Abstract: A new antitumor antibiotic designated BMY-40800 is produced by fermentation of Streptomyces hygroscopicus ATCC 53653. The new compound inhibits the growth of tumors in experimental animals.
Type:
Grant
Filed:
April 26, 1990
Date of Patent:
July 30, 1991
Assignee:
Bristol-Myers Company
Inventors:
King S. Lam, Jacqueline Mattei, John E. Leet, James A. Matson, Koji Tomita, Murray A. Kaplan
Abstract: The compound 8-Chloroadenosine 3',5'-cyclic phosphate is used to treat malignant tumors in warm blooded animals. Two novel single step syntheses of 8-chloroadenosine 3',5'-cyclic phosphate and other related adenine and adenosine compounds from corresponding adenosine 3', 5'-cyclic phosphate and other respective related adenosine compounds are disclosed.
Type:
Grant
Filed:
December 21, 1987
Date of Patent:
August 29, 1989
Assignee:
Nucleic Acid Research Institute
Inventors:
Roland K. Robins, Ganapathi R. Revankar, Yu-an Chang