Patents Examined by John F. Terapane
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Patent number: 4789543Abstract: An hepatobiliary imaging agent is disclosed which is a neutral complex of Tc-99m, a complexing ion, SO.sub.2, and a mono or polydentate organic ligand having one or more donor atoms for complexing with TC-99m to form the neutral complex.Type: GrantFiled: November 30, 1984Date of Patent: December 6, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventor: Karen E. Linder
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Patent number: 4789541Abstract: A composition containing stannous chloride and potassium perchlorate is suitable for oral administration to a patient for tinning red blood cells of the patient in vivo prior to labeling the red blood cells with radioactive .sup.99m Tc. The composition is useful for preparing a patient for blood pool imaging, and especially for carrying out equilibrium gated cardiac imaging.Type: GrantFiled: June 16, 1987Date of Patent: December 6, 1988Inventor: Michael H. Davis
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Patent number: 4788048Abstract: A process for conversion of gaseous UF.sub.6 to UO.sub.2 powders by using a fluidized bed reaction apparatus comprising pyrohydrolizing gaseous UF.sub.6 and steam to obtain UO.sub.2 F.sub.2 particles, hydrating and dehydrating the UO.sub.2 F.sub.2 particles to UO.sub.2 F.sub.2 anhydride and reducing the UO.sub.2 F.sub.2 anhydride to UO.sub.2 powders. The obtained UO.sub.2 powders are suitable for production of nuclear fuels in power plant owing to its good ceramic properties, low fluorine contents and free flowability.Type: GrantFiled: June 9, 1986Date of Patent: November 29, 1988Assignee: Mitsubishi Kinzoku Kabushiki KaishaInventors: Hiroshi Tanaka, Akio Umemura
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Patent number: 4787990Abstract: Disclosed is a low toxicity oil for use in drilling fluids. The oil consists essentially of branched- and cyclic-paraffins having 11 to 17 carbon atoms per molecule and further having a low aromatic content of less than about 1% and a low normal-paraffin content of less than about 5%. The low polynuclear aromatic oil is useful in both oil-based and water-based drilling mud, particularly where low toxicity and lack of water sheen are important such as in offshore drilling environments. The oil also has the advantage of being non-fluorescent so that it does not mask UV fluorescence of formation crudes produced from the drill cuttings in wildcatting operations.Type: GrantFiled: February 4, 1983Date of Patent: November 29, 1988Assignee: Conoco Inc.Inventor: Phillip A. Boyd
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Patent number: 4786681Abstract: The invention provides a process for producing a water-in-oil emulsion of a water-soluble polyacrylamide or polyacrylic acid polymer or copolymer by the inverse emulsion process characterized in that there is used as the emulsifying agent for the water-in-oil emulsion a water-insoluble, oil-soluble surface active agent of the formula (I):X--Y--Z Ior a functional derivative thereof, wherein X- represents a saturated or unsaturated hydrocarbon chain containing from 30 to 500 carbon atoms, --Y-- represents a succinic anhydride residue carried terminally upon the group X--, and --Z represents a hydrophilic group carried by the group --Y--.Type: GrantFiled: August 12, 1986Date of Patent: November 22, 1988Assignee: Imperial Chemical Industries PLCInventors: Alan S. Baker, Stephen J. Butterworth, Ravinder K. Jheeta
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Patent number: 4784843Abstract: Dicyclohexylalkanes, their preparation, cosmetic and pharmaceutical formulations containing these compounds, and their use in these formulations as oil components for cosmetic and pharmaceutical purposes.Type: GrantFiled: February 20, 1986Date of Patent: November 15, 1988Assignee: BASF AktiengesellschaftInventors: Adolph Segnitz, Knut Oppenlaender, Paul Naegele
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Patent number: 4783312Abstract: A radial neutron reflector for a water moderated nuclear reactor. The space surrounding the nuclear core is provided with a plurality of side-by-side stacked reflector roads having a square cross-sectional shape. Blocks of reflector material having axial grooves are fitted within a square enclosure. The assembly is subjected to high pressures and temperatures which collapse the enclosure onto the blocks eliminating the assembly clearance. The enclosure material flows into the grooves of the blocks leaving wrinkle-free surfaces over the flat remainder of the enclosure. Square shaped reflector rods result in high solid-to-void ratios in the radial reflector region of the reactor. The resulting grooves allow for coolant flow and cooling of the rods.Type: GrantFiled: August 8, 1986Date of Patent: November 8, 1988Assignee: Westinghouse Electric Corp.Inventors: Robert K. Gjertsen, John F. Wilson
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Patent number: 4783305Abstract: A generator of radionuclides comprises a generator column (10) containing the radionuclide and provided with an inlet (12) and an outlet (14) for eluent, first and second reservoirs (16, 18) for eluent, and connecting means for passing a pre-determined column of eluent from the second reservoir through the generator column. A part defining the second reservoir, which part may be the second reservoir itself, is rotatable to determine the volume of eluent passed through the column. The second reservoir is preferably shaped as a sector of a cylinder rotatable around a horizontal axis.The generator is well suited for vacuum elution of a variable pre-determined volume of eluent into a single size collection vial with subsequent drying of the generator column.Type: GrantFiled: March 11, 1987Date of Patent: November 8, 1988Assignee: Amersham International plc.Inventor: Terence R. F. Forrest
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Patent number: 4782190Abstract: 4-Nitrophenetol is prepared by reaction of 4-chloronitrobenzene with ethanol and alkali metal hydroxides in the presence of phase-transfer catalysts by carrying out the reaction at temperatures from 60.degree. to 95.degree. C. and under pressure in the presence of oxygen-containing gases diluted with inert gases, there being at the start of the reaction 0.2 to 1.0 mol of alkali metal hydroxide metered each hour into the reaction mixture for each 1 mol of 4-chloronitrobenzene.Type: GrantFiled: March 6, 1987Date of Patent: November 1, 1988Assignee: Bayer AktiengesellschaftInventors: Josef Kasbauer, Karlfried Wedemeyer
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Patent number: 4781989Abstract: A surface-coated cutting member includes a substrate, a metal layer vapor-deposited on a surface of the substrate and a hard coating vapor-deposited on the metal layer. The substrate is made of hard material selected from the group consisting of tungsten carbide-based cemented carbide, titanium carbo-nitride based cermet and high speed steel. The metal layer is made of metal selected from Group IVa of the Periodic Table and has an average thickness of 0.1 to 1 .mu.m. The hard coating has an average thickness of 1 to 9 .mu.m, and includes an inner layer of an average thickness of 0.2 to 4 .mu.m vapor-deposited on the metal layer, an intermediate layer of an average thickness of 0.2 to 4 .mu.m vapor-deposited on the inner layer and an outer layer of an average thickness of 0.2 to 3 .mu.m vapor-deposited on the intermediate layer.Type: GrantFiled: March 5, 1987Date of Patent: November 1, 1988Assignee: Mitsubishi Kinzoku Kabushiki KaishaInventors: Hironori Yoshimura, Munenori Kato
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Patent number: 4781912Abstract: The invention relates to a cationic complex of technetium-99m with(a) at least one bidendate ligand X having the formulaR.sub.1 R.sub.2 ZQZR.sub.3 R.sub.4whereeach Z is phosphorus or arsenic,Q is a (CH.sub.2).sub.n linking group where n is 2 to 8 or a 1,2-phenylene linking group,each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is hydrogen, C.sub.1 to C.sub.5 alkyl or phenyl; and(b) at least one monodentate isonitrile ligand Y.The invention also relates to a radiopharmaceutical composition comprising said complex, to a kit for preparing said composition, and to the use of said composition for a radiodiagnostic examination.Type: GrantFiled: December 15, 1986Date of Patent: November 1, 1988Assignee: Mallinckrodt, Inc.Inventors: Giuseppe D. Zanelli, Frank Brady, Niranjan M. Patel, Avijit Lahiri
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Patent number: 4780560Abstract: Novel nitrate derivatives are disclosed. As examples of said nitrate derivative are described N-(.beta.-hydroxyethyl)-5-(3,4,5-trimethoxyphenyl)2,4-pentadienoic acid amide nitrate, N-(.beta.-hydroxyethyl)-3,4,5-trimethoxycinnamic acid amide nitrate and the like. These nitrate derivatives are useful as vasodilators.Type: GrantFiled: March 2, 1987Date of Patent: October 25, 1988Assignee: Terumo CorporationInventors: Takahiro Kumonaka, Shigeru Taguchi, Yasushi Suwabe, Toshio Wakabayashi
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Patent number: 4780243Abstract: Apparatus and methods are provided for producing a proppant carrying foamed fracturing fluid or the like having very high ratios of proppant material to the liquid phase of the foam, which can be substantially higher than even the theoretical maximum ratio available when the proppant is introduced into a foaming apparatus as a proppant/liquid slurry. This is accomplished by a dry sand foam generation process wherein the sand or other particulate material is introduced into a foam generator apparatus as a dry particulate material in a stream of gas which is subsequently mixed with a second liquid stream.Type: GrantFiled: May 19, 1986Date of Patent: October 25, 1988Assignee: Halliburton CompanyInventors: Kevin D. Edgley, James L. Stromberg
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Patent number: 4780245Abstract: The instant invention relates to liquid compositions useful in cosmetic applications comprising a polysiloxane selected from the group consisting of cyclic and non-cyclic dimethyl polysiloxanes and mixtures thereof, at least one nonionic polyoxyalkylene block copolymer, and water. This polyoxyalkylene copolymer is a cogeneric mixture of conjugated polyoxyalkylene compounds containing in their structure the residue of an active hydrogen-containing compound having from 2 to 4 carbon atoms, 2 to 4 active hydrogen atoms at least one hydrophobic oxyalkylene chain in which the oxygen-carbon atom ratio does not exceed 0.4 and at least one hydrophilic oxyalkylene chain in which the oxygen-carbon atom ratio is greater than 0.4 and water.Type: GrantFiled: March 19, 1986Date of Patent: October 25, 1988Assignee: BASF CorporationInventors: John J. Burke, Robert R. Roelofs
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Patent number: 4780273Abstract: A nuclear reactor fuel assembly for accommodating mutually parallel rods disposed side by side therein includes a spacer formed of two mutually parallel grid sections, each of the grid sections including outer straps flatly facing the rods, each of the grid sections including main sleeves being positioned like positions of the same color in rows and columns disposed at right angles on a chess board leaving a free intermediate position between each two occupied positions, the main sleeves dividing the grid sections into grid mesh openings at the positions each able to receive a respective rod therein, each main sleeve in one of the grid sections being aligned with a main sleeve in the other grid section forming pairs of main sleeves, connecting straps each interconnecting the main sleeves of a pair of main sleeves forming contact springs for rods, each of the connecting straps having a width being smaller than the circumference of one of the main sleeves, and spacer sleeves each being disposed between and restType: GrantFiled: February 6, 1986Date of Patent: October 25, 1988Assignee: Kraftwerk Union AktiengesellschaftInventor: Heinrich Dressel
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Patent number: H543Abstract: This disclosure pertains to an electrodeposited chromium composite having ternating layers of high contraction and low contraction chromium. The laminated composite properties are enhanced because of thin layers of the same metal existing under different states of hardness, stress, orientation and microstructure. Thin layers of HC chromium are produced with a random orientation, low residual stress, and crack-free structure. The alternating LC chromium layers tend to duplicate the random structure of HC chromium through epitaxial growth. Accordingly, crack-free laminated chromium are produced having hardness values ranging from 655 to 1084 Knoop Hardness Numbers. By comparison, conventional high-contraction chromium shows hardness values between 1000 and 1100 KHN. However, the latter deposits are invariably micro-cracked.Type: GrantFiled: October 10, 1986Date of Patent: November 1, 1988Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Edward S. Chen, George P. Capsimalis
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Patent number: H545Abstract: The present invention involves labeling monoclonal antibodies with intermediate half-life radionuclides which decay to much shorter half-life daughters with desirable high energy beta emissions. Since the daughter will be in equilibrium with the parent, it can exert an in-situ tumoricidal effect over a prolonged period in a localized fashion, essentially as an "in-vivo generator". This approach circumvents the inverse relationship between half-life and beta decay energy. Compartmental modeling was used to determine the relative distribution of dose from both parent and daughter nuclei in target and non-target tissues. Actual antibody biodistribution data have been used to fit realistic rate constants for a model containing tumor, blood, and non-tumor compartments. These rate constants were then used in a variety of simulations for two generator systems, Ba-128/Cs-128 (t.sub.1/2 =2.4d/3.6m) and Pd-112/Ag-112 (t.sub.1/2 =0.9d/192m).Type: GrantFiled: October 30, 1987Date of Patent: November 1, 1988Assignee: The United States of America as represented by the United States Department of EnergyInventors: Leonard F. Mausner, Suresh G. Srivastava, Rita F. Straub
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Patent number: H547Abstract: A composite target for an X-ray tube has a graphite substrate portion and a metal portion, the two portions being bonded together by successive interspersed layers of platinum and tantalum. The platinum layer is disposed between the graphite substrate portion and the tantalum layer. The tantalum layer acts to bond the metal portion to the platinum layer and also acts as an isolator to prevent the formation of carbides by migration through the bonding layers.Type: GrantFiled: November 13, 1986Date of Patent: November 1, 1988Assignee: General Electric CompanyInventors: Andrew L. Lux, Robert M. Guezuraga
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Patent number: H558Abstract: Radiation pellets having an outer shell, preferably, of Mo, W or depleted U nd an inner filling of lithium hydride wherein the outer shell material has a greater melting point than does the inner filling material.Type: GrantFiled: February 27, 1987Date of Patent: December 6, 1988Assignee: The United States of America as represented by the Department of EnergyInventors: Edmund P. Coomes, Andrzej T. Luksic
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Patent number: H559Abstract: A method for curing resin in the fabrication of a composite material is described comprising enclosing the composite material within a flexible vacuum enclosure, and substantially simultaneously pressing the material within the enclosure between first and second platens of a press to preselected pressure, evacuating the enclosure, selectively heating one of the platens according to a preselected scheme to preselected cure temperature to cure the resin within the material, and cooling the other platen to maintain a preselected temperature differential between the platens across the thickness of the material, whereby cure of the resin is effected in the material first near the heated platen and progresses through the thickness of the material toward the cooler platen as the material is heated to the cure temperature.Type: GrantFiled: May 12, 1987Date of Patent: December 6, 1988Assignee: The United States of America as represented by the Secretary of the Air ForceInventor: Scott C. Brown