Abstract: The present invention discloses a system and method for providing sealable access to a viscus region or hollow organ and performing surgical procedures therein. The present invention is particularly useful in providing access to a patients heart without arresting the heart. The access system comprises a tissue stabilizer to provide a stable work area in a dynamic environment. A puncture device is inserted into the tissue stabilizer, which forms a puncture hole within the heart tissue. Thereafter, a sealing device, for example a sealing balloon, is inserted through the puncture hole and engages the interior tissue. A sealing cannula may then be advanced into and sealably engages the tissue.