Abstract: The present disclosure provides RNA-guided CRISPR-Cas effector proteins, nucleic acids encoding same, and compositions comprising same. The present disclosure provides ribonucleoprotein complexes comprising: an RNA-guided CRISPR-Cas effector protein of the present disclosure; and a guide RNA. The present disclosure provides methods of modifying a target nucleic acid, using an RNA-guided CRISPR-Cas effector protein of the present disclosure and a guide RNA. The present disclosure provides methods of modulating transcription of a target nucleic acid.

Abstract: The present invention relates to methods to improve the absolute rate of homology-directed repair (HDR) and/or to improve the relative rate of HDR compared with non-homologous end joining (NHEJ).

Abstract: The present invention provides: an extracellular matrix of which the biocompatibility is greatly increased through fat removal and decellularization and which contains growth factors so as to control physiological activities of cells; and a method for preparing the same. In addition, the extracellular matrix may be effectively obtained through a solvent extraction process using supercritical fluid, and a preservation solution comprising the extracellular matrix may be preserved for a long time by preventing contamination, and has increased manageability so that usability of the extracellular matrix may be greatly increased.

Abstract: Disclosed are a method for preparing exosomes from bovine placenta, lyophilized powder of the exosomes, as well as a composition containing exosomes from animal placenta and a preparation method and use thereof in anti-wrinkle on skin.