Patents Examined by John D. Randolph
  • Patent number: 4360696
    Abstract: A process is disclosed whereby acrylonitrile and diacetone alcohol are reacted in at least 93% sulfuric acid to form a novel intermediate reaction product which is recovered as a crystalline solid, washed with an organic solvent to remove colored oily impurities along with sulfuric acid, and hydrolyzed to produce diacetone acrylamide, a reactive monomer useful for preparing polymeric components of photographic films and adhesives. The intermediate reaction product is identified as 5,6-dihydro-6-hydroxy-4,4,6-trimethyl-2-vinyl-1,3(4H)-oxazine sulfate (1:1).
    Type: Grant
    Filed: June 2, 1980
    Date of Patent: November 23, 1982
    Assignee: American Cyanamid Company
    Inventor: Henry Richmond
  • Patent number: 4349555
    Abstract: Novel compounds of formula I ##STR1## are described wherein R is lower alkyl, phenyl or aralkyl of 7 to 12 carbon atoms, R.sup.1 is hydrogen, lower alkyl, hydroxyloweralkyl, loweralkoxyloweralkyl, lower alkoxy, halogen, formyl, phenyl, phenylalkyl or acetal [CH(OR.sup.2).sub.2 where R.sup.2 is lower alkyl, or two R.sup.4 radicals are joined to form a lower alkylene chain], m is 1 or 2, Z is an anion, A is an alkylene radical having from 1 to 3 carbon atoms, which may be substituted by lower alkyl of 1 to 6 carbon atoms, S is sulphur and X is a benzothiazole, benzimidazole, benzoxazole, or phenyl radical which may be substituted and acid addition or quaternary ammonium salts of compounds wherein X is a benzimidazole radical. The compounds are used for the treatment of ulcers or hypersecretion. Treatment methods are claimed as well as pharmaceutical compositions.
    Type: Grant
    Filed: November 29, 1979
    Date of Patent: September 14, 1982
    Assignee: John Wyeth & Brother Limited
    Inventors: Roger Crossley, David G. Hill
  • Patent number: 4327110
    Abstract: Symmetrical N-substituted bis-carbamoyloximino disulfide compounds exhibit outstanding nematocidal, miticidal and insecticidal activity, coupled with substantially reduced mammalian toxicity and phytotoxicity as compared to known pesticidal compounds having a comparable spectrum of activity against insect, arachnid and nematode pests.
    Type: Grant
    Filed: March 28, 1977
    Date of Patent: April 27, 1982
    Assignee: Union Carbide Corporation
    Inventor: Themistocles D. J. D'Silva
  • Patent number: 4316020
    Abstract: A process for the preparation of isatoic anhydrides of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different and each is hydrogen, alkyl, alkoxy, halogen, nitro, haloalkyl or haloalkoxy, by reacting an isatin of the formula ##STR2## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the stated meanings, with hydrogen peroxide in an acid medium.
    Type: Grant
    Filed: June 2, 1980
    Date of Patent: February 16, 1982
    Assignee: BASF Aktiengesellschaft
    Inventor: Gernot Reissenweber
  • Patent number: 4314845
    Abstract: N.sup.4 -Phenoxyalkanoylsulfanilamides of the formula: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each independently represents hydrogen, halogen, nitro or lower alkyl, R.sup.5 represents hydrogen or lower alkyl, and R.sup.6 represents hydrogen, lower alkoxycarbonyl, lower alkanoyl or carbamoyl) and alkali metal or alkaline earth metal salt thereof, and a herbicidal composition containing at least one of said N.sup.4 -phenoxyalkanoylsulfanilamides are disclosed.
    Type: Grant
    Filed: September 9, 1980
    Date of Patent: February 9, 1982
    Assignee: Shionogi & Co., Ltd.
    Inventors: Kanji Ito, Kenji Ikawa, Hisajiro Yukinaga, Jitsuo Sugita
  • Patent number: 4311643
    Abstract: A process for producing red metal corrinoids comprising reacting yellow metal-free corrinoids having main absorptions .lambda..sub.max of 480 and 290 nm, in a liquid medium, with complex-forming metal ions to give yellow metal corrinoids, and alkalizing said metal corrinoids by treatment with an alkali.
    Type: Grant
    Filed: March 4, 1980
    Date of Patent: January 19, 1982
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH
    Inventors: Volker Koppenhagen, Gerhard Schlingmann, Bernd Dresow, Ortrud Ebelmann
  • Patent number: 4310527
    Abstract: A compound of the formula ##STR1## in which R.sub.1 denotes optionally substituted lower alkyl which is optionally branched at the linking carbon atom, R.sub.2 represents hydrogen or lower alkanoyl and R.sub.3 is a group of the formula --R.sub.3.sup.a --(R.sub.3.sup.b).sub.n -- (Ia), in which R.sub.3.sup.a represents the radical of the formula --N(R.sub.4)-- or --O-- and R.sub.4 represents hydrogen or lower alkyl, R.sub.3.sup.b denotes the radical of the formula --CH.sub.2 -- or, if R.sub.3.sup.a represents --N(R.sub.4)--, denotes the radical of the formula --C(.dbd.O)-- and n represents nought or 1, and a group of the formula Ia, in which n represents 1, can be linked to the carbonyl group of the carbamoyl grouping either via the group R.sub.3.sup.a or the group R.sub.3.sup.b, or acid addition salts thereof, which can be used pharmaceutically can be used as beta-receptor blocking agents for the treatment of disorders in the cardiac rhythm and coronary heart diseases.
    Type: Grant
    Filed: March 8, 1979
    Date of Patent: January 12, 1982
    Assignee: Ciba-Geigy Corporation
    Inventors: Knut A. Jaeggi, Franz Ostermayer, Herbert Schroter
  • Patent number: 4309547
    Abstract: Process for the preparation of (phenoxy- or benzyl-)-phenoxypropionic acids by simultaneous addition of 2-chloropropionic acid (ester) and the double molar amount of an aqueous alkali hydroxide to a solution of a phenoxyphenol or benzylphenol in a solvent forming an azeotropic mixture with water, while continuously distilling off the water formed or introduced.
    Type: Grant
    Filed: May 30, 1980
    Date of Patent: January 5, 1982
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Manfred Koch, Hans J. Nestler
  • Patent number: 4309554
    Abstract: 3-(2-Thiophenesulfonyl)-2-halopropanenitriles of the formula ##STR1## wherein R is H, C.sub.1-4 alkyl, Br or Cl and X is Br or Cl. The compounds have antimicrobial utility.
    Type: Grant
    Filed: April 28, 1980
    Date of Patent: January 5, 1982
    Assignee: The Dow Chemical Company
    Inventor: Christian T. Goralski
  • Patent number: 4308390
    Abstract: Sulphoalkyl and sulphoalkenyl quaternary salts of heterocyclic nitrogen compounds are prepared by reacting heterocyclic compounds containing a tertiary ring nitrogen atom at an elevated temperature with an O-sulphoalkyl or O-sulphoalkenylisourea compound.
    Type: Grant
    Filed: March 6, 1980
    Date of Patent: December 29, 1981
    Assignee: Agfa-Gevaert Aktiengesellschaft
    Inventors: Helmut Kampfer, Max Glass
  • Patent number: 4307231
    Abstract: The invention provides a new vitamin D compound, 1.alpha.,25-dihydroxy-vitamin D.sub.3 26,23-lactone.The compound is characterized by vitamin D-like activity.
    Type: Grant
    Filed: July 18, 1980
    Date of Patent: December 22, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Yoko Tanaka, Herbert E. Paaren, Joseph K. Wichmann
  • Patent number: 4307084
    Abstract: An aqueous, biologically-compatible, reversible, oxygen-carrying system comprising a novel metallated porphine-carbohydrate-fatty acid complex, particularly a novel tetra-(p-carboxyphenyl)porphine-iron(II)-dextran-octanoate complex, useful as a synthetic respiratory pigment, and a method for preparing same. The complexes may be dissolved in a suitable electrolyte and used as a substitute for red blood cells.
    Type: Grant
    Filed: November 28, 1980
    Date of Patent: December 22, 1981
    Assignee: Villanova University
    Inventors: Joseph J. Drabick, Saul I. Shupack
  • Patent number: 4304937
    Abstract: A process of preparing a carboxylic acid amide which comprises reacting (a) an aldehyde with (b) at least one compound selected from the group consisting of ammonia, a primary amine and a secondary amine in the presence of a molecular oxygen-containing gas and palladium metal or platinum metal as the catalyst.
    Type: Grant
    Filed: November 13, 1979
    Date of Patent: December 8, 1981
    Assignee: Asahi Kasei Kogyo Kabushiki Kaisha
    Inventors: Nishikido Joji, Tamura Nobuhiro, Fukuoka Yohei
  • Patent number: 4304719
    Abstract: An iodine-doped polyfluorometallophthalocyanine having the repeating unit [(PcMF) (I).sub.x ] wherein Pc represents a phthalocyanine moiety, M represents a III-A metal selected from the class consisting of aluminum and gallium, and x is from about 0.01 to about 3.4 if M is aluminum and x is from about 0.01 to about 2.3 if M is gallium.
    Type: Grant
    Filed: January 23, 1981
    Date of Patent: December 8, 1981
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Kenneth J. Wynne, Paul Kuznesof, Ronald Nohr, Malcolm Kenney
  • Patent number: 4304907
    Abstract: Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.
    Type: Grant
    Filed: May 10, 1972
    Date of Patent: December 8, 1981
    Assignee: The Upjohn Company
    Inventor: Norman A. Nelson
  • Patent number: 4298750
    Abstract: The novel borane-1,4-thioxane is synthesized by adding the calculated quantity of diborane to 1,4-thioxane. It is a stable liquid at 25.degree. C. The neat liquid is approximately 8.0 M in borane. The product, in spite of the additional oxygen atom in the ring, exhibits the desirable hydroborating and reducing action of borane-methyl sulfide. However, it possesses a major advantage over the latter in that the donor component, 1,4-thioxane, in contrast to methyl sulfide, is readily soluble in water and can be washed out of typical reaction mixtures. This greatly facilitates the synthetic applications of borane-1,4-thioxane over borane-methyl sulfide.
    Type: Grant
    Filed: February 19, 1980
    Date of Patent: November 3, 1981
    Assignee: Aldrich-Boranes, Inc.
    Inventor: Herbert C. Brown
  • Patent number: 4298526
    Abstract: A process for the preparation of pigmentary forms of phthalocyanine and of insoluble polycyclic compounds, wherein the crude pigment is milled in the presence of one or more acids which have a pK of <4.9 and are non-oxidizing under the milling conditions, until the primary particle size is .ltoreq.0.1 .mu.m, the milled material is then finished in the conventional manner in a solvent in the presence or absence of water, and the pigment is isolated.The pigments give very deep colorations and are very easily dispersible in the media in which they are used.
    Type: Grant
    Filed: November 16, 1979
    Date of Patent: November 3, 1981
    Assignee: BASF Aktiengesellschaft
    Inventors: Reinhard Sappok, Fritz Guellich, Karl Roth, Alois Wiesenberger
  • Patent number: 4297491
    Abstract: A process for the preparation of a 2,3-dioxo-1,4-benzoxazine derivative of the formula I ##STR1## where R.sup.1 and R.sup.2 are identical or different and each is hydrogen, alkyl, halogen, haloalkyl, alkoxy, haloalkoxy or nitro, by oxidizing an isatin of the formula II ##STR2## where R.sup.1 and R.sup.2 have the above meanings, with a peroxydisulfate dissolved or suspended in 30-98% strength sulfuric acid.The 2,3-dioxo-1,4-benzoxazine derivatives obtainable by the novel process have fungicidal or fungistatic properties.
    Type: Grant
    Filed: November 3, 1980
    Date of Patent: October 27, 1981
    Assignee: BASF Aktiengesellschaft
    Inventors: Gernot Reissenweber, Dietrich Mangold
  • Patent number: 4297281
    Abstract: A process for halogenating copper phthalocyanine to a halogen content of about 14 to about 15.5 halogen atoms per CuPc molecule, in an aluminium chloride/sulphuryl chloride mixture which contains 8 to 25% by weight, relative to the amount of AlCl.sub.3, of an anhydrous alkali metal halide, characterized in that the AlCl.sub.3 /SO.sub.2 Cl.sub.2 mixture contains 70 to 150% by weight, relative to the amount of AlCl.sub.3, of sulphuryl chloride and the halogenation is carried out under an excess pressure of 1 to 20 bars.
    Type: Grant
    Filed: December 31, 1979
    Date of Patent: October 27, 1981
    Assignee: Bayer Aktiengesellschaft
    Inventor: Diether Wessling
  • Patent number: 4295875
    Abstract: New tetrahydro-1,3-oxazines of the formula ##STR1## where R denotes linear or branched haloalkyl of up to 3 carbon atoms, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are identical or different and each denotes hydrogen or linear or branched alkyl of up to 3 carbon atoms, R.sup.6 denotes hydrogen or linear or branched alkyl of up to 8 carbon atoms, R.sup.7 denotes hyrogen, linear or branched alkyl of up to 8 carbon atoms, alkoxyalkyl of up to 6 carbon atoms or dialkoxyalkyl of up to 8 carbon atoms, and R.sup.6 and R.sup.7 may together form a methylene chain of 4 or 5 carbon atoms.The compounds are antagonistic agents and, as such, increase the tolerance of herbicidal acetanilides by crop plants. Herbicidal agents containing the tetrahydro-1,3-oxazines in combination with haloacetanilides are suitable for combating unwanted plant growth in Indian corn and cereal crops.
    Type: Grant
    Filed: March 24, 1980
    Date of Patent: October 20, 1981
    Assignee: BASF Aktiengesellschaft
    Inventors: Karl Eicken, Wolfgang Rohr, Hans J. Pander, Bruno Wuerzer