Abstract: A drinking straw having an internal coating for delivery of an active agent when the straw is used to consume a beverage is provided. The active agent includes sweetener, flavour, a nutrient and/or a pharmaceutical and optionally colour. The coating is prepared by mixing a modified cellulose with water to form a paste or gel. The coating is then used to coat the inside surface of a drinking straw to a thickness of up to 1 mm. The coating is dried to reduce the water content to less than 5% by weight. Liquid drawn through the straw breaks down the modified cellulose releasing the active agent into the liquid, for consumption.

Abstract: The disclosure relates to antimicrobial compositions and their methods of use and manufacture. In particular, the antimicrobial compositions described herein comprise an antimicrobial active, a primary foaming agent, and an L-amino acid to provide rapid antimicrobial efficacy. In a preferred embodiment, the antimicrobial compositions are dermal cleansers. In a most preferred embodiment, the antimicrobial compositions comprise a foam structure enhancing agent.

Abstract: The N2,N4-disubstituted pyrimidine-2,4-diamine derivative compounds are antibacterial agents having broad spectrum antibacterial activity. The present N2,N4-disubstituted pyrimidine-2,4-diamine compounds have antimicrobial activity against various susceptible and resistant gram-positive and gram-negative bacteria as well as drug resistant bacteria, such as MRSA and VRSA. The molecular target of these compounds was identified as DNA Gyrase B. Based on their pharmacological profiles, the present compounds may find important clinical applications for severe infectious diseases and tuberculosis.

Abstract: An herbicidal composition and method. An herbicidal composition including of one or more herbicidally active ingredients dissolved and/or suspended in an MCPA-2-ethylhexyl carrier, where the active ingredient carrier is otherwise oil and solvent free and the composition is chemically and physically stable. A method of preparing an herbicidal composition and a method of controlling weeds are also described.

Abstract: Copper ion treatments for dermatological areas of the body include solutions, creams, lotions, gets, foams, wound dressings, skin patches and suture material, each containing copper ions that bring about therapeutic effects when the copper ion treatments are applied to dermatological tissue. Methods of treating dermatological areas of the body include treatments for use on the skin and nails to treat conditions including disease, infection, inflammation, damaged or injured tissue, tissue needing to be sutured, rashes and other undesirable dermatological conditions.

Abstract: The present invention relates to a functional feed and an oral delivery system for delivery of bioactive macromolecules. The oral delivery system comprises ethylenediammonium alginate which is a vehicle for delivery of macromolecular drugs. The oral delivery system according to the present invention is particularly suitable for use in combination with functional feeds in fish.

Abstract: The present disclosure relates to preservative compositions for and methods of preserving household formulations, such as detergents, or preserving topical cosmetic or toiletry formulations against microbiological contamination or growth. Specifically, the disclosure relates to preservative compositions comprising an effective amount of a quaternary amine compound, an effective amount of an antifungal, and a solvent. Further, the disclosure relates to cosmetic or toiletry formulations comprising such preservative compositions. The disclosure further relates to method of making and using such preservative compositions and such cosmetic or toiletry formulations comprising the same.

Abstract: The present invention provides probiotic compositions for promoting plant growth. The compositions include bacterial cultures of phyllobacteria and rhizobacteria isolated from media supplemented with rare earth elements. Applicants have found that such bacteria act synergistically with rare earth elements to enhance plant growth. Inoculums of the plant growth promoting bacteria for application to plants, plant seeds, or plant growth media are provided. Also provided are methods for stimulating plant growth by applying the bacterial cultures and inoculums.

Abstract: The present invention relates to a composition comprising a selective herbicide, an algal extract and manganese and/or a silicate, to the use of an algal extract, optionally combined with manganese and/or a silicate, to detoxify plants subjected to a treatment by a selective herbicide and to a method for selective herbicide treatment of a crop comprising the simultaneous, combined or sequential application of a selective herbicide and an algal extract, optionally combined with manganese and/or a silicate.

Abstract: The use of a one or more Isoflavonoid compound Signals which may be with an agriculturally acceptable carrier, applied prior to planting, up to 365 days or more, either directly to the seed or transplant of a non-legume crop or a legume crop, or applied to the soil that will be planted either to a non-legume crop or a legume crop, for the purpose of increasing yield and/or improving seed germination and/or improving earlier seed emergence and/or improving nodulation and/or increasing crop stand density and/or improving plant vigour and/or improving plant growth, and/or increasing biomass, and/or earlier fruiting, all including in circumstances of seedling and plant transplanting.

Abstract: The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.

Abstract: The present disclosure relates to a flower-thinning composition, which is safe for honeybees when sprayed at a low concentration, and a flower-thinning method using the same.

Abstract: The present invention provides a method of improving the ability of plants to resistance diseases, comprising using a strain of Bacillus amyloliquefaciens and a Bidens plant extract; and the Bidens plant extract enhances the ability of the Bacillus amyloliquefaciens to inhibit the growth of the Acidovorax avenae subsp. citrulli, increases the metabolic activity of the Bacillus amyloliquefaciens, increases the amount of the biofilm formation of the Bacillus amyloliquefaciens, and maintains the alive number of the Bacillus amyloliquefaciens.

Abstract: Provided herein are radiopharmaceutical compositions and uses thereof. The radiopharmaceutical compositions can comprise one or more stabilizing agents, an aqueous vehicle, and a conjugate that comprises a targeting ligand and a radionuclide bound to a metal chelator. The targeting ligand can be a small molecule compound or a peptide such as a monocyclic peptide. The targeting ligand can be configured to bind with a tumor target. The stabilizing agent can comprise a radiolysis stabilizer, a free metal chelator, and/or a pH stabilizer. Further provided herein are methods of preparing the radiopharmaceutical compositions and methods of treating cancer by administering the described radiopharmaceutical compositions.

Abstract: Disclosed is a method for preparing an attapulgite-based pH-responsive antibacterial material, including: directly spraying a natural aldehyde-based antibacterial agent onto an attapulgite powder under stirring, and constantly stirring the attapulgite powder for 20-30 min; grinding the attapulgite powder in a ball mill for 30-60 min to obtain a ground attapulgite powder; placing the ground attapulgite powder in a stirred tank, and spraying a chitosan-citric acid aqueous solution onto the ground attapulgite powder; after spraying, constantly stirring the ground attapulgite powder for 30-120 min; and finally drying the ground attapulgite powder to obtain a dried attapulgite powder, sieving the dried attapulgite powder to obtain a sieved attapulgite powder, and packaging the sieved attapulgite powder to obtain the antibacterial material.

Abstract: Methods of treating diseases caused by repeat DNA instability are described herein. The methods described herein can inhibit the further expansion of repeat DNA and, in some instances, reduce the size of the repeat DNA (e.g., reduce the number of repeats).

Abstract: The present disclosure relates to parenteral nutrition formulations, including ready-to-use parenteral nutrition formulations which are reconstituted from multi-chamber containers and amino acid formulations. More particularly, the present disclosure is directed to formulations comprising butyrate derivatives, specifically arginine butyrate, for use with adult or pediatric patients. The disclosure further provides for methods of reducing or preventing systemic and local inflammation of patients receiving parenteral nutrition, and methods of maintaining or ameliorating their systemic immunity and local immunity, as well as the patients' gut barrier functions.

Abstract: Described herein are mixtures including as active components at least one specific nitrification inhibitor (compound I) and at least one urease inhibitor (compound II). Also described herein are a method for improving the nitrification-inhibiting effect, or for increasing the health of a plant using mixtures of at least one compound I and at least one compound II and a method of using the mixtures comprising compounds I and compounds II for increasing the health of a plant. Also described herein are agrochemical compositions including these mixtures. Also described herein is plant propagation material including these mixtures or these agrochemical compositions.

Abstract: Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element. The compounds additionally include a detectable element, such as a fluorescent label, a radiolabel, or a chelator. In some cases, the compounds additionally include a quenching element that is released upon reaction with the protease. Also provided are compositions comprising the compounds and methods for using the compounds, for example in labeling a protease in an animal and in visualizing a tumor in an animal.

Abstract: An oral gastro-retentive delivery device is provided which unfolds rapidly upon contact with gastric juice. The device is configured in a collapsed configuration for oral intake and unfolding for gastric retention for a predetermined period of time and eventually reducing in size for passage through the rest of the GI track.