough running through the proximal end of the first jaw and a surface on either side of the trough. The second jaw has a surface facing the surface of the first jaw. The waveguide extends beyond the shaft and slidably engages the trough and has a blade with a tissue compressing surface upwardly sloping proximally from a distal end thereof the blade and having an upper portion and a substantially horizontal top surface portion at the upper portion. The tissue compressing surface and/or the top surface portion forms a cutting surface. When the jaws compress tissue therebetween, the blade slides within the trough to further compress and cut the compressed tissue as the blade moves distally.

Abstract: Systems and methods for medical interventional procedures, including approaches to valve implantation. In one aspect, the methods and systems involve a modular approach to mitral valve therapy.

Abstract: The device is intended to be positioned in a sealed introducer arranged in the thoracic cavity between two ribs in order to penetrate into the left ventricle, passing through the apex of the heart. According to the invention, the device includes a body having a handle and at least one control member capable of acting on an assembly for installing and securing a braid to the mitral annulus by means of suturing elements, the assembly has a mechanism capable of enabling the extraction of a suture through the mitral valve while also being capable of enclosing the braid and becoming anchored to the periphery of the mitral annulus under the clamping effect of the suture, exerting two opposing pressure-bearing forces.

Abstract: An elastic percutaneous elastic introducer sheath is disclosed which can locally expand and reduce to accommodate a transcatheter medical device. The elastic introducer sheath includes a non-circumferentially continuous elastic frame, a liner, and a jacket.

Abstract: A catheter (14), advanced toward an anatomical site, has a proximal end and a steerable distal end. An anchor (32, 2332) is advanced through the catheter. An anchor driver (36) drives the anchor out of the catheter's distal end (104), anchoring the anchor at the site. A first constraining member (1602, 1652) engages tissue, and inhibits, after the anchor has been driven out of the catheter and before the anchoring, movement of at least the anchor driver's distal end, on a first axis between the anchor driver's distal end and a site at which the first constraining member engages the tissue. A second constraining member (26) inhibits, after the anchor has been driven out of the catheter and before the anchoring, movement of at least the anchor driver's distal end, on a second axis. Other embodiments are also described.

Abstract: An injector (1) for folding and injecting into the eye of a patient a flexible intraocular lens, the injector comprising an assembly of an injection nozzle (202), a lens compartment that holds an unfolded flexible intraocular lens (400) and is in communication with the injection nozzle, an injector body (3) communicating with the lens compartment and a plunger (2) that is inserted in the free end of the injector body, wherein lens compartment and injector body comprise a mechanism whereby the lens is first folded by forces compressing the lens in a non-axial direction in response to an axial movement of the plunger over a first distance and is subsequently expelled from the injector through the injection nozzle in response to an axial movement of the plunger over a second distance.

Abstract: A reduced-pressure, deep-tissue closure device for applying a closing force on a deep tissue includes a contractible matrix that is formed with a first plurality of apertures and which has a first side and a second, inward-facing side. The contractible matrix is for disposing proximate to the deep tissue. A reduced-pressure source is fluidly coupled to the contractible matrix and operable to deliver reduced pressure to the contractible matrix. When under reduced pressure, the contractible matrix grips the deep tissue adjacent the contractible matrix and provides a closing force on the deep tissue. A system and method are also presented.

Abstract: A stent delivery system includes a pusher guide wire for delivering a stent having an anchor member. The pusher guide wire includes a core shaft, a coil body that is disposed around a distal portion of the core shaft and includes a tapered portion having an outer diameter that decreases toward a distal end of the coil body, and a protruded portion fixed to the coil body at a position distal to the tapered portion. The anchor member is positioned between the tapered portion and the protruded portion when the stent is delivered using the pusher guide wire. The anchor member can therefore be pushed in the distal direction by the tapered portion of the coil body. Moreover, the stent can be retracted into the catheter by pulling the pusher guide wire in the proximal direction so that the protruded portion contacts the anchor member.

Abstract: A minimally invasive system and method for providing weight loss by inducing the feeling of satiety whereby an intragastric device is inserted into the gastric lumen via the esophagus and an external magnetic device is used as needed to magnetically attract the intragastric device towards the inner wall of the stomach and impart tactile stimulation sufficient to induce the feeling of satiety.

Abstract: A distance between a surface of a treatment head and tip opening of a skin treatment hand piece is adjustable. In an implementation, the distance is adjusted by moving the tip opening relative to the treatment head surface. Different distances may be used to treat different skin types, problems, and conditions. In an implementation, the hand piece includes a fluid delivery and a vacuum or suction mechanism to provide various therapeutic benefits to the skin.

Abstract: An elastic percutaneous elastic introducer sheath is disclosed which can locally expand and reduce to accommodate a transcatheter medical device. The elastic introducer sheath includes a non-circumferentially continuous elastic frame, a liner, and a jacket.

Abstract: A vein filter can switch from a collapsed state to a deployed filtering state and further from this filtering state to an open non-filtering state. The filter includes a plurality of primary filter legs and a plurality of secondary filter legs. The primary filter legs are grouped at one end in a common filter head. One secondary filter leg is connected to each of the primary filter legs in proximity of the filter head. Each secondary filter leg is connected to the adjacent primary leg to which it is not already fixed in proximity of the filter head by a connecting wire attached in the area of the free ends of the legs.