Abstract: Hydroxamic derivatives of the formula (I): ##STR1## in which A represents hydrogen or a grouping which can be readily eliminated;A.sup.1 represents hydrogen or alkyl;Ar represents optionally substituted arylene or heteroarylene;E represents a 1-alkene-1,1-diyl grouping which contains a radical R.sup.1 in the 2-position, or represents a 2-aza-1-alkene-1,1-diyl grouping which contains a radical R.sup.2 in the 2-position, or represents an optionally substituted imino grouping ("azamethylone", N--R.sup.3);G represents a bridge member as defined herein; andZ represents in each case optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aryl or heterocyclyl;are useful as fungicides. Also disclosed is a process for preparing the compounds of formula (I).

Abstract: The invention relates to a pharmaceutical composition comprising a pyrrole derivative of the following formula [1] or a pharmaceutically acceptable salt thereof, or a solvate of either of them, as an active ingredient. ##STR1## (wherein R.sup.1 represents hydrogen or alkoxycar91 bonylamino, R.sup.2 represents alkyl, aryl which may be substituted, aromatic heterocyclyl which may be substituted, unsubstituted amino, monoalkylamino, dialkylamino, or cyclic amino which may be substituted; R.sup.3 represents cyano or carbamoyl; R.sup.4 represents hydrogen or alkyl; E represents alkylene; q is equal to 0 or 1, A represents methyl, aryl which may be substituted, or aromatic heterocyclyl which may be substituted). The pharmaceutical composition of the invention is effective for the treatment of pollakiuria or urinary incontinence.

Abstract: An improved process for the preparation of alkyl 4-halomethyl -2-methylthiazole-5-carboxylate comprising contacting a solution of alkyl 4-(halo)-2-chloroacetoacetate in acetonitrile with thioacetamide in the presence of an amine, such as triethylamine.